Risteys · CD2_BENIGN

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D11 Cause of death: ICD-10 — D11 2 out of 7 registries used, show all original rules.	3456
4. Check minimum number of events None	3456
5. Include endpoints CD2_BENIGN_PAROTID CD2_BENIGN_SALIVARY_NOS	3853
6. Filter based on genotype QC (FinnGen only)	3853

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	24561	12823	11557
Only index persons	21875	11713	10162
Unadjusted period prevalence (%)
Whole population	0.35	0.37	0.32
Only index persons	0.41	0.43	0.39
Median age at first event (years)
Whole population	58.45	58.19	58.72
Only index persons	57.54	57.27	57.85

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	3853	1999	1854
Unadjusted period prevalence (%)	0.75	0.68	0.82
Median age at first event (years)	58.20	55.57	61.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
3462: Matched controls
34622

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D11.70

ICD-10 Finland

Gland sublingual

3720.9

323.0

347

D11.0

ICD-10 Finland

Benign neoplasm: Parotid gland

4503599627370496.0

323.0

2700

ELB40

NOMESCO Finland

Partial parotidectomy

1452.9

323.0

1497

EP1AE

NOMESCO Finland

Neck ultrasound examination

10.7

323.0

761

888

R22.1

ICD-10 Finland

Localized swelling, mass and lump, neck

13.4

301.3

552

483

EL4AT

NOMESCO Finland

Salivary gland cytology with ultrasound guidance

188.0

252.0

261

2102A

ICD-9 Finland

Benign neoplasm of lip, oral cavity and pharynx, Major salivary glands

+∞

226.6

215

21020

ICD-8 Finland

Benign neoplasm of buccal cavity and pharynx, Salivary gland

+∞

214.8

204

ELB30

NOMESCO Finland

Excision of submandibular gland

67.5

211.9

245

ELB00

NOMESCO Finland

Excision or exploration of lesion of salivary gland

363.3

207.2

207

D37.00

ICD-10 Finland

Aryepiglottic fold marginal zone

66.9

174.5

202

ELB50

NOMESCO Finland

Total parotidectomy

147.7

172.1

182

D11.9

ICD-10 Finland

Benign neoplasm: Major salivary gland, unspecified

705.8

138.8

136

4405

FHL

Partial removal of the parotid gland

151.2

137.4

145

EL3AE

NOMESCO Finland

Salivary gland ultrasound examination

35.0

130.0

170

WX408

NOMESCO Finland

General anesthesy, balanced

2.5

118.6

1231

6219

EP1CG

NOMESCO Finland

Extensive MRI examination of soft tissue of neck with high intesity magnet

14.7

115.5

199

143

C07.70

ICD-10 Finland

Malignant tumor of the superficial part of the parotid gland

125.3

112.8

121

K11.2

ICD-10 Finland

Sialoadenitis

7.1

101.4

262

396

XW1AT

NOMESCO Finland

Biopsy from other organ close to skin with ultrasound quidance

23.8

100.9

146

R22.0

ICD-10 Finland

Localized swelling, mass and lump, head

5.6

70.5

216

406

EP1DG

NOMESCO Finland

Very extensive examination of soft tissue of neck with high intesity magnet

16.0

67.9

112

ZXE10

NOMESCO Finland

More than one and less than three hours

1.8

56.1

1338

8881

ZXE20

NOMESCO Finland

More than three and less than five hours

2.3

54.8

590

2853

ZXA05

NOMESCO Finland

Left side

1.9

54.8

1001

6042

R59.0

ICD-10 Finland

Localized enlarged lymph nodes

4.9

54.6

186

394

ZXD10

NOMESCO Finland

Scheduled procedure

1.8

51.0

1389

9539

ZXA00

NOMESCO Finland

Right side

1.9

50.5

1041

6521

EP2AT

NOMESCO Finland

Neck soft tissue cytology with ultrasound guidance

28.9

50.1

D11.7

ICD-10 Finland

Benign neoplasm: Other major salivary glands

+∞

43.8

WX402

NOMESCO Finland

General anaesthesia

2.0

42.7

608

3293

PJD41

NOMESCO Finland

Excision of cervical lymph nodes

7.3

41.5

102

143

K11.9

ICD-10 Finland

Disease of salivary gland, unspecified

14.4

39.9

4404

FHL

Complete removal of the parotid gland

391.8

39.1

PJD81

NOMESCO Finland

Excision of lymph nodes from upper part of neck

12.0

39.0

EL3AT

NOMESCO Finland

Salivary gland biopsy with ultrasound guidance

74.4

39.0

QX4AT

NOMESCO Finland

Ultrsound guided needle biopsy of skin

16.9

37.6

ELB99

NOMESCO Finland

Other excision of salivary gland

361.0

36.0

R22.9

ICD-10 Finland

Localized swelling, mass and lump, unspecified

2.6

35.8

274

1097

C07.71

ICD-10 Finland

Malignant tumor in the deep part of the parotid gland

181.8

34.8

J01DB01

ATC

cefalexin; oral

1.6

33.4

2684

23439

PJ3AT

NOMESCO Finland

Cytology of lymphnode with ultrasound guidance

6.7

31.8

124

S04

ICPC

Lump/swelling localized

2.3

31.7

321

1484

8550/3-C07.9

ICD-O-3

Acinar cell carcinoma of parotid gland

315.6

30.9

EN1BD

NOMESCO Finland

Very extensive CT examination of mouth and soft tissues of neck

5.1

30.2

194

BA3AT

NOMESCO Finland

Cytology of thyroid with ultrasound quidance

4.9

26.5

187

WX110

NOMESCO Finland

Local anesthesy

1.5

26.3

2137

18063

L04.0

ICD-10 Finland

Acute lymphadenitis of face, head and neck

7.4

25.9

DWD00

NOMESCO Finland

Reoperation for superficial heamorrhage in surgery of ear, nose and larynx

32.3

24.6

TDW99

NOMESCO Finland

Other minor procedure in surgery of ear, nose and larynx

3.1

24.4

139

461

8430/3-C07.9

ICD-O-3

Mucoepidermoid carcinoma of parotid gland

+∞

24.0

S18

ICPC

Laceration/cut

1.5

23.7

1342

10454

N02BE01

ATC

paracetamol; systemic, rectal

1.6

23.6

2836

25714

Z71.2

ICD-10 Finland

Person consulting for explanation of investigation findings

1.6

22.0

718

4929

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

1.9

21.8

357

2004

UDQ12

NOMESCO Finland

Flexible laryngoscopy

2.3

20.1

198

904

C08.89

ICD-10 Finland

Malignant overall tumor the large salivary glands anna or unspecified histology

73.9

19.7

EP1CM

NOMESCO Finland

Extensive MRI examination of soft tissue of neck with 3 Tesla magnet

16.5

19.6

PJD91

NOMESCO Finland

Excision of lymph nodes in neck, 1 to 2 areas in total

21.7

19.5

EN1AD

NOMESCO Finland

CT examination of mouth and soft tissues of neck

5.3

18.1

105

K11.88

ICD-10 Finland

Other diseases of salivary glands

15.7

17.5

ZXE30

NOMESCO Finland

More than five and less than seven hours

2.2

17.4

182

854

J01DA01

ATC

[U] cefalexin; systemic

1.4

17.4

1963

16951

C83.80

ICD-10 Finland

B-cell lymphoma in marginal zone

11.1

17.2

R03BB04

ATC

tiotropium bromide; inhalant

1.7

17.1

341

2037

C08.94

ICD-10 Finland

Mucoepidermoid carcinoma of an unspecified large salivary gland

+∞

16.7

D11.71

ICD-10 Finland

Gland submandibular

+∞

16.7

C08.09

ICD-10 Finland

Malignant tumor of the submandibular or submaxillary gland, other or unspecified histology

90.5

16.6

TQA05

NOMESCO Finland

Puncture of skin of head or neck

27.7

16.5

R59.1

ICD-10 Finland

Generalized enlarged lymph nodes

3.9

16.0

168

C82.1

ICD-10 Finland

Follicular lymphoma grade II

6.2

15.9

C08.99

ICD-10 Finland

Malignant tumor of unspecified large salivary gland, other or unspecified histology

85.5

15.6

TPJ05

NOMESCO Finland

Needle biopsy of lymph node

38.2

15.4

B02

ICPC

Lymph gland(s) enlarged/painful

6.6

15.3

4403

FHL

Submandibular gland removal

14.0

15.0

ZY020

NOMESCO Finland

Telephone, letter or other consultation without direct patient contact

1.9

14.9

210

1114

K11.3

ICD-10 Finland

Abscess of salivary gland

18.4

14.7

TEL00

NOMESCO Finland

Needle biopsy of salivary gland

+∞

14.6

C85.9

ICD-10 Finland

Non-Hodgkin lymphoma, unspecified

5.9

14.5

YA1BD

NOMESCO Finland

Extensive CT examination of head and neck for dose design of radiotherapy

4.4

13.5

110

UDC00

NOMESCO Finland

Ear microscopy

1.8

13.5

221

1240

QAE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in head or neck

1.7

13.4

273

1642

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

1.6

13.3

327

2073

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.4

12.8

951

7570

Q18.0

ICD-10 Finland

Sinus, fistula and cyst of branchial cleft

7.2

12.7

C08.90

ICD-10 Finland

Malignant tumor in unspecified large salivary gland without histology

+∞

12.5

9699/3-C07.9

ICD-O-3

Marginal zone B-cell lymphoma, NOS, of parotid gland

+∞

12.5

PJD71

NOMESCO Finland

Extended sparing excision of cervical lymph nodes

5.0

12.4

M01AE03

ATC

ketoprofen; systemic, rectal

1.3

12.4

1160

9550

EP1BG

NOMESCO Finland

MRI examination of soft tissue of neck with high intesity magnet

6.9

12.4

ZXE00

NOMESCO Finland

One hour or less

1.3

12.3

1174

9690

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.4

12.3

595

4389

SPAT1153

SPAT

Removal of sutures

1.3

12.3

960

7690

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

1.4

12.3

716

5469

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.3

12.0

1149

9485

E04.2

ICD-10 Finland

Nontoxic multinodular goitre

2.2

11.9

123

576

K11.5

ICD-10 Finland

Sialolithiasis

3.4

11.4

161

J01FF01

ATC

clindamycin; systemic

1.4

11.3

784

6153

ZXC99

NOMESCO Finland

Other special technic in surgery

12.7

11.1

NAR20

NOMESCO Finland

Complete excision of soft tissue tumour of spine, unspecified

12.7

11.1

CBK11

NOMESCO Finland

Operation for lagophtalmus with implant

12.7

11.1

C77.0

ICD-10 Finland

Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck

5.6

11.0

WF003

NOMESCO Finland

Adjuvant radiotherapy

2.1

10.9

117

560

EP1AE

SPAT

3.5

10.8

137

K11.4

ICD-10 Finland

Fistula of salivary gland

60.2

10.6

JN4KR

NOMESCO Finland

Whole body very extensive metabolic PET with CT

4.4

10.6

A10BA02

ATC

metformin; oral

1.3

10.5

839

6718

4402

FHL

Removal or exploration of a salivary change (eg ranula)

+∞

10.4

UDH02

NOMESCO Finland

Rhinopharyngoscopy

1.8

10.4

187

1080

N02AX02

ATC

tramadol; systemic, rectal

1.3

10.3

1266

10748

Z3231

NOMESCO Finland

Registered nurse

1.3

10.3

798

6354

J44.0

ICD-10 Finland

Chronic obstructive pulmonary disease with acute lower respiratory infection

1.9

10.3

145

773

C82.01

ICD-10 Finland

Follicular nodular lymphoma, grade I

7.1

10.3

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.3

10.1

1318

11274

D44.0

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Thyroid gland

3.1

10.0

178

J44.9

ICD-10 Finland

Chronic obstructive pulmonary disease, unspecified

1.9

10.0

138

730

ELW99

NOMESCO Finland

Other operation on salivary gland

26.1

9.8

Z72.0

ICD-10 Finland

Tobacco use

2.4

9.7

332

EWE00

NOMESCO Finland

Reoperation for deep haemorrhage in surgery of teeth, jaws, mouth and pharynx

13.4

9.7

C08.00

ICD-10 Finland

Malignant tumor of submandibular or submaxillary gland, not histology

55.1

9.6

A02BC02

ATC

pantoprazole; systemic

1.3

9.6

1977

17812

A07AA02

ATC

nystatin; oral

1.7

9.6

185

1093

C83.31

ICD-10 Finland

Diffuse lymphoma with large B cells

3.1

9.6

162

J44.1

ICD-10 Finland

Chronic obstructive pulmonary disease with acute exacerbation, unspecified

2.1

9.5

100

477

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

1.5

9.5

297

1998

Z2221

NOMESCO Finland

Medical doctor

1.3

9.4

787

6330

8070/3-C07.9

ICD-O-3

Squamous cell carcinoma, NOS, of parotid gland

+∞

9.4

C73.91

ICD-10 Finland

Papillary carcinoma of the thyroid gland (thyroid gland)

3.1

9.1

162

C07

ICD-10 Finland

Malignant neoplasm of parotid gland

36.8

9.0

130

Kela drug reimbursment

Malignant tumour

1.6

9.0

238

1539

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

1.8

8.9

151

860

AAH50

NOMESCO Finland

Cranial nerve anastomosis

18.6

8.9

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

1.8

8.6

133

734

R02

ICPC

Shortness of breath/dyspnoea

1.5

8.6

321

2243

EP1DM

NOMESCO Finland

Very extensive MRI examination of soft tissue of neck with 3 Tesla magnet

11.6

8.6

K11.1

ICD-10 Finland

Hypertrophy of salivary gland

16.3

8.5

Z01.8

ICD-10 Finland

Other specified special examinations

1.3

8.5

588

4587

8260/3-C73.9

ICD-O-3

Papillary adenocarcinoma, NOS, of thyroid gland

3.1

8.5

148

EP3AT

NOMESCO Finland

Neck soft tissue biopsy with ultrasound guidance

20.1

8.5

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

1.9

8.4

125

682

ELB70

NOMESCO Finland

Excision of parotid gland neoplasm or other lesion extending into parapharyngeal space

+∞

8.3

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

1.5

8.2

271

1844

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

1.7

8.2

158

937

ELA30

NOMESCO Finland

Biopsy of salivary gland

7.5

8.1

H02AB06

ATC

prednisolone; systemic

1.2

8.1

1367

11950

UGC12

NOMESCO Finland

Flexible bronchoscopy

1.6

8.1

229

1506

YA1CD

NOMESCO Finland

Very extensive CT examination of head and neck for dose design of radiotherapy

6.8

8.1

UDQ22

NOMESCO Finland

Microlaryngoscopy

3.8

8.0

JN4BD

NOMESCO Finland

Extensive body CT

1.5

8.0

315

2228

C03CA01

ATC

furosemide; systemic

1.3

8.0

849

7029

R03AC02

ATC

salbutamol; inhalant

1.2

7.8

1486

13153

Z3226

NOMESCO Finland

Physiotherapist

1.3

7.7

511

3955

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.2

7.7

1161

10010

J01AA02

ATC

doxycycline; systemic

1.2

7.7

2421

22571

R61.0

ICD-10 Finland

Localized hyperhidrosis

6.4

7.7

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.2

7.7

1410

12420

J01CE02

ATC

phenoxymethylpenicillin; oral

1.2

7.6

1981

18092

K11

ICD-10 Finland

Diseases of salivary glands

11.9

7.6

PJA10

NOMESCO Finland

Exploration of lymph nodes

2.8

7.5

162

D14.0

ICD-10 Finland

Benign neoplasm: Middle ear, nasal cavity and accessory sinuses

3.4

7.5

101

K11.0

ICD-10 Finland

Atrophy of salivary gland

80.3

7.4

8200/3-C07.9

ICD-O-3

Adenoid cystic carcinoma of parotid gland

80.3

7.4

EP1AT

NOMESCO Finland

Punction of soft tissue of neck with ultrasound guidance

13.4

7.4

ZXD05

NOMESCO Finland

Urgent procedure

1.3

7.3

848

7080

SAA03

NOMESCO Finland

Extended examination of mouth

1.2

7.3

996

8479

R4110

NOMESCO Finland

Physiotherapy

1.3

7.3

751

6180

C08.92

ICD-10 Finland

Coastal adenocarcinoma of unspecified salivary gland

+∞

7.3

8147/3-C07.9

ICD-O-3

Basal cell adenocarcinoma of parotid gland

+∞

7.3

4704

FHL

Neck tumor removal

9.4

7.3

QAA99

NOMESCO Finland

Other local destruction of skin of head or neck

5.8

7.2

C82.00

ICD-10 Finland

Follicular nodular non-Hodgkin's lymphoma, ungraded

7.3

7.2

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

2.4

7.1

248

8500/3-C07.9

ICD-O-3

Infiltrating duct carcinoma, NOS, of parotid gland

30.1

7.1

YA1AD

NOMESCO Finland

CT examination of head and neck for dose design of radiotherapy

3.3

7.1

100

T90

ICPC

Diabetes non-insulin dependent

1.3

7.1

657

5335

N07BA03

ATC

varenicline; oral

1.7

7.1

129

755

L28

ICPC

Limited function/disability (L)

1.4

7.1

434

3320

P01AB01

ATC

metronidazole; oral, rectal

1.2

7.0

1094

9446

XX3DW

NOMESCO Finland

Time consuming IT work

1.4

7.0

286

2036

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.2

7.0

1313

11563

A03FA01

ATC

metoclopramide; systemic, rectal

1.3

7.0

559

4450

QAA05

NOMESCO Finland

Incision for biopsy of skin of head or neck

2.1

6.9

346

G51.0

ICD-10 Finland

Bell palsy

2.1

6.9

338

R59.9

ICD-10 Finland

Enlarged lymph nodes, unspecified

3.3

6.8

D37.09

ICD-10 Finland

Lip, oral cavity and pharynx

10.9

6.8

103

Kela drug reimbursment

Diabetes, insulin-treated

1.3

6.8

784

6544

XW1XT

NOMESCO Finland

Biopsy from other organ close to skin with other quidance

40.1

6.8

C08.02

ICD-10 Finland

Cystic adenocarcinoma of the submandibular or submaxillary glands

40.1

6.8

K11.70

ICD-10 Finland

Hypoptyalism

3.8

6.7

D17.0

ICD-10 Finland

Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck

2.4

6.7

229

QAE30

NOMESCO Finland

Excision and repair of surgical scar in head or neck

7.2

6.7

215

Kela drug reimbursment

Diabetes, non-insulin-treated

1.3

6.7

690

5678

ZZK00

NOMESCO Finland

Graft of nerve

22.5

6.7

C82.9

ICD-10 Finland

Follicular lymphoma, unspecified

5.9

6.6

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.3

6.6

525

4177

8941/3-C07.9

ICD-O-3

Carcinoma ex pleomorphic adenoma of parotid gland

70.0

6.4

EJA10

NOMESCO Finland

Biopsy of tongue or floor of mouth

2.3

6.4

242

104

Kela drug reimbursment

Thyroid insufficiency

1.5

6.4

191

1276

DEB00

NOMESCO Finland

Cortical mastoidectomy

14.3

6.4

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

1.4

6.4

312

2298

N30.0

ICD-10 Finland

Acute cystitis

1.4

6.3

338

2529

N02AA05

ATC

oxycodone; systemic

1.3

6.3

394

3022

D14.1

ICD-10 Finland

Benign neoplasm: Larynx

3.5

6.3

BAA60

NOMESCO Finland

Total thyroidectomy

2.1

6.3

326

H03AA01

ATC

levothyroxine sodium; systemic

1.3

6.3

612

5001

8502/3-C07.9

ICD-O-3

Secretory carcinoma of parotid gland

+∞

6.2

8430/3-C08.0

ICD-O-3

Mucoepidermoid carcinoma of submandibular gland

+∞

6.2

C08.91

ICD-10 Finland

Adenocarcinoma of mixed cell type in unspecified large salivary gland

+∞

6.2

D21.0

ICD-10 Finland

Benign neoplasm: Connective and other soft tissue of head, face and neck

4.3

6.2

H92.0

ICD-10 Finland

Otalgia

1.7

6.1

115

684

ENB99

NOMESCO Finland

Other excision of pharynx and adjacent structures

12.5

6.1

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

1.5

6.1

196

1333

R52.9

ICD-10 Finland

Pain, unspecified

1.5

6.0

207

1426

D41.0

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Kidney

2.0

6.0

381

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_SALIVARY and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_SALIVARY	1.266 [1.15, 1.4]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.298

During the follow-up period (1.1.1998 — 31.12.2019), 1813 out of 9078 females with CD2_BENIGN_SALIVARY died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_SALIVARY	1.404 [1.27, 1.55]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.016

During the follow-up period (1.1.1998 — 31.12.2019), 2119 out of 8404 males with CD2_BENIGN_SALIVARY died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_SALIVARY.

N-year risk	Females	Males
1	0.116%	0.207%
5	0.742%	1.619%
10	1.878%	4.099%
15	3.653%	7.984%
20	6.59%	13.355%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_SALIVARY – Benign neoplasm of major salivary glands

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	CD2_BENIGN_SALIVARY
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	CD2_BENIGN_PAROTID\|CD2_BENIGN_SALIVARY_NOS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D11
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D11
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Benign neoplasm of major salivary glands

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints