No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
365 |
4. Check minimum number of eventsNone |
365 |
5. Include endpointsNone |
365 |
6. Filter based on genotype QC (FinnGen only) |
365 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D35
- Name in latin
- Neoplasma benignum glandulae parathyreoideae
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Parathyroid gland
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Parathyroid gland
- Benign neoplasm of other and unspecified endocrine glands
- Benign neoplasm of other and unspecified endocrine glands
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2464 | 1832 | 617 |
| Only index persons | 2183 | 1635 | 548 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 63.70 | 64.32 | 61.99 |
| Only index persons | 62.91 | 63.38 | 61.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 365 | 259 | 106 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.05 |
| Median age at first event (years) | 60.83 | 60.15 | 62.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 330
- Matched controls
- 3299
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
4503599627370496.0
323.0
301
*
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
240.1
181.2
173
15
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
88.0
133.8
145
29
E21.0
ICD-10 Finland
Primary hyperparathyroidism
74.9
89.7
100
19
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
65.5
70.2
80
16
BBA20
NOMESCO Finland
Exploration of parathyroid gland
101.2
40.9
44
5
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
59.3
32.0
37
7
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.0
31.8
205
951
E83.50
ICD-10 Finland
Hypercalcemia
31.0
31.0
41
15
E21.2
ICD-10 Finland
Other hyperparathyroidism
64.9
30.8
35
6
2271A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Parathyroid gland
+∞
27.5
26
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
15.5
24.3
40
29
2522
FHL
Removal of parathyroidism or multiple parathyroidism (including removal of adenoma or total removal)
+∞
24.3
23
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.9
18.9
181
973
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
18.0
134
607
H05BX01
ATC
cinacalcet; oral
39.1
17.8
22
6
321
Kela drug reimbursment
Paricalcitol and cinacalcet
39.1
17.8
22
6
A11CC03
ATC
alfacalcidol; systemic
11.3
17.1
32
31
E21
ICD-10 Finland
Hyperparathyroidism and other disorders of parathyroid gland
89.4
15.7
17
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.3
15.2
48
103
BB1BQ
NOMESCO Finland
Extensive scintigraphy of parathyroid gland, 2 isotopes, SPECT and low-dose CT
55.8
13.9
16
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
22.3
13.5
19
9
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.1
12.9
52
143
N20.0
ICD-10 Finland
Calculus of kidney
9.9
12.2
24
26
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
9.5
12.0
24
27
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
48.5
12.0
14
*
N20.9
ICD-10 Finland
Urinary calculus, unspecified
10.2
11.9
23
24
2520A
ICD-9 Finland
Disorders of parathyroid gland, Hyperparathyroidism
+∞
11.5
11
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
11.1
10.9
20
19
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
10.8
152
912
KAT00
NOMESCO Finland
Extracorporeal shock wave lithotripsy of pelvis of kidney
22.4
10.8
15
7
ZXE00
NOMESCO Finland
One hour or less
2.2
10.8
152
914
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
24.3
10.3
14
6
KH1AA
NOMESCO Finland
Urinary tract X-ray examination without contrast
15.6
9.6
15
10
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.3
9.5
22
32
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
6.6
9.3
23
37
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
6.7
8.9
22
35
E23.00
ICD-10 Finland
Panhypopituitarism
51.4
8.7
10
*
106
Kela drug reimbursment
Hypoparathyroidism
28.3
8.5
11
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
92.3
8.5
9
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
7.4
8.4
19
27
N18.8
ICD-10 Finland
Other chronic renal failure
6.9
8.0
19
29
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
8.1
8.0
17
22
I10
ICD-10 Finland
Essential (primary) hypertension
2.0
7.9
218
1637
A12AA04
ATC
calcium carbonate; oral
8.8
7.9
16
19
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
5.8
7.8
21
38
V03AE02
ATC
sevelamer; oral
46.1
7.7
9
*
KH1AD
NOMESCO Finland
CT of urinary organs
5.5
7.5
21
40
E21.5
ICD-10 Finland
Disorder of parathyroid gland, unspecified
81.9
7.4
8
*
M04AA01
ATC
allopurinol; systemic
2.7
7.4
53
222
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
16.2
7.3
11
7
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
6.7
85
466
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
23.1
6.7
9
*
H02AB09
ATC
hydrocortisone; systemic
8.1
6.7
14
18
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
12.6
6.6
11
9
H03AA01
ATC
levothyroxine sodium; systemic
2.0
6.6
96
557
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.9
6.5
17
30
N20.1
ICD-10 Finland
Calculus of ureter
4.6
6.5
21
48
ZXD20
NOMESCO Finland
Day surgery
2.4
6.5
55
251
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
71.2
6.4
7
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
4.5
6.4
21
49
A11CC02
ATC
dihydrotachysterol; oral
27.2
6.3
8
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.3
6.2
30
98
KBE12
NOMESCO Finland
Transluminal endoscopic extraction of calculus of ureter
12.8
6.1
10
8
C08CA01
ATC
amlodipine; oral
1.8
6.1
135
910
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.0
6.0
34
122
WX199
NOMESCO Finland
Other local analgesia
4.9
6.0
18
38
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_PARATHYROID and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_PARATHYROID | 1.159 [1.0, 1.35] | 0.058 |
| Birth year | 0.995 [0.99, 1.0] | 0.266 |
During the follow-up period (1.1.1998 — 31.12.2019), 274 out of 1306 females with CD2_BENIGN_PARATHYROID died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_PARATHYROID | 1.321 [1.02, 1.71] | 0.035 |
| Birth year | 0.989 [0.98, 1.0] | 0.021 |
During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 462 males with CD2_BENIGN_PARATHYROID died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_PARATHYROID.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.225% |
| 5 | 0.641% | 1.462% |
| 10 | 1.589% | 3.921% |
| 15 | 3.173% | 7.784% |
| 20 | 5.666% | 13.282% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_PARATHYROID – Benign neoplasm: Parathyroid gland
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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