Benign neoplasm of male genital organs

CD2_BENIGN_MALE_GEN

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only males	226837
2. Check conditions None	226837
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D29 Cause of death: ICD-10 — D29 2 out of 7 registries used, show all original rules.	609
4. Check minimum number of events None	609
5. Include endpoints CD2_BENIGN_PENIS CD2_BENIGN_PROSTATE CD2_BENIGN_TESTIS CD2_BENIGN_EPIDIDYMIS CD2_BENIGN_SCROTUM CD2_BENIGN_MALE_GEN_NOS	737
6. Filter based on genotype QC (FinnGen only)	737

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 2
First used in FinnGen datafreeze: DF3
Parent code in ICD-10: D10-D36
Name in latin: Neoplasmata benigna organorum genitalium masculinorum

NAME	CD2_BENIGN_MALE_GEN
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	1
INCLUDE	CD2_BENIGN_PENIS\|CD2_BENIGN_PROSTATE\|CD2_BENIGN_TESTIS\|CD2_BENIGN_EPIDIDYMIS\|CD2_BENIGN_SCROTUM\|CD2_BENIGN_MALE_GEN_NOS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D29
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D29
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Benign neoplasm of male genital organs based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	5564	-	5564
Only index persons	4801	-	4801
Unadjusted period prevalence (%)
Whole population	0.16	-	0.16
Only index persons	0.18	-	0.18
Median age at first event (years)
Whole population	-	-	52.91
Only index persons	-	-	50.02

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	737	-	737
Unadjusted period prevalence (%)	0.32	-	0.32
Median age at first event (years)	58.18	-	58.18

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
673: Matched controls
6730

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D29.1

ICD-10 Finland

Benign neoplasm: Prostate

490.3

215.3

204

D29.2

ICD-10 Finland

Benign neoplasm: Testis

+∞

110.5

103

D29.4

ICD-10 Finland

Benign neoplasm: Scrotum

1183.9

106.3

101

D29.3

ICD-10 Finland

Benign neoplasm: Epididymis

982.0

89.9

D29.0

ICD-10 Finland

Benign neoplasm: Penis

+∞

50.7

D40.1

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Testis

28.9

41.4

KFC00

NOMESCO Finland

Unilateral orchiectomy

21.6

36.7

KF8AE

NOMESCO Finland

Ultrasound examination of scrotum

7.6

29.1

101

KFD16

NOMESCO Finland

Partial excision of epididymis

44.7

24.8

22288

ICD-8 Finland

Benign neoplasm of male genital organs, Loco alio definito

+∞

24.1

22200

ICD-8 Finland

Benign neoplasm of male genital organs, Testis

+∞

24.1

KFA00

NOMESCO Finland

Exploration of testis

26.4

17.0

2223A

ICD-9 Finland

Benign neoplasm of male genital organs, Epididymis

+∞

16.7

C61

ICD-10 Finland

Malignant neoplasm of prostate

2.4

15.4

155

758

JN3CD

NOMESCO Finland

Abdominal CT examination both without and with contrast

4.5

14.7

126

22210

ICD-8 Finland

Benign neoplasm of male genital organs, Penis

+∞

14.6

8140/3-C61.9

ICD-O-3

Adenocarcinoma, NOS, of prostate gland

2.3

13.8

145

721

2220A

ICD-9 Finland

Benign neoplasm of male genital organs, Testis

+∞

13.6

KGB00

NOMESCO Finland

Biopsy of penis

29.0

13.0

22280

ICD-8 Finland

Benign neoplasm of male genital organs, Scroti

+∞

12.5

D29.9

ICD-10 Finland

Benign neoplasm: Male genital organ, unspecified

+∞

12.5

N40

ICD-10 Finland

Hyperplasia of prostate

1.8

11.8

285

1941

9061/3-C62.9

ICD-O-3

Seminoma, NOS, of testis, NOS

30.6

11.7

D29.7

ICD-10 Finland

Benign neoplasm: Other male genital organs

+∞

11.5

XKD00

NOMESCO Finland

Uroflowmetry

1.9

11.1

199

1221

J01DB01

ATC

cefalexin; oral

1.8

10.6

514

4290

UKC02

NOMESCO Finland

Cystoscopy

1.9

10.4

170

1003

ZXC96

NOMESCO Finland

Robot assisted procedure

3.8

10.1

116

KC1EE

NOMESCO Finland

Ultrasound measurement of residual urine

1.9

9.9

160

939

KEC01

NOMESCO Finland

Percutaneous endoscopic radical prostatectomy

3.5

9.3

130

C62.11

ICD-10 Finland

Malignant tumor of the descending testicle, seminoma

15.8

9.1

7501

FHL

Testicular exploration (includes removal of biopsy, detorsion or appendix test)

37.2

9.0

J01MA02

ATC

ciprofloxacin; systemic

1.7

9.0

275

1966

7511

FHL

Orchidectomy (unilateral), also includes funicularectomy

18.9

9.0

KE1BE

NOMESCO Finland

Rectal ultrasound examinaiton of prostata

2.0

8.9

113

603

NK6AN

NOMESCO Finland

Total body bone isotope imaging

3.7

8.7

105

JN3BD

NOMESCO Finland

Extensive abdominal CT

2.2

8.1

382

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.6

7.7

295

2214

D40.7

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Other male genital organs

25.3

7.6

G04CA02

ATC

tamsulosin; oral

1.6

7.5

271

1998

22299

ICD-8 Finland

Benign neoplasm of male genital organs, Unspecified site

+∞

7.3

Y05

ICPC

Scrotum/testis sympt/compl other

4.9

7.2

KFW96

NOMESCO Finland

Other operation on scrotum or scrotal organs

30.3

7.2

WX408

NOMESCO Finland

General anesthesy, balanced

1.7

7.1

176

1173

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

2.2

7.1

369

N45.9

ICD-10 Finland

Orchitis, epididymitis and epididymo-orchitis without abscess

3.3

6.8

105

N43.4

ICD-10 Finland

Spermatocele

3.3

6.8

105

R31

ICD-10 Finland

Unspecified haematuria

1.9

6.6

101

576

M02AA10

ATC

ketoprofen; topical

1.9

6.6

509

C60.9

ICD-10 Finland

Malignant neoplasm: Penis, unspecified

70.5

6.4

116

Kela drug reimbursment

Prostate cancer

2.1

6.4

387

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

1.8

6.3

118

720

KFD70

NOMESCO Finland

Excision of lesion of skin of scrotum

+∞

6.3

A06AC01

ATC

ispaghula (psylla seeds); oral

1.8

6.2

121

748

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.8

6.2

106

627

N02BE01

ATC

paracetamol; systemic, rectal

1.6

6.1

515

4535

C05AA08

ATC

fluocortolone; rectal, topical

1.9

6.0

499

Mortality – FinRegistry

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Association

Association between endpoint CD2_BENIGN_MALE_GEN and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_MALE_GEN	1.301 [1.15, 1.47]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 965 out of 3809 males with CD2_BENIGN_MALE_GEN died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_MALE_GEN.

N-year risk	Females	Males
1	No data	0.238%
5	No data	1.447%
10	No data	3.479%
15	No data	6.681%
20	No data	11.102%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_MALE_GEN – Benign neoplasm of male genital organs

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm of male genital organs

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints