Benign neoplasm of other and unspecified intrathoracic organs

CD2_BENIGN_INTRATHORACIC

uterine neoplasm: ['Tumors of the UTERUS.']

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D15 Cause of death: ICD-10 — D15 2 out of 7 registries used, show all original rules.	328
4. Check minimum number of events None	328
5. Include endpoints CD2_BENIGN_THYMUS CD2_BENIGN_HEART CD2_BENIGN_MEDIASTINUM CD2_BENIGN_INTRATHORACIC_NOS	381
6. Filter based on genotype QC (FinnGen only)	381

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 2
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D10-D36
Name in latin: Neoplasmata benigna organorum endothoracicorum aliorum sive non specificatorum

NAME	CD2_BENIGN_INTRATHORACIC
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	CD2_BENIGN_THYMUS\|CD2_BENIGN_HEART\|CD2_BENIGN_MEDIASTINUM\|CD2_BENIGN_INTRATHORACIC_NOS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D15
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D15
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm of other and unspecified intrathoracic organs based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2498	1388	1085
Only index persons	2049	1198	851
Unadjusted period prevalence (%)
Whole population	0.04	0.04	0.03
Only index persons	0.04	0.04	0.03
Median age at first event (years)
Whole population	54.47	56.23	51.98
Only index persons	52.89	55.50	49.23

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	381	208	173
Unadjusted period prevalence (%)	0.07	0.07	0.08
Median age at first event (years)	56.40	55.68	57.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
340: Matched controls
3398

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D15.1

ICD-10 Finland

Benign neoplasm: Heart

+∞

115.3

104

D15.2

ICD-10 Finland

Benign neoplasm: Mediastinum

+∞

82.8

FFA10

NOMESCO Finland

Excision of lesion of atrium

+∞

66.9

D15.0

ICD-10 Finland

Benign neoplasm: Thymus

+∞

64.7

D15.9

ICD-10 Finland

Benign neoplasm: Intrathoracic organ, unspecified

+∞

41.5

D15.7

ICD-10 Finland

Benign neoplasm: Other specified intrathoracic organs

+∞

35.0

D38.3

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Mediastinum

73.1

34.8

GEC24

NOMESCO Finland

Thoracoscopic thymectomy

182.1

32.3

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

6.8

31.9

166

FM1BE

NOMESCO Finland

Cardiac ultrasound examination through oesophagus

8.0

26.5

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

4.4

26.0

110

332

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.4

25.0

208

1085

GEB30

NOMESCO Finland

Mediastinotomy and excision of lesion

+∞

23.2

FXA00

NOMESCO Finland

Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure

8.9

20.8

21250

ICD-8 Finland

Benign neoplasm of respiratory system, Mediastinum

+∞

20.0

GEC23

NOMESCO Finland

Transsternal thymectomy

200.6

18.7

WX408

NOMESCO Finland

General anesthesy, balanced

3.0

18.1

135

609

D38.4

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Thymus

+∞

17.9

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

5.2

14.3

D48.7

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Other specified sites

44.5

14.2

ZXD10

NOMESCO Finland

Scheduled procedure

2.5

13.9

163

922

AJX

Other surgery on the heart or aorta

+∞

13.6

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

3.0

13.3

356

GAB10

NOMESCO Finland

Antero- or postero-lateral thoracotomy

72.6

12.7

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

2.7

12.4

447

R4110

NOMESCO Finland

Physiotherapy

2.5

11.9

118

601

8580/3-C37.9

ICD-O-3

Thymoma, NOS, of thymus

+∞

11.5

WX872

NOMESCO Finland

Intensive care

4.7

11.4

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.6

10.9

420

C37

ICD-10 Finland

Malignant neoplasm of thymus

113.4

10.5

AMX

Other surgical procedure for a demanding cardiac patient

+∞

10.5

2125A

ICD-9 Finland

Benign neoplasm of respiratory and intrathoracic organs, Mediastinum

+∞

10.5

UGC12

NOMESCO Finland

Flexible bronchoscopy

3.7

9.9

132

GAE06

NOMESCO Finland

Excision of lesion of chest wall

102.8

9.5

8582/3-C37.9

ICD-O-3

Thymoma, type AB of thymus

+∞

9.4

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

4.1

9.2

WZC30

NOMESCO Finland

Teaching

2.8

9.1

259

ZXE10

NOMESCO Finland

More than one and less than three hours

2.1

8.8

136

825

B01AB05

ATC

enoxaparin; parenteral

2.1

8.5

122

715

ZXE03

NOMESCO Finland

Procedure duration 20 to 29 minutes

4.1

8.4

N07AA02

ATC

pyridostigmine; systemic

22.7

8.1

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.3

8.1

435

C03CA01

ATC

furosemide; systemic

2.1

8.0

112

647

G70.0

ICD-10 Finland

Myasthenia gravis

18.9

7.6

ZXE00

NOMESCO Finland

One hour or less

1.9

7.6

140

901

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

3.2

7.4

128

GD1CG

NOMESCO Finland

Extensive examination of lungs and pleura with high intensity magnet

+∞

7.3

ZXE05

NOMESCO Finland

Procedure duration 40 to 49 minutes

4.0

7.1

WX402

NOMESCO Finland

General anaesthesia

2.4

7.0

304

108

Kela drug reimbursment

Myasthenia gravis

23.0

6.7

ZXE20

NOMESCO Finland

More than three and less than five hours

2.4

6.5

271

Other heart surgery

71.1

6.4

D38.1

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung

6.2

6.4

AN1

Coronary angiography

2.5

6.4

207

GD1CT

NOMESCO Finland

Biopsy of the lung with CT guidance

9.5

6.3

ZXC96

NOMESCO Finland

Robot assisted procedure

5.0

6.3

2129X

ICD-9 Finland

Benign neoplasm of respiratory and intrathoracic organs, Site unspecified

+∞

6.3

GAA31

NOMESCO Finland

Thoracoscopy

27.2

6.3

GEA00

NOMESCO Finland

Mediastinoscopy

27.2

6.3

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.9

6.2

104

635

TFP20

NOMESCO Finland

Cardiodefibrillation

3.2

6.2

104

N02AX02

ATC

tramadol; systemic, rectal

1.8

6.1

147

1017

XF404

NOMESCO Finland

Ambulatory ECG

2.7

6.0

154

Mortality – FinRegistry

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Association

Association between endpoint CD2_BENIGN_INTRATHORACIC and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_INTRATHORACIC	1.723 [1.35, 2.2]	< 0.001
Birth year	0.99 [0.98, 1.0]	0.024

During the follow-up period (1.1.1998 — 31.12.2019), 170 out of 792 females with CD2_BENIGN_INTRATHORACIC died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_INTRATHORACIC	1.914 [1.5, 2.44]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.013

During the follow-up period (1.1.1998 — 31.12.2019), 144 out of 631 males with CD2_BENIGN_INTRATHORACIC died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_INTRATHORACIC.

N-year risk	Females	Males
1	0.14%	0.406%
5	0.988%	2.501%
10	2.339%	6.167%
15	4.24%	11.267%
20	7.286%	18.197%

Relationships between endpoints

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Index endpoint: CD2_BENIGN_INTRATHORACIC – Benign neoplasm of other and unspecified intrathoracic organs

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm of other and unspecified intrathoracic organs

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints