Benign neoplasm: Hypopharynx

CD2_BENIGN_HYPOPHARYNX

uterine corpus cancer: A uterine cancer that is located_in the uterine corpus.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D10.7& Hospital discharge: ICD-9 — 2108 Hospital discharge: ICD-8 — 2108 Cause of death: ICD-10 — D10.7& Cause of death: ICD-9 — 2108 Cause of death: ICD-8 — 2108 2 out of 7 registries used, show all original rules.	159
4. Check minimum number of events None	159
5. Include endpoints None	159
6. Filter based on genotype QC (FinnGen only)	159

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D10
Name in latin: Neoplasma benignum hypopharyngis

NAME	CD2_BENIGN_HYPOPHARYNX
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D107
HD_ICD_9	2108
HD_ICD_8	2108
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D107
COD_ICD_9	2108
COD_ICD_8	2108
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Hypopharynx based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Benign neoplasm: Hypopharynx

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	787	363	414
Only index persons	644	303	341
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	59.62	57.19	61.60
Only index persons	59.07	56.24	61.58

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	159	61	98
Unadjusted period prevalence (%)	0.03	0.02	0.04
Median age at first event (years)	58.38	49.61	63.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
140: Matched controls
1401

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D10.7

ICD-10 Finland

Benign neoplasm: Hypopharynx

+∞

155.9

119

UJC01

NOMESCO Finland

Scopy of lower throat

99.8

44.4

JDB10

NOMESCO Finland

Percutaneous gastrostomy

49.4

23.7

504

Kela drug reimbursment

Conditions requiring daily forced enteral nutrition

40.1

23.5

2108A

ICD-9 Finland

Benign neoplasm of lip, oral cavity and pharynx, Hypopharynx

+∞

17.0

C13.8

ICD-10 Finland

Malignant neoplasm: Overlapping lesion of hypopharynx

+∞

17.0

UDQ12

NOMESCO Finland

Flexible laryngoscopy

10.9

15.5

D14.1

ICD-10 Finland

Benign neoplasm: Larynx

38.3

13.9

WF002

NOMESCO Finland

Radical radiotherapy

9.9

13.3

130

Kela drug reimbursment

Malignant tumour

7.2

13.2

UDQ22

NOMESCO Finland

Microlaryngoscopy

35.8

12.9

DQB10

NOMESCO Finland

Endoscopic excision of lesion of larynx

17.0

11.7

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

6.1

11.0

8070/3-C13.9

ICD-O-3

Squamous cell carcinoma, NOS, of hypopharynx, NOS

118.5

10.6

EN1BD

NOMESCO Finland

Very extensive CT examination of mouth and soft tissues of neck

20.8

10.5

WX408

NOMESCO Finland

General anesthesy, balanced

3.5

10.2

247

C12

ICD-10 Finland

Malignant neoplasm of piriform sinus

+∞

9.5

R07.0

ICD-10 Finland

Pain in throat

7.8

9.3

GBB00

NOMESCO Finland

Tracheostomy

17.1

9.2

ZXE00

NOMESCO Finland

One hour or less

3.1

9.2

399

ZXC10

NOMESCO Finland

Use of laser

13.8

9.1

YA1BD

NOMESCO Finland

Extensive CT examination of head and neck for dose design of radiotherapy

29.6

8.6

WB103

NOMESCO Finland

Simple adjuvant cytostatic therapy

10.3

8.0

R13

ICD-10 Finland

Dysphagia

6.1

7.9

ENA10

NOMESCO Finland

Biopsy of pharynx

47.7

7.8

R4190

NOMESCO Finland

Nutritional therapy

9.7

7.8

EP1AE

NOMESCO Finland

Neck ultrasound examination

6.3

7.7

ZXD10

NOMESCO Finland

Scheduled procedure

2.8

7.5

364

EP1DG

NOMESCO Finland

Very extensive examination of soft tissue of neck with high intesity magnet

84.4

7.5

QA1S1

NOMESCO Finland

Photography of skin or subcutaneous tissue in head

+∞

7.3

D38.0

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Larynx

21.4

7.2

UJC02

NOMESCO Finland

Rigid oesophagoscopy

23.9

6.8

K04.5

ICD-10 Finland

Chronic apical periodontitis

2.7

6.4

243

WX402

NOMESCO Finland

General anaesthesia

3.3

6.3

124

ENB00

NOMESCO Finland

Excision or exploration of lesion of pharynx

+∞

6.3

A02BC05

ATC

esomeprazole; systemic

2.5

6.2

402

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

4.9

6.1

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

5.9

6.1

N02AA05

ATC

oxycodone; systemic

3.2

6.0

123

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(4035726)

132

3.59

9.89

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

147

3.41

9.49

1.9

1.5

—

(3023368) Bacteria identified in Blood by Culture

366

2.77

8.93

5.9

4.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

103

632

2.79

8.74

10.8

6.7

mmol/l

1.2

1.17

544

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

232

2.93

8.67

2.8

2.7

e6/l

1.1

0.9

0.13

134

(3019198) Lymphocytes [#/volume] in Blood

105

655

2.78

8.55

7.0

5.8

e9/l

1.7

1.9

0.76

582

(3018418) pH of Serum or Plasma

389

2.69

8.50

5.4

4.2

7.4

—

(40768804) Tissue Pathology biopsy report

515

2.65

8.38

2.8

2.1

—

(3006315) Basophils [#/volume] in Blood

103

646

2.69

8.14

6.8

5.8

e9/l

0.0

0.01

560

(3002030) Lymphocytes/100 leukocytes in Blood

613

2.63

7.97

6.7

5.9

24.2

27.7

2.37

571

(3006504) Eosinophils/100 leukocytes in Blood

596

2.61

7.91

6.6

5.9

2.9

0.09

558

(42870588) Differential panel, method unspecified - Blood

416

2.58

7.90

7.0

5.7

—

(3022096) Basophils/100 leukocytes in Blood

579

2.59

7.87

6.7

5.9

0.6

0.7

0.28

541

(3001604) Monocytes [#/volume] in Blood

102

644

2.63

7.83

6.9

5.8

e9/l

0.6

0.07

558

(3018095) Leukocytes [#/volume] in Urine

469

2.55

7.73

4.3

3.6

e6/l

55.2

141.1

0.62

347

(36304419) Bacteria [Presence] in Urine

356

2.59

7.72

3.7

3.0

—

(3019069) Monocytes/100 leukocytes in Blood

602

2.57

7.66

6.7

6.1

8.6

8.8

0.13

565

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

489

2.52

7.58

4.4

3.1

—

(3030467) Casts [#/volume] in Urine by Automated count

375

2.55

7.54

3.8

3.1

e6/l

0.4

0.5

0.00

287

(3018010) Neutrophils/100 leukocytes in Blood

605

2.55

7.53

6.5

5.7

61.4

57.5

2.55

566

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

220

2.77

7.53

3.0

2.9

e6/l

2.1

1.9

0.09

124

(3013650) Neutrophils [#/volume] in Blood by Automated count

113

763

2.66

7.34

13.9

10.0

e9/l

4.2

4.0

0.51

105

666

(40758558) Short blood count panel - Blood

328

2.52

7.13

8.8

7.1

—

(3002582) Erythrocytes [#/volume] in Urine

419

2.43

6.94

3.8

3.1

e6/l

58.5

46.7

0.10

329

(3013115) Eosinophils [#/volume] in Blood

102

667

2.48

6.92

7.3

5.9

e9/l

0.2

0.23

591

(3024561) Albumin [Mass/volume] in Serum or Plasma

559

2.41

6.82

7.4

4.3

g/l

33.5

35.5

2.54

527

(3015377) Calcium [Moles/volume] in Serum or Plasma

428

2.36

6.52

5.0

3.6

mmol/l

2.3

2.4

0.60

377

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

5.33

5.84

1.4

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.35

5.45

2.0

1.9

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

263

2.31

5.30

1.5

2.0

mg/l

1.2

1.4

0.26

209

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

4.29

5.29

2.3

2.4

u/ml

0.3

0.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

201

2.40

5.08

2.2

1.8

—

(3021589) Normoblasts [#/volume] in Blood

591

2.10

4.96

13.3

10.1

e9/l

0.0

0.52

487

(3044640) Blood type and Crossmatch panel - Blood

408

2.11

4.89

3.2

2.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

296

2.19

4.81

2.9

2.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

588

2.01

4.46

4.7

4.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

516

2.00

4.44

2.0

1.9

pmol/l

86.7

92.5

0.45

279

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

120

927

2.20

4.43

5.3

3.8

pmol/l

14.7

14.8

0.15

112

825

(3037467) Urinalysis macro (dipstick) panel - Urine

114

866

2.12

4.37

5.3

4.0

—

(3000850) Epithelial cells [#/volume] in Urine

282

2.07

4.03

2.9

2.5

e6/l

4.1

0.00

250

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

128

1030

2.24

4.03

12.4

7.7

u/l

86.1

79.6

0.56

123

967

(3000494) Fungus identified in Specimen by Culture

155

2.33

4.02

1.5

1.4

—

(3032080) INR in Blood by Coagulation assay

538

1.93

4.02

11.4

8.7

inr

1.5

1.3

0.27

166

(3026782) Osmolality of Urine

273

2.02

3.74

3.5

3.0

mosm/kgh2o

508.4

563.4

1.10

235

(3027945) Reticulocytes/100 erythrocytes in Blood

153

2.27

3.72

2.6

2.3

1.8

0.06

140

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

243

2.05

3.68

3.2

3.3

mmol/l

2.5

0.20

214

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

147

2.28

3.66

2.1

1.7

—

(3023520) Reticulocytes [#/volume] in Blood

113

2.44

3.65

3.0

2.2

e9/l

71.6

72.0

0.01

(3000991) Gas panel - Venous blood

107

2.46

3.60

13.2

8.7

—

(3026389) Candida sp identified in Specimen by Organism specific culture

8.07

3.59

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

143

2.26

3.49

2.0

1.7

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.43

3.42

1.8

2.9

219.6

204.1

0.27

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

136

1148

2.28

3.39

6.2

4.5

mu/l

2.0

0.00

128

1027

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

106

2.37

3.22

3.0

2.5

ml/min/173m2

63.0

64.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.56

3.20

1.6

1.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.62

3.18

3.4

3.0

g/l

124.4

128.3

0.22

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

4.70

3.16

1.4

1.2

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.25

3.16

1.5

2.6

97.1

84.8

1.00

(3011397) Hemoglobin [Presence] in Urine by Test strip

289

1.89

3.12

3.6

3.0

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

250

1.92

3.07

3.8

3.5

ng/l

57.5

152.9

1.06

196

(3038177) Helicobacter pylori Ab [Presence] in Serum

6.04

3.05

1.0

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

308

1.85

3.03

1.9

mg/l

2.8

3.2

0.66

271

(3026493) Urate [Moles/volume] in Serum or Plasma

368

1.81

3.00

3.2

2.8

umol/l

7605.4

6907.3

0.03

313

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

146

1288

2.63

2.98

28.0

14.5

mg/l

29.2

22.4

1.71

129

1036

(3004588) Protein electrophoresis panel - Serum or Plasma

2.43

2.90

1.4

2.7

—

(3002256) Pathology report gross observation

157

2.04

2.75

1.3

1.2

—

(40768797) Stomach Pathology biopsy report

160

1.99

2.61

1.5

1.2

—

(3003396) Base excess in Arterial blood by calculation

140

2.02

2.50

13.3

7.7

mmol/l

2.0

1.1

0.73

110

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.95

2.50

1.3

1.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

5.15

2.42

1.2

1.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.34

2.34

1.6

1.2

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

169

1.88

2.23

4.2

2.4

26.6

23.5

0.35

148

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

185

1.84

2.22

1.5

—

(3003181) Sodium [Moles/volume] in Urine

3.45

2.21

1.5

1.3

mmol/l

56.5

60.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.12

2.18

1.8

1.4

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.12

2.18

1.3

1.2

—

(3026008) Bacteria identified in Urine by Culture

371

1.64

2.17

3.5

2.8

—

(3022313) Gas panel - Capillary blood

2.39

2.04

4.5

4.2

—

(3042936) Bacteria identified in Isolate by Culture

191

1.77

2.00

2.3

1.8

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.04

2.00

5.2

5.0

0.0

0.2

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

4.65

1.95

1.0

1.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

138

1239

1.86

1.91

25.0

14.1

ml/min/173m2

80.2

79.3

0.16

122

1021

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

750

1.54

1.89

2.7

—

(3021788) Differential panel - Synovial fluid

3.62

1.85

1.3

1.2

—

(3021901) Oxygen saturation in Capillary blood

3.13

1.82

3.3

2.4

—

(3022948) Iron [Moles/volume] in Serum or Plasma

206

1.69

1.78

4.2

2.2

umol/l

13.7

13.5

0.02

185

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

102

858

1.53

1.76

4.0

3.1

u/l

75.1

51.3

1.16

813

(1616796) Gas panel - Central venous blood

2.75

1.75

4.5

2.5

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

3.93

1.73

1.2

1.4

—

(3044941) Cell count panel - Synovial fluid

3.93

1.73

1.2

—

(3013707) Erythrocyte sedimentation rate by Westergren method

111

953

1.55

1.72

5.4

4.0

mm/h

14.3

11.5

0.92

105

877

(3020682) Albumin/Creatinine [Ratio] in Urine

417

1.53

1.72

6.9

4.0

mg/mmol

27.6

11.2

0.56

262

(3009508) Creatinine [Moles/volume] in Urine

409

1.53

1.69

5.0

3.1

mmol/l

7.2

7.9

0.52

328

(3017181) Myelocytes/100 leukocytes in Blood

106

1.90

1.67

5.2

4.9

1.6

1.0

—

(3000492) Spirometry study

122

1.83

1.64

1.2

1.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.29

1.61

1.2

2.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

128

1144

1.61

1.57

29.1

15.4

38.0

40.3

1.80

100

826

(3052851) Hemolysis interference index of Serum or Plasma

2.36

1.56

2.1

3.3

—

(3045142) Bone marrow Pathology biopsy report

3.41

1.53

1.0

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

653

1.45

1.52

4.7

3.5

estimate

0.0

0.00

122

(3021601) Nitrite [Presence] in Urine by Test strip

645

1.45

1.49

6.5

4.7

estimate

0.0

0.00

127

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.38

1.45

1.7

1.5

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

505

1.45

1.44

3.6

2.6

ug/l

183.0

140.3

0.80

461

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.02

1.43

14.8

8.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

237

1.55

1.38

1.7

1.6

nmol/l

1014.5

1211.9

0.61

183

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.67

1.38

4.5

2.6

e9/l

2.8

4.9

—

(3012516) Albumin [Mass/volume] in Urine

397

1.46

1.38

4.9

3.2

mg/l

234.8

66.0

0.49

257

(3019060) Gas panel - Arterial blood

1.89

1.36

5.2

3.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

122

1.73

1.35

1.9

1.6

—

(3035350) Ketones [Presence] in Urine by Test strip

646

1.41

1.31

4.5

3.5

estimate

0.0

0.00

130

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.56

1.31

4.7

3.3

54.2

57.6

—

(3037756) Immunofixation for Serum or Plasma

2.56

1.31

1.0

1.7

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

2.83

1.29

1.2

1.1

—

(3025941) Bacteria identified in Stool by Culture

1.90

1.23

1.1

1.3

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

2.68

1.22

1.0

1.6

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.68

1.22

1.0

1.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.36

1.20

1.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.92

1.17

3.9

2.5

2.4

1.3

0.81

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.39

1.14

1.1

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.05

1.14

2.0

1.7

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.05

1.14

1.9

2.7

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

133

1226

1.52

1.13

8.0

6.0

mmol/mol

43.4

40.2

1.87

126

1142

(46235355) HIV 1 and 2 tests - Meaningful Use set

171

1.55

1.11

1.9

1.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.82

1.10

17.2

6.7

mmol/l

25.4

24.5

0.41

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.78

1.09

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.06

1.07

2.6

2.1

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

425

1.37

1.04

5.7

2.2

u/l

46.0

57.7

2.74

398

(3020564) Creatinine [Moles/volume] in Serum or Plasma

146

1381

1.70

1.02

31.1

17.1

umol/l

84.4

81.3

0.29

146

1381

(40761511) CBC panel - Blood by Automated count

144

1361

1.62

0.96

21.7

13.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

143

1.54

0.96

6.9

3.5

—

(3044889) 12 lead EKG panel

106

952

1.34

0.95

5.0

4.0

—

(3020891) Body temperature

1.77

0.94

4.8

4.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

144

1.53

0.93

1.8

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.11

0.90

1.0

1.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

197

1.45

0.90

1.3

1.2

iu/ml

33.1

39.9

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

400

1.33

0.84

2.5

3.4

ng/l

2261.2

1310.2

0.52

332

(3013512) EKG study

393

1.32

0.81

5.5

4.2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

138

1304

1.44

0.79

5.3

5.2

mmol/l

2.7

0.26

129

1190

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.59

0.78

1.6

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.79

0.77

1.5

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

106

0.55

0.75

1.8

1.7

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.12

0.75

1.8

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.12

0.75

2.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.12

0.75

1.8

1.5

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.12

0.75

1.6

7.8

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

2.03

0.73

1.2

1.5

—

6.5

—

(4094501)

1.78

0.72

1.0

1.1

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

1.95

0.71

1.0

1.2

—

(3024928) Oxygen saturation in Venous blood

1.95

0.71

2.8

2.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

525

1.26

0.69

4.3

3.9

ng/l

32.5

52.6

0.76

378

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

1.88

0.69

1.4

1.5

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.88

0.69

1.2

1.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.75

0.64

2.0

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

1.75

0.64

6.2

2.7

—

(3038515) Glucose [Moles/volume] in Venous blood

1.75

0.64

5.2

3.8

mmol/l

11.1

8.0

—

(40761535) Cells panel - Urine sediment

105

1.47

0.62

4.1

3.3

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.60

0.0

3.5

—

51.1

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.60

0.0

1.1

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.74

0.58

1.8

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.48

0.57

1.3

1.5

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.69

0.57

1.8

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.57

0.57

1.9

1.6

—

(1761868) Lipid panel - Serum or Plasma

482

0.80

0.57

3.7

2.9

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

133

1270

1.29

0.52

4.5

4.7

mmol/l

1.3

1.4

2.57

124

1160

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

370

1.22

0.48

2.5

3.1

ug/l

0.8

0.06

240

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

133

1274

1.27

0.47

4.6

4.7

mmol/l

4.5

4.6

0.71

124

1175

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.42

0.47

1.2

1.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

131

1255

1.25

0.45

5.4

4.7

mmol/l

6.3

6.0

1.05

125

1141

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

129

1234

1.24

0.45

4.1

4.2

mmol/l

1.3

0.35

117

1128

(36660697) Celiac disease serology panel - Serum

0.62

0.43

1.3

1.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.58

0.42

1.4

1.5

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.58

0.42

1.6

1.3

—

(3003694) ABO and Rh group [Type] in Blood

318

1.21

0.42

1.3

1.4

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

1.44

0.39

1.6

1.3

—

2.9

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.44

0.39

1.0

1.3

—

(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose

0.00

0.39

0.0

1.2

—

7.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

292

1.21

0.39

8.0

4.9

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

1.40

0.38

1.6

1.3

—

2.5

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

360

1.19

0.37

1.6

1.7

mmol/l

1.5

1.3

0.85

301

(21494755) Public health laboratory ask at order entry panel

121

0.73

0.37

1.1

1.4

—

(40761536) Microorganisms panel - Urine sediment

108

1.32

0.37

7.7

3.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

132

0.74

0.33

1.7

1.6

—

(3029937) Albumin [Presence] in Urine by Test strip

347

1.16

0.31

5.7

3.7

estimate

0.0

0.00

123

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.31

0.28

2.1

2.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.24

0.27

1.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.29

0.23

2.4

1.4

—

(3045414) Leukocytes [Presence] in Urine

1.23

0.22

2.4

1.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.21

0.0

2.9

—

13.8

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.5

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.21

0.0

2.1

—

3.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.23

0.17

1.8

1.5

—

(40768443) Skin Pathology biopsy report

1.19

0.17

1.4

1.3

—

(3019225) pH of Specimen

112

1.18

0.15

8.3

4.8

—

(3022145) Colonoscopy Study observation

151

1.14

0.14

1.2

1.3

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.11

0.10

3.6

1.8

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.05

0.08

1.3

1.4

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.12

0.08

1.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

166

1.10

0.08

9.7

7.6

—

(3022621) pH of Urine by Test strip

1.10

0.07

3.9

2.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

253

0.94

0.06

2.4

1.4

g/l

2.2

2.6

0.42

152

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

507

1.04

0.04

5.7

3.7

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

629

1.03

0.03

4.3

5.1

ug/l

2.0

2.8

0.83

567

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

137

0.94

0.01

1.5

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

366

0.98

0.00

5.3

3.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

506

1.01

0.00

4.1

4.6

26.1

21.2

0.97

249

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

275

0.98

0.00

1.3

1.2

u/ml

1.1

0.7

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

14.3

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3000330) Specific gravity of Urine by Test strip

0.97

0.00

5.8

4.7

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.00

0.00

1.2

1.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.8

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

1.7

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(4281824)

0.00

0.0

1.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.7

—

(4198724)

0.00

0.0

1.0

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.4

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.3

—

(40758355) Pancreatic polypeptide [Moles/volume] in Serum or Plasma

0.00

0.0

3.4

—

67.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.98

0.00

1.4

2.2

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

5.8

—

0.6

—

(3029536) Hepatitis C virus RNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3037826) lamoTRIgine [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

13.3

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.2

—

10.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

13.4

—

1483.6

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

0.0

1.2

—

1.2

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.4

—

(3035509) Tobramycin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

1.2

—

(1002224) Polysomnography panel

0.89

0.00

1.0

1.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3001501) Glucose [Moles/volume] in Capillary blood by Glucometer

0.00

0.0

1.2

—

9.7

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

4.6

—

(3022493) Free Hemoglobin [Mass/volume] in Plasma

0.00

0.0

1.0

—

72.8

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.1

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.0

1.0

—

152.9

—

(4010399)

100

1.00

0.00

1.2

1.5

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

9.3

—

1045.1

—

(44813793)

0.00

0.0

1.0

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.0

—

10.3

—

(4034850)

0.92

0.00

8.6

12.1

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_HYPOPHARYNX and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_HYPOPHARYNX	1.911 [1.25, 2.93]	0.003
Birth year	0.988 [0.98, 1.0]	0.006

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 188 females with CD2_BENIGN_HYPOPHARYNX died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_HYPOPHARYNX	2.396 [1.56, 3.67]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.073

During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 275 males with CD2_BENIGN_HYPOPHARYNX died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_HYPOPHARYNX.

N-year risk	Females	Males
1	0.142%	0.394%
5	0.951%	2.999%
10	2.338%	8.24%
15	4.195%	14.837%
20	6.865%	24.105%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_HYPOPHARYNX – Benign neoplasm: Hypopharynx

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Hypopharynx

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints