Risteys · CD2_BENIGN_HEAMANGIOMA

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D18 Cause of death: ICD-10 — D18 2 out of 7 registries used, show all original rules.	3160
4. Check minimum number of events None	3160
5. Include endpoints CD2_BENIGN_HEMANGIOMA CD2_BENIGN_LYMPHANGIOMA	3588
6. Filter based on genotype QC (FinnGen only)	3588

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	31154	18400	12629
Only index persons	26146	15515	10631
Unadjusted period prevalence (%)
Whole population	0.45	0.53	0.35
Only index persons	0.50	0.57	0.41
Median age at first event (years)
Whole population	37.79	37.79	37.66
Only index persons	42.29	42.73	41.64

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	3588	2308	1280
Unadjusted period prevalence (%)	0.71	0.79	0.56
Median age at first event (years)	51.03	48.63	55.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
3201: Matched controls
32011

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D18.0

ICD-10 Finland

Haemangioma, any site

1822.2

323.0

2622

22700

ICD-8 Finland

Haemangioma and lymphangioma, Haemangioma

+∞

239.6

227

D18.1

ICD-10 Finland

Lymphangioma, any site

+∞

215.0

204

2280A

ICD-9 Finland

Haemangioma and lymphangioma, any site, Haemangioma, any site

+∞

205.4

195

D18

ICD-10 Finland

Haemangioma and lymphangioma, any site

78.4

61.2

EAA10

NOMESCO Finland

Excision of lesion of lip

11.0

57.1

111

104

ZXC12

NOMESCO Finland

Pulse colorlaser

23.1

48.4

Q27.3

ICD-10 Finland

Peripheral arteriovenous malformation

75.6

46.1

Q27.4

ICD-10 Finland

Congenital phlebectasia

86.4

45.9

Q82.50

ICD-10 Finland

Naevus flammeus

40.6

38.5

QAA40

NOMESCO Finland

Laser therapy or photocoagulation of skin of head or neck

14.4

38.2

Q27.9

ICD-10 Finland

Congenital malformation of peripheral vascular system, unspecified

135.0

37.8

D37.6

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts

7.1

34.5

124

22701

ICD-8 Finland

Haemangioma and lymphangioma, Lymphangioma

+∞

34.4

QAE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in head or neck

2.5

34.3

298

1283

2281A

ICD-9 Finland

Haemangioma and lymphangioma, any site, Lymphangioma, any site

+∞

32.3

QX3LT

NOMESCO Finland

Subcutaneous sclerotherapy

48.0

31.6

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

2.2

28.9

320

1542

XX6KT

NOMESCO Finland

Other sclerotherapy

39.3

28.0

JN1CG

NOMESCO Finland

Extensive MRI examination of upper part of abdomen with high intensity magnet

3.9

27.7

118

313

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.6

27.4

827

5640

QAA25

NOMESCO Finland

Destruction of lesion of head or neck

4.2

24.8

238

Q82.51

ICD-10 Finland

Naevus portwine

16.3

23.2

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.5

22.7

1047

7828

ZXD10

NOMESCO Finland

Scheduled procedure

1.5

20.2

1101

8473

QCE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in upper limb

3.5

20.0

283

Q82.58

ICD-10 Finland

Congenital non-neoplastic naevus

6.6

19.9

QBE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin of trunk

2.1

19.8

222

1074

D13.4

ICD-10 Finland

Benign neoplasm: Liver

9.6

19.8

9736

FHL

Subcutaneous tumor removal in operating room or anesthesia

4.6

19.4

147

Z01.8

ICD-10 Finland

Other specified special examinations

1.6

18.1

607

4186

R23.8

ICD-10 Finland

Other and unspecified skin changes

1.7

18.1

433

2735

UJF32

NOMESCO Finland

Coloscopy

1.5

18.0

695

4952

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

1.9

18.0

259

1388

QDE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in lower limb

2.9

17.4

110

393

JN1DG

NOMESCO Finland

Very extensive MRI examination of upper part of abdomen with high intensity magnet

3.9

17.0

183

D48.1

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue

3.7

16.7

206

Q27.88

ICD-10 Finland

Other specified congenital malformation of peripheral vascular system

27.7

16.5

S18

ICPC

Laceration/cut

1.4

15.7

1142

9158

Q28.3

ICD-10 Finland

Other malformations of cerebral vessels

8.8

15.7

R22.0

ICD-10 Finland

Localized swelling, mass and lump, head

2.8

15.6

104

385

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

2.2

15.5

153

699

A02BC02

ATC

pantoprazole; systemic

1.4

15.4

1803

15606

WX408

NOMESCO Finland

General anesthesy, balanced

1.4

14.9

763

5728

R07.4

ICD-10 Finland

Chest pain, unspecified

1.4

14.7

700

5179

ZXA00

NOMESCO Finland

Right side

1.4

14.6

714

5311

SPAT1153

SPAT

Removal of sutures

1.4

14.5

865

6680

N02BE01

ATC

paracetamol; systemic, rectal

1.4

14.4

2539

23370

AAB00

NOMESCO Finland

Extirpation of intracranial lesion

3.8

14.1

157

R93.2

ICD-10 Finland

Abnormal findings on diagnostic imaging of liver and biliary tract

6.0

13.7

EP1LT

NOMESCO Finland

Percutaneous sclerotherapy of vascular malformation of head and neck

75.4

13.6

NDR20

NOMESCO Finland

Incomplete excision of soft tissue tumour of wrist or hand

3.9

13.6

143

9744

FHL

+∞

13.5

EJA10

NOMESCO Finland

Biopsy of tongue or floor of mouth

3.2

13.4

217

J01DB01

ATC

cefalexin; oral

1.4

13.2

2410

22077

ZXE10

NOMESCO Finland

More than one and less than three hours

1.4

12.8

985

7905

ZQX00

NOMESCO Finland

0-4% of the skin

14.1

12.7

QAE99

NOMESCO Finland

Other excision or repair surgery of skin and subcutaneous tissue in head and neck

3.0

12.7

238

EP1AE

NOMESCO Finland

Neck ultrasound examination

2.0

12.7

165

851

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

1.6

12.6

371

2464

XX4BW

NOMESCO Finland

12.3

12.6

ZXC50

NOMESCO Finland

Cryotherapy

2.7

12.6

325

R22.1

ICD-10 Finland

Localized swelling, mass and lump, neck

2.3

12.4

112

494

D48.5

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Skin

2.0

12.4

159

818

SAA02

NOMESCO Finland

Basic examination of mouth

1.3

12.2

1868

16542

J01MA02

ATC

ciprofloxacin; systemic

1.3

12.2

1010

8186

A02BC03

ATC

lansoprazole; oral

1.4

12.2

761

5891

WX110

NOMESCO Finland

Local anesthesy

1.3

12.2

1997

17858

L82

ICD-10 Finland

Seborrhoeic keratosis

1.5

11.9

390

2657

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.3

11.8

1077

8848

EP1CG

NOMESCO Finland

Extensive MRI examination of soft tissue of neck with high intesity magnet

3.9

11.7

122

ZXC10

NOMESCO Finland

Use of laser

2.8

11.7

263

A02BC01

ATC

omeprazole; systemic

1.4

11.6

726

5616

QAA05

NOMESCO Finland

Incision for biopsy of skin of head or neck

2.9

11.4

245

D22.9

ICD-10 Finland

Melanocytic naevi, unspecified

2.1

11.2

124

602

N02AX02

ATC

tramadol; systemic, rectal

1.3

11.1

1091

9045

D22.5

ICD-10 Finland

Melanocytic naevi of trunk

1.9

10.9

148

778

ZXA05

NOMESCO Finland

Left side

1.4

10.9

646

4941

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

1.7

10.7

217

1307

TPH04

NOMESCO Finland

Cathetrisation of vein

1.4

10.5

535

3987

PG1HT

NOMESCO Finland

Extensive endovascular embolisation of arterio-venous malformation not elsewhere classified

+∞

10.4

JN3BD

NOMESCO Finland

Extensive abdominal CT

1.6

10.3

276

1787

A06AC01

ATC

ispaghula (psylla seeds); oral

1.4

10.2

625

4808

D48.9

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Neoplasm of uncertain or unknown behaviour, unspecified

3.1

10.2

182

QBA40

NOMESCO Finland

Laser therapy or photocoagulation of skin of trunk

13.1

10.1

QX3HE

NOMESCO Finland

Ultrsound examination of lesion close to skin

3.3

10.0

146

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.3

9.9

1107

9296

M25.5

ICD-10 Finland

Pain in joint

1.3

9.8

755

6016

Q28.8

ICD-10 Finland

Other specified congenital malformations of circulatory system

26.1

9.8

SPAT1263

SPAT

Sampling

1.3

9.8

1153

9756

SAA03

NOMESCO Finland

Extended examination of mouth

1.3

9.7

1077

9028

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

1.3

9.7

849

6894

XQ845

NOMESCO Finland

Dermatoscopy

3.6

9.7

118

A02BC05

ATC

esomeprazole; systemic

1.3

9.7

1069

8963

4704

FHL

Neck tumor removal

13.4

9.7

R10.1

ICD-10 Finland

Pain localized to upper abdomen

1.4

9.6

420

3034

SAA01

NOMESCO Finland

Simple examination of mouth

1.3

9.6

2030

18447

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

1.5

9.5

309

2100

ZXE00

NOMESCO Finland

One hour or less

1.3

9.5

1065

8945

JN3CD

NOMESCO Finland

Abdominal CT examination both without and with contrast

2.2

9.4

450

JN3AD

NOMESCO Finland

Abdominal CT examination

1.7

9.4

191

1150

WX002

NOMESCO Finland

Sedation and analgesia

1.4

9.4

501

3758

QXA25

NOMESCO Finland

Destruction of lesion of skin, site unspecified

2.5

9.3

271

M75.1

ICD-10 Finland

Rotator cuff syndrome

1.4

9.3

581

4476

9733

FHL

Excision of skin change in operating room or anesthesia

3.0

9.3

166

Q28.2

ICD-10 Finland

Arteriovenous malformation of cerebral vessels

7.3

9.2

B02AA02

ATC

tranexamic acid; systemic

1.4

9.2

394

2839

QX2XE

NOMESCO Finland

Ultrsound examination of soft tissue not elsewhere classified

2.4

9.2

331

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.3

9.2

1338

11596

UJD02

NOMESCO Finland

Gastroscopy

2.0

9.2

115

587

K57.3

ICD-10 Finland

Diverticular disease of large intestine without perforation or abscess

1.4

9.1

416

3033

N03AX12

ATC

gabapentin; oral

1.4

9.0

396

2866

M01AH05

ATC

etoricoxib; oral

1.3

9.0

1611

14301

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

1.4

8.9

573

4427

ZXE20

NOMESCO Finland

More than three and less than five hours

1.5

8.9

345

2433

TEA00

NOMESCO Finland

Biopsy of lip

3.6

8.8

107

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

1.8

8.7

136

754

9749

FHL

Other measure in this category

5.4

8.7

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

1.9

8.6

115

601

P01AB01

ATC

metronidazole; oral, rectal

1.3

8.6

1063

9011

I86.8

ICD-10 Finland

Varicose veins of other specified sites

11.6

8.6

9734

FHL

Excision and local plastic or associated free skin grafting

4.4

8.5

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

1.6

8.5

212

1349

C07AB02

ATC

metoprolol; systemic

1.4

8.4

474

3589

R22.3

ICD-10 Finland

Localized swelling, mass and lump, upper limb

2.6

8.3

226

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.4

8.3

475

3599

QX3KT

NOMESCO Finland

+∞

8.3

JN5LT

NOMESCO Finland

Sclerotherapy with direct puncture body area

+∞

8.3

QBA25

NOMESCO Finland

Destruction of lesion of skin of trunk

3.0

8.3

157

E04.2

ICD-10 Finland

Nontoxic multinodular goitre

2.0

8.3

102

520

XQ848

NOMESCO Finland

Dermatological photography

2.3

8.3

302

Z3226

NOMESCO Finland

Physiotherapist

1.4

8.2

471

3572

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

1.4

8.2

393

2885

Z31.5

ICD-10 Finland

Genetic counselling

1.8

8.2

135

764

ZXA10

NOMESCO Finland

Bilateral

1.4

8.2

456

3445

UJF30

NOMESCO Finland

Ileoscopy through colon

1.6

8.2

236

1561

R03BA08

ATC

ciclesonide; inhalant

1.6

8.1

206

1321

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.2

8.0

1210

10481

Z2221

NOMESCO Finland

Medical doctor

1.3

8.0

727

5912

R4120

NOMESCO Finland

Occupational therapy

1.7

7.9

154

919

J01DA01

ATC

[U] cefalexin; systemic

1.2

7.9

1739

15696

J45.9

ICD-10 Finland

Asthma, unspecified

1.4

7.9

448

3394

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.3

7.9

888

7424

S04

ICPC

Lump/swelling localized

1.5

7.8

238

1593

UDQ12

NOMESCO Finland

Flexible laryngoscopy

1.7

7.8

144

843

QA4S1

NOMESCO Finland

Photography of skin or subcutaneous tissue in face

4.7

7.8

M03BX02

ATC

tizanidine; oral

1.2

7.8

1713

15453

QAE40

NOMESCO Finland

Repair of anomaly or lesion after disease of skin of head or neck

9.4

7.8

SBB00

NOMESCO Finland

Fotograf of mouth and teeth

1.9

7.8

112

604

N03AX16

ATC

pregabalin; oral

1.3

7.8

592

4694

Z01.0

ICD-10 Finland

Examination of eyes and vision

1.4

7.7

410

3069

D21.1

ICD-10 Finland

Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder

3.3

7.7

109

Q87.21

ICD-10 Finland

Klippel-Trénaunay-Weber syndrome

45.1

7.7

R22.9

ICD-10 Finland

Localized swelling, mass and lump, unspecified

1.6

7.7

180

1132

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

1.8

7.6

124

700

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.2

7.6

1093

9402

D23.3

ICD-10 Finland

Benign neoplasm: Skin of other and unspecified parts of face

2.2

7.6

335

N02AJ06

ATC

codeine and paracetamol; systemic

1.3

7.5

963

8163

JDA52

NOMESCO Finland

Other endoscopic procedure using diathermy or heat in stomach or pylorus

10.0

7.5

WX400

NOMESCO Finland

Inhalation anesthesy

1.8

7.5

118

658

EJB10

NOMESCO Finland

Excision of lesion of apex or body of tongue

4.6

7.5

M54.5

ICD-10 Finland

Low back pain

1.3

7.5

841

7021

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.2

7.4

1461

12992

PG1GT

NOMESCO Finland

Endovascular embolisation of arterio-venous malformation with radiological guidance not elsewhere classified

80.3

7.4

Q82.5

ICD-10 Finland

Congenital non-neoplastic naevus

6.5

7.4

K11.69

ICD-10 Finland

Mukocele UNS

5.3

7.4

SAA04

NOMESCO Finland

Special inverstigation of mouth

1.7

7.3

155

947

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.2

7.3

1563

14014

N05BA04

ATC

oxazepam; oral

1.3

7.3

608

4876

PG1JT

NOMESCO Finland

Very extensive endovascular embolisation of arterio-venous malformation not elsewhere classified

+∞

7.3

K14.9

ICD-10 Finland

Disease of tongue, unspecified

6.2

7.2

R03BA02

ATC

budesonide; inhalant

1.4

7.2

444

3407

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

1.5

7.2

228

1542

I78.8

ICD-10 Finland

Other diseases of capillaries

7.3

7.2

TQW99

NOMESCO Finland

Other minor procedure on skin

1.8

7.2

117

663

G40.22

ICD-10 Finland

Complex partial epileptic seizure with secondary generalization

2.4

7.2

229

R06.0

ICD-10 Finland

Dyspnoea

1.3

7.1

583

4665

K76.80

ICD-10 Finland

Hepatic cyst

3.6

7.0

J33.0

ICD-10 Finland

Polyp of nasal cavity

2.2

7.0

296

R51.80

ICD-10 Finland

Headache

1.4

7.0

377

2828

XXA00

NOMESCO Finland

Clinical examination requiring general anaesthesia

4.1

7.0

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.4

6.9

422

3232

S82

ICPC

Naevus/mole

1.4

6.9

303

2189

KMAK

NOMESCO Finland

1.2

6.8

1400

12468

QB9S1

NOMESCO Finland

Photography of skin or subcutaneous tissue in torso, unspecified

4.0

6.8

DM1CM

NOMESCO Finland

Paranasal sinuses extensive MRI examination with 3 Tesla magnet

40.1

6.8

JN1BD

NOMESCO Finland

Extensive CT examination of upper part of abdomen

3.8

6.8

PA5AC

NOMESCO Finland

Angiography of arteries to the face with X-ray

16.7

6.7

EP1AT

NOMESCO Finland

Punction of soft tissue of neck with ultrasound guidance

16.7

6.7

K80.2

ICD-10 Finland

Calculus of gallbladder without cholecystitis

1.4

6.7

275

1964

R01AD09

ATC

mometasone; nasal

1.2

6.7

1231

10828

C05AA08

ATC

fluocortolone; rectal, topical

1.4

6.7

348

2596

9474

FHL

Soft tissue tumor removal (subcutaneous tumor 9736 skin tumor 9733)

7.2

6.7

AA1AD

NOMESCO Finland

CT of head and brain

1.3

6.7

542

4327

J01EA01

ATC

trimethoprim; systemic

1.3

6.7

631

5144

A07AA02

ATC

nystatin; oral

1.6

6.6

145

896

C44.31

ICD-10 Finland

Basocellular carcinoma of the skin on another or unspecified part of the face

1.7

6.6

133

805

X59

ICD-10 Finland

Exposure to unspecified factor

1.3

6.6

451

3515

R42

ICD-10 Finland

Dizziness and giddiness

1.3

6.6

517

4112

D12.6

ICD-10 Finland

Benign neoplasm: Colon, unspecified

1.8

6.5

111

639

DM1AD

NOMESCO Finland

CT of paranasal sinuses and face area

1.9

6.4

486

9161/1-C71.6

ICD-O-3

Hemangioblastoma of cerebellum, NOS

70.0

6.4

Q28.9

ICD-10 Finland

Congenital malformation of circulatory system, unspecified

70.0

6.4

SHA02

NOMESCO Finland

Correction of physiology of bite - basic therapy visit

1.6

6.4

167

1082

H04.10

ICD-10 Finland

Dry eye syndrome

1.5

6.4

243

1709

R01AD08

ATC

fluticasone; nasal

1.3

6.4

728

6068

R03AC02

ATC

salbutamol; inhalant

1.2

6.4

1423

12752

ZXD20

NOMESCO Finland

Day surgery

1.4

6.3

320

2377

J01FA10

ATC

azithromycin; systemic

1.2

6.3

1619

14695

DM1CG

NOMESCO Finland

Paranasal sinuses and face area extensive MRI examination with high intensity magnet

9.3

6.3

SFA30

NOMESCO Finland

Filling on tree or more surfaces of tooth

1.2

6.3

1034

8977

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.3

6.3

542

4366

EAB20

NOMESCO Finland

Plastic repair of lip

18.0

6.3

J01AA02

ATC

doxycycline; systemic

1.2

6.3

2178

20355

D22.7

ICD-10 Finland

Melanocytic naevi of lower limb, including hip

2.4

6.2

200

WZC05

NOMESCO Finland

Specialty-specific consultation based on referral by dentist or doctor

1.6

6.2

136

843

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

2.2

6.2

252

M79.6

ICD-10 Finland

Pain in limb

1.2

6.2

890

7620

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

1.5

6.1

224

1562

CBB30

NOMESCO Finland

Excision of lesion of eyelid

2.1

6.1

334

EKB00

NOMESCO Finland

Excision of lesion of cheek

5.3

6.1

WX702

NOMESCO Finland

Supraglottic ventilation device

1.6

6.1

132

814

QAE30

NOMESCO Finland

Excision and repair of surgical scar in head or neck

7.7

6.1

XCW99

NOMESCO Finland

Other investigative procedure of eye

1.4

6.1

248

1769

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

2.3

6.0

217

L57.0

ICD-10 Finland

Actinic keratosis

1.5

6.0

198

1351

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_HEAMANGIOMA_LYMPHANGIOMA and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_HEAMANGIOMA_LYMPHANGIOMA	0.963 [0.86, 1.08]	0.536
Birth year	0.995 [0.99, 1.0]	0.208

During the follow-up period (1.1.1998 — 31.12.2019), 979 out of 13789 females with CD2_BENIGN_HEAMANGIOMA_LYMPHANGIOMA died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_HEAMANGIOMA_LYMPHANGIOMA	1.126 [1.0, 1.27]	0.046
Birth year	0.987 [0.98, 1.0]	0.009

During the follow-up period (1.1.1998 — 31.12.2019), 1156 out of 9406 males with CD2_BENIGN_HEAMANGIOMA_LYMPHANGIOMA died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_HEAMANGIOMA_LYMPHANGIOMA.

N-year risk	Females	Males
1	0.066%	0.222%
5	0.478%	1.371%
10	1.339%	3.372%
15	2.605%	6.383%
20	4.503%	10.786%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_HEAMANGIOMA_LYMPHANGIOMA – Haemangioma and lymphangioma, any site

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	CD2_BENIGN_HEAMANGIOMA_LYMPHANGIOMA
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	CD2_BENIGN_HEMANGIOMA\|CD2_BENIGN_LYMPHANGIOMA
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D18
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D18
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Haemangioma and lymphangioma, any site

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints