cutaneous melanoma: A primary melanoma arising from atypical melanocytes in the skin. Precursor lesions include acquired and congenital melanocytic nevi, and dysplastic nevi. Several histologic variants have been recognized, including superficial spreading melanoma, acral lentiginous melanoma, nodular melanoma, and lentigo maligna melanoma.
Benign neoplasm of middle ear and respiratory system
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_EAR_RESP
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2674 |
4. Check minimum number of eventsNone |
2674 |
5. Include endpoints |
3134 |
6. Filter based on genotype QC (FinnGen only) |
3134 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D10-D36
- Name in latin
- Neoplasma benignum auris mediae sive systematis respiratorii
Similar endpoints
↥List of similar endpoints to
Benign neoplasm of middle ear and respiratory system
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of middle ear and respiratory system
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20664 | 8807 | 11667 |
| Only index persons | 17527 | 7830 | 9697 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.25 | 0.33 |
| Only index persons | 0.33 | 0.29 | 0.37 |
| Median age at first event (years) | |||
| Whole population | 55.29 | 55.15 | 55.31 |
| Only index persons | 53.78 | 53.91 | 53.68 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3134 | 1303 | 1831 |
| Unadjusted period prevalence (%) | 0.66 | 0.44 | 0.81 |
| Median age at first event (years) | 56.26 | 52.93 | 58.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2832
- Matched controls
- 28321
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
DQB10
NOMESCO Finland
Endoscopic excision of lesion of larynx
67.9
323.0
428
74
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
4141.2
323.0
907
*
D14.3
ICD-10 Finland
Benign neoplasm: Bronchus and lung
+∞
323.0
315
*
D14.0
ICD-10 Finland
Benign neoplasm: Middle ear, nasal cavity and accessory sinuses
9430.0
323.0
1167
*
UDQ22
NOMESCO Finland
Microlaryngoscopy
52.8
230.3
277
58
UDH02
NOMESCO Finland
Rhinopharyngoscopy
7.8
217.9
545
835
DHB10
NOMESCO Finland
Excision of lesion of internal nose
134.3
209.7
223
18
B97.7
ICD-10 Finland
Papillomavirus as the cause of diseases classified to other chapters
191.7
206.1
213
12
DHA10
NOMESCO Finland
Biopsy of cavity of nose
56.7
205.4
244
47
UDQ12
NOMESCO Finland
Flexible laryngoscopy
7.0
162.8
436
719
DQA10
NOMESCO Finland
Biopsy of larynx
70.9
162.3
186
28
ZXC10
NOMESCO Finland
Use of laser
12.1
132.1
250
225
C32.0
ICD-10 Finland
Malignant neoplasm: Glottis
59.3
119.7
141
25
21210
ICD-8 Finland
Benign neoplasm of respiratory system, Larynx
+∞
110.1
105
*
2121A
ICD-9 Finland
Benign neoplasm of respiratory and intrathoracic organs, Larynx
+∞
103.8
99
*
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
38.4
103.3
132
36
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
5.9
102.6
309
579
2120A
ICD-9 Finland
Benign neoplasm of respiratory and intrathoracic organs, Nasal cavities, middle ear and accessory sinuses
+∞
89.0
85
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
7.4
87.8
220
320
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
83.9
938
4848
J38.3
ICD-10 Finland
Other diseases of vocal cords
15.1
82.6
140
97
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
6.3
77.2
216
365
1420
FHL
Laryngomicroscopy
17.5
75.7
121
72
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.2
75.6
459
1635
UDM02
NOMESCO Finland
Sinoscopy
8.5
74.9
170
211
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
7.2
74.8
189
277
2123A
ICD-9 Finland
Benign neoplasm of respiratory and intrathoracic organs, Bronchus and lung
+∞
72.2
69
*
J38.1
ICD-10 Finland
Polyp of vocal cord and larynx
17.2
70.9
114
69
ZXE00
NOMESCO Finland
One hour or less
2.1
70.7
1228
7613
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.4
70.1
374
1207
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.3
67.9
376
1246
J37.0
ICD-10 Finland
Chronic laryngitis
6.0
65.6
190
335
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
64.4
1200
7564
D14.4
ICD-10 Finland
Benign neoplasm: Respiratory system, unspecified
+∞
63.8
61
*
8070/3-C32.0
ICD-O-3
Squamous cell carcinoma, NOS, of glottis
65.2
60.6
70
11
UDQ02
NOMESCO Finland
Direct laryngoscopy
14.0
59.2
103
76
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.5
58.5
293
894
DM1BD
NOMESCO Finland
Extensive CT of paranasal sinuses and face area
19.7
57.7
88
46
J33.0
ICD-10 Finland
Polyp of nasal cavity
5.5
57.0
176
335
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
55.8
653
3329
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
21.6
54.2
80
38
DNB30
NOMESCO Finland
Excision of lesion of ethmoidal sinus
+∞
49.1
47
*
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
22.8
47.6
69
31
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
14.7
47.1
80
56
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
45.2
1073
7108
8070/3-C32.9
ICD-O-3
Squamous cell carcinoma, NOS, of larynx, NOS
36.3
44.5
57
16
DM1DG
NOMESCO Finland
Paranasal sinuses and face area very extensive MRI examination with high intensity magnet
52.9
43.7
52
10
UJC01
NOMESCO Finland
Scopy of lower throat
10.0
42.9
87
89
C30.0
ICD-10 Finland
Malignant neoplasm: Nasal cavity
41.5
42.6
53
13
R01AD08
ATC
fluticasone; nasal
1.9
42.2
786
4764
H02AB06
ATC
prednisolone; systemic
1.7
41.6
1329
9589
DHB20
NOMESCO Finland
Polypectomy of internal nose
7.2
41.1
102
146
TDM10
NOMESCO Finland
Puncture of maxillary antrum
4.1
39.9
162
411
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
39.6
1240
8847
DPA30
NOMESCO Finland
Sphenotomy
13.1
38.4
68
53
J33.8
ICD-10 Finland
Other polyp of sinus
5.4
37.9
118
227
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
37.9
1331
9773
WX402
NOMESCO Finland
General anaesthesia
2.1
37.7
497
2620
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.3
36.8
200
645
R01AD09
ATC
mometasone; nasal
1.7
36.5
1144
8100
GDA21
NOMESCO Finland
Thoracoscopic excision of lesion of lung
81.2
35.9
40
5
DHB40
NOMESCO Finland
Conchotomy
23.6
35.8
51
22
21200
ICD-8 Finland
Benign neoplasm of respiratory system, Cavi nasi
+∞
35.5
34
*
DMB10
NOMESCO Finland
Radical maxillary antrotomy
15.5
35.2
58
38
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
6.0
35.1
99
169
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.1
34.7
198
661
21202
ICD-8 Finland
Benign neoplasm of respiratory system, Sinus maxillaris
+∞
34.4
33
*
DJW00
NOMESCO Finland
Removal of local lesion of nasal septum
341.1
34.0
34
*
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
36.3
33.7
43
12
21230
ICD-8 Finland
Benign neoplasm of respiratory system, Bronchus and lung
+∞
33.4
32
*
B977, D141
ICD-10 Finland
NA
+∞
33.4
32
*
GDA20
NOMESCO Finland
Excision of lesion of lung
41.5
33.1
41
10
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.9
32.7
141
378
C32.1
ICD-10 Finland
Malignant neoplasm: Supraglottis
48.1
31.6
38
8
DMB30
NOMESCO Finland
Transmaxillary excision of lesion of maxillary antrum
53.5
31.3
37
7
C32.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of larynx
60.7
31.1
36
6
DQB30
NOMESCO Finland
Laryngectomy
86.1
30.8
34
*
4256
FHL
Nasal or sinus tumor removal
111.3
30.7
33
*
A02BC02
ATC
pantoprazole; systemic
1.6
30.6
1744
14198
WX734
NOMESCO Finland
JET-ventilation
38.5
30.2
38
10
A02BC05
ATC
esomeprazole; systemic
1.6
30.2
1087
7872
D14.2
ICD-10 Finland
Benign neoplasm: Trachea
+∞
28.2
27
*
J31.0
ICD-10 Finland
Chronic rhinitis
2.5
28.1
229
952
ZXA05
NOMESCO Finland
Left side
1.7
27.6
724
4779
R49.0
ICD-10 Finland
Dysphonia
5.6
27.0
80
146
ZXD20
NOMESCO Finland
Day surgery
2.0
27.0
372
1975
DQE00
NOMESCO Finland
Implantation of prosthetic replacement for larynx
62.6
27.0
31
5
J01AA02
ATC
doxycycline; systemic
1.6
26.9
2078
17920
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
4.4
26.6
99
232
R03AC02
ATC
salbutamol; inhalant
1.5
26.6
1320
10241
WX110
NOMESCO Finland
Local anesthesy
1.5
26.2
1734
14350
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
6.6
25.9
67
103
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
5.6
25.4
75
137
R01AD12
ATC
fluticasone furoate; nasal
1.7
24.8
678
4506
N02BE01
ATC
paracetamol; systemic, rectal
1.6
24.4
2286
20357
WX002
NOMESCO Finland
Sedation and analgesia
1.7
24.4
543
3401
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.0
24.3
346
1857
J34.8
ICD-10 Finland
Other specified disorders of nose and nasal sinuses
6.8
24.1
61
91
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
8.3
23.8
53
65
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
7.4
23.4
56
77
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
23.3
775
5409
DHB00
NOMESCO Finland
Excision of lesion of external nose
6.6
23.3
60
92
R49.01
ICD-10 Finland
Functional dysphonia
3.6
23.0
108
312
DNB40
NOMESCO Finland
Sublabial rhinotomy
+∞
22.9
22
*
B977, D140
ICD-10 Finland
NA
+∞
22.9
22
*
DKW40
NOMESCO Finland
Ligature of artery of internal nose
26.1
22.6
31
12
ZXA00
NOMESCO Finland
Right side
1.6
22.6
741
5146
5823
FHL
Lung avobiopsy and wedge resection
121.0
22.6
24
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
22.5
859
6196
J33.9
ICD-10 Finland
Nasal polyp, unspecified
6.2
22.3
60
98
DQB70
NOMESCO Finland
Total excision of vocal cord
52.4
22.1
26
5
Z2221
NOMESCO Finland
Medical doctor
1.6
22.0
719
4986
J01DB01
ATC
cefalexin; oral
1.5
22.0
2140
18882
N02AX02
ATC
tramadol; systemic, rectal
1.5
22.0
1127
8675
DMB35
NOMESCO Finland
Endoscopic excision of neoplasm or another lesion from maxillary sinus
80.7
21.7
24
*
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
21.2
482
3022
R03BB04
ATC
tiotropium bromide; inhalant
1.9
21.2
315
1716
DM1CG
NOMESCO Finland
Paranasal sinuses and face area extensive MRI examination with high intensity magnet
34.0
21.1
27
8
R13
ICD-10 Finland
Dysphagia
2.3
21.0
200
900
UDC00
NOMESCO Finland
Ear microscopy
2.2
20.1
214
1015
J38.7
ICD-10 Finland
Other diseases of larynx
10.4
20.1
39
38
JDB10
NOMESCO Finland
Percutaneous gastrostomy
4.9
19.9
65
134
R49.08
ICD-10 Finland
Other specified dysphonia
3.9
19.5
82
217
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
19.2
443
2781
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
6.0
19.2
53
90
J01DA01
ATC
[U] cefalexin; systemic
1.4
19.1
1626
13712
UJC02
NOMESCO Finland
Rigid oesophagoscopy
6.5
19.0
49
76
R06.0
ICD-10 Finland
Dyspnoea
1.6
18.9
630
4366
A02BC01
ATC
omeprazole; systemic
1.5
18.5
716
5134
J38.2
ICD-10 Finland
Nodules of vocal cords
11.5
18.5
34
30
A07AA02
ATC
nystatin; oral
2.3
18.4
183
841
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
18.1
416
2609
D36.7
ICD-10 Finland
Benign neoplasm: Other specified sites
15.4
17.9
29
19
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
17.7
1143
9091
A02BC03
ATC
lansoprazole; oral
1.5
17.7
753
5507
130
Kela drug reimbursment
Malignant tumour
2.0
17.6
248
1321
ZXA10
NOMESCO Finland
Bilateral
1.6
17.6
477
3131
WF002
NOMESCO Finland
Radical radiotherapy
2.3
17.4
166
748
DMA00
NOMESCO Finland
Biopsy of maxillary antrum
21.0
17.3
25
12
ZXE20
NOMESCO Finland
More than three and less than five hours
1.7
17.2
375
2312
J01CA04
ATC
amoxicillin; systemic
1.4
17.0
2031
18049
R04.0
ICD-10 Finland
Epistaxis
2.0
16.9
214
1092
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
16.8
543
3724
ZXC95
NOMESCO Finland
Use of surgical navigator
5.5
16.6
49
91
8070/3-C30.0
ICD-O-3
Squamous cell carcinoma, NOS, of nasal cavity
170.9
16.5
17
*
XX3DW
NOMESCO Finland
Time consuming IT work
1.8
16.5
285
1633
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
16.3
490
3295
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
11.2
16.2
30
27
N07BA03
ATC
varenicline; oral
2.4
16.1
141
608
GD1AD
NOMESCO Finland
Thorax CT examination
2.4
15.8
136
581
R07.0
ICD-10 Finland
Pain in throat
2.3
15.8
145
642
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
15.8
646
4663
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
15.8
2308
21143
DHB50
NOMESCO Finland
Turbinoplasty
3.3
15.4
79
247
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
15.4
882
6812
J01FA10
ATC
azithromycin; systemic
1.4
15.3
1334
11097
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
5.7
15.2
43
76
J34.2
ICD-10 Finland
Deviated nasal septum
2.2
15.2
154
716
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
15.2
551
3871
UGB02
NOMESCO Finland
Tracheoscopy
17.8
15.1
23
13
J01MA12
ATC
levofloxacin; systemic
1.6
15.1
490
3350
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
15.0
534
3737
GB3AV
NOMESCO Finland
NA
25.1
14.7
20
8
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
14.6
783
5962
D38.50
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of maxillary sinus
150.7
14.5
15
*
R04.2
ICD-10 Finland
Haemoptysis
2.6
14.3
108
433
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
14.1
408
2711
GBB00
NOMESCO Finland
Tracheostomy
4.2
13.8
52
126
DPB00
NOMESCO Finland
Partial excision of frontal sinus
23.9
13.8
19
8
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.2
13.7
143
671
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
13.5
354
2293
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
2.7
13.4
91
343
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
13.4
935
7442
N03AX16
ATC
pregabalin; oral
1.5
13.3
558
4031
4509
FHL
Other measure in this category
40.2
13.1
16
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.2
13.1
127
579
J01FA06
ATC
roxithromycin; oral
1.4
13.1
977
7854
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
13.1
853
6700
UJF32
NOMESCO Finland
Coloscopy
1.4
13.1
650
4858
D10.6
ICD-10 Finland
Benign neoplasm: Nasopharynx
13.0
12.9
22
17
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
3.4
12.9
61
181
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
12.8
229
1325
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.1
12.5
142
694
H02AB04
ATC
methylprednisolone; systemic
1.6
12.5
360
2385
DMB40
NOMESCO Finland
Excision of lesion of maxillary antrum trough lateral rhinotomy
+∞
12.5
12
*
R4110
NOMESCO Finland
Physiotherapy
1.4
12.5
645
4850
DPW99
NOMESCO Finland
Other operation on frontal or sphenoidal sinus
11.7
12.3
22
19
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
7.1
12.3
29
41
J32.1
ICD-10 Finland
Chronic frontal sinusitis
6.4
12.1
31
49
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
3.7
12.1
51
138
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
4.7
12.1
40
86
R21
ICPC
Throat symptom/complaint
1.6
12.0
369
2481
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
12.0
477
3406
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.4
11.9
103
445
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
5.4
11.9
35
66
R49.8
ICD-10 Finland
Other and unspecified voice disturbances
4.9
11.9
38
79
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.8
11.8
188
1048
5822
FHL
Exploratory thoracotomy and small procedure (eg lung suture)
30.1
11.6
15
5
R03BA02
ATC
budesonide; inhalant
1.5
11.6
392
2697
R03DC03
ATC
montelukast; oral
1.6
11.6
347
2317
GBB13
NOMESCO Finland
Revision of tracheostomy
23.0
11.6
16
7
J34.1
ICD-10 Finland
Cyst and mucocele of nose and nasal sinus
3.6
11.5
51
144
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.5
11.5
417
2910
DQE10
NOMESCO Finland
Injection of foreign material into vocal cord
11.1
11.5
21
19
ZXE40
NOMESCO Finland
More than seven and less than nine hours
2.8
11.4
71
255
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
11.3
928
7532
N05CF01
ATC
zopiclone; oral
1.4
11.3
796
6306
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
11.3
567
4235
UGC02
NOMESCO Finland
Rigid bronchoscopy
10.6
11.2
21
20
GDB21
NOMESCO Finland
Thoracoscopic segmental resection of lung
9.6
11.2
22
23
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
11.2
928
7538
K02.1
ICD-10 Finland
Caries of dentine
1.3
11.2
1270
10812
J01CE02
ATC
phenoxymethylpenicillin; oral
1.3
11.1
1654
14630
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
11.1
874
7039
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
1.9
11.1
153
811
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.2
11.1
115
541
R53
ICD-10 Finland
Malaise and fatigue
1.5
11.1
463
3331
7931A
ICD-9 Finland
Nonspecific abnormal findings on radiological and other examination of body structure, Lung field
8.1
11.1
24
30
ZXD05
NOMESCO Finland
Urgent procedure
1.4
11.0
742
5833
R49.09
ICD-10 Finland
Unspecified dysphonia
4.4
10.9
38
87
M54.4
ICD-10 Finland
Lumbago with sciatica
1.5
10.8
360
2463
R02
ICPC
Shortness of breath/dyspnoea
1.6
10.8
271
1729
DJA10
NOMESCO Finland
Biopsy of septum of nose
15.5
10.8
17
11
R29
ICPC
Respiratory symptom/complaint other
2.0
10.8
136
697
J01FA09
ATC
clarithromycin; systemic
1.4
10.7
698
5449
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.7
10.7
205
1213
D10.7
ICD-10 Finland
Benign neoplasm: Hypopharynx
21.5
10.7
15
7
1430
FHL
Laryngoscopy (direct)
12.9
10.6
18
14
D10.5
ICD-10 Finland
Benign neoplasm: Other parts of oropharynx
12.9
10.6
18
14
M54.5
ICD-10 Finland
Low back pain
1.4
10.6
731
5759
D38.51
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of other accessory sinus
60.2
10.6
12
*
Z01.2
ICD-10 Finland
Dental examination
1.3
10.5
881
7152
J02AC01
ATC
fluconazole; systemic
1.3
10.5
806
6454
J32.8
ICD-10 Finland
Other chronic sinusitis
11.2
10.5
19
17
DPA20
NOMESCO Finland
Trephine of frontal sinus
9.2
10.5
21
23
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
10.4
293
1925
21299
ICD-8 Finland
Benign neoplasm of respiratory system, Unspecified site
+∞
10.4
10
*
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
2.7
10.4
70
265
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
10.4
610
4676
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.3
10.3
97
437
ZXC99
NOMESCO Finland
Other special technic in surgery
18.8
10.3
15
8
ZXB10
NOMESCO Finland
Medial
5.5
10.2
29
53
AA1AD
NOMESCO Finland
CT of head and brain
1.4
10.2
573
4352
D38.58
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of other respiratory organ
23.4
10.2
14
6
R95
ICPC
Chron obstructive pulmonary disease
2.5
10.2
79
324
EMA30
NOMESCO Finland
Biopsy of rhinopharynx
13.1
10.1
17
13
KMAK
NOMESCO Finland
NA
1.3
10.1
1151
9754
Z3226
NOMESCO Finland
Physiotherapist
1.5
10.0
430
3104
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.0
9.9
131
684
8070/3-C32.1
ICD-O-3
Squamous cell carcinoma, NOS, of supraglottis
26.1
9.8
13
5
ENA10
NOMESCO Finland
Biopsy of pharynx
7.0
9.8
23
33
J01FF01
ATC
clindamycin; systemic
1.4
9.8
629
4890
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
9.7
185
1094
C14.1
ICD-10 Finland
Malignant neoplasm of laryngopharynx unspecified
55.2
9.6
11
*
R06AE07
ATC
cetirizine; oral
1.3
9.6
946
7841
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
9.6
410
2960
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.0
9.6
127
665
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
15.1
9.5
15
10
M03BC01
ATC
orphenadrine (citrate); systemic
1.4
9.5
492
3683
A02BA02
ATC
ranitidine; systemic
1.4
9.5
479
3569
J39.2
ICD-10 Finland
Other diseases of pharynx
4.8
9.4
30
63
8070/2-C32.0
ICD-O-3
Squamous cell carcinoma in situ, NOS, of glottis
100.3
9.4
10
*
D14
ICD-10 Finland
Benign neoplasm of middle ear and respiratory system
100.3
9.4
10
*
DJB10
NOMESCO Finland
Excision of septum of nose
+∞
9.4
9
*
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
1.9
9.3
131
702
4784A
ICD-9 Finland
Other diseases of upper respiratory tract, Polyp of vocal cord or larynx[POLYPUS PLICAE VOCALIS]
10.7
9.3
17
16
J01MA14
ATC
moxifloxacin; systemic
1.6
9.3
213
1331
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
1.9
9.3
134
724
R01AD01
ATC
beclometasone; nasal
1.5
9.2
341
2392
R08
ICPC
Nose symptom/complaint other
2.4
9.2
74
312
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
9.1
1404
12323
1240
FHL
Bronchoscopy
3.5
9.1
41
119
DMA10
NOMESCO Finland
Exploration of maxillary antrum
15.6
9.0
14
9
4760A
ICD-9 Finland
Chronic laryngitis and laryngotracheitis, Chronic laryngitis
7.0
9.0
21
30
P01AB01
ATC
metronidazole; oral, rectal
1.3
9.0
878
7253
R03AK07
ATC
formoterol and budesonide; inhalant
1.4
9.0
419
3074
WX400
NOMESCO Finland
Inhalation anesthesy
2.2
9.0
93
440
J38.6
ICD-10 Finland
Stenosis of larynx
24.1
8.9
12
5
R05
ICD-10 Finland
Cough
1.4
8.9
431
3185
M02AA07
ATC
piroxicam; topical
1.3
8.9
869
7183
Z50.5
ICD-10 Finland
Speech therapy
3.5
8.8
40
117
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.7
8.8
174
1040
N06AX16
ATC
venlafaxine; oral
1.5
8.8
274
1846
B01AB05
ATC
enoxaparin; parenteral
1.3
8.8
706
5670
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
3.2
8.8
44
139
G47.3
ICD-10 Finland
Sleep apnoea
1.4
8.8
502
3822
J04.0
ICD-10 Finland
Acute laryngitis
2.6
8.8
60
231
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.5
8.7
314
2184
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.6
8.7
226
1457
Z3231
NOMESCO Finland
Registered nurse
1.3
8.7
645
5115
4226
FHL
Posterior radical surgery and possible etmoidectomy
4.2
8.7
31
74
TPH07
NOMESCO Finland
Cathetrisation of artery
1.6
8.7
247
1631
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
8.6
1604
14368
R51.80
ICD-10 Finland
Headache
1.5
8.6
289
1980
N05BA01
ATC
diazepam; systemic, rectal
1.5
8.6
313
2183
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
8.6
332
2347
H02AB07
ATC
prednisone; oral
1.5
8.6
343
2443
DKW99
NOMESCO Finland
Other procedures for control of epistaxis
11.6
8.6
15
13
A01AB09
ATC
miconazole; local oral
1.7
8.6
190
1178
R03BA05
ATC
fluticasone; inhalant
1.4
8.5
395
2894
J20
ICD-10 Finland
Acute bronchitis
1.6
8.5
211
1345
DPB10
NOMESCO Finland
Partial excision of sphenoidal sinus
90.3
8.4
9
*
DPC35
NOMESCO Finland
Extensive endoscopic excision of lesion or neoplasm extending to more than one paranasal sinus
90.3
8.4
9
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.6
8.4
238
1567
21220
ICD-8 Finland
Benign neoplasm of respiratory system, Trachea
+∞
8.3
8
*
DM1BG
NOMESCO Finland
Paranasal sinuses and face area standard MRI examination with high intensity magnet
+∞
8.3
8
*
51925
ICD-8 Finland
Other diseases of respiratory system, Infiltratio pulmonis NUD
6.2
8.3
21
34
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
8.3
649
5185
S18
ICPC
Laceration/cut
1.3
8.3
988
8364
J01DA06
ATC
[U] cefuroxime; systemic
1.5
8.3
325
2304
M25.5
ICD-10 Finland
Pain in joint
1.3
8.2
586
4615
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.6
8.2
239
1585
Z01.9
ICD-10 Finland
Special examination, unspecified
1.8
8.2
129
719
2391A
ICD-9 Finland
Neoplasm of unspecified nature, Respiratory system
6.5
8.2
20
31
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.1
8.1
92
454
GAA31
NOMESCO Finland
Thoracoscopy
6.0
8.1
21
35
XF400
NOMESCO Finland
ECG with 12 standard connections
1.4
8.1
399
2952
C31.0
ICD-10 Finland
Malignant neoplasm: Maxillary sinus
33.4
8.1
10
*
DKW30
NOMESCO Finland
Cauterisation of artery of internal nose
4.8
8.1
25
52
N05BA04
ATC
oxazepam; oral
1.4
8.0
528
4103
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
2.2
8.0
77
356
D38.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Mediastinum
5.9
8.0
21
36
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
7.2
7.9
18
25
R07.3
ICD-10 Finland
Other chest pain
1.6
7.9
207
1336
R06AX22
ATC
ebastine; oral
1.4
7.9
345
2496
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
1.7
7.9
157
945
EL3AE
NOMESCO Finland
Salivary gland ultrasound examination
4.9
7.9
24
49
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
1.9
7.9
107
567
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
2.3
7.9
68
299
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
5.1
7.8
23
45
J45
ICD-10 Finland
Asthma
1.6
7.8
200
1285
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
7.8
1232
10772
N02AA05
ATC
oxycodone; systemic
1.4
7.8
346
2515
M03BC51
ATC
orphenadrine, combinations; systemic
1.3
7.7
596
4745
R06AX27
ATC
desloratadine; oral
1.3
7.7
521
4063
SAA04
NOMESCO Finland
Special inverstigation of mouth
1.8
7.7
118
653
E0000UV
ATC
NA
1.3
7.7
871
7311
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.4
7.7
402
3010
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
3.7
7.6
31
84
M79.1
ICD-10 Finland
Myalgia
1.5
7.6
257
1768
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
1.6
7.6
202
1312
J32.4
ICD-10 Finland
Chronic pansinusitis
2.9
7.6
42
144
L02
ICPC
Back symptom/complaint
1.6
7.6
172
1073
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.4
7.5
387
2887
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
2.6
7.5
52
203
R42
ICD-10 Finland
Dizziness and giddiness
1.4
7.4
472
3648
GDC00
NOMESCO Finland
Lobectomy of lung
4.4
7.4
25
57
C320, 8077, 2
ICD-O-3
NA
80.3
7.4
8
*
50808
ICD-8 Finland
Other diseases of upper respiratory tract, Alii definiti
5.3
7.4
21
40
R09
ICPC
Sinus symptom/complaint
1.7
7.3
134
787
21208
ICD-8 Finland
Benign neoplasm of respiratory system, Nasi, loco multiplici
+∞
7.3
7
*
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
2.3
7.3
64
284
UJC12
NOMESCO Finland
Flexible oesophagoscopy
4.2
7.3
26
63
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
1.9
7.3
100
532
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.6
7.3
183
1172
D07AC01
ATC
betamethasone; topical
1.3
7.3
770
6399
H01
ICPC
Ear pain/earache
1.6
7.2
195
1271
WF003
NOMESCO Finland
Adjuvant radiotherapy
2.0
7.2
81
401
XG410
NOMESCO Finland
Flow-volume spirometry
1.9
7.2
100
537
-1
NOMESCO Finland
NA
1.3
7.2
672
5491
4222
FHL
Endonasal etmoidectomy
4.1
7.2
26
64
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
7.2
624
5049
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
3.7
7.1
29
79
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.4
7.1
308
2224
J01MA02
ATC
ciprofloxacin; systemic
1.3
7.1
927
7895
H65.3
ICD-10 Finland
Chronic mucoid otitis media
2.8
7.1
43
157
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
3.6
7.1
30
85
R03AC12
ATC
salmeterol; inhalant
1.8
7.1
112
628
EBA15
NOMESCO Finland
Extraction of large number of teeth
1.9
7.1
99
534
N06AB10
ATC
escitalopram; oral
1.4
7.1
374
2803
GDA10
NOMESCO Finland
Biopsy of lung
8.8
7.0
14
16
M79.6
ICD-10 Finland
Pain in limb
1.3
7.0
769
6413
R05
ICPC
Cough
1.3
7.0
448
3462
4239
FHL
Other measure in this category
4.7
7.0
22
47
R96
ICPC
Asthma
1.6
7.0
177
1137
JN4BD
NOMESCO Finland
Extensive body CT
1.5
7.0
255
1783
J01DC02
ATC
cefuroxime; systemic
1.7
7.0
124
723
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.3
6.9
782
6544
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.6
6.9
178
1147
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
1.7
6.9
129
763
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.6
6.9
167
1061
M01AH05
ATC
etoricoxib; oral
1.2
6.9
1340
11929
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.5
6.9
224
1525
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.5
6.8
249
1740
5826
FHL
Lobectomy or bilobectomy
10.9
6.8
12
11
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
6.8
1238
10940
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
3.0
6.8
36
121
D10.39
ICD-10 Finland
Benign tumor in other or unspecified part of oral cavity UNS
6.1
6.8
17
28
DQW99
NOMESCO Finland
Other operation on larynx
40.1
6.8
8
*
C32.2
ICD-10 Finland
Malignant neoplasm: Subglottis
40.1
6.8
8
*
R51.81
ICD-10 Finland
Facial pain NOS
2.4
6.7
54
229
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
1.6
6.7
185
1216
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
6.7
1036
8989
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.3
6.7
535
4275
8240/3-C34.9
ICD-O-3
Neuroendocrine tumor, NOS, of lung, NOS
22.6
6.7
9
*
SPAT1301
SPAT
No procedures
1.3
6.7
711
5904
ZXC60
NOMESCO Finland
Application of heat
2.6
6.6
44
169
EP1BG
NOMESCO Finland
MRI examination of soft tissue of neck with high intesity magnet
5.5
6.6
18
33
ZX070
NOMESCO Finland
Intensity modified radiotherapy
2.3
6.6
54
233
J45.1
ICD-10 Finland
Nonallergic asthma
1.6
6.6
149
929
R01AD11
ATC
triamcinolone; nasal
1.5
6.6
188
1245
ENB00
NOMESCO Finland
Excision or exploration of lesion of pharynx
12.3
6.6
11
9
4252
FHL
Resection, coagulation or cryo on the cortex and nasal mucosa
12.3
6.6
11
9
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.5
6.6
240
1678
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.3
6.5
516
4113
WZC30
NOMESCO Finland
Teaching
1.4
6.5
292
2125
EP1CM
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with 3 Tesla magnet
10.0
6.5
12
12
J33
ICD-10 Finland
Nasal polyp
4.8
6.5
20
42
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.5
6.5
205
1388
ELB40
NOMESCO Finland
Partial parotidectomy
3.0
6.5
35
119
A28
ICPC
Limited function/disability NOS
1.4
6.5
328
2438
UJH02
NOMESCO Finland
Anoscopy
1.9
6.5
92
499
C05AA08
ATC
fluocortolone; rectal, topical
1.4
6.5
308
2266
DJD20
NOMESCO Finland
Plastic repair of septum of nose
1.9
6.4
88
472
M48.0
ICD-10 Finland
Spinal stenosis
1.4
6.4
277
2001
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
2.9
6.4
37
129
DM1CD
NOMESCO Finland
Very extensive CT of paranasal sinuses and face area
70.0
6.4
7
*
23130
ICD-8 Finland
Neoplasm of unspecified nature of respiratory organs, Bronchus and lung
70.0
6.4
7
*
G44.2
ICD-10 Finland
Tension-type headache
1.5
6.4
248
1752
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
1.7
6.4
126
758
C07AB07
ATC
bisoprolol; oral
1.2
6.4
1150
10125
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
6.4
649
5356
AA1BD
NOMESCO Finland
Extensive CT of head and brain
2.1
6.3
65
311
GD6AD
NOMESCO Finland
CT of chest and neck
8.2
6.3
13
16
M01AB05
ATC
diclofenac; systemic, rectal
1.2
6.3
1584
14434
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.2
6.3
1146
10100
R5140
NOMESCO Finland
Monitoring the use of the aid
1.5
6.3
235
1651
J01
ICD-10 Finland
Acute sinusitis
1.9
6.3
90
489
21209
ICD-8 Finland
Benign neoplasm of respiratory system, Nasi, NUD
+∞
6.2
6
*
DQB00
NOMESCO Finland
Excision of lesion of larynx
+∞
6.2
6
*
N06AX11
ATC
mirtazapine; oral
1.3
6.2
680
5655
J47
ICD-10 Finland
Bronchiectasis
2.5
6.2
45
182
A06AD11
ATC
lactulose; oral
1.4
6.2
336
2529
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
1.9
6.2
80
421
M54.2
ICD-10 Finland
Cervicalgia
1.6
6.2
137
854
Z98.8
ICD-10 Finland
Other specified postsurgical states
3.3
6.1
28
85
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
1.7
6.1
113
667
Z2446
NOMESCO Finland
Social worker
1.6
6.1
136
847
R20.2
ICD-10 Finland
Paraesthesia of skin
1.7
6.1
126
768
C13.9
ICD-10 Finland
Malignant neoplasm: Hypopharynx, unspecified
12.5
6.1
10
8
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.1
6.1
63
303
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
1.3
6.0
388
3001
R03AC03
ATC
terbutaline; inhalant
1.4
6.0
285
2096
H04.4
ICD-10 Finland
Chronic inflammation of lacrimal passages
6.7
6.0
14
21
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
6.0
670
5580
R06.5
ICD-10 Finland
Mouth breathing
1.5
6.0
189
1280
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
6.0
580
4748
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_EAR_RESP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_EAR_RESP | 1.387 [1.24, 1.55] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 1065 out of 5721 females with CD2_BENIGN_EAR_RESP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_EAR_RESP | 1.589 [1.44, 1.76] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1926 out of 7557 males with CD2_BENIGN_EAR_RESP died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_EAR_RESP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.271% |
| 5 | 0.805% | 1.641% |
| 10 | 1.946% | 4.303% |
| 15 | 3.24% | 7.829% |
| 20 | 5.823% | 12.915% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_EAR_RESP – Benign neoplasm of middle ear and respiratory system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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