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Benign neoplasm: Central nervous system, other parts/unspecified

DOID Endpoint Browser PheWeb

CD2_BENIGN_CNS_NOS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D33.7&
  • Hospital discharge: ICD-9 — 2259
  • Hospital discharge: ICD-8 — 2259
  • Cause of death: ICD-10 — D33.7&
  • Cause of death: ICD-9 — 2259
  • Cause of death: ICD-8 — 2259

2 out of 7 registries used, show all original rules.

127

4. Check minimum number of events

None

127

5. Include endpoints

None

127

6. Filter based on genotype QC (FinnGen only)

127

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D33
Name in latin
Neoplasma benignum alterius partis specificatae systematis nervosi centralis

Similar endpoints

↥

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1132 596 527
Only index persons 873 465 408
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 48.75 50.58 46.64
Only index persons 46.11 47.21 44.85

-FinnGen-

Key figures

All Female Male
Number of individuals 127 63 64
Unadjusted period prevalence (%) 0.02 0.02 0.03
Median age at first event (years) 50.87 50.19 51.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
117
Matched controls
1169
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D33.7
ICD-10 Finland
Benign neoplasm: Other specified parts of central nervous system
+∞
110.7
88
*
2259X
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Nervous system, part unspecified
+∞
18.2
17
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
28.0
14.3
19
8
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
9.3
13.2
28
38
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
+∞
12.7
12
*
22599
ICD-8 Finland
Benign neoplasm of brain and other parts of nervous system, Unspecified site
+∞
10.6
10
*
9560/0-C72.9
ICD-O-3
Schwannoma, NOS, of nervous system, NOS
+∞
8.4
8
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
14.4
8.1
13
10
XCK00
NOMESCO Finland
Perimetry
6.2
6.6
17
31
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
73.7
6.5
7
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
6.3
6
*
D32.1
ICD-10 Finland
Benign neoplasm: Spinal meninges
+∞
6.3
6
*
D33.07
ICD-10 Finland
Colloid coast in cerebral ventricle
+∞
6.3
6
*
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
+∞
6.3
6
*
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
36
179
2.41
4.41
2.4
2.5
mmol/l
2.4
2.5
0.81
29
154
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
28
138
2.32
3.45
4.6
7.7
—
—
—
0
0
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
8
15
5.61
3.24
1.9
1.6
nmol/l
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
52
339
1.90
3.03
2.4
3.5
mmol/l
2.4
2.4
0.25
43
287
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
8
17
4.94
2.97
1.9
1.5
—
—
—
0
0
(3003396) Base excess in Arterial blood by calculation
24
118
2.27
2.96
6.8
13.5
mmol/l
1.2
1.7
0.29
19
95
(3044640) Blood type and Crossmatch panel - Blood
48
318
1.82
2.58
2.8
2.5
—
—
—
0
0
(3020891) Body temperature
11
39
2.99
2.54
6.0
4.8
—
—
—
0
0
(40761535) Cells panel - Urine sediment
20
97
2.26
2.54
3.5
3.3
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
8
22
3.81
2.41
1.5
1.5
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
36
224
1.85
2.34
2.4
2.5
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
14
60
2.50
2.31
1.2
1.3
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
61
445
1.71
2.30
4.9
4.4
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
65
483
1.71
2.29
8.2
9.1
mmol/l
1.2
1.2
0.02
56
406
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
8
24
3.49
2.22
1.3
1.1
—
—
—
0
0
(3016502) Oxygen saturation in Arterial blood
20
104
2.10
2.15
7.4
14.7
%
94.4
95.8
0.27
20
99
(3023368) Bacteria identified in Blood by Culture
42
281
1.74
2.13
4.9
4.3
—
—
—
0
0
(3000093) Morphology [Interpretation] in Blood Narrative
5
10
5.15
2.09
1.2
1.4
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
91
759
1.70
1.93
5.2
3.9
pmol/l
15.0
14.7
0.49
85
675
(3045414) Leukocytes [Presence] in Urine
9
35
2.69
1.84
2.4
1.5
—
—
—
0
0
(3047007) Chlamydophila sp Ab [Presence] in Serum
5
12
4.29
1.84
1.6
1.2
—
—
—
0
0
(4034850)
8
29
2.87
1.82
10.1
15.2
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
54
400
1.61
1.82
6.5
9.2
inr
1.1
1.3
0.41
14
120
(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma
14
68
2.19
1.78
1.1
1.1
iu/ml
22.2
129.6
—
5
26
(3000991) Gas panel - Venous blood
16
83
2.06
1.74
9.1
10.3
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
8
31
2.68
1.69
1.3
1.4
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
41
291
1.60
1.62
5.0
3.9
estimate
0.0
0.0
0.49
11
84
(3013650) Neutrophils [#/volume] in Blood by Automated count
74
603
1.54
1.59
7.2
9.5
e9/l
4.4
4.2
0.27
66
536
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
33
224
1.64
1.55
1.6
1.8
mg/l
0.9
1.4
1.03
26
185
(3002256) Pathology report gross observation
20
118
1.82
1.52
1.2
1.3
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
7
28
2.58
1.47
1.1
2.3
—
—
—
0
0
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
7
28
2.58
1.47
2.6
2.6
g/l
0.0
0.0
—
7
28
(3019060) Gas panel - Arterial blood
14
74
2.00
1.45
3.6
10.7
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
112
1020
1.83
1.38
17.8
14.4
mg/l
22.1
23.6
0.19
93
799
(3044290) Cell count panel - Cerebral spinal fluid
5
17
3.02
1.37
1.0
1.8
—
—
—
0
0
(3013115) Eosinophils [#/volume] in Blood
66
536
1.48
1.37
5.7
5.9
e9/l
0.2
0.2
0.26
60
478
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
52
403
1.49
1.36
3.9
3.7
ng/l
62.2
30.5
0.48
39
291
(3013707) Erythrocyte sedimentation rate by Westergren method
89
769
1.53
1.35
4.3
4.1
mm/h
10.7
12.4
0.58
83
696
(3052851) Hemolysis interference index of Serum or Plasma
8
34
2.44
1.32
1.6
3.4
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
114
1048
1.86
1.30
21.4
16.7
mmol/l
3.9
4.0
1.00
114
1015
(3019198) Lymphocytes [#/volume] in Blood
64
525
1.44
1.22
5.9
5.6
e9/l
1.8
2.0
0.55
58
472
(40768443) Skin Pathology biopsy report
8
38
2.18
1.21
1.3
1.3
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
49
383
1.45
1.20
2.3
2.1
—
—
—
0
0
(3018418) pH of Serum or Plasma
41
310
1.48
1.19
3.2
4.3
ph
7.4
7.4
—
7
55
(3019550) Sodium [Moles/volume] in Serum or Plasma
113
1043
1.76
1.17
21.8
16.6
mmol/l
139.6
139.6
0.05
113
1011
(4035726)
16
96
1.76
1.17
1.3
1.3
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
46
357
1.45
1.16
3.5
3.1
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
40
302
1.47
1.16
3.1
3.0
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
7
32
2.25
1.10
1.1
1.2
—
—
—
0
0
(3027273) Bicarbonate [Moles/volume] in Venous blood
10
52
2.00
1.09
4.6
4.1
mmol/l
24.8
24.4
—
10
52
(42529406) Shigella sp [Presence] in Stool by Culture
7
33
2.18
1.07
1.1
1.2
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
7
33
2.18
1.07
1.1
1.2
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
62
516
1.39
1.04
4.5
3.7
estimate
0.0
0.0
—
10
92
(3013512) EKG study
38
291
1.44
1.02
4.8
4.1
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
62
518
1.38
1.01
5.3
5.1
estimate
0.0
0.0
0.00
11
91
(3006184) Hemoglobin [Mass/volume] in Capillary blood
0
28
0.00
0.99
0.0
2.2
—
126.5
—
0
18
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
25
340
0.67
0.98
2.5
3.2
u/l
29.8
31.7
0.25
25
323
(3022313) Gas panel - Capillary blood
7
37
1.94
0.95
2.4
4.5
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
6
28
2.20
0.93
1.7
1.1
—
—
—
0
0
(3006315) Basophils [#/volume] in Blood
61
515
1.35
0.91
6.0
5.6
e9/l
0.0
0.0
0.10
56
454
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
8
43
1.92
0.89
2.6
2.2
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
78
686
1.36
0.88
4.5
4.2
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
30
228
1.41
0.83
2.5
2.0
mg/l
2.9
3.1
0.17
25
203
(3007853) Bacteria identified in Skin by Aerobe culture
18
123
1.54
0.83
1.6
1.7
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
61
522
1.32
0.80
4.6
3.7
estimate
0.0
0.0
0.00
11
86
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
25
0.00
0.80
0.0
1.6
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
24
177
1.44
0.78
1.4
1.8
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
43
351
1.34
0.78
3.6
3.7
e6/l
20.7
67.5
1.65
38
249
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
5
23
2.22
0.77
1.0
1.6
—
—
—
0
0
(3009343) pH of Capillary blood
9
54
1.72
0.76
2.1
4.0
—
7.4
—
0
8
(3004716) Salmonella sp identified in Stool by Organism specific culture
9
55
1.68
0.75
1.1
1.3
—
—
—
0
0
(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
7
38
1.89
0.75
2.6
2.4
g/l
2.8
3.2
—
7
30
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
7
38
1.89
0.75
2.6
1.8
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
10
60
1.72
0.74
10.2
7.2
mmol/l
26.8
25.4
—
10
60
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
23
170
1.43
0.74
1.3
1.2
iu/ml
19.2
37.6
—
5
57
(3046279) Procalcitonin [Mass/volume] in Serum or Plasma
7
42
1.70
0.69
2.3
1.9
ug/l
1.0
7.5
—
7
37
(40760892) CBC W Ordered Manual Differential panel - Blood
31
245
1.35
0.69
3.9
4.5
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
5
28
1.82
0.67
1.2
1.3
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
5
29
1.75
0.64
1.4
1.3
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
25
193
1.37
0.64
1.9
1.7
nmol/l
1404.8
1275.1
0.30
20
141
(3011397) Hemoglobin [Presence] in Urine by Test strip
31
248
1.33
0.63
4.6
3.5
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
5
30
1.69
0.62
1.2
1.4
—
—
—
0
0
(3027008) Opiates [Presence] in Urine
5
30
1.69
0.62
1.2
1.4
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
5
30
1.69
0.62
1.2
1.4
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
11
72
1.58
0.61
3.7
2.6
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
0
20
0.00
0.61
0.0
3.7
—
—
—
0
0
(3016650) Hepatitis A virus Ab [Presence] in Serum
0
20
0.00
0.61
0.0
1.0
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay
0
20
0.00
0.61
0.0
1.3
—
1.6
—
0
8
(3050449) Albumin [Mass/time] in Urine collected for unspecified duration
0
22
0.00
0.60
0.0
2.2
—
136.6
—
0
12
(40767503) Oxygen content in Capillary blood by calculation
0
22
0.00
0.60
0.0
2.8
—
16.5
—
0
9
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
8
53
1.54
0.59
1.1
1.5
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay
0
23
0.00
0.59
0.0
1.2
—
4.8
—
0
12
(3044889) 12 lead EKG panel
79
720
1.26
0.57
3.9
3.8
—
—
—
0
0
(40758558) Short blood count panel - Blood
32
262
1.30
0.56
6.5
7.0
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
99
928
1.30
0.55
6.0
4.6
mu/l
1.8
1.9
0.64
93
820
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
17
126
1.40
0.55
1.4
1.7
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
19
144
1.38
0.54
1.3
1.2
—
—
—
0
0
(3008898) HLA-B27 [Presence]
7
45
1.59
0.50
1.0
1.1
—
—
—
0
0
(3013742) Prealbumin [Mass/volume] in Serum or Plasma
14
102
1.42
0.50
1.9
2.6
g/l
0.2
0.2
0.02
14
92
(1761868) Lipid panel - Serum or Plasma
33
389
0.80
0.49
2.4
2.9
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
11
152
0.70
0.47
1.5
1.5
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
5
85
0.57
0.47
1.4
1.2
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
9
130
0.67
0.46
2.4
1.6
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
13
95
1.41
0.46
4.2
3.6
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
17
131
1.34
0.45
1.5
1.8
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
89
943
0.81
0.44
17.1
15.2
%
40.7
40.3
0.29
66
683
(3027944) Amphetamines [Presence] in Urine
5
31
1.64
0.43
1.2
1.4
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
47
415
1.21
0.43
5.1
3.8
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
71
652
1.20
0.43
3.4
3.1
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
5
33
1.54
0.42
3.0
1.6
—
—
—
0
0
(3029080) Hemoglobin [Entitic mass] in Reticulocytes
0
15
0.00
0.41
0.0
1.8
—
32.1
—
0
15
(3019230) Fractional oxyhemoglobin in Venous blood
0
15
0.00
0.41
0.0
2.5
—
61.4
—
0
15
(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
(3022806) Fractional oxyhemoglobin in Capillary blood
0
16
0.00
0.41
0.0
2.1
—
88.7
—
0
16
(21494755) Public health laboratory ask at order entry panel
7
105
0.65
0.41
1.6
1.4
—
—
—
0
0
(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
(4306422)
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
5
34
1.49
0.41
2.0
1.9
—
—
—
0
0
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
(3013327) Hepatitis A virus IgM Ab [Presence] in Serum
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
5
35
1.45
0.40
1.0
1.2
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
5
35
1.45
0.40
1.2
2.0
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
(4268621)
0
19
0.00
0.39
0.0
2.1
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
5
36
1.40
0.38
4.0
2.7
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
10
134
0.72
0.37
1.6
1.6
—
—
—
0
0
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
20
242
0.79
0.37
1.2
1.3
u/ml
0.8
1.5
—
10
63
(3021879) Hepatitis B virus core Ab [Presence] in Serum
5
79
0.62
0.37
1.0
1.5
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
21
173
1.26
0.36
2.1
1.5
—
—
—
0
0
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
103
987
1.23
0.35
4.0
4.1
mmol/l
1.2
1.3
0.77
94
892
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
12
91
1.35
0.35
1.5
1.5
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
26
303
0.82
0.34
3.2
4.0
mg/mmol
1.4
9.3
3.17
15
193
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
23
193
1.23
0.34
3.3
3.4
ng/l
18.1
174.1
1.84
16
147
(3022145) Colonoscopy Study observation
14
110
1.31
0.33
1.3
1.3
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
44
395
1.17
0.33
2.4
2.0
pmol/l
88.0
91.0
0.23
26
201
(3041096) Erythrocytes [Presence] in Urine by Automated
25
290
0.83
0.31
5.1
3.5
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
10
75
1.36
0.31
1.5
1.6
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
108
1044
1.23
0.30
4.7
5.0
mmol/l
2.8
2.7
0.11
100
954
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
7
55
1.29
0.30
5.4
2.5
%
1.5
1.4
—
7
55
(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma
8
108
0.72
0.30
2.8
4.0
ug/l
2.3
51.3
—
8
89
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
7
56
1.26
0.30
15.0
18.6
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
21
177
1.22
0.30
1.8
1.7
—
—
—
0
0
(3022621) pH of Urine by Test strip
8
64
1.27
0.28
2.8
2.1
—
—
—
0
0
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
113
1100
1.25
0.27
12.2
10.3
u/l
24.0
25.7
0.65
113
1051
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
100
965
1.17
0.25
18.4
12.9
ml/min/173m2
81.7
80.9
0.14
89
774
(4010399)
9
76
1.20
0.25
1.3
1.4
—
—
—
0
0
(3002582) Erythrocytes [#/volume] in Urine
34
306
1.15
0.24
3.6
3.1
e6/l
18.0
47.2
0.94
34
235
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
13
156
0.81
0.23
2.8
2.9
e6/l
6.5
3.2
—
8
88
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
105
1020
1.17
0.22
4.4
4.5
mmol/l
4.7
4.6
0.16
97
937
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
12
145
0.81
0.22
1.5
1.4
—
—
—
0
0
(3036489) Thrombin time
5
42
1.20
0.21
1.0
2.0
s
26.4
20.7
—
5
37
(3044941) Cell count panel - Synovial fluid
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
2.1
—
15.9
—
0
10
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(3028308) Erythrocytes [#/volume] in Pleural fluid
0
10
0.00
0.21
0.0
1.3
—
19596.0
—
0
5
(40768806) Pleura Pathology biopsy report
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(4027681)
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(3011363) Streptococcus pneumoniae Ag [Presence] in Urine
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3045142) Bone marrow Pathology biopsy report
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
0
12
0.00
0.21
0.0
3.3
—
—
—
0
0
(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
(3025130) Human papilloma virus identified in Specimen
0
12
0.00
0.21
0.0
2.5
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
51
476
1.12
0.21
6.5
5.7
%
2.4
2.8
0.64
46
438
(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
6
50
1.21
0.20
4.3
4.4
—
—
—
0
0
(3009508) Creatinine [Moles/volume] in Urine
28
306
0.89
0.16
2.7
3.0
mmol/l
7.2
7.8
0.34
23
254
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
99
965
1.12
0.16
6.0
5.7
mmol/mol
38.9
39.8
0.46
94
889
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
9
78
1.17
0.16
2.1
1.4
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
12
102
1.19
0.16
1.5
1.9
—
—
—
0
0
(3026782) Osmolality of Urine
22
198
1.13
0.15
3.6
2.9
mosm/kgh2o
515.8
555.0
0.34
22
169
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
104
1017
1.12
0.15
4.3
4.5
mmol/l
1.5
1.5
0.03
96
924
(36304419) Bacteria [Presence] in Urine
29
269
1.10
0.13
3.5
2.8
—
—
—
0
0
(3024731) MCV [Entitic volume]
115
1133
1.16
0.12
26.7
20.7
fl
90.7
91.1
0.37
115
1114
(3035941) MCH [Entitic mass]
115
1133
1.16
0.12
26.6
20.7
pg
30.3
30.3
0.22
115
1114
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
18
163
1.12
0.11
2.2
2.7
e6/l
0.4
1.1
1.54
13
93
(3000963) Hemoglobin [Mass/volume] in Blood
115
1134
1.15
0.11
27.0
20.9
g/l
136.3
135.9
0.12
115
1112
(3003694) ABO and Rh group [Type] in Blood
27
251
1.10
0.11
1.5
1.5
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
44
419
1.08
0.11
2.8
2.4
nmol/l
75.5
75.3
0.02
39
369
(1002224) Polysomnography panel
5
45
1.12
0.10
1.6
1.2
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
109
1074
1.11
0.09
16.1
13.4
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
6
53
1.14
0.09
1.3
1.3
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
12
107
1.13
0.09
1.7
1.8
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
6
72
0.83
0.08
1.5
1.5
—
—
—
0
0
(3019225) pH of Specimen
9
83
1.09
0.07
9.2
5.7
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
27
284
0.94
0.06
2.7
3.2
mg/l
25.3
280.9
0.60
18
184
(3042936) Bacteria identified in Isolate by Culture
16
149
1.08
0.05
2.6
2.1
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
11
100
1.11
0.05
2.3
1.8
—
—
—
0
0
(3000492) Spirometry study
11
101
1.10
0.04
1.3
1.5
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
29
291
1.00
0.00
4.6
4.3
%
21.2
21.6
0.06
17
137
(42870588) Differential panel, method unspecified - Blood
32
323
0.99
0.00
7.0
5.5
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
21
212
0.99
0.00
3.0
2.7
ug/l
0.8
0.9
0.15
15
123
(3021589) Normoblasts [#/volume] in Blood
44
436
1.01
0.00
11.8
10.0
e9/l
0.0
0.0
0.71
37
353
(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline
0
5
0.00
0.00
0.0
1.0
—
6.5
—
0
5
(3044927) Protein electrophoresis panel - Urine
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum
0
5
0.00
0.00
0.0
1.4
—
18.4
—
0
5
(44806071)
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
6.1
—
0.6
—
0
9
(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3028433) Virus identified in Specimen by Culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3045788) Cell count panel - Pleural fluid
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3014271) Vancomycin [Susceptibility]
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction
0
9
0.00
0.00
0.0
1.2
—
197.6
—
0
9
(3017704) Immunofixation for Urine
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3025018) Bordetella pertussis Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.5
—
1.1
—
0
8
(3029075) Extractable nuclear Ab panel - Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3035320) C reactive protein [Mass/volume] in Body fluid
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3000012) Reticulocyte production index
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3035880) pH of Pleural fluid
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
5
52
0.96
0.00
2.4
2.1
—
—
—
0
0
(3037692) Legionella sp identified in Specimen by Organism specific culture
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
5
52
0.96
0.00
1.0
1.0
—
—
—
0
0
(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.6
—
30.4
—
0
7
(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3011648) Oxygen content in Venous blood
0
8
0.00
0.00
0.0
2.5
—
12.9
—
0
8
(3035933) Granulocytes/100 leukocytes in Blood
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
8
84
0.95
0.00
5.3
3.3
—
—
—
0
0
(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
6
61
0.98
0.00
1.3
1.3
—
—
—
0
0
(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(21491868) Cryoglobulin [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3012441) Differential panel - Pleural fluid
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3042975) Streptococcus sp identified in Isolate by Organism specific culture
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
4.7
—
—
—
0
0
(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid
0
6
0.00
0.00
0.0
1.3
—
14.3
—
0
6
(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
9
90
1.00
0.00
1.4
1.8
—
—
—
0
0
(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3017569) Oxygen content in Arterial blood
0
6
0.00
0.00
0.0
12.8
—
—
—
0
0
(3038026) Centromere Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum
0
6
0.00
0.00
0.0
1.8
—
77.0
—
0
6
(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_CNS_NOS and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CNS_NOS 1.387 [1.01, 1.9] 0.041
Birth year 1.001 [0.99, 1.01] 0.808

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 315 females with CD2_BENIGN_CNS_NOS died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_CNS_NOS 1.853 [1.28, 2.68] 0.001
Birth year 0.989 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 283 males with CD2_BENIGN_CNS_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CNS_NOS.

N-year risk Females Males
1 0.154% 0.343%
5 0.934% 2.159%
10 2.392% 5.722%
15 4.796% 10.819%
20 8.598% 17.648%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_CNS_NOS – Benign neoplasm: Central nervous system, other parts/unspecified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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