No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4945 |
4. Check minimum number of eventsNone |
4945 |
5. Include endpointsNone |
4945 |
6. Filter based on genotype QC (FinnGen only) |
4945 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D10-D36
- Name in latin
- Neoplasma benignum mammae
Similar endpoints
↥List of similar endpoints to
Benign neoplasm of breast
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of breast
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 36691 | 36691 | - |
| Only index persons | 33454 | 33454 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.05 | 1.05 | - |
| Only index persons | 1.23 | 1.23 | - |
| Median age at first event (years) | |||
| Whole population | - | 43.94 | - |
| Only index persons | - | 42.89 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4945 | 4945 | - |
| Unadjusted period prevalence (%) | 1.69 | 1.69 | - |
| Median age at first event (years) | 42.55 | 42.55 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 4473
- Matched controls
- 44730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
2170A
ICD-9 Finland
Benign neoplasm of breast[NEOPLASMA BENIGNUM MAMMAE]
+∞
323.0
621
*
HAB00
NOMESCO Finland
Excision of lesion of mammary gland
36.0
323.0
1360
536
N63
ICD-10 Finland
Unspecified lump in breast
6.8
323.0
1095
2030
9702
FHL
Breast exploration and possible tumor removal
21.4
323.0
530
279
21799
ICD-8 Finland
Benign neoplasm of breast
+∞
323.0
927
*
D24
ICD-10 Finland
Benign neoplasm of breast
3842.7
323.0
2984
23
HAB99
NOMESCO Finland
Other partial excision of mammary gland
8.2
207.9
495
672
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
3.6
150.2
761
2385
HAA10
NOMESCO Finland
Biopsy of mammary gland
13.8
116.5
206
156
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
6.0
115.9
338
598
N60.2
ICD-10 Finland
Fibroadenosis of breast
14.8
111.5
191
134
HAB40
NOMESCO Finland
Wedge excision of mammary gland
3.2
93.0
537
1814
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
4.5
87.3
327
763
D48.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Breast
5.7
85.0
259
481
HA1AA
NOMESCO Finland
X-ray mammography
2.6
83.7
683
2873
9703
FHL
Breast resection
9.0
82.2
180
208
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
3.7
69.0
328
947
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
55.5
1103
6742
N64.5
ICD-10 Finland
Other signs and symptoms in breast
4.2
54.4
219
545
N60.1
ICD-10 Finland
Diffuse cystic mastopathy
7.5
53.7
130
177
N64.9
ICD-10 Finland
Disorder of breast, unspecified
5.4
41.4
128
242
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
2.3
40.4
389
1751
X19
ICPC
Breast lump/mass female
3.9
38.0
163
430
ZXE00
NOMESCO Finland
One hour or less
1.5
35.9
1762
13437
XX2AT
NOMESCO Finland
Other injection with ultrasound examination
4.4
35.9
134
311
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
3.7
35.4
161
447
115
Kela drug reimbursment
Breast cancer
1.9
35.2
575
3225
HAB20
NOMESCO Finland
Excision of lactiferous duct
11.0
32.9
63
58
HA4GT
NOMESCO Finland
Labeling mammary gland pathology with galactographic guidance
16.4
32.4
52
32
HA1CG
NOMESCO Finland
Extensive MRI examination of mammary gland with high intensity magnet
3.7
32.3
148
414
C50.99
ICD-10 Finland
Breast, unspecified
2.7
31.8
222
836
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
31.4
1704
13163
ZXA05
NOMESCO Finland
Left side
1.6
30.8
1101
7739
N60.8
ICD-10 Finland
Other benign mammary dysplasias
9.5
28.6
59
63
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
2.9
27.8
171
595
HA3ST
NOMESCO Finland
Removal of lesion of breast with radiological guidance
9.3
26.4
55
60
ZXA00
NOMESCO Finland
Right side
1.5
26.1
1150
8421
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
1.9
25.3
386
2099
HAC20
NOMESCO Finland
Total mastectomy
2.1
25.2
292
1425
HA5CB
NOMESCO Finland
Galactography
11.3
24.6
46
41
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
24.3
1090
7990
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
2.8
23.9
163
606
HA6BA
NOMESCO Finland
Breast tomosynthesis specimen
3.6
23.0
104
290
PJA12
NOMESCO Finland
Sentinel node biopsy
1.7
22.8
471
2837
N60.0
ICD-10 Finland
Solitary cyst of breast
5.5
22.7
68
126
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
3.4
22.2
108
320
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
2.7
22.1
160
617
Z2221
NOMESCO Finland
Medical doctor
1.4
22.0
1183
8966
R92
ICD-10 Finland
Abnormal findings on diagnostic imaging of breast
6.4
21.4
56
88
L02BA01
ATC
tamoxifen; oral
2.0
20.5
262
1330
HAE99
NOMESCO Finland
Other reconstruction of breast
4.3
20.3
75
175
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
1.9
19.3
276
1466
HAE10
NOMESCO Finland
Reconstruction of breast using graft or flap
3.1
19.1
109
361
8500/2-C50.9
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of breast, NOS
3.2
18.8
99
313
N64.8
ICD-10 Finland
Other specified disorders of breast
6.0
17.9
49
82
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
2.0
17.9
240
1244
HAD30
NOMESCO Finland
Reduction mammoplasty with transposition of areola
2.0
17.3
217
1097
9736
FHL
Subcutaneous tumor removal in operating room or anesthesia
3.8
17.2
73
195
ZXD20
NOMESCO Finland
Day surgery
1.5
17.1
562
3815
C50
ICD-10 Finland
Malignant neoplasm of breast
2.3
16.6
153
673
HA1AE
SPAT
NA
2.8
16.3
106
387
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
16.1
1339
10817
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
15.9
1501
12354
A02BC05
ATC
esomeprazole; systemic
1.3
15.3
1679
14093
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
15.3
1458
11994
L02BG04
ATC
letrozole; oral
1.7
15.3
364
2278
Z85.3
ICD-10 Finland
Personal history of malignant neoplasm of breast
3.8
15.3
64
170
N64.4
ICD-10 Finland
Mastodynia
2.2
15.2
160
751
N61
ICD-10 Finland
Inflammatory disorders of breast
2.4
14.8
128
549
A03FA01
ATC
metoclopramide; systemic, rectal
1.4
14.8
914
7024
TQW20
NOMESCO Finland
Tatoe
3.1
14.2
79
262
WX702
NOMESCO Finland
Supraglottic ventilation device
1.9
14.1
224
1238
J01DB01
ATC
cefalexin; oral
1.3
14.1
3435
31934
X21
ICPC
Breast sympt/compl female other
2.4
14.1
123
531
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
2.6
14.0
101
393
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
1.7
13.9
291
1753
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
2.6
13.9
102
401
R4110
NOMESCO Finland
Physiotherapy
1.3
13.8
1020
8053
61000
ICD-8 Finland
Chronic cystic disease of breast, Fibroadenomatosis mammae
3.7
13.7
59
161
HA2AT
NOMESCO Finland
Cytology of mammary gland with ultrasound guidance
4.6
13.5
46
101
WX402
NOMESCO Finland
General anaesthesia
1.4
13.2
622
4541
6101A
ICD-9 Finland
Benign mammary dysplasias, Diffuse cystic mastopathy
4.6
13.0
44
96
Z00.0
ICD-10 Finland
General medical examination
1.4
12.9
694
5191
N02BE01
ATC
paracetamol; systemic, rectal
1.3
12.6
3720
35145
HA1TE
NOMESCO Finland
Supplementary or limited ultrasound examination of mammary glands
2.8
12.1
76
273
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
1.8
12.1
210
1196
61099
ICD-8 Finland
Chronic cystic disease of breast, Unspecified
4.7
12.1
40
86
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
12.0
1521
12901
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
2.3
12.0
106
462
N60.9
ICD-10 Finland
Benign mammary dysplasia, unspecified
4.3
11.9
43
101
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
1.5
11.9
366
2446
Z80.3
ICD-10 Finland
Family history of malignant neoplasm of breast
2.4
11.8
96
401
R51.80
ICD-10 Finland
Headache
1.4
11.8
607
4503
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
1.6
11.7
308
1978
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
11.7
971
7780
N60.4
ICD-10 Finland
Mammary duct ectasia
7.7
11.6
26
34
THA00
NOMESCO Finland
Needle biopsy of mamilla
8.1
11.5
25
31
HA3RT
NOMESCO Finland
Coagulation of mammary neoplasm under radiological guidance
15.0
11.3
18
12
C50.4
ICD-10 Finland
Malignant neoplasm: Upper-outer quadrant of breast
2.9
11.1
67
237
WX110
NOMESCO Finland
Local anesthesy
1.2
11.0
2778
25423
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
10.9
1027
8362
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.4
10.9
529
3880
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.3
10.6
1396
11855
X18
ICPC
Breast pain female
2.5
10.6
83
342
8520/2-C50.9
ICD-O-3
Lobular carcinoma in situ, NOS, of breast, NOS
11.2
10.5
19
17
Z31.5
ICD-10 Finland
Genetic counselling
1.7
10.5
211
1259
J02AC01
ATC
fluconazole; systemic
1.2
10.5
1981
17518
N62
ICD-10 Finland
Hypertrophy of breast
1.7
10.5
197
1153
D05.0
ICD-10 Finland
Lobular carcinoma in situ
6.2
10.4
27
44
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.7
10.4
232
1430
A04AA02
ATC
granisetron; systemic, transdermal
1.6
10.1
233
1444
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
10.1
1069
8822
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
2.0
9.9
130
673
HAC25
NOMESCO Finland
Radical mastectomy
3.9
9.8
38
97
ZZR10
NOMESCO Finland
Flap of skin and muscle
3.3
9.6
46
140
C50.9
ICD-10 Finland
Malignant neoplasm: Breast, unspecified
3.3
9.5
45
136
J01FA10
ATC
azithromycin; systemic
1.2
9.2
2456
22380
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
9.0
159
917
J01DA01
ATC
[U] cefalexin; systemic
1.2
9.0
2549
23353
HA1RA
SPAT
NA
1.9
8.9
128
685
Z3226
NOMESCO Finland
Physiotherapist
1.3
8.9
678
5338
HAE00
NOMESCO Finland
Reconstruction of breast using prosthesis
3.8
8.8
35
92
17402
ICD-8 Finland
Malignant neoplasm of breast, Glandulae
4.1
8.7
32
78
R22.2
ICD-10 Finland
Localized swelling, mass and lump, trunk
1.9
8.7
120
634
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
2.3
8.6
73
315
H02AB02
ATC
dexamethasone; systemic
1.4
8.5
402
2931
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
1.6
8.5
224
1442
HAD50
NOMESCO Finland
Removal of prosthetic implant from breast
4.1
8.4
31
76
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
1.9
8.3
123
670
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
1.4
8.2
423
3132
A03FA02
ATC
cisapride; oral, rectal
1.5
8.2
299
2077
Z3231
NOMESCO Finland
Registered nurse
1.3
8.2
953
7934
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
1.6
8.1
201
1276
9719
FHL
Other measure in this category
4.8
8.0
25
52
D01
ICPC
Abdominal pain/cramps general
1.4
8.0
410
3032
5702
FHL
Local lymph node removal (eg armpit, groin)
4.1
7.9
29
71
PJD42
NOMESCO Finland
Excision of axillary lymph nodes
2.5
7.9
58
232
HAC15
NOMESCO Finland
Subcutaneous mastectomy with excision of mamilla
3.0
7.8
43
146
C50.92
ICD-10 Finland
Malignant tumor in another specified localization in lobular gland, lobular tumor
3.6
7.8
33
92
N60.3
ICD-10 Finland
Fibrosclerosis of breast
9.4
7.8
15
16
Z42.1
ICD-10 Finland
Follow-up care involving plastic surgery of breast
3.1
7.8
40
130
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.3
7.8
557
4348
ZZF00
NOMESCO Finland
Graft of adipose tissue
2.6
7.7
51
194
HAB10
NOMESCO Finland
Microductectomy of mammary gland
45.0
7.7
9
*
QBE20
NOMESCO Finland
Excision and repair of scar or web of skin of trunk
3.0
7.7
42
142
HA3AT
NOMESCO Finland
Pucture of mammary gland cyst with ultrasound examination
2.9
7.7
44
151
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
1.6
7.7
204
1317
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
7.6
633
5043
C50.51
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, ductal tumor
2.0
7.6
89
446
A02BC02
ATC
pantoprazole; systemic
1.2
7.5
2623
24297
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.3
7.5
457
3483
N03AX16
ATC
pregabalin; oral
1.2
7.5
885
7373
ZZQ10
NOMESCO Finland
Free microvascular graft of skin and muscle
3.7
7.4
30
81
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.2
7.4
908
7591
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.3
7.4
798
6574
J01MA02
ATC
ciprofloxacin; systemic
1.2
7.4
1326
11549
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
7.3
1688
15046
C50.31
ICD-10 Finland
Malignant tumor of the lower inner quadrant of the mammary gland, ductal tumor
2.3
7.3
62
270
ZSH00
NOMESCO Finland
Procedure related to previous procedure classified in chapter H
3.1
7.3
38
125
X79
ICPC
Benign neoplasm breast female
6.8
7.3
17
25
SPAT1336
SPAT
Request for examination
1.7
7.2
139
824
HA1CM
NOMESCO Finland
Mammary gland extensive MRI examination with 3 Tesla magnet
3.7
7.1
29
79
A02BC01
ATC
omeprazole; systemic
1.2
7.1
1024
8711
UJF32
NOMESCO Finland
Coloscopy
1.2
7.1
930
7831
C07AA05
ATC
propranolol; systemic
1.3
7.1
772
6365
L82
ICD-10 Finland
Seborrhoeic keratosis
1.3
7.1
566
4488
EB1SA
SPAT
NA
1.7
7.0
132
777
HWD00
NOMESCO Finland
Reoperation for deep haemorrhage in surgery of mammary gland
2.8
6.8
41
149
M01AE03
ATC
ketoprofen; systemic, rectal
1.2
6.8
1403
12362
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.2
6.7
2523
23399
L02
ICPC
Back symptom/complaint
1.4
6.7
337
2487
HAC10
NOMESCO Finland
Subcutaneous mastectomy with preservation of mamilla
5.2
6.6
19
37
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
1.6
6.5
175
1137
ZXA10
NOMESCO Finland
Bilateral
1.3
6.5
690
5664
C50.82
ICD-10 Finland
Overall malignant tumor of the mammary gland, lobular tumor
2.5
6.5
46
182
S18
ICPC
Laceration/cut
1.2
6.5
1484
13181
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.5
6.4
198
1327
6117B
ICD-9 Finland
Other disorders of breast, Signs and symptoms in breast[TUMOR MAMMAE]
2.9
6.4
35
120
R05
ICPC
Cough
1.2
6.4
854
7201
N05CF01
ATC
zopiclone; oral
1.2
6.4
1203
10501
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
1.5
6.3
191
1274
S04
ICPC
Lump/swelling localized
1.4
6.3
333
2475
6262A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Excessive or frequent menstruation[HYPERMENORRHOEA]
1.7
6.3
120
711
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.3
6.3
465
3647
R42
ICD-10 Finland
Dizziness and giddiness
1.2
6.3
801
6719
C50.00
ICD-10 Finland
Malignant tumor of nipple and areola, no histological veryfication
2.7
6.2
38
140
8113
FHL
Fractional scraping
1.4
6.2
326
2426
1744A
ICD-9 Finland
Malignant neoplasm of female breast, Upper-outer quadrant
2.6
6.2
41
157
HA1BG
NOMESCO Finland
MRI examination of mammary gland with high intensity magnet
2.6
6.2
41
157
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
1.3
6.1
378
2884
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.3
6.1
421
3267
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
1.9
6.1
81
429
R07.4
ICD-10 Finland
Chest pain, unspecified
1.2
6.1
928
7929
N02AX02
ATC
tramadol; systemic, rectal
1.2
6.0
1490
13304
C50.5
ICD-10 Finland
Malignant neoplasm: Lower-outer quadrant of breast
4.4
6.0
20
46
9733
FHL
Excision of skin change in operating room or anesthesia
2.3
6.0
53
237
P01AB01
ATC
metronidazole; oral, rectal
1.2
6.0
1673
15085
HAE05
NOMESCO Finland
Reconstruction of breast using soft tissue and prosthesis
3.0
6.0
31
103
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_BREAST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_BREAST | 1.045 [0.95, 1.15] | 0.36 |
| Birth year | 0.999 [0.99, 1.01] | 0.807 |
During the follow-up period (1.1.1998 — 31.12.2019), 1574 out of 17928 females with CD2_BENIGN_BREAST died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_BREAST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.102% | No data |
| 5 | 0.61% | No data |
| 10 | 1.804% | No data |
| 15 | 3.457% | No data |
| 20 | 6.259% | No data |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_BREAST – Benign neoplasm of breast
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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