extra-adrenal sympathetic paraganglioma: A benign or malignant sympathetic paraganglioma arising from paraganglia outside the adrenal gland. Clinical symptoms are related to secretion of catecholamines. Representative examples include the superior and inferior paraaortic and bladder paragangliomas.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2662 |
4. Check minimum number of eventsNone |
2662 |
5. Include endpointsNone |
2662 |
6. Filter based on genotype QC (FinnGen only) |
2662 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D35
- Name in latin
- Neoplasma benignum glandulae suprarenalis
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Adrenal gland
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Adrenal gland
- Benign neoplasm of other and unspecified endocrine glands
- Benign neoplasm of other and unspecified endocrine glands
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12586 | 7260 | 5280 |
| Only index persons | 12040 | 7010 | 5030 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.21 | 0.15 |
| Only index persons | 0.23 | 0.26 | 0.19 |
| Median age at first event (years) | |||
| Whole population | 63.85 | 63.72 | 64.13 |
| Only index persons | 63.88 | 63.69 | 64.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2662 | 1527 | 1135 |
| Unadjusted period prevalence (%) | 0.51 | 0.52 | 0.50 |
| Median age at first event (years) | 63.53 | 61.84 | 65.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2334
- Matched controls
- 23341
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
BC1AD
NOMESCO Finland
CT of adrenal glands
120.4
323.0
509
54
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
4503599627370496.0
323.0
2296
*
D44.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Adrenal gland
112.0
323.0
582
69
BCA31
NOMESCO Finland
Endoscopic unilateral adrenalectomy
301.5
242.5
243
9
BC1CD
NOMESCO Finland
Very extensive CT of adrenal glands
100.4
222.2
243
27
E26.0
ICD-10 Finland
Primary hyperaldosteronism
45.2
139.1
172
41
C03DA01
ATC
spironolactone; oral
3.5
79.3
415
1344
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.2
71.9
424
1494
BC4WT
NOMESCO Finland
Selective blood sample from adrenal gland with radiological guidance
146.3
67.3
71
5
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.4
65.2
704
3557
I10
ICD-10 Finland
Essential (primary) hypertension
2.1
63.5
1545
11190
BCA30
NOMESCO Finland
Unilateral adrenalectomy
113.1
61.1
66
6
A10BA02
ATC
metformin; oral
2.2
57.9
792
4429
BC1BD
NOMESCO Finland
Extensive CT of adrenal glands
191.1
54.2
56
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
52.7
901
5488
N02BE01
ATC
paracetamol; systemic, rectal
2.6
52.0
2090
17907
E24.8
ICD-10 Finland
Other Cushing syndrome
266.3
51.3
52
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.5
51.0
159
308
H02AB09
ATC
hydrocortisone; systemic
7.1
50.7
128
188
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.1
49.4
703
3942
C07AB07
ATC
bisoprolol; oral
1.9
48.4
1227
8587
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
47.9
1144
7821
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.0
47.1
305
1124
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
16.4
46.2
75
47
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
46.0
752
4438
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
11.6
45.5
86
77
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.2
44.8
533
2737
I15.2
ICD-10 Finland
Hypertension secondary to endocrine disorders
59.0
44.5
52
9
C08CA01
ATC
amlodipine; oral
1.9
44.5
954
6220
E27.5
ICD-10 Finland
Adrenomedullary hyperfunction
445.8
44.4
44
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.0
44.2
722
4244
T90
ICPC
Diabetes non-insulin dependent
2.0
42.9
653
3723
E260, I152
ICD-10 Finland
NA
139.0
38.8
41
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
37.7
565
3174
Z3231
NOMESCO Finland
Registered nurse
1.9
37.2
690
4202
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
36.0
326
1451
N02AX02
ATC
tramadol; systemic, rectal
1.7
35.5
1055
7480
J01DB01
ATC
cefalexin; oral
1.9
33.9
1915
16448
205
Kela drug reimbursment
Chronic hypertension
1.8
33.6
709
4486
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
33.5
246
970
B01AB05
ATC
enoxaparin; parenteral
1.8
32.8
795
5252
A02BC02
ATC
pantoprazole; systemic
1.7
32.4
1560
12606
C03CA01
ATC
furosemide; systemic
1.8
31.4
677
4293
R03AC02
ATC
salbutamol; inhalant
1.7
31.1
1205
9100
UJF32
NOMESCO Finland
Coloscopy
1.8
30.3
664
4224
P01AB01
ATC
metronidazole; oral, rectal
1.7
30.1
944
6692
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.4
29.3
282
1288
R03BB04
ATC
tiotropium bromide; inhalant
2.4
29.2
280
1274
C02AC05
ATC
moxonidine; oral
3.2
27.9
155
510
N07BA03
ATC
varenicline; oral
3.0
27.8
166
574
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
27.4
721
4822
R06.0
ICD-10 Finland
Dyspnoea
1.8
27.2
602
3817
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.3
25.6
259
1207
WX402
NOMESCO Finland
General anaesthesia
1.9
25.6
418
2384
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
25.5
474
2829
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
25.1
397
2238
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
3.2
24.5
132
425
WX110
NOMESCO Finland
Local anesthesy
1.6
24.1
1535
12779
Z3226
NOMESCO Finland
Physiotherapist
1.8
23.7
455
2736
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
23.7
853
6165
JN1AD
NOMESCO Finland
CT examination of upper part of abdomen
16.1
23.7
38
24
E66.00
ICD-10 Finland
Metabolic syndrome
2.8
23.6
162
611
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
23.5
399
2301
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.9
23.3
400
2317
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
23.2
858
6231
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.3
23.0
218
984
E26.9
ICD-10 Finland
Hyperaldosteronism, unspecified
20.3
23.0
34
17
2270A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Adrenal gland
+∞
22.9
22
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
8.2
22.9
51
63
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.9
22.9
390
2252
N03AX16
ATC
pregabalin; oral
1.7
22.1
570
3746
H02AB06
ATC
prednisolone; systemic
1.5
22.1
1059
8165
C74.9
ICD-10 Finland
Malignant neoplasm: Adrenal gland, unspecified
80.9
21.7
24
*
A10BH01
ATC
sitagliptin; oral
2.1
21.2
263
1341
E87.6
ICD-10 Finland
Hypokalaemia
3.4
21.0
104
315
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
20.8
345
1967
A02BC05
ATC
esomeprazole; systemic
1.5
20.7
937
7086
N06AX11
ATC
mirtazapine; oral
1.6
20.7
710
5026
C74.0
ICD-10 Finland
Malignant neoplasm: Cortex of adrenal gland
111.0
20.6
22
*
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.8
20.3
133
489
E66.8
ICD-10 Finland
Other obesity
2.7
20.3
143
549
SPAT1262
SPAT
Handing over of treatment supplies
1.7
20.1
446
2794
G47.3
ICD-10 Finland
Sleep apnoea
1.7
20.1
503
3266
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.9
20.1
123
434
R4110
NOMESCO Finland
Physiotherapy
1.6
20.1
625
4308
E66.01
ICD-10 Finland
Obesity due to excess calories
2.3
20.0
196
900
JN4BD
NOMESCO Finland
Extensive body CT
2.0
19.3
284
1546
WZC30
NOMESCO Finland
Teaching
1.8
19.3
340
1977
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
19.2
501
3286
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
3.5
19.1
92
273
E24.9
ICD-10 Finland
Cushing syndrome, unspecified
34.6
18.9
24
7
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
18.7
402
2487
C10AA01
ATC
simvastatin; oral
1.5
18.7
1027
8051
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
18.7
219
1088
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.2
18.7
210
1025
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.5
18.3
146
604
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.9
18.1
279
1545
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
18.0
1033
8153
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.6
17.8
640
4545
C74.1
ICD-10 Finland
Malignant neoplasm: Medulla of adrenal gland
+∞
17.7
17
*
C10AA05
ATC
atorvastatin; oral
1.5
17.5
901
6940
Z72.0
ICD-10 Finland
Tobacco use
3.6
17.2
78
221
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
9.3
17.1
35
38
I15.9
ICD-10 Finland
Secondary hypertension, unspecified
6.7
17.1
43
65
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
16.9
284
1620
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
3.7
16.9
74
204
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
16.9
373
2324
B01AC04
ATC
clopidogrel; oral
1.7
16.5
360
2230
D01
ICPC
Abdominal pain/cramps general
2.0
16.4
227
1205
J01FF01
ATC
clindamycin; systemic
1.5
16.3
611
4369
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.9
16.2
100
356
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
16.1
303
1794
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
16.0
555
3893
C08CA13
ATC
lercanidipine; oral
1.8
16.0
317
1906
R5140
NOMESCO Finland
Monitoring the use of the aid
1.9
16.0
251
1397
Z71.8
ICD-10 Finland
Other specified counselling
1.6
15.9
491
3347
Z2221
NOMESCO Finland
Medical doctor
1.5
15.8
595
4252
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.8
15.8
271
1554
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.7
15.8
106
397
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.4
15.7
132
560
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
15.6
267
1529
2533
FHL
Unilateral removal of additional egg
85.6
15.6
17
*
ZXE00
NOMESCO Finland
One hour or less
1.5
15.6
850
6577
N06AX16
ATC
venlafaxine; oral
1.8
15.3
299
1788
A02BA02
ATC
ranitidine; systemic
1.6
15.3
442
2960
N06AB04
ATC
citalopram; systemic
1.6
15.1
466
3170
C09CA01
ATC
losartan; oral
1.5
15.1
554
3930
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.3
15.1
137
607
R02
ICPC
Shortness of breath/dyspnoea
1.8
15.0
276
1620
R10.0
ICD-10 Finland
Acute abdomen
3.0
14.9
86
293
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.8
14.9
273
1601
WX892
NOMESCO Finland
Monitored bed care
2.0
14.8
185
945
N03AX12
ATC
gabapentin; oral
1.7
14.8
355
2259
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
14.8
1062
8638
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
14.7
379
2461
8700/3-C74.9
ICD-O-3
Pheochromocytoma, NOS, of adrenal gland, NOS
150.9
14.5
15
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.7
14.4
306
1877
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
14.3
841
6577
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
14.2
144
673
K30
ICD-10 Finland
Functional dyspepsia
1.8
14.1
237
1349
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
14.1
397
2634
D35.9
ICD-10 Finland
Benign neoplasm: Endocrine gland, unspecified
42.7
14.1
17
*
A46
ICD-10 Finland
Erysipelas
1.7
14.0
307
1901
S10
ICPC
Boil/carbuncle
2.3
14.0
128
569
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
13.9
224
1257
N28.1
ICD-10 Finland
Cyst of kidney
4.0
13.8
54
136
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
13.8
499
3517
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
13.8
495
3487
I50.9
ICD-10 Finland
Heart failure, unspecified
1.8
13.7
270
1617
SPAT1254
SPAT
Administration of medicine
1.7
13.7
306
1906
M03BC01
ATC
orphenadrine (citrate); systemic
1.5
13.7
486
3412
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
3.0
13.7
78
263
N05BA04
ATC
oxazepam; oral
1.5
13.6
513
3652
S18
ICPC
Laceration/cut
1.4
13.6
938
7538
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
13.5
372
2451
101
Kela drug reimbursment
Anterior pituitary hypofunction
11.0
13.5
25
23
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.2
13.5
134
620
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.4
13.4
120
525
J01MA02
ATC
ciprofloxacin; systemic
1.4
13.4
857
6783
ZX120
NOMESCO Finland
Intravenous
1.9
13.4
216
1212
A10AE04
ATC
insulin glargine; parenteral
1.9
13.3
208
1154
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.5
13.3
468
3279
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
13.3
862
6840
C08CA02
ATC
felodipine; oral
1.9
13.2
215
1209
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
3.6
13.2
59
167
207
Kela drug reimbursment
Chronic arrhythmias
1.7
13.2
321
2046
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
13.2
358
2350
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
3.6
13.0
58
164
M54.5
ICD-10 Finland
Low back pain
1.4
12.8
675
5143
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
12.8
592
4396
M79.6
ICD-10 Finland
Pain in limb
1.4
12.8
758
5904
UKC02
NOMESCO Finland
Cystoscopy
1.6
12.6
356
2360
R60.0
ICD-10 Finland
Localized oedema
1.7
12.6
250
1501
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.8
12.6
79
286
E23.00
ICD-10 Finland
Panhypopituitarism
11.0
12.5
23
21
N05CF01
ATC
zopiclone; oral
1.4
12.5
690
5301
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
5.8
12.4
34
59
M48.0
ICD-10 Finland
Spinal stenosis
1.7
12.4
285
1789
Z3229
NOMESCO Finland
Other healthcare associate professional
1.9
12.3
189
1044
C09CA03
ATC
valsartan; oral
1.8
12.3
223
1302
K05.31
ICD-10 Finland
Periodontitis pronounced
1.8
12.2
236
1409
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
12.1
726
5655
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
11.1
12.0
22
20
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.0
11.9
150
768
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
3.9
11.8
48
126
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
11.8
467
3348
N06AB10
ATC
escitalopram; oral
1.6
11.7
374
2555
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
11.6
704
5484
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.1
11.6
139
696
N06AX21
ATC
duloxetine; oral
1.7
11.6
232
1396
EBA00
NOMESCO Finland
Extraction of tooth
1.4
11.6
661
5091
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
23.0
11.6
16
7
A10BK01
ATC
dapagliflozin; oral
2.2
11.6
113
519
A10BJ02
ATC
liraglutide; parenteral
3.0
11.5
67
231
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
3.5
11.5
52
150
N05AH04
ATC
quetiapine; oral
1.6
11.4
305
1991
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
11.4
603
4576
D06
ICPC
Abdominal pain localized other
1.9
11.4
170
929
M01AB05
ATC
diclofenac; systemic, rectal
1.4
11.3
1461
12871
WX002
NOMESCO Finland
Sedation and analgesia
1.5
11.3
434
3086
R53
ICD-10 Finland
Malaise and fatigue
1.5
11.3
396
2759
A10BK03
ATC
empagliflozin; oral
1.9
11.2
167
910
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
11.1
464
3355
A98
ICPC
Health maint/preventive medicine
1.8
11.1
2203
21072
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.6
10.9
318
2122
J01MA12
ATC
levofloxacin; systemic
1.5
10.8
400
2823
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
10.8
470
3431
AN1
HP
Coronary angiography
1.6
10.7
258
1637
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
10.7
810
6533
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.5
10.7
456
3311
J01AA02
ATC
doxycycline; systemic
1.4
10.7
1743
15872
R95
ICPC
Chron obstructive pulmonary disease
2.7
10.7
71
267
C07AB02
ATC
metoprolol; systemic
1.5
10.6
430
3087
A02BC03
ATC
lansoprazole; oral
1.4
10.6
636
4926
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.9
10.6
158
863
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
8.0
10.6
23
29
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
10.6
388
2731
WX290
NOMESCO Finland
Other blockade of nerve
1.4
10.5
839
6818
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.6
10.5
283
1850
Z2446
NOMESCO Finland
Social worker
2.0
10.5
129
657
ZXA00
NOMESCO Finland
Right side
1.4
10.5
589
4512
A01
ICPC
Pain general/multiple sites
1.8
10.4
166
930
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
10.3
324
2199
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.9
10.3
144
768
E21.0
ICD-10 Finland
Primary hyperparathyroidism
3.5
10.3
46
132
N06AA09
ATC
amitriptyline; systemic
1.7
10.3
227
1407
ZXD05
NOMESCO Finland
Urgent procedure
1.4
10.3
623
4832
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
10.1
225
1395
Z01.7
ICD-10 Finland
Laboratory examination
1.7
10.1
228
1419
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
2.7
10.1
65
241
AA1AD
NOMESCO Finland
CT of head and brain
1.4
10.1
501
3748
C09AA02
ATC
enalapril; systemic
1.5
10.0
419
3025
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
10.0
1145
9811
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
10.0
968
8090
B01AA03
ATC
warfarin; systemic
1.5
10.0
391
2785
WX725
NOMESCO Finland
Noninvasive ventilation
2.1
10.0
110
534
TKC20
NOMESCO Finland
Catheterisation of bladder
1.9
10.0
155
861
L28
ICPC
Limited function/disability (L)
1.5
9.9
318
2167
A10BH05
ATC
linagliptin; oral
2.1
9.8
108
524
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.4
9.8
478
3557
C10AA07
ATC
rosuvastatin; oral
1.4
9.8
543
4143
A02BC01
ATC
omeprazole; systemic
1.4
9.8
572
4405
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
3.8
9.7
39
103
R04.2
ICD-10 Finland
Haemoptysis
2.5
9.7
76
315
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.7
9.6
219
1370
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
2.3
9.6
88
395
A12BA01
ATC
potassium chloride; oral
2.2
9.6
95
442
D02
ICPC
Abdominal pain epigastric
2.0
9.5
120
618
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.6
9.5
274
1823
LCA06
NOMESCO Finland
Biopsy of endometrium
1.6
9.4
234
1495
L17
ICPC
Foot/toe symptom/complaint
1.4
9.4
522
3973
E27.0
ICD-10 Finland
Other adrenocortical overactivity
100.4
9.4
10
*
A28
ICPC
Limited function/disability NOS
1.5
9.4
299
2033
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
3.0
9.4
52
176
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
2.2
9.4
98
465
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
2.6
9.4
64
246
C09DA01
ATC
losartan and diuretics; oral
1.6
9.4
235
1509
M03BX02
ATC
tizanidine; oral
1.3
9.4
1321
11624
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.6
9.3
253
1654
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
3.3
9.3
45
138
E66
ICD-10 Finland
Obesity
2.2
9.3
93
434
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.8
9.3
169
990
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.5
9.3
286
1929
K02.1
ICD-10 Finland
Caries of dentine
1.3
9.2
1116
9601
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.9
9.1
142
788
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
2.1
9.1
96
457
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.6
9.1
274
1838
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.7
9.1
207
1294
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.6
9.0
217
1377
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.0
9.0
117
609
L03
ICPC
Low back symptom/complaint
1.4
8.9
483
3659
C09BA02
ATC
enalapril and diuretics; systemic
1.7
8.9
186
1131
E24.0
ICD-10 Finland
Pituitary-dependent Cushing disease
18.7
8.9
13
7
K57.2
ICD-10 Finland
Diverticular disease of large intestine with perforation and abscess
2.8
8.9
56
203
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
4.5
8.8
30
68
JN4AD
NOMESCO Finland
Body CT examination
1.7
8.8
180
1089
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
2.2
8.8
89
417
R31
ICD-10 Finland
Unspecified haematuria
1.6
8.8
210
1329
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
1.9
8.7
119
631
M54.4
ICD-10 Finland
Lumbago with sciatica
1.5
8.7
328
2317
M01AB55
ATC
diclofenac, combinations; oral
1.8
8.6
149
859
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
1.9
8.6
119
637
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.4
8.6
460
3477
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
8.5
292
2017
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.0
8.5
99
494
KH1AD
NOMESCO Finland
CT of urinary organs
2.3
8.5
74
323
SPAT1263
SPAT
Sampling
1.3
8.5
862
7205
A10BJ06
ATC
semaglutide; parenteral
2.2
8.4
79
359
R03AK07
ATC
formoterol and budesonide; inhalant
1.4
8.4
373
2722
XG466
NOMESCO Finland
Sleep oxymetry
2.2
8.4
82
381
R60.9
ICD-10 Finland
Oedema, unspecified
2.0
8.4
100
504
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
3.0
8.4
46
156
E26
ICD-10 Finland
Hyperaldosteronism
+∞
8.3
8
*
J01CE02
ATC
phenoxymethylpenicillin; oral
1.3
8.3
1409
12614
JEA01
NOMESCO Finland
Laparoscopic appendectomy
2.3
8.3
70
303
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
8.3
548
4292
K92.1
ICD-10 Finland
Melaena
2.0
8.3
104
537
N02AA05
ATC
oxycodone; systemic
1.5
8.2
287
1991
J01FA06
ATC
roxithromycin; oral
1.3
8.2
833
6953
M01AH05
ATC
etoricoxib; oral
1.3
8.2
1252
11041
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.5
8.2
328
2345
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.7
8.2
154
912
A10BD07
ATC
metformin and sitagliptin; systemic
2.0
8.2
101
517
162
Kela drug reimbursment
liraglutide
3.4
8.2
37
109
SPAT1059
SPAT
Spirometry at the office
1.9
8.2
115
617
E89.6
ICD-10 Finland
Postprocedural adrenocortical(-medullary) hypofunction
17.2
8.1
12
7
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.6
8.0
203
1307
C03AA03
ATC
hydrochlorothiazide; oral
1.6
8.0
204
1314
UGC12
NOMESCO Finland
Flexible bronchoscopy
1.7
8.0
157
940
J20
ICD-10 Finland
Acute bronchitis
1.6
8.0
201
1293
A06AD11
ATC
lactulose; oral
1.5
7.9
268
1849
N06AB06
ATC
sertraline; oral
1.6
7.9
192
1220
H01
ICPC
Ear pain/earache
1.6
7.9
189
1199
L86
ICPC
Back syndrome with radiating pain
1.8
7.9
126
706
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
3.5
7.9
35
102
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
7.9
158
955
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.6
7.9
231
1542
A10BB12
ATC
glimepiride; oral
1.7
7.8
144
847
M25.5
ICD-10 Finland
Pain in joint
1.3
7.8
564
4470
SPAT1058
SPAT
PEF monitoring instruction
1.7
7.8
169
1042
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
2.6
7.8
54
210
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.6
7.8
180
1132
R42
ICD-10 Finland
Dizziness and giddiness
1.4
7.8
430
3265
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.6
7.8
212
1388
J01DA01
ATC
[U] cefalexin; systemic
1.3
7.7
1306
11629
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
3.3
7.7
36
109
M01AH01
ATC
celecoxib; oral (coxibs)
1.4
7.7
382
2842
R51.80
ICD-10 Finland
Headache
1.5
7.7
265
1833
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
2.5
7.7
58
239
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
7.6
594
4768
A10BX07
ATC
[U] liraglutide; parenteral
3.0
7.6
40
133
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.7
7.6
143
849
N06AX12
ATC
bupropion; oral
1.9
7.5
100
526
M03BC51
ATC
orphenadrine, combinations; systemic
1.3
7.5
564
4499
358
Kela drug reimbursment
liraglutide
4.8
7.4
23
48
-1
NOMESCO Finland
NA
1.3
7.4
621
5027
J01FA10
ATC
azithromycin; systemic
1.3
7.4
1139
9999
J45
ICD-10 Finland
Asthma
1.6
7.4
187
1200
M04AA01
ATC
allopurinol; systemic
1.5
7.4
252
1739
R03BA02
ATC
budesonide; inhalant
1.4
7.4
335
2449
WX704
NOMESCO Finland
Intubation
1.7
7.4
151
916
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.6
7.3
194
1261
A04
ICPC
Weakness/tiredness general
1.5
7.3
228
1540
J01FA15
ATC
telithromycin; oral
1.6
7.3
203
1337
XW000
NOMESCO Finland
Bone marrow biopsy
2.0
7.3
92
475
XA800
NOMESCO Finland
Neuropsychological investigation
2.1
7.3
81
398
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
3.0
7.3
39
131
8700/3-C74.1
ICD-O-3
Pheochromocytoma, NOS, of medulla of adrenal gland
+∞
7.3
7
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
10.9
7.3
13
12
R4140
NOMESCO Finland
Psychotherapy
9.4
7.3
14
15
K86.2
ICD-10 Finland
Cyst of pancreas
4.0
7.3
27
68
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
2.7
7.3
47
177
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
2.0
7.2
90
465
I11
ICD-10 Finland
Hypertensive heart disease
5.2
7.2
21
41
D11
ICPC
Diarrhoea
1.6
7.2
190
1236
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
1.9
7.2
100
538
M01AX17
ATC
nimesulide; oral
1.3
7.2
523
4145
B01AB10
ATC
tinzaparin; parenteral
1.7
7.2
148
901
C08DB01
ATC
diltiazem; oral
1.9
7.2
95
499
RD211
NOMESCO Finland
NA
1.9
7.2
99
529
UJF30
NOMESCO Finland
Ileoscopy through colon
1.6
7.2
198
1301
E27.9
ICD-10 Finland
Disorder of adrenal gland, unspecified
30.1
7.1
9
*
R03BA05
ATC
fluticasone; inhalant
1.4
7.1
338
2491
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.6
7.1
186
1208
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
7.1
1046
9113
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
2.5
7.1
53
215
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.6
7.1
202
1337
ZXC86
NOMESCO Finland
Use of endoscopic device
5.0
7.1
21
42
D30.0
ICD-10 Finland
Benign neoplasm: Kidney
4.2
7.1
25
60
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
3.3
7.1
33
101
105
Kela drug reimbursment
Adrenal cortical hypofunction
8.8
7.0
14
16
C10AC01
ATC
colestyramine; oral
2.3
7.0
59
256
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.7
7.0
138
829
N20.0
ICD-10 Finland
Calculus of kidney
2.7
7.0
45
168
N05BA01
ATC
diazepam; systemic, rectal
1.5
7.0
268
1897
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
7.0
1423
12889
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.7
6.9
141
857
RD210
NOMESCO Finland
NA
2.9
6.9
40
140
F17.20
ICD-10 Finland
Addiction relationship caused by tobacco addiction relationship currently independent
5.5
6.9
19
35
R11
ICD-10 Finland
Nausea and vomiting
1.7
6.9
135
811
C09DA03
ATC
valsartan and diuretics; oral
1.8
6.9
110
620
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
3.8
6.9
27
72
N05CF02
ATC
zolpidem; oral
1.4
6.8
351
2627
XCK10
NOMESCO Finland
Photography of fundus of eye
1.5
6.8
211
1425
I71.4
ICD-10 Finland
Abdominal aortic aneurysm, without mention of rupture
2.6
6.8
45
172
A10AE05
ATC
insulin detemir; parenteral
1.8
6.8
106
592
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.6
6.8
154
962
S06.0
ICD-10 Finland
Concussion
1.6
6.7
186
1226
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
6.7
741
6217
XKD00
NOMESCO Finland
Uroflowmetry
1.4
6.7
311
2283
I50.0
ICD-10 Finland
Congestive heart failure
1.7
6.7
123
725
B01AF02
ATC
apixaban; oral
1.5
6.7
199
1333
ZXA05
NOMESCO Finland
Left side
1.3
6.7
524
4194
C07AG02
ATC
carvedilol; oral
1.7
6.7
119
695
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
6.6
262
1868
R93.8
ICD-10 Finland
Abnormal findings on diagnostic imaging of other specified body structures
5.2
6.6
19
37
PDQ05
NOMESCO Finland
Insertion of endovascular graft into infrarenal abdominal aorta
4.6
6.6
21
46
C09AA05
ATC
ramipril; oral
1.3
6.6
496
3946
R52.9
ICD-10 Finland
Pain, unspecified
1.6
6.6
161
1028
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
2.8
6.5
39
141
P17
ICPC
Tobacco abuse
3.0
6.5
34
113
C08CA10
ATC
nilvadipine; oral
2.4
6.5
50
208
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
1.7
6.5
137
841
XG410
NOMESCO Finland
Flow-volume spirometry
1.9
6.5
88
468
C07BB07
ATC
bisoprolol and thiazides; systemic
1.9
6.5
88
468
X59
ICD-10 Finland
Exposure to unspecified factor
1.4
6.5
336
2514
U05
ICPC
Urination problems other
1.9
6.5
88
469
J01CA04
ATC
amoxicillin; systemic
1.3
6.5
1679
15577
PD7ZT
NOMESCO Finland
Stent grafting of abdominal aorta
5.7
6.4
17
30
R07.3
ICD-10 Finland
Other chest pain
1.6
6.4
181
1196
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
1.9
6.4
83
435
160
Kela drug reimbursment
exenatide
2.3
6.4
53
231
H02AB07
ATC
prednisone; oral
1.4
6.3
281
2047
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
1.9
6.3
85
454
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
2.5
6.3
45
180
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.3
6.3
493
3943
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.4
6.3
291
2139
TUPKY
NOMESCO Finland
NA
4.6
6.3
20
44
E27.8
ICD-10 Finland
Other specified disorders of adrenal gland
18.1
6.3
9
5
XF402
NOMESCO Finland
ECG with work load test
1.5
6.3
234
1650
K57.9
ICD-10 Finland
Diverticular disease of intestine, part unspecified, without perforation or abscess
2.4
6.3
51
219
JAD11
NOMESCO Finland
Laparoscopic repair of incisional hernia
3.1
6.3
31
100
D350, E260
ICD-10 Finland
NA
+∞
6.3
6
*
E260, D350
ICD-10 Finland
NA
+∞
6.3
6
*
J96.1
ICD-10 Finland
Chronic respiratory failure
2.5
6.2
46
189
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.3
6.2
513
4132
A11
ICPC
Chest pain NOS
1.6
6.2
150
956
C73.94
ICD-10 Finland
Medullary thyroid carcinoma (thyroid)
26.7
6.2
8
*
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.0
6.2
77
396
B82
ICPC
Anaemia other/unspecified
2.4
6.2
48
202
L20
ICPC
Joint symptom/complaint NOS
2.0
6.2
71
357
R4190
NOMESCO Finland
Nutritional therapy
2.1
6.2
66
321
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
6.2
230
1617
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
2.8
6.2
37
135
JAH01
NOMESCO Finland
Laparoscopy
1.9
6.2
85
456
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
1.8
6.2
102
582
GD1AD
NOMESCO Finland
Thorax CT examination
1.8
6.1
91
502
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
1.8
6.1
102
584
N30.0
ICD-10 Finland
Acute cystitis
1.4
6.1
253
1820
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.4
6.1
269
1956
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.5
6.1
188
1270
L72.1
ICD-10 Finland
Trichilemmal cyst
1.7
6.1
128
787
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
1.8
6.1
107
622
A03
ICPC
Fever
1.4
6.1
259
1874
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.0
6.1
68
339
J01DA06
ATC
[U] cefuroxime; systemic
1.4
6.1
276
2018
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
1.8
6.1
96
542
A03FA01
ATC
metoclopramide; systemic, rectal
1.3
6.0
411
3218
R05FA02
ATC
opium derivatives and expectorants; systemic
1.3
6.0
811
6952
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_ADRENAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_ADRENAL | 1.647 [1.44, 1.89] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.066 |
During the follow-up period (1.1.1998 — 31.12.2019), 815 out of 5459 females with CD2_BENIGN_ADRENAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_ADRENAL | 1.624 [1.4, 1.88] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 823 out of 4080 males with CD2_BENIGN_ADRENAL died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_ADRENAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.128% | 0.353% |
| 5 | 0.798% | 1.877% |
| 10 | 2.077% | 4.48% |
| 15 | 3.984% | 8.262% |
| 20 | 6.997% | 14.096% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_ADRENAL – Benign neoplasm: Adrenal gland
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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