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Malignant neoplasm of other and unspecified urinary organs, excluding all cancers (controls excluding all cancers)

C3_URINARY_TRACT_NAS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C68
  • Hospital discharge: ICD-9 189[4-9]
  • Hospital discharge: ICD-8 1899
  • Cause of death: ICD-10 C68
  • Cause of death: ICD-9 189[4-9]
  • Cause of death: ICD-8 1899
  • Cancer registry: Topography ICD-O-3 C68
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

251

4. Check minimum number of events

None

251

5. Include endpoints

None

251

6. Filter based on genotype QC (FinnGen only)

251

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of other and unspecified urinary organs, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 251 59 192
Unadjusted period prevalence (%) 0.07 0.02 0.08
Median age at first event (years) 70.59 68.37 71.28

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
93
Matched controls
931
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UKC02
NOMESCO Finland
Cystoscopy
47.0
52.1
79
99
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
50.7
44
*
KCD02
NOMESCO Finland
Transurethral resection of bladder
315.4
40.3
38
*
8120/3-C68.9
ICD-O-3
Transitional cell carcinoma, NOS, of urinary system, NOS
+∞
33.3
30
*
130
Kela drug reimbursment
Malignant tumour
+∞
31.0
28
*
R31
ICD-10 Finland
Unspecified haematuria
16.0
27.1
49
60
C65
ICD-10 Finland
Malignant neoplasm of renal pelvis
+∞
26.3
24
*
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
336.9
26.1
25
*
KBJ10
NOMESCO Finland
Cutaneous ureteroenterostomy
+∞
25.1
23
*
KAC20
NOMESCO Finland
Nephroureterectomy
+∞
21.7
20
*
UKB02
NOMESCO Finland
Retrograde ureteroscopy
75.2
21.0
23
*
C68.0
ICD-10 Finland
Malignant neoplasm: Urethra
+∞
20.6
19
*
KCD32
NOMESCO Finland
Cystoscopic destruction of tumour of bladder
251.3
20.4
20
*
H02AB02
ATC
dexamethasone; systemic
71.0
19.9
22
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
19.4
18
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
19.4
18
*
KCD05
NOMESCO Finland
Excision of bladder lesion during urinary tract endoscopy with photodynamic diagnosis (PDD)
+∞
19.4
18
*
C66
ICD-10 Finland
Malignant neoplasm of ureter
+∞
18.3
17
*
UKC05
NOMESCO Finland
Cystoscopy and bladder biopsy
35.4
17.5
22
8
WX302
NOMESCO Finland
Thoracal epidural anesthesy
50.2
17.1
20
5
8120/3-C68.0
ICD-O-3
Transitional cell carcinoma, NOS, of urethra
+∞
16.1
15
*
WX408
NOMESCO Finland
General anesthesy, balanced
7.5
15.6
43
95
D41.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bladder
95.1
15.1
16
*
8120/3-C68.8
ICD-O-3
Transitional cell carcinoma, NOS, of overlapping lesion of urinary organs
+∞
15.0
14
*
ZX136
NOMESCO Finland
Intravesicalis
+∞
15.0
14
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
27.8
15.0
20
9
C67.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of bladder
+∞
13.9
13
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
13.9
13
*
KH1CD
NOMESCO Finland
Very extensive urinary tract ultrasound examination
162.8
13.8
14
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
6.9
13.2
37
81
JN4AD
NOMESCO Finland
Body CT examination
19.5
12.8
19
12
KCC10
NOMESCO Finland
Cystoprostatectomy
+∞
12.8
12
*
A03FA01
ATC
metoclopramide; systemic, rectal
8.2
12.6
30
51
B01AB10
ATC
tinzaparin; parenteral
16.7
12.1
19
14
D41.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Renal pelvis
+∞
11.7
11
*
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
+∞
11.7
11
*
JN4CD
NOMESCO Finland
Very extensive body CT
23.8
11.6
16
8
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
29.4
11.6
15
6
JN4BD
NOMESCO Finland
Extensive body CT
14.6
11.5
19
16
Z51.5
ICD-10 Finland
Palliative care
15.6
11.2
18
14
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
25.1
11.1
15
7
J01EA01
ATC
trimethoprim; systemic
5.1
10.8
40
119
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
123.3
10.7
11
*
C67.0
ICD-10 Finland
Malignant neoplasm: Trigone of bladder
+∞
10.6
10
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
10.6
10
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
10.6
10
*
8000/3-C68.9
ICD-O-3
Neoplasm, malignant of urinary system, NOS
+∞
10.6
10
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.6
10.3
25
43
XKD00
NOMESCO Finland
Uroflowmetry
4.8
9.9
39
122
XX3DW
NOMESCO Finland
Time consuming IT work
12.7
9.8
17
16
D41.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Urethra
+∞
9.5
9
*
TJF80
NOMESCO Finland
Ostomy education
+∞
9.5
9
*
PJD54
NOMESCO Finland
Block dissection of iliac lymph nodes
+∞
9.5
9
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
9.5
9
*
KAC21
NOMESCO Finland
Percutaneous endoscopic nephroureterectomy
+∞
9.5
9
*
J01MA12
ATC
levofloxacin; systemic
4.8
9.4
36
108
A04AA01
ATC
ondansetron; systemic, rectal
41.1
9.2
11
*
C68.9
ICD-10 Finland
Malignant neoplasm: Urinary organ, unspecified
+∞
8.5
8
*
J01MA02
ATC
ciprofloxacin; systemic
3.5
7.8
57
290
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.2
7.5
32
104
WF002
NOMESCO Finland
Radical radiotherapy
86.7
7.5
8
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
17.6
7.4
11
7
ZXE10
NOMESCO Finland
More than one and less than three hours
3.5
7.4
44
189
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
+∞
7.4
7
*
TKW99
NOMESCO Finland
Other minor surgical procedure in urology
+∞
7.4
7
*
8070/3-C68.0
ICD-O-3
Squamous cell carcinoma, NOS, of urethra
+∞
7.4
7
*
116
Kela drug reimbursment
Prostate cancer
+∞
7.4
7
*
KCC30
NOMESCO Finland
Cystectomy with excision of female internal genital organs
+∞
7.4
7
*
WC305
NOMESCO Finland
Simple therapy of local tumor recidive with biomodifiers
+∞
7.4
7
*
TKC20
NOMESCO Finland
Catheterisation of bladder
6.2
7.1
19
37
R33
ICD-10 Finland
Retention of urine
4.8
7.0
24
63
ZXE30
NOMESCO Finland
More than five and less than seven hours
8.9
6.9
14
18
U99
ICPC
Urinary disease other
43.3
6.9
8
*
ZXE20
NOMESCO Finland
More than three and less than five hours
4.8
6.8
23
59
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.9
6.7
16
27
R82.8
ICD-10 Finland
Abnormal findings on cytological and histological examination of urine
74.8
6.5
7
*
KH1BD
NOMESCO Finland
Extensive urinary tract CT examination
28.8
6.3
8
*
A04AD12
ATC
aprepitant; systemic
+∞
6.3
6
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
6.3
6
*
C67
ICD-10 Finland
Malignant neoplasm of bladder
+∞
6.3
6
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
6.3
6
*
L01BC06
ATC
capecitabine; oral
+∞
6.3
6
*
PJD44
NOMESCO Finland
Excision of iliac lymph nodes
+∞
6.3
6
*
KCC20
NOMESCO Finland
Cystoprostatourethrectomy
+∞
6.3
6
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
6.3
6
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
6.3
6
*
D41.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Ureter
+∞
6.3
6
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
6.2
6.2
16
30
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.1
6.2
25
77
N02AA05
ATC
oxycodone; systemic
4.5
6.2
22
60
WZC30
NOMESCO Finland
Teaching
5.3
6.1
18
40
N30.0
ICD-10 Finland
Acute cystitis
5.0
6.1
19
45

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_URINARY_TRACT_NAS_EXALLC – Malignant neoplasm of other and unspecified urinary organs, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).