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Papillary adenocarcinoma of thyroid gland

C3_THYROID_PAPILLARY_ADENO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C73.91&
  • Cause of death: ICD-9 193A
  • Cancer registry: Topography ICD-O-3 C73
  • Cancer registry: Morphology ICD-O-3 8260
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

1816

4. Check minimum number of events

None

1816

5. Include endpoints

None

1816

6. Filter based on genotype QC (FinnGen only)

1741

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF8

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1741 1317 424
Unadjusted period prevalence (%) 0.44 0.52 0.21
Median age at first event (years) 49.37 47.16 56.22

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1815
Matched controls
18147
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
75.6
323.0
528
98
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
825.5
323.0
487
8
BAA60
NOMESCO Finland
Total thyroidectomy
172.2
323.0
1094
159
H03AA01
ATC
levothyroxine sodium; systemic
129.3
323.0
1748
3045
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
8660.0
323.0
1597
19
104
Kela drug reimbursment
Thyroid insufficiency
87.9
323.0
1417
705
EP1AE
NOMESCO Finland
Neck ultrasound examination
37.5
323.0
913
477
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
205.8
323.0
527
36
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
323.0
1815
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
58.5
323.0
420
93
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
838.1
296.7
284
*
ZX114
NOMESCO Finland
Intramuscular
47.1
278.8
342
89
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
775.7
276.9
266
*
4CJ01
NOMESCO Finland
NA
1406.7
256.5
244
*
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
674.7
244.1
236
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.0
220.0
1103
4307
1930A
ICD-9 Finland
Malignant neoplasm of thyroid gland[CARCINOMA PAPILLARE THYREOIDEAE]
+∞
211.7
199
*
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
337.2
209.2
208
7
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
19.7
204.4
319
194
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
26.8
178.4
251
108
BA1NN
NOMESCO Finland
I-131 dose capsel measurement
904.9
170.8
165
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
21.5
142.4
214
112
2506
FHL
Thyroidectomy
369.4
138.8
138
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
99.2
133.3
146
16
T71
ICPC
Malignant neoplasm thyroid
448.0
127.5
126
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
73.9
120.5
137
20
A11CC03
ATC
alfacalcidol; systemic
15.5
115.0
195
140
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
30.5
114.0
154
55
106
Kela drug reimbursment
Hypoparathyroidism
108.0
111.5
121
12
19399
ICD-8 Finland
Malignant neoplasm of thyroid gland
537.6
103.7
102
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
7.7
101.7
253
376
Z51.88
ICD-10 Finland
Other specified medical care
13.0
90.4
165
139
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
21.3
88.9
133
67
C739
ICD-10 Finland
NA
+∞
87.2
83
*
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
105.2
82.7
90
9
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
79.8
687
3233
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
49.4
77.6
94
20
A11CC02
ATC
dihydrotachysterol; oral
78.3
66.6
75
10
ZXE10
NOMESCO Finland
More than one and less than three hours
2.4
65.9
837
4758
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.7
64.0
554
2542
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
10.6
62.0
124
125
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
24.5
57.6
82
35
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
22.8
57.1
83
38
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
8.8
55.0
122
148
E83.51
ICD-10 Finland
Hypocalcemia
25.5
54.1
76
31
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
8.0
54.1
127
169
A12AA04
ATC
calcium carbonate; oral
13.2
52.6
94
75
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
13.8
52.0
91
69
A12AA06
ATC
calcium lactate gluconate; oral
241.0
46.2
47
*
ZXE20
NOMESCO Finland
More than three and less than five hours
2.8
44.5
332
1355
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
37.8
43.3
55
15
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
5.0
43.0
144
305
WX402
NOMESCO Finland
General anaesthesia
2.5
41.8
398
1861
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
41.2
802
5155
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
31.4
39.3
52
17
JN5SN
NOMESCO Finland
NA
204.3
39.0
40
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.7
37.7
175
506
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
13.5
36.6
64
49
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.0
36.4
676
4206
PJD91
NOMESCO Finland
Excision of lymph nodes in neck, 1 to 2 areas in total
99.6
35.8
39
*
130
Kela drug reimbursment
Malignant tumour
3.2
34.2
191
636
GD1AD
NOMESCO Finland
Thorax CT examination
4.4
33.7
128
308
WB223
NOMESCO Finland
Demanding adjuvant hormone therapy of malignancy
32.2
33.6
44
14
T86
ICPC
Hypothyroidism/myxoedema
4.1
32.3
132
341
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
18.9
31.4
48
26
ZXA10
NOMESCO Finland
Bilateral
2.1
30.3
394
2096
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
16.0
29.0
47
30
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.3
29.0
112
274
WW200
NOMESCO Finland
Immunization
4.7
27.0
94
208
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
32.4
26.9
35
11
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
8.2
26.2
59
74
XX9AQ
NOMESCO Finland
Supplementary SPECT-CT or additional scan
27.4
25.8
35
13
BA1AQ
NOMESCO Finland
Thyroid SPECT with low dose CT
+∞
24.0
23
*
XX1MN
NOMESCO Finland
Isotope examination with measurement
+∞
24.0
23
*
PJD51
NOMESCO Finland
Block dissection of cervical lymph nodes
54.8
23.1
27
5
E8901, C7391
ICD-10 Finland
NA
232.8
22.7
23
*
ZSB00
NOMESCO Finland
Procedure related to previous procedure classified in chapter B
121.5
22.6
24
*
BAA99
NOMESCO Finland
Other operation on thyroid gland
121.5
22.6
24
*
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
7.0
21.0
52
76
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
5.4
20.5
62
118
TPH07
NOMESCO Finland
Cathetrisation of artery
2.3
19.8
197
917
DQE10
NOMESCO Finland
Injection of foreign material into vocal cord
21.8
19.5
28
13
GD6AD
NOMESCO Finland
CT of chest and neck
18.4
19.1
29
16
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
18.2
399
2514
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
8.8
17.9
38
44
ZXA05
NOMESCO Finland
Left side
1.7
17.8
454
2988
1930X
ICD-9 Finland
Malignant neoplasm of thyroid gland[NEOPLASMA MALIGNUM THYREOIDEAE EI HISTOL VAHV]
+∞
17.7
17
*
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
17.1
17.4
27
16
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
17.4
717
5348
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
42.4
17.3
21
5
WX704
NOMESCO Finland
Intubation
2.4
17.2
150
655
R49.01
ICD-10 Finland
Functional dysphonia
3.4
17.0
84
257
N02BE01
ATC
paracetamol; systemic, rectal
1.7
16.9
1544
13901
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
5.6
16.7
48
87
2504
FHL
Unilateral resection or enucleation
7.8
16.4
37
48
E20.9
ICD-10 Finland
Hypoparathyroidism, unspecified
47.9
16.0
19
*
PJD99
NOMESCO Finland
Excision of other lymph nodes
24.7
16.0
22
9
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.6
15.7
113
444
1AB01
NOMESCO Finland
NA
+∞
15.6
15
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.8
15.6
103
382
WZC30
NOMESCO Finland
Teaching
1.9
15.4
240
1345
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
5.0
14.8
47
96
198
Kela drug reimbursment
Sorafenib
21.2
14.7
21
10
WA039
NOMESCO Finland
Radiotherapy with free isotopes
+∞
14.6
14
*
E20.8
ICD-10 Finland
Other hypoparathyroidism
80.8
14.6
16
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
7.2
14.3
34
48
Z50.5
ICD-10 Finland
Speech therapy
5.7
14.2
40
71
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
24.0
13.8
19
8
ZXE00
NOMESCO Finland
One hour or less
1.5
13.7
690
5300
BA2MN
NOMESCO Finland
Thyroid radiation dose measurement during isotope therapy
+∞
13.6
13
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.8
13.3
227
1309
XX9XW
NOMESCO Finland
NA
8.3
13.0
28
34
E03
ICD-10 Finland
Other hypothyroidism
2.2
12.6
123
568
ZXA00
NOMESCO Finland
Right side
1.5
12.0
451
3231
BA2AT
NOMESCO Finland
Biopsy of thyroid with ultrasound quidance
47.0
11.9
14
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
6.5
11.9
30
47
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
11.9
74
268
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
2.9
11.7
72
256
R49.08
ICD-10 Finland
Other specified dysphonia
3.4
11.5
55
166
L01XE29
ATC
[U] lenvatinib; oral
+∞
11.5
11
*
3019
Kela drug reimbursment
Lenvatinib
120.7
11.4
12
*
1508
Kela drug reimbursment
Lenvatinib
120.7
11.4
12
*
BWD00
NOMESCO Finland
Reoperation for deep haemorrhage in endocrine surgery
35.2
11.3
14
*
323
Kela drug reimbursment
Sorafenib
25.2
11.1
15
6
EP1DM
NOMESCO Finland
Very extensive MRI examination of soft tissue of neck with 3 Tesla magnet
25.2
11.1
15
6
L01XE05
ATC
[U] sorafenib; oral
25.2
11.1
15
6
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
12.8
11.1
19
15
2397A
ICD-9 Finland
Neoplasm of unspecified nature, Endocrine glands and other parts of nervous system
43.6
10.9
13
*
Z3226
NOMESCO Finland
Physiotherapist
1.6
10.9
311
2080
ENB50
NOMESCO Finland
Excision of cyst or fistula of thyroglossic duct
28.2
10.7
14
5
H03BB01
ATC
carbimazole; oral
2.5
10.7
83
343
2410A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic uninodular goitre
10.1
10.5
20
20
R13
ICD-10 Finland
Dysphagia
2.1
10.4
114
554
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
2.9
10.3
60
208
JN6AD
NOMESCO Finland
CT of torso and neck
4.4
10.2
36
84
QX4AT
NOMESCO Finland
Ultrsound guided needle biopsy of skin
7.7
9.9
22
29
4701
FHL
Neck lymph node removal
16.8
9.9
15
9
GD6BD
NOMESCO Finland
Extensive CT of chest and neck
11.4
9.6
17
15
T85
ICPC
Hyperthyroidism/thyrotoxicosis
8.1
9.3
20
25
R4130
NOMESCO Finland
Speech therapy
3.4
9.3
43
128
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
2.8
9.3
58
211
JN4BD
NOMESCO Finland
Extensive body CT
1.7
8.8
172
1034
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
8.7
319
2250
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
2.7
8.7
59
225
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
11.6
8.6
15
13
Z31.5
ICD-10 Finland
Genetic counselling
2.1
8.6
95
468
RL210
NOMESCO Finland
NA
6.4
8.5
21
33
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
14.5
8.2
13
9
S18
ICPC
Laceration/cut
1.4
8.1
647
5269
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
4.2
8.1
29
70
EP1CM
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with 3 Tesla magnet
11.7
8.1
14
12
BB1BQ
NOMESCO Finland
Extensive scintigraphy of parathyroid gland, 2 isotopes, SPECT and low-dose CT
9.0
8.0
16
18
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
5.1
8.0
24
48
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
7.9
595
4800
WF049
NOMESCO Finland
Radiotherapy of metastasis
2.6
7.8
54
210
HA1AA
NOMESCO Finland
X-ray mammography
1.7
7.8
148
880
R49.09
ICD-10 Finland
Unspecified dysphonia
4.3
7.8
27
63
E21.0
ICD-10 Finland
Primary hyperparathyroidism
3.5
7.7
34
99
C08CA01
ATC
amlodipine; oral
1.4
7.7
500
3935
2411A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic multinodular goitre
7.4
7.7
17
23
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
3.8
7.7
30
79
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
7.6
235
1596
EP1AT
NOMESCO Finland
Punction of soft tissue of neck with ultrasound guidance
25.1
7.6
10
*
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
1.8
7.6
130
751
D25.1
ICD-10 Finland
Intramural leiomyoma of uterus
1.8
7.5
115
642
WX400
NOMESCO Finland
Inhalation anesthesy
2.1
7.5
77
367
2509
FHL
Other measure in this category
80.4
7.4
8
*
D09.3
ICD-10 Finland
Carcinoma in situ: Thyroid and other endocrine glands
80.4
7.4
8
*
GAB20
NOMESCO Finland
Median sternotomy
80.4
7.4
8
*
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
1.6
7.3
170
1075
R01AD09
ATC
mometasone; nasal
1.3
7.3
754
6358
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
1.8
7.3
117
661
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
7.2
846
7262
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
3.1
7.2
37
121
DQE20
NOMESCO Finland
Implantation of foreign material in vocal chord
30.1
7.1
9
*
PJA10
NOMESCO Finland
Exploration of lymph nodes
3.8
7.1
28
75
A02BC05
ATC
esomeprazole; systemic
1.3
6.9
667
5557
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
2.8
6.9
42
154
JN5AN
NOMESCO Finland
Total body isotope imaging
13.8
6.9
11
8
UDQ02
NOMESCO Finland
Direct laryngoscopy
4.4
6.8
23
53
2502
FHL
Thyroid exploration and possible biopsy
40.2
6.8
8
*
E83.50
ICD-10 Finland
Hypercalcemia
3.4
6.6
29
85
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
5.9
6.6
17
29
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.9
6.6
96
525
B01AB05
ATC
enoxaparin; parenteral
1.3
6.6
467
3712
205
Kela drug reimbursment
Chronic hypertension
1.4
6.6
359
2732
2260A
ICD-9 Finland
Benign neoplasm of thyroid gland[NEOPLASMA BENIGNUM GLANDULAE THYREOIDEAE]
10.1
6.5
12
12
Q18.0
ICD-10 Finland
Sinus, fistula and cyst of branchial cleft
6.9
6.5
15
22
ZX070
NOMESCO Finland
Intensity modified radiotherapy
3.1
6.5
33
108
BAA30
NOMESCO Finland
Excision of thyroid isthmus
14.4
6.4
10
7
UGB02
NOMESCO Finland
Tracheoscopy
18.1
6.3
9
5
C75
ICD-10 Finland
Malignant neoplasm of other endocrine glands and related structures
+∞
6.3
6
*
D73.9
ICD-10 Finland
Disease of spleen, unspecified
+∞
6.3
6
*
4707
FHL
Dissection Colli radicalis
+∞
6.3
6
*
2374A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Other and unspecified endocrine glands
+∞
6.3
6
*
XX3DW
NOMESCO Finland
Time consuming IT work
1.6
6.1
162
1060
Q18.8
ICD-10 Finland
Other specified congenital malformations of face and neck
12.6
6.1
10
8
R07.0
ICD-10 Finland
Pain in throat
1.8
6.0
97
550

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_THYROID_PAPILLARY_ADENO – Papillary adenocarcinoma of thyroid gland

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).