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Neuroendocrine tumor and carcinoma of small intestine

Endpoint Browser PheWeb

C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 — C17
  • Cancer registry: Morphology ICD-O-3 — 8240|824[2-4]|8246|8249
  • Cancer registry: Behaviour codes — 3

1 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF8

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2013 906 1078
Only index persons 1543 723 820
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 65.45 65.94 65.01
Only index persons 65.12 65.42 64.85

-FinnGen-

Key figures

All Female Male
Number of individuals 410 198 212
Unadjusted period prevalence (%) 0.09 0.08 0.11
Median age at first event (years) 62.80 61.09 64.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
419
Matched controls
4188
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C17.9
ICD-10 Finland
Malignant neoplasm: Small intestine, unspecified
+∞
301.9
252
*
130
Kela drug reimbursment
Malignant tumour
+∞
296.2
248
*
JFB00
NOMESCO Finland
Partial resection of small intestine
210.8
199.3
194
17
8240/3-C17.9
ICD-O-3
Neuroendocrine tumor, NOS, of small intestine, NOS
+∞
153.9
138
*
D37.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Small intestine
1051.1
153.5
141
*
C17.2
ICD-10 Finland
Malignant neoplasm: Ileum
+∞
146.7
132
*
H01CB03
ATC
lanreotide; parenteral
1915.7
144.6
132
*
E34.0
ICD-10 Finland
Carcinoid syndrome
+∞
134.8
122
*
H01CB02
ATC
octreotide; parenteral
851.0
131.0
122
*
8240/3-C17.2
ICD-O-3
Neuroendocrine tumor, NOS, of ileum
+∞
117.3
107
*
JN4BD
NOMESCO Finland
Extensive body CT
27.1
114.0
163
96
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
102.4
94
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
43.4
101.5
126
41
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
87.6
81
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
11.4
77.0
161
217
JN7AQ
NOMESCO Finland
Somatostatin receptor SPET med low dose CT
+∞
72.0
67
*
JN5ER
NOMESCO Finland
PET-CT of receptors in whole body
+∞
69.8
65
*
XX7JT
NOMESCO Finland
Somatostatin isotope ablative therapy
+∞
69.8
65
*
JN4AD
NOMESCO Finland
Body CT examination
19.8
65.6
102
67
JN4CD
NOMESCO Finland
Very extensive body CT
42.0
63.5
79
23
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
+∞
60.9
57
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
58.7
55
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
22.9
57.9
85
46
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
17.0
57.8
95
71
D77
ICPC
Malignant digestive neopl other/NOS
+∞
57.6
54
*
JFB30
NOMESCO Finland
Right hemicolectomy
214.7
55.4
56
*
B01AB05
ATC
enoxaparin; parenteral
5.5
55.3
227
743
8249/3-C17.9
ICD-O-3
Neuroendocrine tumor, grade 2 of small intestine, NOS
+∞
52.2
49
*
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
24.3
50.9
73
36
8249/3-C17.2
ICD-O-3
Neuroendocrine tumor, grade 2 of ileum
+∞
50.0
47
*
XX9AN
NOMESCO Finland
Complementary isotope examination or additional picture
537.2
49.4
48
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.8
48.0
234
880
C17.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of small intestine
+∞
44.6
42
*
A03FA01
ATC
metoclopramide; systemic, rectal
6.6
44.4
130
268
WX408
NOMESCO Finland
General anesthesy, balanced
4.6
40.9
182
598
UJF32
NOMESCO Finland
Coloscopy
4.5
40.5
190
656
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
28.0
39.6
54
22
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
26.2
39.5
55
24
JFB31
NOMESCO Finland
Laparoscopic right hemicolectomy
113.3
38.5
41
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
35.9
37.5
48
15
A04AA02
ATC
granisetron; systemic, transdermal
196.3
35.3
36
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.0
34.6
178
648
TPH07
NOMESCO Finland
Cathetrisation of artery
6.3
34.4
101
202
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.8
34.1
199
805
JAH00
NOMESCO Finland
Laparotomy
17.8
33.0
52
33
302
Kela drug reimbursment
Interferon alfa
+∞
32.7
31
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
32.7
31
*
C10AC01
ATC
colestyramine; oral
15.8
32.1
53
38
L01BC06
ATC
capecitabine; oral
+∞
31.7
30
*
Z51.5
ICD-10 Finland
Palliative care
16.5
30.9
50
34
JN3AD
NOMESCO Finland
Abdominal CT examination
7.5
30.5
76
120
JKA20
NOMESCO Finland
Cholecystectomy
13.6
30.2
53
44
A79
ICPC
Malignancy NOS
+∞
29.5
28
*
C17.1
ICD-10 Finland
Malignant neoplasm: Jejunum
+∞
29.5
28
*
T73
ICPC
Neoplasm endocrine other/unspecified
+∞
29.5
28
*
H02AB02
ATC
dexamethasone; systemic
32.0
29.1
38
13
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
28.5
27
*
JFB20
NOMESCO Finland
Ileocaecal resection
83.6
28.2
31
*
L01AX03
ATC
temozolomide; systemic
+∞
27.4
26
*
UJF30
NOMESCO Finland
Ileoscopy through colon
5.9
27.1
82
167
C61
ICD-10 Finland
Malignant neoplasm of prostate
288.5
27.0
27
*
L03AB05
ATC
interferon alfa-2b; parenteral
149.6
27.0
28
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
276.6
26.0
26
*
A09AA02
ATC
multienzymes (lipase, protease etc.)
22.4
25.7
37
18
D13.3
ICD-10 Finland
Benign neoplasm: Other and unspecified parts of small intestine
41.6
25.2
31
8
C17.0
ICD-10 Finland
Malignant neoplasm: Duodenum
+∞
24.2
23
*
115
Kela drug reimbursment
Breast cancer
+∞
24.2
23
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
24.2
23
*
B01AB10
ATC
tinzaparin; parenteral
7.1
24.0
61
98
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
28.7
23.9
32
12
TPH04
NOMESCO Finland
Cathetrisation of vein
3.5
23.8
131
477
8246/3-C17.9
ICD-O-3
Neuroendocrine carcinoma, NOS, of small intestine, NOS
+∞
23.1
22
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
15.3
23.1
38
27
ZXE10
NOMESCO Finland
More than one and less than three hours
2.9
22.5
192
943
JN7SN
NOMESCO Finland
Somatostatin receptor SPECT
+∞
22.1
21
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
22.1
21
*
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
23.8
22.0
31
14
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
9.9
21.7
44
49
8240/3-C17.0
ICD-O-3
Neuroendocrine tumor, NOS, of duodenum
+∞
21.0
20
*
JN7AN
NOMESCO Finland
Somatostatin receptor isotope imaging
220.4
20.8
21
*
N02AA05
ATC
oxycodone; systemic
4.0
20.8
91
270
JAH01
NOMESCO Finland
Laparoscopy
9.8
20.6
42
47
ZXE20
NOMESCO Finland
More than three and less than five hours
4.0
20.2
90
270
R4190
NOMESCO Finland
Nutritional therapy
13.1
20.0
35
29
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
+∞
19.9
19
*
116
Kela drug reimbursment
Prostate cancer
+∞
19.9
19
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.8
19.3
89
275
WX402
NOMESCO Finland
General anaesthesia
3.8
18.8
87
269
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
24.1
18.0
25
11
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
69.7
17.9
20
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.6
17.9
47
79
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
17.8
17
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
17.8
17
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
99.3
17.7
19
*
A04AA01
ATC
ondansetron; systemic, rectal
11.8
17.5
32
29
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
13.4
17.4
30
24
JF1BD
NOMESCO Finland
Very extensive small bowel CT
52.3
17.1
20
*
Y77
ICPC
Malignant neoplasm prostate
+∞
16.8
16
*
L02BG04
ATC
letrozole; oral
49.6
16.1
19
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.5
16.1
49
99
UJF92
NOMESCO Finland
Capsular endoscopy
9.8
16.0
32
35
XX3DW
NOMESCO Finland
Time consuming IT work
6.1
15.9
44
79
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
+∞
15.7
15
*
8246/3-C17.2
ICD-O-3
Neuroendocrine carcinoma, NOS, of ileum
+∞
15.7
15
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
165.9
15.6
16
*
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
39.7
15.5
19
5
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.3
15.4
59
153
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
15.0
213
1295
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
14.7
14
*
JN4DD
NOMESCO Finland
Scout CT scan of torso
+∞
14.7
14
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
14.7
14
*
A02BC02
ATC
pantoprazole; systemic
2.3
14.3
293
2097
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.3
14.3
209
1277
K56.7
ICD-10 Finland
Ileus, unspecified
11.5
14.2
26
24
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.9
14.1
94
375
WZC30
NOMESCO Finland
Teaching
3.5
13.9
69
224
D75
ICPC
Malignant neoplasm colon/rectum
+∞
13.6
13
*
HAB40
NOMESCO Finland
Wedge excision of mammary gland
26.8
13.5
18
7
ZX112
NOMESCO Finland
Subcutaneous
19.8
13.0
19
10
N02BE01
ATC
paracetamol; systemic, rectal
2.9
12.9
372
3072
WF002
NOMESCO Finland
Radical radiotherapy
72.1
12.7
14
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
12.6
12
*
XX9AD
NOMESCO Finland
Complementary CT
+∞
12.6
12
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
12.6
12
*
L02AE02
ATC
leuprorelin; implant, parenteral
22.1
12.1
17
8
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
48.1
11.9
14
*
Z51.88
ICD-10 Finland
Other specified medical care
8.5
11.7
25
31
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
66.8
11.7
13
*
WW500
NOMESCO Finland
Blood transfusion
9.7
11.6
23
25
ZXD05
NOMESCO Finland
Urgent procedure
2.2
11.6
145
803
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
11.5
11
*
JFA73
NOMESCO Finland
Excision of lesion of small intestine
+∞
11.5
11
*
C78.8
ICD-10 Finland
Secondary malignant neoplasm of other and unspecified digestive organs
+∞
11.5
11
*
WD205
NOMESCO Finland
Therapy of methastized malignancy with hormones
+∞
11.5
11
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
11.5
11
*
C18.09
ICD-10 Finland
Malignant tumor of caecum other or unspecified histology
+∞
11.5
11
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
11.5
11
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
11.5
11
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.6
11.2
51
154
A55
ICPC
General and Unspecified, Local injection/infiltration
44.5
11.0
13
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.7
10.9
49
146
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
61.6
10.7
12
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
10.5
10
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
10.5
10
*
C50.99
ICD-10 Finland
Breast, unspecified
+∞
10.5
10
*
C18.99
ICD-10 Finland
Malignant tumor in unspecified location in the colon other or unspecified histology
+∞
10.5
10
*
ZX114
NOMESCO Finland
Intramuscular
12.5
10.4
18
15
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
8.2
10.2
22
28
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
15.1
10.1
16
11
R10.0
ICD-10 Finland
Acute abdomen
6.6
10.0
25
40
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
18.0
9.5
14
8
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
102.2
9.5
10
*
JFB21
NOMESCO Finland
Laparoscopic ileocaecal resection
102.2
9.5
10
*
ZXK00
NOMESCO Finland
Conversion from percutaneous endoscopic to open procedure
30.8
9.4
12
*
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
+∞
9.4
9
*
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
+∞
9.4
9
*
C26.0
ICD-10 Finland
Malignant neoplasm: Intestinal tract, part unspecified
+∞
9.4
9
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
9.4
9
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
9.4
9
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
9.4
9
*
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
9.4
9
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
9.4
9
*
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
9.4
9
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
9.2
77
346
SPAT1153
SPAT
Removal of sutures
2.0
9.2
145
873
HA1AA
NOMESCO Finland
X-ray mammography
5.5
9.1
26
50
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
3.9
9.0
36
98
R4110
NOMESCO Finland
Physiotherapy
2.1
9.0
113
619
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
8.9
58
223
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.4
8.9
78
360
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
6.8
8.8
21
32
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
8.7
167
1074
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
11.9
8.6
15
13
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
4.1
8.6
32
82
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
91.8
8.4
9
*
C26.9
ICD-10 Finland
Malignant neoplasm: Ill-defined sites within the digestive system
+∞
8.4
8
*
1522B
ICD-9 Finland
Malignant neoplasm of small intestine, including duodenum, Ileum[NEOPLASMA MALIGNUM ILEI,ALIA DEFINITA SEU NUD]
+∞
8.4
8
*
JN5SR
NOMESCO Finland
Very extensive PET-CT of receptors in upper body
+∞
8.4
8
*
JJB10
NOMESCO Finland
Atypcal resection of liver
+∞
8.4
8
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
8.4
8
*
8140/3-C18.2
ICD-O-3
Adenocarcinoma, NOS, of ascending colon
+∞
8.4
8
*
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
+∞
8.4
8
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
8.4
8
*
8240/3-C17.1
ICD-O-3
Neuroendocrine tumor, NOS, of jejunum
+∞
8.4
8
*
C17
ICD-10 Finland
Malignant neoplasm of small intestine
+∞
8.4
8
*
NK6AN
NOMESCO Finland
Total body bone isotope imaging
34.0
8.1
10
*
K56.0
ICD-10 Finland
Paralytic ileus
10.3
8.1
15
15
B03BA03
ATC
hydroxocobalamin; parenteral
3.5
8.1
36
108
WX600
NOMESCO Finland
Single shot through catheter
22.5
8.0
11
5
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
4.7
8.0
26
58
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.1
7.9
93
493
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
45.8
7.7
9
*
6402
FHL
Small bowel resection
45.8
7.7
9
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.0
7.7
30
80
N02AX02
ATC
tramadol; systemic, rectal
1.8
7.7
178
1210
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
5.3
7.7
22
43
JWA00
NOMESCO Finland
Repair of wound dehiscence in gastroenterological surgery
25.5
7.6
10
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
10.3
7.6
14
14
J01MA02
ATC
ciprofloxacin; systemic
1.8
7.5
169
1136
JJA20
NOMESCO Finland
Open biopsy of liver
81.4
7.4
8
*
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
81.4
7.4
8
*
WX704
NOMESCO Finland
Intubation
3.2
7.4
38
127
JEA00
NOMESCO Finland
Appendectomy
3.4
7.4
35
110
-50
ICPC
Medication/prescr/renewal
4.3
7.3
26
64
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
6.4
7.3
18
29
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
4.8
7.3
23
50
C18.00
ICD-10 Finland
Malignant tumor of the caecum without histology
+∞
7.3
7
*
C26.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of digestive system
+∞
7.3
7
*
E340, C179
ICD-10 Finland
NA
+∞
7.3
7
*
C50
ICD-10 Finland
Malignant neoplasm of breast
+∞
7.3
7
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
7.3
7
*
L02BA01
ATC
tamoxifen; oral
+∞
7.3
7
*
C17.3
ICD-10 Finland
Malignant neoplasm: Meckel diverticulum
+∞
7.3
7
*
Z3226
NOMESCO Finland
Physiotherapist
2.2
7.3
83
431
K92.1
ICD-10 Finland
Melaena
3.6
7.2
31
91
Z2221
NOMESCO Finland
Medical doctor
1.9
7.1
115
686
R11
ICD-10 Finland
Nausea and vomiting
3.0
6.9
39
138
SPAT1254
SPAT
Administration of medicine
2.2
6.9
70
343
J01DB01
ATC
cefalexin; oral
1.9
6.8
328
2762
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
9.5
6.8
13
14
S55
ICPC
Skin, Local injection/infiltration
40.7
6.8
8
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.3
6.8
61
286
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
6.7
42
159
B81
ICPC
Anaemia vit B12/folate deficiency
3.9
6.5
25
67
R50.9
ICD-10 Finland
Fever, unspecified
2.4
6.5
56
255
JAL00
NOMESCO Finland
Biopsy of peritoneum
70.9
6.4
7
*
128
Kela drug reimbursment
Cancers of female genital organs
70.9
6.4
7
*
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
70.9
6.4
7
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.7
6.4
26
73
D37.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Colon
8.3
6.4
13
16
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
3.9
6.3
24
64
KCD02
NOMESCO Finland
Transurethral resection of bladder
18.3
6.3
9
5
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
18.3
6.3
9
5
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
7.2
6.3
14
20
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
6.3
6
*
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
+∞
6.3
6
*
C77.9
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph node, unspecified
+∞
6.3
6
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
6.3
6
*
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
+∞
6.3
6
*
L03AA02
ATC
filgrastim; parenteral
+∞
6.3
6
*
C18.90
ICD-10 Finland
Malignant tumor in unspecified location in the colon without histology
+∞
6.3
6
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
6.3
6
*
D78
ICPC
Neoplasm digestive benign/unspecif
+∞
6.3
6
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
6.3
6
*
JLC30
NOMESCO Finland
Pancreatoduodenectomy
+∞
6.3
6
*
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
+∞
6.3
6
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
6.2
111
686
K50.9
ICD-10 Finland
Crohn disease, unspecified
7.8
6.2
13
17

Mortality – FinRegistry

↥

Association

Association between endpoint C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC 2.489 [1.93, 3.22] < 0.001
Birth year 0.997 [0.99, 1.01] 0.529

During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 616 females with C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC 2.678 [2.08, 3.45] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 287 out of 747 males with C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC.

N-year risk Females Males
1 0.251% 0.392%
5 1.451% 2.6%
10 3.394% 7.285%
15 7.384% 13.646%
20 12.983% 22.83%

Relationships between endpoints

↥

Index endpoint: C3_SMALL_INTESTINE_NEUROENDOCRINE_EXALLC – Neuroendocrine tumor and carcinoma of small intestine

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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