No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE
Extra metadata
- First used in FinnGen datafreeze
- DF8
Similar endpoints
↥List of similar endpoints to
Adenocarcinoma of small intestine
based on the number of shared cases.
Similar with more cases:
- Adenocarcinoma of small intestine
- Malignant neoplasm of small intestine
- Malignant neoplasm of small intestine
- Malignant neoplasm of digestive organs
- Malignant neoplasm of digestive organs
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 982 | 425 | 537 |
| Only index persons | 555 | 249 | 306 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 67.59 | 67.19 | 67.87 |
| Only index persons | 68.43 | 67.19 | 69.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 82 | 33 | 49 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 69.65 | 65.83 | 72.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 83
- Matched controls
- 830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
65.5
54
*
L01BC06
ATC
capecitabine; oral
+∞
42.4
37
*
8140/3-C17.0
ICD-O-3
Adenocarcinoma, NOS, of duodenum
+∞
42.4
37
*
C17.0
ICD-10 Finland
Malignant neoplasm: Duodenum
+∞
34.9
31
*
H02AB02
ATC
dexamethasone; systemic
188.0
34.8
34
*
A03FA01
ATC
metoclopramide; systemic, rectal
22.1
29.5
47
46
JFB00
NOMESCO Finland
Partial resection of small intestine
115.1
29.1
30
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
98.2
25.6
27
*
D37.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Small intestine
+∞
25.3
23
*
A04AA02
ATC
granisetron; systemic, transdermal
331.9
25.1
24
*
JLC30
NOMESCO Finland
Pancreatoduodenectomy
+∞
24.1
22
*
C17.1
ICD-10 Finland
Malignant neoplasm: Jejunum
+∞
23.0
21
*
8140/3-C17.9
ICD-O-3
Adenocarcinoma, NOS, of small intestine, NOS
+∞
23.0
21
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
21.8
20
*
C17.9
ICD-10 Finland
Malignant neoplasm: Small intestine, unspecified
+∞
21.8
20
*
A09AA02
ATC
multienzymes (lipase, protease etc.)
80.8
17.6
19
*
C17.2
ICD-10 Finland
Malignant neoplasm: Ileum
+∞
17.3
16
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
17.3
16
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
23.5
16.9
24
14
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
45.2
15.2
18
5
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
180.5
15.0
15
*
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
22.9
14.8
21
12
A04AA01
ATC
ondansetron; systemic, rectal
52.5
14.8
17
*
JN4AD
NOMESCO Finland
Body CT examination
25.8
14.6
20
10
Z51.5
ICD-10 Finland
Palliative care
32.2
14.1
18
7
8140/3-C17.2
ICD-O-3
Adenocarcinoma, NOS, of ileum
+∞
13.9
13
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.1
13.4
50
165
JN4BD
NOMESCO Finland
Extensive body CT
14.0
13.3
23
22
JAH00
NOMESCO Finland
Laparotomy
36.0
12.1
15
5
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
11.7
11
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
11.7
11
*
8140/3-C17.1
ICD-O-3
Adenocarcinoma, NOS, of jejunum
+∞
11.7
11
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.3
11.1
21
24
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
10.6
10
*
JN3AD
NOMESCO Finland
Abdominal CT examination
10.0
10.4
21
27
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
20.0
10.3
15
9
N02AA05
ATC
oxycodone; systemic
6.2
10.2
30
69
TPX10
NOMESCO Finland
Implantation of vascular injection port
30.4
10.2
13
5
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
10.2
10.1
20
25
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.6
9.9
24
42
D13.2
ICD-10 Finland
Benign neoplasm: Duodenum
41.7
9.3
11
*
B01AB10
ATC
tinzaparin; parenteral
12.1
9.0
16
16
UJF92
NOMESCO Finland
Capsular endoscopy
56.1
8.9
10
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.7
8.9
36
117
C17.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of small intestine
+∞
8.5
8
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.4
8.0
33
107
WX402
NOMESCO Finland
General anaesthesia
5.9
7.6
22
48
UJF32
NOMESCO Finland
Coloscopy
4.1
7.6
37
137
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
87.6
7.5
8
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
7.4
7
*
C25.0
ICD-10 Finland
Malignant neoplasm: Head of pancreas
+∞
7.4
7
*
Z80.0
ICD-10 Finland
Family history of malignant neoplasm of digestive organs
+∞
7.4
7
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
7.4
7
*
WW500
NOMESCO Finland
Blood transfusion
22.4
7.3
10
5
R4190
NOMESCO Finland
Nutritional therapy
33.2
7.3
9
*
TPH07
NOMESCO Finland
Cathetrisation of artery
5.8
7.3
21
46
JAH01
NOMESCO Finland
Laparoscopy
15.6
7.1
11
8
A02BC02
ATC
pantoprazole; systemic
3.8
6.9
65
402
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.5
6.7
40
174
ZXE20
NOMESCO Finland
More than three and less than five hours
5.4
6.6
20
46
R11
ICD-10 Finland
Nausea and vomiting
6.8
6.6
16
28
K83.1
ICD-10 Finland
Obstruction of bile duct
+∞
6.3
6
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
6.3
6
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
6.3
6
*
JDE00
NOMESCO Finland
Gastrojejunostomy
+∞
6.3
6
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
6.3
6
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
6.3
6
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
6.3
6
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
6.3
6
*
D64.9
ICD-10 Finland
Anaemia, unspecified
4.5
6.1
22
61
TPH04
NOMESCO Finland
Cathetrisation of vein
3.9
6.0
27
92
Mortality – FinRegistry
↥Association
Association between endpoint C3_SMALL_INTESTINE_ADENO_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_SMALL_INTESTINE_ADENO_EXALLC | 7.932 [4.73, 13.3] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.624 |
During the follow-up period (1.1.1998 — 31.12.2019), 175 out of 271 females with C3_SMALL_INTESTINE_ADENO_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_SMALL_INTESTINE_ADENO_EXALLC | 5.814 [3.51, 9.64] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 201 out of 317 males with C3_SMALL_INTESTINE_ADENO_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_SMALL_INTESTINE_ADENO_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.88% | 1.062% |
| 5 | 4.673% | 6.154% |
| 10 | 12.461% | 15.468% |
| 15 | 21.632% | 28.029% |
| 20 | 35.721% | 44.716% |
Relationships between endpoints
↥Index endpoint: C3_SMALL_INTESTINE_ADENO_EXALLC – Adenocarcinoma of small intestine
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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