info icon

This is a non-core endpoint: only basic statistics are computed.

See its core counterpart C3_RECTUM_SQUAM_EXALLC for full statistics.

Squamous cell neoplasms and carcinoma of rectum

C3_RECTUM_SQUAM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C19|C20
  • Cancer registry: Morphology ICD-O-3 8070
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

37

4. Check minimum number of events

None

37

5. Include endpoints

None

37

6. Filter based on genotype QC (FinnGen only)

37

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF8

Similar endpoints

List of similar endpoints to Squamous cell neoplasms and carcinoma of rectum based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 37 30 7
Unadjusted period prevalence (%) 0.01 0.01 0.00
Median age at first event (years) 62.27 60.13 71.42

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3022145) Colonoscopy Study observation
24
35
17.67
18.18
2.8
1.1
—
—
—
0
0
(4035726)
17
27
10.80
11.41
1.4
1.2
—
—
—
0
0
(3024561) Albumin [Mass/volume] in Serum or Plasma
28
138
5.21
4.92
9.1
5.5
g/l
35.7
35.1
0.34
28
130
(3012095) Magnesium [Moles/volume] in Serum or Plasma
16
53
4.56
4.65
2.0
2.8
mmol/l
0.8
0.8
0.67
16
48
(3023368) Bacteria identified in Blood by Culture
19
75
4.15
4.33
6.0
4.9
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
27
138
4.54
4.27
3.6
1.8
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
22
112
3.38
3.20
8.4
4.6
mmol/l
2.3
2.3
0.30
22
96
(40758558) Short blood count panel - Blood
18
83
3.28
3.05
10.1
9.7
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
7
14
5.89
2.88
6.1
5.5
mmol/l
24.7
25.8
—
7
14
(3002256) Pathology report gross observation
11
41
3.39
2.54
2.0
1.2
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
13
54
3.17
2.54
2.5
2.8
e6/l
2.7
4.2
—
7
29
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
8
23
4.14
2.43
1.0
1.4
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
15
70
2.92
2.39
2.4
2.1
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
20
110
2.78
2.35
3.7
3.0
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
6
15
4.55
2.13
1.0
1.2
—
—
—
0
0
(3033658) Prothrombin time (PT) actual/Normal
16
83
2.63
2.05
3.4
3.9
%
101.1
93.2
0.53
16
83
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
28
197
2.73
2.04
10.2
7.6
umol/l
7.9
9.9
2.39
28
184
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
5
11
5.06
2.01
6.0
9.9
%
0.4
0.8
—
5
11
(3014007) Fractional oxyhemoglobin in Arterial blood
5
11
5.06
2.01
6.0
10.3
%
97.4
94.7
—
5
11
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
5
11
5.06
2.01
6.0
9.9
%
0.9
1.4
—
5
11
(3037467) Urinalysis macro (dipstick) panel - Urine
29
211
2.73
1.87
5.4
4.3
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
17
95
2.46
1.83
3.7
3.0
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
22
139
2.44
1.81
5.8
4.2
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
5
14
3.95
1.67
1.0
1.0
—
—
—
0
0
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
12
59
2.53
1.66
5.0
4.0
mmol/l
2.5
2.5
0.19
12
48
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
13
68
2.41
1.58
1.9
1.3
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
16
93
2.27
1.53
2.9
2.3
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
5
16
3.44
1.49
9.4
9.2
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
19
120
2.20
1.48
2.2
1.9
pmol/l
87.1
98.3
—
10
50
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
12
63
2.34
1.43
2.1
2.6
e6/l
0.2
1.0
—
6
38
(42870588) Differential panel, method unspecified - Blood
17
104
2.17
1.42
5.0
5.5
—
—
—
0
0
(3001604) Monocytes [#/volume] in Blood
22
150
2.15
1.39
3.4
5.9
e9/l
0.5
0.6
0.34
16
137
(3006315) Basophils [#/volume] in Blood
22
150
2.15
1.39
3.4
6.0
e9/l
0.0
0.0
2.81
16
137
(3032080) INR in Blood by Coagulation assay
19
123
2.12
1.37
5.3
6.9
inr
1.0
1.2
—
5
39
(3021589) Normoblasts [#/volume] in Blood
19
124
2.09
1.33
17.2
10.8
e9/l
0.0
0.0
0.00
13
99
(3002173) Hemoglobin [Mass/volume] in Arterial blood
6
25
2.66
1.30
8.3
8.0
g/l
112.7
119.0
—
6
25
(3019198) Lymphocytes [#/volume] in Blood
22
153
2.08
1.29
3.7
6.0
e9/l
1.3
1.8
2.50
17
141
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
5
19
2.88
1.26
1.6
2.2
—
—
—
0
0
(3000991) Gas panel - Venous blood
5
19
2.88
1.26
6.4
8.1
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
7
30
2.64
1.20
1.3
1.5
—
—
—
0
0
(3013115) Eosinophils [#/volume] in Blood
22
157
1.99
1.16
4.2
5.9
e9/l
0.1
0.2
1.47
17
143
(3048689) Calprotectin [Mass/mass] in Stool
7
32
2.46
1.15
1.3
1.6
ug/g
92.9
94.2
—
7
25
(46235355) HIV 1 and 2 tests - Meaningful Use set
7
33
2.38
1.13
1.1
1.6
—
—
—
0
0
(3000492) Spirometry study
5
21
2.59
1.13
1.0
1.7
—
—
—
0
0
(3016502) Oxygen saturation in Arterial blood
6
27
2.45
0.99
8.3
7.6
%
98.3
95.6
—
6
27
(36660697) Celiac disease serology panel - Serum
0
27
0.00
0.81
0.0
1.1
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
15
104
1.74
0.79
4.9
2.6
u/l
59.5
55.3
0.21
15
95
(3003694) ABO and Rh group [Type] in Blood
11
70
1.81
0.76
1.3
1.3
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
5
26
2.06
0.73
1.0
1.4
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
26
299
0.56
0.72
3.7
5.8
mmol/mol
36.7
39.9
2.05
21
277
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
5
27
1.98
0.71
1.4
2.1
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
7
44
1.73
0.69
1.7
1.5
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
7
44
1.73
0.69
1.7
1.5
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
9
60
1.66
0.61
5.0
5.1
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
29
257
1.59
0.46
33.6
18.6
%
13.8
13.7
0.13
29
252
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
8
57
1.51
0.46
2.4
1.6
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
9
65
1.51
0.43
1.4
1.7
mg/l
3.6
0.8
—
9
56
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
0
16
0.00
0.42
0.0
1.2
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
32
293
1.68
0.41
23.0
15.5
%
37.7
39.6
1.40
25
211
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
0
18
0.00
0.41
0.0
1.2
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
20
172
1.35
0.32
2.8
2.7
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
30
314
0.76
0.32
3.7
4.7
mmol/l
5.7
5.8
0.46
25
289
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
28
296
0.78
0.28
4.7
4.8
mu/l
2.0
1.9
0.24
23
267
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
12
98
1.33
0.25
1.3
2.1
u/l
96.0
113.9
0.21
12
93
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
14
118
1.30
0.24
2.6
3.5
u/l
24.1
30.0
0.87
14
110
(40768443) Skin Pathology biopsy report
0
11
0.00
0.22
0.0
1.4
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
0
11
0.00
0.22
0.0
1.7
—
—
—
0
0
(3004490) Bicarbonate [Moles/volume] standard in Capillary blood
0
10
0.00
0.22
0.0
4.4
—
24.6
—
0
10
(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma
0
10
0.00
0.22
0.0
1.8
—
93.3
—
0
10
(3022313) Gas panel - Capillary blood
0
10
0.00
0.22
0.0
4.4
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
0
10
0.00
0.22
0.0
1.1
—
—
—
0
0
(3020961) Endomysium IgA Ab [Titer] in Serum
0
10
0.00
0.22
0.0
1.1
—
—
—
0
0
(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum
0
10
0.00
0.22
0.0
2.6
—
—
—
0
0
(3020891) Body temperature
0
10
0.00
0.22
0.0
4.1
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
0
10
0.00
0.22
0.0
1.3
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
9
104
0.82
0.15
4.7
2.7
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
10
85
1.24
0.14
4.2
3.6
—
—
—
0
0
(3015736) pH of Urine
10
113
0.84
0.10
2.6
3.4
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
19
177
1.15
0.09
6.6
4.5
mmol/l
6.3
6.5
0.38
19
167
(3011397) Hemoglobin [Presence] in Urine by Test strip
6
69
0.84
0.08
2.7
3.3
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
9
102
0.84
0.07
2.0
3.0
—
—
—
0
0
(3013512) EKG study
10
90
1.15
0.06
3.4
3.5
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
12
129
0.90
0.04
2.6
2.3
nmol/l
74.7
75.8
0.05
12
115
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
12
114
1.08
0.01
3.7
3.9
—
—
—
0
0
(3044889) 12 lead EKG panel
23
234
0.95
0.00
4.1
3.9
—
—
—
0
0
(3001788) Aldosterone [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
283.2
—
0
6
(3026493) Urate [Moles/volume] in Serum or Plasma
8
79
1.02
0.00
1.4
2.4
umol/l
30991.3
6724.3
—
8
64
(3051651) Icteric interference index of Serum or Plasma
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(1002224) Polysomnography panel
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
6
58
1.04
0.00
1.7
1.3
—
—
—
0
0
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(21494890) Protein electrophoresis panel - 24 hour Urine
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.4
—
2.5
—
0
8
(3013327) Hepatitis A virus IgM Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
5.5
—
0
6
(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(1001926) Buprenorphine [Presence] in Urine by Screen method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3012441) Differential panel - Pleural fluid
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3007164) IgA [Mass/volume] in Serum or Plasma
6
63
0.94
0.00
1.3
1.4
g/l
2.0
2.3
—
6
32
(3026389) Candida sp identified in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
(3018405) Lactate [Moles/volume] in Arterial blood
0
7
0.00
-0.00
0.0
4.7
—
1.8
—
0
7
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
(40760888) Immunoglobulin light chains.free panel - Serum
0
7
0.00
-0.00
0.0
3.1
—
—
—
0
0
(3015171) Extractable nuclear Ab [Units/volume] in Serum
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_RECTUM_SQUAM – Squamous cell neoplasms and carcinoma of rectum

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).