No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF8
- Parent code in ICD-10
- C45-C49
- Name in latin
- Mesothelioma
Similar endpoints
↥List of similar endpoints to
Mesothelioma
based on the number of shared cases.
Similar with more cases:
- Mesothelioma
- Melignant neoplasm of mesothelium and soft tissue
- Malignant neoplasm of mesothelium and soft tissue
- Malignant neoplasm
- Malignant neoplasm
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5562 | 1900 | 3473 |
| Only index persons | 2054 | 696 | 1358 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.05 | 0.10 |
| Only index persons | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 67.16 | 67.14 | 67.35 |
| Only index persons | 70.63 | 69.35 | 71.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 390 | 92 | 298 |
| Unadjusted period prevalence (%) | 0.12 | 0.04 | 0.15 |
| Median age at first event (years) | 70.20 | 63.72 | 72.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 404
- Matched controls
- 4040
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C45.0
ICD-10 Finland
Mesothelioma of pleura
+∞
323.0
299
*
130
Kela drug reimbursment
Malignant tumour
+∞
245.7
210
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
84.3
197.4
216
54
H02AB02
ATC
dexamethasone; systemic
322.0
189.3
179
10
9050/3-C38.4
ICD-O-3
Mesothelioma, malignant of pleura, NOS
+∞
135.2
122
*
A03FA01
ATC
metoclopramide; systemic, rectal
19.6
120.9
202
196
9052/3-C38.4
ICD-O-3
Epithelioid mesothelioma, malignant of pleura, NOS
+∞
103.7
95
*
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
438.7
103.1
99
*
N02AA05
ATC
oxycodone; systemic
13.6
98.4
195
259
Z51.5
ICD-10 Finland
Palliative care
36.7
94.3
122
47
A04AA01
ATC
ondansetron; systemic, rectal
71.3
90.5
102
19
J94.8
ICD-10 Finland
Other specified pleural conditions
58.8
81.5
95
21
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
74.3
69
*
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
49.2
73.9
89
23
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
24.2
69.0
100
54
JN4BD
NOMESCO Finland
Extensive body CT
14.9
63.1
111
100
C45.9
ICD-10 Finland
Mesothelioma, unspecified
+∞
59.9
56
*
C45.1
ICD-10 Finland
Mesothelioma of peritoneum
+∞
57.7
54
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
51.1
48
*
GAC00
NOMESCO Finland
Biopsy of pleura
121.5
50.1
53
5
TGA30
NOMESCO Finland
Thoracocentesis
52.9
49.8
59
13
A04AA02
ATC
granisetron; systemic, transdermal
271.3
48.1
48
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
27.4
47.1
65
28
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
21.7
44.5
66
36
1BA04
NOMESCO Finland
NA
+∞
42.4
40
*
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
26.3
42.4
59
26
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
10.7
39.6
80
91
L01CA04
ATC
vinorelbine; systemic
+∞
39.2
37
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
39.2
37
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
402.3
37.7
37
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.2
36.8
111
233
C61
ICD-10 Finland
Malignant neoplasm of prostate
378.2
35.5
35
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
34.9
33
*
9051/3-C38.4
ICD-O-3
Fibrous mesothelioma, malignant of pleura, NOS
+∞
32.7
31
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
30.6
29
*
GAA96
NOMESCO Finland
Other open or percutaneous drainage of pleural cavity
89.6
30.2
33
*
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
52.8
28.9
34
7
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.1
28.7
85
170
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
28.5
241
1251
D38.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pleura
+∞
28.5
27
*
A06AH03
ATC
naloxegol; oral
+∞
27.4
26
*
J94.9
ICD-10 Finland
Pleural condition, unspecified
30.2
27.2
36
13
JN4AD
NOMESCO Finland
Body CT examination
8.9
26.0
57
73
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
144.2
25.9
27
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
25.3
24
*
C38.4
ICD-10 Finland
Malignant neoplasm: Pleura
+∞
25.3
24
*
R84
ICPC
Malignant neoplasm bronchus/lung
+∞
24.2
23
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
24.2
23
*
WX600
NOMESCO Finland
Single shot through catheter
57.6
23.3
27
5
WZC30
NOMESCO Finland
Teaching
5.2
22.5
75
170
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
10.2
22.5
45
49
GD1AT
NOMESCO Finland
Biopsy of the lung with ultrasound guidance
+∞
22.1
21
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.9
22.0
77
184
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
231.9
21.8
22
*
J01MA12
ATC
levofloxacin; systemic
3.5
21.3
119
435
ZX120
NOMESCO Finland
Intravenous
5.7
21.1
64
130
GD1AD
NOMESCO Finland
Thorax CT examination
8.3
20.0
45
60
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
20.0
120
460
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
6.7
18.1
47
78
B03BA03
ATC
hydroxocobalamin; parenteral
4.7
17.9
64
155
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
7.0
17.9
45
71
9053/3-C38.4
ICD-O-3
Mesothelioma, biphasic, malignant of pleura, NOS
+∞
17.8
17
*
A04AD12
ATC
aprepitant; systemic
+∞
17.8
17
*
116
Kela drug reimbursment
Prostate cancer
+∞
17.8
17
*
J01MA14
ATC
moxifloxacin; systemic
4.5
17.8
67
171
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.9
17.2
126
544
L03AA13
ATC
pegfilgrastim; parenteral
+∞
16.8
16
*
L03AA02
ATC
filgrastim; parenteral
94.0
16.7
18
*
N02AA01
ATC
morphine; systemic, rectal
18.9
16.7
25
14
JN4CD
NOMESCO Finland
Very extensive body CT
13.0
16.1
28
23
GAA31
NOMESCO Finland
Thoracoscopy
62.6
15.9
18
*
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
16.9
15.4
24
15
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
46.9
15.2
18
*
GDD20
NOMESCO Finland
Extended pneumonectomy
+∞
14.7
14
*
GAC43
NOMESCO Finland
Total decortication of pleura
+∞
14.7
14
*
QBC00
NOMESCO Finland
Removal of foreign body from skin of trunk or subcutaneous tissue
+∞
14.7
14
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
155.3
14.6
15
*
A79
ICPC
Malignancy NOS
155.3
14.6
15
*
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
13.3
14.1
24
19
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.6
13.9
49
117
C45
ICD-10 Finland
Mesothelioma
+∞
13.6
13
*
JAL30
NOMESCO Finland
Omentectomy
144.6
13.5
14
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
13.0
113
529
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.5
12.8
46
112
C78.2
ICD-10 Finland
Secondary malignant neoplasm of pleura
+∞
12.6
12
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
12.6
12
*
C45.7
ICD-10 Finland
Mesothelioma of other sites
+∞
12.6
12
*
R82
ICPC
Pleurisy/pleural effusion
+∞
12.6
12
*
XX3DW
NOMESCO Finland
Time consuming IT work
5.4
12.3
37
74
WW500
NOMESCO Finland
Blood transfusion
9.1
12.2
25
29
B01AB10
ATC
tinzaparin; parenteral
5.3
12.1
37
76
TK800
NOMESCO Finland
Hemodialysis
7.5
11.7
27
38
R85
ICPC
Malignant neopl respiratory other
+∞
11.5
11
*
GDD96
NOMESCO Finland
Other pneumonectomy
+∞
11.5
11
*
JAL20
NOMESCO Finland
Excision or destruction of lesion of peritoneum
+∞
11.5
11
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
123.3
11.5
12
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
11.6
11.2
20
18
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
11.0
149
859
Z2446
NOMESCO Finland
Social worker
4.5
10.8
38
91
GAC97
NOMESCO Finland
Other endoscopic operation on pleura
61.6
10.7
12
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
10.7
102
496
GAC30
NOMESCO Finland
Artificial pneumothorax
112.7
10.5
11
*
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
19.4
10.3
15
8
AA1BD
NOMESCO Finland
Extensive CT of head and brain
10.4
10.1
19
19
J86.9
ICD-10 Finland
Pyothorax without fistula
13.8
9.7
16
12
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
56.3
9.7
11
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
10.4
9.6
18
18
N03AX16
ATC
pregabalin; oral
2.3
9.4
99
502
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
9.4
9
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
9.4
9
*
A04AA03
ATC
tropisetron; systemic
+∞
9.4
9
*
C34.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bronchus and lung
+∞
9.4
9
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
9.4
9
*
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
7.6
9.3
21
29
R18
ICD-10 Finland
Ascites
10.4
9.1
17
17
H02AB06
ATC
prednisolone; systemic
1.9
9.0
193
1305
R06.0
ICD-10 Finland
Dyspnoea
2.1
8.8
121
687
GA3AT
NOMESCO Finland
Pleural cytology with ultrasound guidance
51.1
8.7
10
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
51.1
8.7
10
*
8140/3-C34.9
ICD-O-3
Adenocarcinoma, NOS, of lung, NOS
+∞
8.4
8
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
8.4
8
*
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
+∞
8.4
8
*
L02BB03
ATC
bicalutamide; oral
+∞
8.4
8
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
+∞
8.4
8
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
8.4
8
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
8.4
8
*
GD2FN
NOMESCO Finland
Lung ventilation distribution isotope examination (radiospirometry)
+∞
8.4
8
*
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
+∞
8.4
8
*
1638X
ICD-9 Finland
Malignant neoplasm of pleura, Other specified sites of pleura
+∞
8.4
8
*
C34.10
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung without histology
+∞
8.4
8
*
C34.99
ICD-10 Finland
Malignant tumor in unspecified localization in bronchial and pulmonary other or unspecified histology
+∞
8.4
8
*
9052/3-C48.2
ICD-O-3
Epithelioid mesothelioma, malignant of peritoneum, NOS
+∞
8.4
8
*
GA2AT
NOMESCO Finland
Pleural biopsy with ultrasound guidance
+∞
8.4
8
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
34.1
8.1
10
*
L02AE02
ATC
leuprorelin; implant, parenteral
34.1
8.1
10
*
Z57.2
ICD-10 Finland
Occupational exposure to dust
13.4
7.9
13
10
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
7.2
7.9
18
26
NK6AN
NOMESCO Finland
Total body bone isotope imaging
45.8
7.7
9
*
GAC37
NOMESCO Finland
Endoscopic chemical pleurodesis
45.8
7.7
9
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
7.7
141
891
SPAT1109
SPAT
Analgesia with portable analgesic pump
18.8
7.6
11
6
XX1XW
NOMESCO Finland
Extensive written report from radiologist
7.3
7.6
17
24
R4110
NOMESCO Finland
Physiotherapy
2.0
7.5
108
620
B01AB05
ATC
enoxaparin; parenteral
2.0
7.5
117
695
SPAT1062
SPAT
Lung clearance therapy
81.5
7.4
8
*
Y77
ICPC
Malignant neoplasm prostate
81.5
7.4
8
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
7.3
151
988
WW200
NOMESCO Finland
Immunization
6.4
7.3
18
29
9050/3-C48.2
ICD-O-3
Mesothelioma, malignant of peritoneum, NOS
+∞
7.3
7
*
1990X
ICD-9 Finland
Malignant neoplasm without specification of site, Disseminated
+∞
7.3
7
*
1580A
ICD-9 Finland
Malignant neoplasm of retroperitoneum and peritoneum, Retroperitoneum
+∞
7.3
7
*
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
+∞
7.3
7
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
7.3
7
*
GA2CT
NOMESCO Finland
Pleural biopsy with CT guidance
+∞
7.3
7
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
7.3
7
*
C34.90
ICD-10 Finland
Malignant tumor in unspecified location in bronchus and lung without histology
+∞
7.3
7
*
GAB10
NOMESCO Finland
Antero- or postero-lateral thoracotomy
16.1
7.3
11
7
J93.8
ICD-10 Finland
Other pneumothorax
30.6
7.2
9
*
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
20.4
7.2
10
5
N02AX02
ATC
tramadol; systemic, rectal
1.8
7.1
170
1166
WX402
NOMESCO Finland
General anaesthesia
2.5
7.0
54
232
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
7.0
55
240
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
40.7
6.8
8
*
6101
FHL
Exploratory laparotomy, includes possible biopases
17.0
6.8
10
6
ZX112
NOMESCO Finland
Subcutaneous
17.0
6.8
10
6
JAH01
NOMESCO Finland
Laparoscopy
6.1
6.7
17
29
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
6.6
54
241
N06DX01
ATC
memantine; oral
0.1
6.5
*
236
GAC46
NOMESCO Finland
Partial decortication of pleura
70.9
6.4
7
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
70.9
6.4
7
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
70.9
6.4
7
*
WF002
NOMESCO Finland
Radical radiotherapy
70.9
6.4
7
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
0.5
6.3
72
1182
GAC96
NOMESCO Finland
Other operation on pleura
+∞
6.3
6
*
GAC20
NOMESCO Finland
Excision or destruction of lesion of pleura
+∞
6.3
6
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
6.3
6
*
C34.00
ICD-10 Finland
Malignant tumor of the main bronchus without histology
+∞
6.3
6
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
+∞
6.3
6
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
6.3
6
*
C34.9
ICD-10 Finland
Malignant neoplasm: Bronchus or lung, unspecified
+∞
6.3
6
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
6.3
6
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
6.3
6
*
SPAT1088
SPAT
Blood transfusion
27.1
6.2
8
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
12.8
6.1
10
8
Mortality – FinRegistry
↥Association
Association between endpoint C3_MESOTHELIOMA_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_MESOTHELIOMA_EXALLC | 5.972 [4.26, 8.37] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.608 |
During the follow-up period (1.1.1998 — 31.12.2019), 551 out of 724 females with C3_MESOTHELIOMA_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_MESOTHELIOMA_EXALLC | 12.814 [8.61, 19.06] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 1391 out of 1598 males with C3_MESOTHELIOMA_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_MESOTHELIOMA_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.559% | 2.316% |
| 5 | 3.196% | 13.386% |
| 10 | 8.392% | 29.649% |
| 15 | 16.269% | 51.616% |
| 20 | 27.686% | 72.816% |
Relationships between endpoints
↥Index endpoint: C3_MESOTHELIOMA_EXALLC – Mesothelioma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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