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Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx

C3_LIP_ORAL_PHARYNX_NAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C14
  • Cause of death: ICD-9 149
  • Cause of death: ICD-8 149
  • Cancer registry: Topography ICD-O-3 C14
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

33

4. Check minimum number of events

None

33

5. Include endpoints

None

33

6. Filter based on genotype QC (FinnGen only)

33

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

None

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 33 5 28
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 68.71 71.45 68.22

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(4035726)
15
21
12.26
11.16
1.5
1.2
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
22
118
3.59
3.00
5.0
4.1
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
24
145
3.39
2.76
16.2
12.3
e9/l
4.4
4.6
0.20
24
126
(40768804) Tissue Pathology biopsy report
18
97
2.88
2.24
2.7
2.0
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
16
85
2.71
2.00
2.7
2.3
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
7
32
2.50
1.16
1.3
1.8
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
6
28
2.39
0.97
8.3
13.1
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
11
65
2.04
0.97
1.3
1.3
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
0
25
0.00
0.83
0.0
1.5
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
13
86
1.84
0.82
7.5
6.8
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
11
69
1.89
0.81
2.5
2.1
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
5
25
2.17
0.76
1.0
1.3
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
8
48
1.88
0.70
6.1
7.7
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
8
50
1.79
0.68
1.0
1.7
—
—
—
0
0
(3012544) pH of Venous blood
5
29
1.85
0.66
1.4
2.4
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
6
39
1.66
0.56
1.2
1.8
—
—
—
0
0
(3019198) Lymphocytes [#/volume] in Blood
16
124
1.56
0.53
6.3
7.3
e9/l
1.7
1.8
0.09
16
107
(3023368) Bacteria identified in Blood by Culture
11
79
1.59
0.49
4.5
5.4
—
—
—
0
0
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
23
196
1.57
0.48
15.0
8.7
u/l
66.5
77.9
2.51
23
187
(3037467) Urinalysis macro (dipstick) panel - Urine
14
173
0.67
0.44
4.6
3.4
—
—
—
0
0
(3002256) Pathology report gross observation
5
34
1.55
0.42
1.2
1.2
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
0
15
0.00
0.42
0.0
1.3
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
(3009508) Creatinine [Moles/volume] in Urine
5
75
0.61
0.42
2.8
3.1
mmol/l
5.8
7.4
—
5
64
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
6
41
1.56
0.39
1.2
2.0
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
8
104
0.70
0.36
4.3
3.4
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
7
52
1.44
0.34
1.6
2.0
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
5
70
0.66
0.30
3.6
2.3
—
—
—
0
0
(3013512) EKG study
10
81
1.34
0.22
2.6
3.7
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
11
0.00
0.22
0.0
1.0
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
0
10
0.00
0.22
0.0
2.8
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
12
0.00
0.21
0.0
3.2
—
—
—
0
0
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
0
12
0.00
0.21
0.0
1.8
—
38.8
—
0
12
(3013139) Helicobacter pylori Ag [Presence] in Stool
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
7
58
1.26
0.20
1.7
1.8
nmol/l
24.1
21.5
—
7
49
(3033658) Prothrombin time (PT) actual/Normal
5
65
0.73
0.19
4.8
4.3
%
69.6
86.4
—
5
65
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
12
102
1.28
0.18
2.6
3.0
—
—
—
0
0
(40758558) Short blood count panel - Blood
8
70
1.19
0.18
10.8
7.9
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
10
118
0.78
0.18
1.8
3.0
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
9
79
1.19
0.17
2.6
2.8
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
18
166
1.19
0.11
5.7
3.6
pmol/l
14.2
15.3
1.00
18
151
(3020564) Creatinine [Moles/volume] in Serum or Plasma
26
267
0.88
0.09
32.6
19.4
umol/l
76.4
82.5
0.81
26
267
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
7
83
0.80
0.08
2.1
2.2
nmol/l
90.9
72.5
—
7
77
(3044889) 12 lead EKG panel
20
190
1.13
0.06
5.1
4.1
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
13
139
0.89
0.04
3.8
3.9
%
20.6
20.9
—
8
71
(3003338) MCHC [Mass/volume]
20
206
0.93
0.01
29.6
22.2
g/l
333.6
333.5
0.03
20
206
(3009542) Hematocrit [Volume Fraction] of Blood
21
208
1.03
0.00
22.4
19.0
%
40.3
39.9
0.11
11
149
(3011397) Hemoglobin [Presence] in Urine by Test strip
6
62
0.96
0.00
3.0
4.0
—
—
—
0
0
(3035285) Chloride [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
1.8
—
106.6
—
0
8
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(4094501)
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.0
—
0.0
—
0
8
(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis
0
9
0.00
0.00
0.0
1.0
—
0.0
—
0
9
(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3023183) Ammonium ion [Moles/volume] in Plasma
0
6
0.00
0.00
0.0
1.3
—
28.8
—
0
6
(3019832) Treponema pallidum Ab [Presence] in Serum
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
1.8
—
4.3
—
0
8
(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis
0
8
0.00
0.00
0.0
1.0
—
0.0
—
0
8
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3051611) Lipemic interference index of Serum or Plasma
0
5
0.00
0.00
0.0
4.4
—
—
—
0
0
(44790048)
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3017766) Complement C4 [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
0.2
—
0
5
(42529406) Shigella sp [Presence] in Stool by Culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
0
5
0.00
0.00
0.0
5.8
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
7
68
1.04
0.00
2.6
2.8
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(44790049)
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
8
87
0.89
0.00
2.4
3.0
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(44806118)
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(44790047)
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
26
258
1.04
0.00
25.4
14.5
—
—
—
0
0
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3021387) Prolactin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.8
—
510.4
—
0
5
(3009214) Lutropin [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.3
—
5.9
—
0
7
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000620) Complement C3 [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
1.2
—
0
5
(3027544) Mycobacterium sp identified in Sputum by Organism specific culture
0
7
0.00
0.00
0.0
3.7
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_LIP_ORAL_PHARYNX_NAS – Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).