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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart C3_LIP_EXALLC for full statistics.

Malignant neoplasm of lip

C3_LIP

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C00&
  • Cause of death: ICD-9 140
  • Cause of death: ICD-8 140
  • Cancer registry: Topography ICD-O-3 C00
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

262

4. Check minimum number of events

None

262

5. Include endpoints

None

262

6. Filter based on genotype QC (FinnGen only)

246

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 246 53 193
Unadjusted period prevalence (%) 0.08 0.02 0.10
Median age at first event (years) 67.29 71.72 66.07

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
262
Matched controls
2618
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8070/3-C00.1
ICD-O-3
Squamous cell carcinoma, NOS, of external lower lip
+∞
232.1
187
*
EAA10
NOMESCO Finland
Excision of lesion of lip
138.5
94.9
97
11
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
401.8
87.3
83
*
C00.1
ICD-10 Finland
Malignant neoplasm: External lower lip
509.1
77.0
73
*
EAA30
NOMESCO Finland
Partial excision of lower lip
252.0
59.7
59
*
TEA00
NOMESCO Finland
Biopsy of lip
69.2
40.8
46
8
EP1AE
NOMESCO Finland
Neck ultrasound examination
13.2
36.0
66
65
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
7.2
29.0
78
146
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
18.6
28.4
44
28
8070/3-C00.9
ICD-O-3
Squamous cell carcinoma, NOS, of lip, NOS
+∞
27.6
26
*
C00.9
ICD-10 Finland
Malignant neoplasm: Lip, unspecified
+∞
23.3
22
*
L57.0
ICD-10 Finland
Actinic keratosis
5.1
21.9
78
200
1401A
ICD-9 Finland
Malignant neoplasm of lip, Lower lip, vermilion border
+∞
20.0
19
*
C44.09
ICD-10 Finland
Malignant tumor of the lip skin other or unspecified histology
+∞
19.0
18
*
D10.09
ICD-10 Finland
Benign tumor of the lip UNS
203.7
18.8
19
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.0
18.6
66
166
C00.4
ICD-10 Finland
Malignant neoplasm: Lower lip, inner aspect
+∞
17.9
17
*
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
11.9
16.4
30
28
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
16.1
15.7
25
17
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
5.9
14.6
42
82
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
8.1
14.2
32
44
4382
FHL
Lip resection and / or plastic
147.1
13.6
14
*
8070/3-C00.0
ICD-O-3
Squamous cell carcinoma, NOS, of external upper lip
+∞
12.6
12
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
39.5
12.3
15
*
14011
ICD-8 Finland
Malignant neoplasm of lip, Lower lip
+∞
11.5
11
*
EAB20
NOMESCO Finland
Plastic repair of lip
125.1
11.5
12
*
D23.0
ICD-10 Finland
Benign neoplasm: Skin of lip
26.3
11.3
15
6
EAA20
NOMESCO Finland
Partial excision of upper lip
+∞
10.5
10
*
C44.00
ICD-10 Finland
Malignant tumor of the lip skin without histology
34.0
10.4
13
*
K13.09
ICD-10 Finland
Disease of the lips UNS
57.1
9.7
11
*
C00.0
ICD-10 Finland
Malignant neoplasm: External upper lip
103.5
9.5
10
*
4381
FHL
Exemption of local change
103.5
9.5
10
*
8070/3-C00.4
ICD-O-3
Squamous cell carcinoma, NOS, of mucosa of lower lip
+∞
9.4
9
*
R23.8
ICD-10 Finland
Other and unspecified skin changes
3.1
9.1
54
203
C00.3
ICD-10 Finland
Malignant neoplasm: Upper lip, inner aspect
+∞
8.4
8
*
D10.00
ICD-10 Finland
Upper lip tumor in upper lip on lip lip border
+∞
8.4
8
*
D06BB10
ATC
imiquimod; topical
4.8
8.0
26
59
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
46.3
7.8
9
*
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.5
7.7
22
43
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
5.5
7.7
22
43
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
10.5
7.6
14
14
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
3.9
7.5
30
84
SPAT1153
SPAT
Removal of sutures
2.2
7.4
93
524
D10.03
ICD-10 Finland
Lower lip tumor in the lower lip at the lip red border
+∞
7.3
7
*
EAB99
NOMESCO Finland
Other reconstructive operations on lip
+∞
7.3
7
*
C44.0
ICD-10 Finland
Malignant neoplasm: Skin of lip
+∞
7.3
7
*
D04.0
ICD-10 Finland
Carcinoma in situ: Skin of lip
+∞
7.3
7
*
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
30.9
7.2
9
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
30.9
7.2
9
*
C44.20
ICD-10 Finland
Malignant tumor of the skin of the outer ear and of the outer ear canal without histology
20.7
7.2
10
5
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
5.1
7.0
21
44
K13.03
ICD-10 Finland
Keilit UNS
41.1
6.8
8
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
5.4
6.8
19
37
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
23.2
6.7
9
*
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
5.3
6.6
19
38
D37.08
ICD-10 Finland
Tumor of uncertain or unknown nature in other part of lip, oral cavity and pharynx
71.4
6.4
7
*
C44.39
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face other or unspecified histology
9.6
6.3
12
13
S77
ICPC
Malignant neoplasm of skin
9.6
6.3
12
13
D00.00
ICD-10 Finland
Cancer in situ on the lip red border
+∞
6.3
6
*
EAA99
NOMESCO Finland
Other excision of lip
+∞
6.3
6
*
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
27.4
6.3
8
*
ZXC50
NOMESCO Finland
Cryotherapy
4.4
6.2
21
51
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
7.0
6.1
14
21

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_LIP – Malignant neoplasm of lip

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).