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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart C3_LARYNX_EXALLC for full statistics.

Malignant neoplasm of larynx

C3_LARYNX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C32
  • Cause of death: ICD-9 161
  • Cause of death: ICD-8 161
  • Cancer registry: Topography ICD-O-3 C32
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

529

4. Check minimum number of events

None

529

5. Include endpoints

None

529

6. Filter based on genotype QC (FinnGen only)

509

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 509 62 447
Unadjusted period prevalence (%) 0.20 0.02 0.22
Median age at first event (years) 67.17 63.73 67.65

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
529
Matched controls
5289
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C32.0
ICD-10 Finland
Malignant neoplasm: Glottis
2993.5
323.0
371
*
8070/3-C32.9
ICD-O-3
Squamous cell carcinoma, NOS, of larynx, NOS
+∞
258.1
226
*
8070/3-C32.0
ICD-O-3
Squamous cell carcinoma, NOS, of glottis
+∞
228.1
202
*
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
495.0
225.6
210
7
DQB10
NOMESCO Finland
Endoscopic excision of lesion of larynx
217.9
215.5
211
16
DQA10
NOMESCO Finland
Biopsy of larynx
491.9
202.7
190
6
UDQ22
NOMESCO Finland
Microlaryngoscopy
246.9
159.7
157
9
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
184.2
145.9
147
11
C32.1
ICD-10 Finland
Malignant neoplasm: Supraglottis
811.1
132.6
125
*
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
695.7
116.8
111
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
53.9
112.9
134
33
UJC01
NOMESCO Finland
Scopy of lower throat
83.8
111.5
123
19
C32.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of larynx
587.6
101.1
97
*
DQB30
NOMESCO Finland
Laryngectomy
1107.9
97.2
92
*
ZXC10
NOMESCO Finland
Use of laser
42.1
92.9
116
35
DQE00
NOMESCO Finland
Implantation of prosthetic replacement for larynx
1050.0
92.7
88
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
16.3
91.6
156
132
WF002
NOMESCO Finland
Radical radiotherapy
14.6
90.8
163
156
JDB10
NOMESCO Finland
Percutaneous gastrostomy
38.9
89.7
114
37
GBB00
NOMESCO Finland
Tracheostomy
55.3
87.3
103
23
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
36.9
83.2
107
36
130
Kela drug reimbursment
Malignant tumour
8.4
74.8
188
326
EP1AE
NOMESCO Finland
Neck ultrasound examination
12.5
60.3
114
114
8070/3-C32.1
ICD-O-3
Squamous cell carcinoma, NOS, of supraglottis
+∞
57.3
54
*
DQB70
NOMESCO Finland
Total excision of vocal cord
572.3
53.5
52
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
46.0
53.3
65
16
J37.0
ICD-10 Finland
Chronic laryngitis
19.6
53.2
82
49
J38.3
ICD-10 Finland
Other diseases of vocal cords
50.9
52.7
63
14
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
39.5
52.4
66
19
UDH02
NOMESCO Finland
Rhinopharyngoscopy
9.4
49.3
108
140
WX408
NOMESCO Finland
General anesthesy, balanced
4.3
49.3
240
848
1420
FHL
Laryngomicroscopy
34.9
48.0
62
20
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
112.6
47.7
51
5
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
14.8
40.4
69
53
GBB13
NOMESCO Finland
Revision of tracheostomy
+∞
40.1
38
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
68.3
38.7
44
7
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.2
38.5
135
328
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
7.5
37.0
93
147
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
36.7
36.9
47
14
1610A
ICD-9 Finland
Malignant neoplasm of larynx, Glottis
+∞
36.9
35
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
12.2
36.1
67
62
R49.0
ICD-10 Finland
Dysphonia
21.6
36.1
53
27
UDQ02
NOMESCO Finland
Direct laryngoscopy
30.2
35.3
47
17
R4190
NOMESCO Finland
Nutritional therapy
14.6
35.1
60
46
UJC02
NOMESCO Finland
Rigid oesophagoscopy
27.2
32.9
45
18
A07AA02
ATC
nystatin; oral
6.5
31.9
88
157
ZXE00
NOMESCO Finland
One hour or less
3.0
31.2
261
1282
EBA15
NOMESCO Finland
Extraction of large number of teeth
8.2
31.0
72
100
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.0
30.9
145
460
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
8.2
30.3
70
96
N02AA05
ATC
oxycodone; systemic
3.6
30.0
162
576
A03FA01
ATC
metoclopramide; systemic, rectal
3.5
29.2
162
586
D02.0
ICD-10 Finland
Carcinoma in situ: Larynx
307.8
29.1
29
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
5.8
29.0
87
172
XX3DW
NOMESCO Finland
Time consuming IT work
4.8
28.6
105
261
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
45.2
28.1
34
8
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
32.9
26.2
34
11
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
26.6
25.6
35
14
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
5.1
25.4
86
195
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.8
25.0
226
1122
ZXD10
NOMESCO Finland
Scheduled procedure
2.7
24.5
248
1314
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
6.8
24.2
63
103
WX734
NOMESCO Finland
JET-ventilation
130.8
23.8
25
*
J38.1
ICD-10 Finland
Polyp of vocal cord and larynx
29.8
23.4
31
11
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
26.1
23.3
32
13
C32.2
ICD-10 Finland
Malignant neoplasm: Subglottis
+∞
23.1
22
*
GBB96
NOMESCO Finland
Other tracheostomy procedure
239.8
22.8
23
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.9
22.6
78
180
GB3AV
NOMESCO Finland
NA
+∞
22.0
21
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.5
22.0
84
215
ZX070
NOMESCO Finland
Intensity modified radiotherapy
10.5
21.5
42
43
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
52.3
21.3
25
5
WX402
NOMESCO Finland
General anaesthesia
3.4
21.2
114
391
C32
ICD-10 Finland
Malignant neoplasm of larynx
218.1
20.7
21
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
34.1
20.4
26
8
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
50.1
20.3
24
5
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.6
20.2
193
959
WF003
NOMESCO Finland
Adjuvant radiotherapy
8.6
20.1
44
55
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
24.5
20.1
28
12
UJC12
NOMESCO Finland
Flexible oesophagoscopy
21.8
20.1
29
14
R13
ICD-10 Finland
Dysphagia
4.4
19.6
75
192
GD1AD
NOMESCO Finland
Thorax CT examination
5.8
18.9
55
104
UGB02
NOMESCO Finland
Tracheoscopy
72.5
18.8
21
*
TGB20
NOMESCO Finland
Tracheostomy tube replacement
103.7
18.7
20
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
17.9
221
1240
R49.08
ICD-10 Finland
Other specified dysphonia
10.6
17.7
34
34
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
11.7
16.9
31
28
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
65.5
16.8
19
*
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
14.0
16.6
28
21
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.3
16.2
62
158
ZXB10
NOMESCO Finland
Medial
16.3
15.8
25
16
H02AB02
ATC
dexamethasone; systemic
3.4
15.7
79
256
GBA00
NOMESCO Finland
Tracheotomy
87.7
15.6
17
*
C13.9
ICD-10 Finland
Malignant neoplasm: Hypopharynx, unspecified
58.4
14.9
17
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
6.6
14.9
38
61
R23
ICPC
Voice symptom/complaint
12.4
14.7
26
22
C14.1
ICD-10 Finland
Malignant neoplasm of laryngopharynx unspecified
+∞
14.6
14
*
K05.31
ICD-10 Finland
Periodontitis pronounced
3.2
14.3
79
272
EBA10
NOMESCO Finland
Surgical removal of tooth
3.7
13.9
63
187
TJD20
NOMESCO Finland
Change of gastrostomy tube
24.5
13.9
19
8
4504
FHL
Laryngectomy
+∞
13.6
13
*
1611A
ICD-9 Finland
Malignant neoplasm of larynx, Supraglottis
+∞
13.6
13
*
N07BA03
ATC
varenicline; oral
5.7
13.6
39
73
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
13.3
13.5
23
18
WZC30
NOMESCO Finland
Teaching
2.9
13.5
89
347
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.0
13.5
43
91
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
21.8
13.4
19
9
GD6BD
NOMESCO Finland
Extensive CT of chest and neck
71.6
12.6
14
*
R85
ICPC
Malignant neopl respiratory other
71.6
12.6
14
*
2391A
ICD-9 Finland
Neoplasm of unspecified nature, Respiratory system
17.9
12.6
19
11
DQB20
NOMESCO Finland
Partial excision of larynx
+∞
12.5
12
*
DQW99
NOMESCO Finland
Other operation on larynx
132.9
12.5
13
*
H03AA01
ATC
levothyroxine sodium; systemic
2.5
12.3
105
476
A02BC05
ATC
esomeprazole; systemic
2.0
12.1
210
1309
A04AA02
ATC
granisetron; systemic, transdermal
4.0
12.1
49
132
R4130
NOMESCO Finland
Speech therapy
6.4
12.0
31
51
UGC02
NOMESCO Finland
Rigid bronchoscopy
47.8
11.9
14
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
7.6
11.9
27
37
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
11.8
261
1778
GD6AD
NOMESCO Finland
CT of chest and neck
30.8
11.7
15
5
C32.3
ICD-10 Finland
Malignant neoplasm: Laryngeal cartilage
+∞
11.5
11
*
J95.0
ICD-10 Finland
Tracheostomy malfunction
122.5
11.5
12
*
R49.09
ICD-10 Finland
Unspecified dysphonia
12.2
11.4
20
17
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.9
11.4
73
278
Z50.5
ICD-10 Finland
Speech therapy
9.9
11.3
22
23
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
13.1
11.2
19
15
R21
ICPC
Throat symptom/complaint
2.8
11.1
73
283
PJD51
NOMESCO Finland
Block dissection of cervical lymph nodes
44.3
11.0
13
*
WX002
NOMESCO Finland
Sedation and analgesia
2.2
10.7
119
610
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
12.4
10.4
18
15
SAA03
NOMESCO Finland
Extended examination of mouth
2.0
10.2
153
887
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
6.0
9.5
25
43
C13.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of hypopharynx
30.6
9.4
12
*
SPAT1064
SPAT
Management of tracheostomy stoma
+∞
9.4
9
*
B97.7
ICD-10 Finland
Papillomavirus as the cause of diseases classified to other chapters
+∞
9.4
9
*
R07.0
ICD-10 Finland
Pain in throat
4.4
9.3
33
79
Z3226
NOMESCO Finland
Physiotherapist
2.2
9.2
103
526
A04AA01
ATC
ondansetron; systemic, rectal
3.3
9.1
45
144
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.0
9.1
53
191
Z43.0
ICD-10 Finland
Attention to tracheostomy
37.3
9.0
11
*
A04AD12
ATC
aprepitant; systemic
7.8
8.7
19
25
1340
FHL
Hypopharyngoscopy
50.8
8.7
10
*
EB1WA
NOMESCO Finland
NA
16.6
8.6
13
8
Z2221
NOMESCO Finland
Medical doctor
1.9
8.4
138
824
4509
FHL
Other measure in this category
+∞
8.3
8
*
Z93.0
ICD-10 Finland
Tracheostomy status
+∞
8.3
8
*
J02AC01
ATC
fluconazole; systemic
2.0
8.3
126
727
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
14.8
8.2
13
9
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.0
8.2
110
606
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
6.2
8.2
21
35
R49.8
ICD-10 Finland
Other and unspecified voice disturbances
11.9
8.1
14
12
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
17.5
8.1
12
7
ENA10
NOMESCO Finland
Biopsy of pharynx
33.9
8.1
10
*
1320
FHL
Esophagoscopy
33.9
8.1
10
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
8.0
165
1058
ZXE40
NOMESCO Finland
More than seven and less than nine hours
5.1
8.0
24
49
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
15.3
7.7
12
8
Z51.5
ICD-10 Finland
Palliative care
2.7
7.7
52
205
RL210
NOMESCO Finland
NA
25.4
7.6
10
*
5802
FHL
Tracheostomy or coniostomy
81.1
7.4
8
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.6
7.3
24
54
N05BA04
ATC
oxazepam; oral
1.9
7.3
117
685
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
11.1
7.3
13
12
4503
FHL
Partial laryngeal removal
+∞
7.3
7
*
16101
ICD-8 Finland
Malignant neoplasm of larynx, Glottis, true vocal cord
+∞
7.3
7
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
3.1
7.3
39
134
1430
FHL
Laryngoscopy (direct)
30.4
7.2
9
*
TJW99
NOMESCO Finland
Other minor procedure in gastrointestinal endoscopy
30.4
7.2
9
*
ZXD20
NOMESCO Finland
Day surgery
2.3
7.1
66
309
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
3.2
7.1
35
113
K08.3
ICD-10 Finland
Retained dental root
2.7
7.1
48
189
ZXA00
NOMESCO Finland
Right side
1.8
6.9
149
964
A06AD11
ATC
lactulose; oral
1.9
6.8
110
648
WX400
NOMESCO Finland
Inhalation anesthesy
4.0
6.8
25
64
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.9
6.7
114
682
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.6
6.7
28
80
RD210
NOMESCO Finland
NA
6.3
6.5
16
26
Z2446
NOMESCO Finland
Social worker
2.8
6.4
39
146
WX707
NOMESCO Finland
Fiberoscopic intubation
14.5
6.4
10
7
R49.01
ICD-10 Finland
Functional dysphonia
4.5
6.4
21
48
GBB18
NOMESCO Finland
Closure of tracheostomy
+∞
6.3
6
*
ENB30
NOMESCO Finland
Laryngopharyngectomy
+∞
6.3
6
*
C10.0
ICD-10 Finland
Malignant neoplasm: Vallecula
+∞
6.3
6
*
SCA04
NOMESCO Finland
Guidance on care of mouth and oral mucosa
27.0
6.2
8
*
RD160
NOMESCO Finland
NA
27.0
6.2
8
*
SAA04
NOMESCO Finland
Special inverstigation of mouth
3.3
6.1
29
92
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
2.9
6.1
35
125
SCA03
NOMESCO Finland
Preventive oral health care, extensive
4.1
6.1
22
56

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_LARYNX – Malignant neoplasm of larynx

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).