Kaposi sarcoma, excluding all cancers (controls excluding all cancers)

C3_KAPOSI_SARCOMA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C46
  • Cause of death: ICD-10 C46

2 out of 7 registries used, show all original rules.

61

4. Check minimum number of events

None

61

5. Include endpoints

None

61

6. Filter based on genotype QC (FinnGen only)

61

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12
Parent code in ICD-10
C45-C49
Name in latin
Sarcoma Kaposi

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 61 16 45
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 72.97 66.89 75.13

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
52
Matched controls
519
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C46.0
ICD-10 Finland
Kaposi sarcoma of skin
+∞
39.7
33
*
9140/3-C44.7
ICD-O-3
Kaposi sarcoma of skin of lower limb and hip
+∞
18.8
17
*
C46.9
ICD-10 Finland
Kaposi sarcoma, unspecified
+∞
11.9
11
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
27.1
8.4
11
5
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
7.4
7
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
10.1
7.2
14
18
ZZA00
NOMESCO Finland
Split skin graft
46.0
6.9
8
*
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
15.0
6.4
10
8
C46.7
ICD-10 Finland
Kaposi sarcoma of other sites
+∞
6.4
6
*
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
+∞
6.4
6
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
6.4
6
*
C46.3
ICD-10 Finland
Kaposi sarcoma of lymph nodes
+∞
6.4
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(4035726)
16
9
23.47
11.47
2.1
1.2
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
18
32
7.56
10.46
1.7
1.3
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
12
19
7.62
7.55
4.6
1.6
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
29
104
4.41
7.49
3.9
1.4
—
—
—
0
0
(3002256) Pathology report gross observation
14
27
6.43
7.37
2.4
1.1
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
10
14
8.35
6.92
4.7
1.4
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
16
46
4.36
5.32
1.8
1.9
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
7
8
9.68
3.88
1.6
1.3
—
—
—
0
0
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
34
189
2.81
3.79
12.4
3.1
umol/l
9.9
13.1
1.61
34
178
(3044640) Blood type and Crossmatch panel - Blood
23
107
2.85
3.55
5.1
2.0
—
—
—
0
0
(3037121) Protein [Mass/volume] in Urine
8
14
6.39
3.47
9.1
2.3
g/l
0.4
0.2
—
8
6
(42870588) Differential panel, method unspecified - Blood
24
117
2.73
3.37
11.0
4.8
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
12
39
3.59
3.30
2.4
1.5
—
—
—
0
0
(40768443) Skin Pathology biopsy report
8
17
5.24
3.03
1.6
1.1
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
8
17
5.24
3.03
3.7
1.6
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
29
164
2.46
2.94
14.4
5.1
%
58.0
59.4
0.26
29
147
(3008757) Leukocyte morphology finding [Identifier] in Blood
5
6
8.93
2.80
4.2
5.8
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
13
51
2.97
2.65
2.4
1.9
—
—
—
0
0
(3004789) Transferrin [Mass/volume] in Serum or Plasma
12
47
2.93
2.44
2.8
2.7
g/l
2.3
2.2
0.12
12
42
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
24
134
2.30
2.42
3.8
3.1
—
—
—
0
0
(3015736) pH of Urine
25
143
2.27
2.37
4.8
3.3
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
6
13
4.99
2.33
1.7
1.5
—
—
—
0
0
(3046279) Procalcitonin [Mass/volume] in Serum or Plasma
6
13
4.99
2.33
5.7
1.7
ug/l
0.5
0.7
—
6
8
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
25
146
2.21
2.24
8.8
3.4
—
—
—
0
0
(3022948) Iron [Moles/volume] in Serum or Plasma
13
56
2.68
2.23
2.8
2.5
umol/l
11.5
12.1
0.08
13
51
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
8
25
3.52
2.18
2.5
1.3
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
37
255
2.15
2.15
6.2
4.1
—
—
—
0
0
(40758558) Short blood count panel - Blood
16
78
2.43
2.15
15.7
3.5
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
6
15
4.31
2.09
4.3
1.4
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
11
45
2.76
2.06
4.3
3.0
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
7
21
3.62
2.03
1.4
1.3
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
18
95
2.27
2.02
4.4
2.6
umol/l
361.3
5267.1
0.50
18
84
(3021601) Nitrite [Presence] in Urine by Test strip
28
179
2.04
1.94
7.2
4.7
estimate
0.0
0.0
—
5
32
(3030981) Hyaline casts [#/volume] in Urine by Automated count
7
23
3.30
1.86
5.6
3.7
e6/l
0.1
0.2
—
7
23
(3020630) Protein [Mass/volume] in Serum or Plasma
7
23
3.30
1.86
1.6
1.7
g/l
60.6
65.2
—
7
17
(3035350) Ketones [Presence] in Urine by Test strip
27
175
1.97
1.76
5.1
3.5
estimate
0.0
0.0
—
6
32
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
14
70
2.30
1.76
2.9
1.9
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
28
184
1.96
1.76
5.2
3.6
estimate
0.0
0.0
—
6
31
(3008037) Lactate [Moles/volume] in Venous blood
5
13
4.09
1.75
4.6
1.9
mmol/l
1.4
1.3
—
5
13
(3038515) Glucose [Moles/volume] in Venous blood
5
13
4.09
1.75
4.6
1.9
mmol/l
10.4
6.9
—
5
13
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
13
66
2.23
1.57
2.3
2.5
e6/l
1.5
0.7
—
7
35
(3021589) Normoblasts [#/volume] in Blood
24
155
1.90
1.55
17.8
8.3
e9/l
0.0
0.0
0.48
19
125
(40768797) Stomach Pathology biopsy report
10
46
2.40
1.49
1.1
1.1
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
6
22
2.91
1.47
1.0
1.5
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
5
16
3.31
1.47
5.8
3.6
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
13
68
2.16
1.47
3.1
2.7
e6/l
1.4
1.5
—
7
37
(40760892) CBC W Ordered Manual Differential panel - Blood
11
55
2.22
1.37
15.0
4.1
—
—
—
0
0
(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma
6
24
2.66
1.34
3.2
5.8
ng/l
71.5
99.2
—
6
19
(3023368) Bacteria identified in Blood by Culture
19
119
1.87
1.32
5.5
4.1
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
25
171
1.78
1.31
35.8
11.6
inr
1.8
1.5
—
6
55
(36304419) Bacteria [Presence] in Urine
17
104
1.88
1.26
2.3
2.8
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
16
96
1.90
1.26
1.7
1.8
mmol/l
1.4
1.3
0.25
16
81
(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood
5
19
2.77
1.24
3.6
2.0
%
1.8
1.5
—
5
19
(3007930) Methemoglobin/Hemoglobin.total in Blood
5
19
2.77
1.24
3.6
2.0
%
0.6
0.9
—
5
19
(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
7
35
2.13
1.04
1.4
1.4
u/l
33.6
27.1
—
7
29
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
11
62
1.94
1.02
2.1
1.5
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
23
164
1.65
1.00
1.7
2.0
pmol/l
86.0
83.3
0.12
17
78
(40761536) Microorganisms panel - Urine sediment
6
30
2.11
0.89
4.0
3.2
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
15
98
1.70
0.89
4.3
3.7
estimate
0.0
0.0
—
5
30
(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation
6
31
2.03
0.87
5.3
2.4
mmol/l
1.2
2.0
—
6
23
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
43
366
1.59
0.84
25.6
13.1
ml/min/173m2
76.4
72.2
0.46
34
292
(3002173) Hemoglobin [Mass/volume] in Arterial blood
6
32
1.97
0.84
1.8
7.1
g/l
108.0
121.2
—
6
32
(3022145) Colonoscopy Study observation
6
33
1.91
0.81
1.5
1.2
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
24
0.00
0.81
0.0
1.6
—
—
—
0
0
(3022313) Gas panel - Capillary blood
5
23
2.27
0.78
6.0
2.5
—
—
—
0
0
(3004119) Hemoglobin [Mass/volume] in Venous blood
5
23
2.27
0.78
4.6
2.3
g/l
131.6
128.5
—
5
23
(3041096) Erythrocytes [Presence] in Urine by Automated
16
111
1.60
0.76
6.1
3.1
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
7
40
1.85
0.74
1.4
1.6
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
7
41
1.80
0.73
1.1
1.5
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
5
26
2.00
0.72
1.0
1.5
—
—
—
0
0
(3022621) pH of Urine by Test strip
5
29
1.79
0.65
2.2
3.0
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
11
72
1.64
0.64
3.6
3.6
—
—
—
0
0
(3012095) Magnesium [Moles/volume] in Serum or Plasma
8
51
1.65
0.63
6.8
1.9
mmol/l
0.7
0.8
—
8
46
(3013512) EKG study
18
134
1.49
0.62
8.4
4.0
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
19
144
1.46
0.60
5.4
3.5
—
—
—
0
0
(3002032) Base excess in Venous blood by calculation
6
40
1.55
0.53
4.3
3.9
mmol/l
2.9
2.5
—
6
29
(3012544) pH of Venous blood
6
40
1.55
0.53
4.3
4.0
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
46
417
1.42
0.49
34.4
16.0
umol/l
83.3
88.6
0.68
46
417
(1761868) Lipid panel - Serum or Plasma
16
124
1.39
0.44
3.3
3.2
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
44
400
1.36
0.43
32.4
13.3
mg/l
23.9
25.0
0.10
38
311
(3019225) pH of Specimen
6
42
1.47
0.37
7.8
3.2
—
—
—
0
0
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
15
119
1.35
0.36
1.9
1.7
u/l
52.1
57.6
0.17
15
111
(3003694) ABO and Rh group [Type] in Blood
11
83
1.40
0.35
1.3
1.2
—
—
—
0
0
(3027946) Carbon dioxide [Partial pressure] in Arterial blood
6
46
1.34
0.34
1.8
6.3
kpa
4.8
4.9
—
6
41
(3027801) Oxygen [Partial pressure] in Arterial blood
6
46
1.34
0.34
1.8
6.3
kpa
10.4
9.6
—
6
41
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
23
197
1.27
0.32
2.1
2.4
—
—
—
0
0
(3022217) INR in Platelet poor plasma by Coagulation assay
5
71
0.68
0.28
16.4
28.7
—
1.4
—
0
9
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
9
71
1.31
0.27
1.1
1.2
—
1.0
—
0
19
(3000963) Hemoglobin [Mass/volume] in Blood
47
442
1.28
0.27
43.4
18.9
g/l
131.6
137.4
1.27
47
427
(3019550) Sodium [Moles/volume] in Serum or Plasma
44
411
1.25
0.27
31.4
17.0
mmol/l
139.0
139.8
1.22
44
393
(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma
5
38
1.34
0.24
2.8
1.4
%
1.4
1.8
—
5
32
(3026008) Bacteria identified in Urine by Culture
14
117
1.26
0.23
4.6
3.3
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
44
415
1.22
0.22
31.5
16.9
mmol/l
4.0
4.0
0.06
44
397
(3039443) Prostate specific Ag panel - Serum or Plasma
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
(4094501)
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
14
122
1.19
0.15
3.1
2.7
ug/l
0.7
0.8
—
9
77
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
19
171
1.16
0.15
5.9
3.5
%
18.0
25.6
—
6
72
(3003338) MCHC [Mass/volume]
35
330
1.14
0.14
39.2
16.5
g/l
332.0
332.7
0.13
35
325
(3035941) MCH [Entitic mass]
46
442
1.17
0.14
43.9
18.8
pg
30.7
30.4
0.47
46
426
(3024731) MCV [Entitic volume]
46
442
1.17
0.14
44.0
18.7
fl
92.2
91.2
0.75
46
426
(3044889) 12 lead EKG panel
30
282
1.13
0.12
4.8
4.5
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
40
387
1.10
0.07
13.7
5.1
mmol/l
6.1
6.2
0.11
35
341
(3012516) Albumin [Mass/volume] in Urine
15
139
1.10
0.06
3.7
3.2
mg/l
198.8
542.7
—
9
86
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
15
139
1.10
0.06
2.3
2.3
u/l
150.5
211.0
0.53
15
130
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
28
269
1.08
0.05
4.1
3.3
pmol/l
15.7
14.8
0.75
23
232
(40761511) CBC panel - Blood by Automated count
40
410
0.93
0.04
27.7
12.5
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
35
343
1.05
0.01
27.5
13.8
%
38.3
40.6
0.37
22
229
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3026389) Candida sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3014271) Vancomycin [Susceptibility]
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3019230) Fractional oxyhemoglobin in Venous blood
0
7
0.00
0.00
0.0
3.0
—
68.0
—
0
7
(3024928) Oxygen saturation in Venous blood
0
5
0.00
0.00
0.0
4.2
—
—
—
0
0
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
5.4
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_KAPOSI_SARCOMA_EXALLC – Kaposi sarcoma, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).