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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart C3_HYPOPHARYNX_EXALLC for full statistics.

Malignant neoplasm of hypopharynx

C3_HYPOPHARYNX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C12&, C13
  • Cause of death: ICD-9 148
  • Cause of death: ICD-8 148
  • Cancer registry: Topography ICD-O-3 C1[23]
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

126

4. Check minimum number of events

None

126

5. Include endpoints

126

6. Filter based on genotype QC (FinnGen only)

124

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 124 13 111
Unadjusted period prevalence (%) 0.05 0.01 0.06
Median age at first event (years) 69.16 69.73 69.09

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
126
Matched controls
1259
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UJC01
NOMESCO Finland
Scopy of lower throat
620.3
96.3
84
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
209.2
86.0
82
11
JDB10
NOMESCO Finland
Percutaneous gastrostomy
189.9
85.1
82
12
8070/3-C13.9
ICD-O-3
Squamous cell carcinoma, NOS, of hypopharynx, NOS
+∞
79.9
68
*
C13.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of hypopharynx
+∞
65.4
57
*
130
Kela drug reimbursment
Malignant tumour
31.8
59.2
89
88
C13.9
ICD-10 Finland
Malignant neoplasm: Hypopharynx, unspecified
+∞
48.0
43
*
WF002
NOMESCO Finland
Radical radiotherapy
19.4
36.8
60
56
GBB00
NOMESCO Finland
Tracheostomy
81.2
28.5
31
5
A03FA01
ATC
metoclopramide; systemic, rectal
8.9
26.1
69
151
UJC02
NOMESCO Finland
Rigid oesophagoscopy
113.5
25.8
27
*
R4190
NOMESCO Finland
Nutritional therapy
27.9
25.7
35
17
D10.7
ICD-10 Finland
Benign neoplasm: Hypopharynx
+∞
24.8
23
*
C12
ICD-10 Finland
Malignant neoplasm of piriform sinus
+∞
23.7
22
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
14.1
23.5
42
43
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
56.6
23.5
27
6
C13.1
ICD-10 Finland
Malignant neoplasm: Aryepiglottic fold, hypopharyngeal aspect
278.6
23.5
23
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
24.4
23.3
33
18
N02AA05
ATC
oxycodone; systemic
7.7
22.8
65
152
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
97.5
22.6
24
*
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
263.9
22.4
22
*
C13.2
ICD-10 Finland
Malignant neoplasm: Posterior wall of hypopharynx
+∞
21.5
20
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
16.1
19.5
32
26
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
83.1
19.4
21
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
221.6
19.1
19
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
20.8
18.9
28
17
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
32.5
18.6
24
9
C13.0
ICD-10 Finland
Malignant neoplasm: Postcricoid region
+∞
18.2
17
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
208.0
18.0
18
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
12.0
17.6
33
36
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
9.3
17.2
38
56
UDQ22
NOMESCO Finland
Microlaryngoscopy
104.2
17.0
18
*
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
44.2
15.9
19
5
UDH02
NOMESCO Finland
Rhinopharyngoscopy
9.5
14.2
30
40
D37.08
ICD-10 Finland
Tumor of uncertain or unknown nature in other part of lip, oral cavity and pharynx
84.2
13.9
15
*
8070/3-C12.9
ICD-O-3
Squamous cell carcinoma, NOS, of pyriform sinus
+∞
13.8
13
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
156.1
13.7
14
*
H02AB02
ATC
dexamethasone; systemic
6.6
13.5
37
74
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
32.4
13.4
17
6
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.4
13.2
64
240
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
9.8
13.2
27
34
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
8.4
12.9
29
43
DQE00
NOMESCO Finland
Implantation of prosthetic replacement for larynx
+∞
12.7
12
*
8070/3-C13.2
ICD-O-3
Squamous cell carcinoma, NOS, of posterior wall of hypopharynx
+∞
12.7
12
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.2
12.4
62
237
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
13.7
12.4
21
18
EBA15
NOMESCO Finland
Extraction of large number of teeth
9.1
12.2
26
35
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.9
12.0
70
303
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
12.3
11.8
21
20
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
+∞
11.6
11
*
R07.0
ICD-10 Finland
Pain in throat
14.7
11.6
19
15
WZC30
NOMESCO Finland
Teaching
5.3
11.5
38
94
ZX095
NOMESCO Finland
Combined chemoradiotherapy
22.6
11.5
16
8
XX3DW
NOMESCO Finland
Time consuming IT work
5.8
11.4
34
75
TJD20
NOMESCO Finland
Change of gastrostomy tube
47.9
11.1
13
*
R13
ICD-10 Finland
Dysphagia
7.0
11.1
28
49
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
10.7
11.0
21
23
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
6.2
11.0
31
63
ZX090
NOMESCO Finland
Other technic of radiotherapy
12.2
10.7
19
18
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
119.5
10.6
11
*
ENA10
NOMESCO Finland
Biopsy of pharynx
119.5
10.6
11
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
119.5
10.6
11
*
PJD51
NOMESCO Finland
Block dissection of cervical lymph nodes
+∞
10.6
10
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
43.9
10.2
12
*
UJC12
NOMESCO Finland
Flexible oesophagoscopy
43.9
10.2
12
*
UDQ02
NOMESCO Finland
Direct laryngoscopy
43.9
10.2
12
*
WX402
NOMESCO Finland
General anaesthesia
4.8
10.1
36
96
WX002
NOMESCO Finland
Sedation and analgesia
4.0
9.9
46
159
GD1AD
NOMESCO Finland
Thorax CT examination
7.6
9.8
23
36
DQA10
NOMESCO Finland
Biopsy of larynx
59.7
9.8
11
*
A06AD11
ATC
lactulose; oral
4.3
9.6
39
118
TGB20
NOMESCO Finland
Tracheostomy tube replacement
107.8
9.6
10
*
Z51.5
ICD-10 Finland
Palliative care
6.2
9.2
25
48
Z2446
NOMESCO Finland
Social worker
8.3
9.2
20
28
ZXB10
NOMESCO Finland
Medial
39.8
9.2
11
*
A02BC05
ATC
esomeprazole; systemic
3.3
8.9
62
289
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
53.8
8.8
10
*
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
21.9
8.6
12
6
EBA10
NOMESCO Finland
Surgical removal of tooth
5.5
8.6
26
57
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
29.8
8.6
11
*
A07AA02
ATC
nystatin; oral
7.8
8.5
19
28
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
+∞
8.4
8
*
8070/3-C13.1
ICD-O-3
Squamous cell carcinoma, NOS, of hypopharyngeal aspect of aryepiglottic fold
+∞
8.4
8
*
ENB30
NOMESCO Finland
Laryngopharyngectomy
+∞
8.4
8
*
ZXE00
NOMESCO Finland
One hour or less
3.1
8.4
69
357
WF049
NOMESCO Finland
Radiotherapy of metastasis
7.5
8.3
19
29
A04AA01
ATC
ondansetron; systemic, rectal
5.9
8.2
23
46
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
23.9
8.2
11
5
K02.1
ICD-10 Finland
Caries of dentine
2.9
7.9
73
401
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
8.6
7.7
16
21
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
17.0
7.4
11
7
JDB00
NOMESCO Finland
Gastrostomy
+∞
7.4
7
*
GBB13
NOMESCO Finland
Revision of tracheostomy
+∞
7.4
7
*
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
+∞
7.4
7
*
DQB30
NOMESCO Finland
Laryngectomy
+∞
7.4
7
*
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
21.5
7.3
10
5
N06AX11
ATC
mirtazapine; oral
3.0
7.1
49
218
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
6.6
51
240
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.0
6.6
27
81
A04AA02
ATC
granisetron; systemic, transdermal
5.4
6.6
19
40
A04AD12
ATC
aprepitant; systemic
15.4
6.5
10
7
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.8
6.5
21
50
C32.1
ICD-10 Finland
Malignant neoplasm: Supraglottis
73.4
6.5
7
*
RD210
NOMESCO Finland
NA
11.9
6.4
11
10
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
+∞
6.3
6
*
D10.9
ICD-10 Finland
Benign neoplasm: Pharynx, unspecified
+∞
6.3
6
*
N05CF01
ATC
zopiclone; oral
2.7
6.2
55
283
ZZA00
NOMESCO Finland
Split skin graft
6.4
6.1
15
26
WW500
NOMESCO Finland
Blood transfusion
6.4
6.1
15
26
SAA03
NOMESCO Finland
Extended examination of mouth
2.7
6.0
50
245

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_HYPOPHARYNX – Malignant neoplasm of hypopharynx

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).