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Malignant neoplasm of gallbladder

C3_GALLBLADDER_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C23&
  • Cause of death: ICD-9 1560
  • Cause of death: ICD-8 1560
  • Cancer registry: Topography ICD-O-3 C23
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 135 83 52
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 72.66 72.80 72.44

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
138
Matched controls
1379
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C23
ICD-10 Finland
Malignant neoplasm of gallbladder
+∞
162.4
122
*
8140/3-C23.9
ICD-O-3
Adenocarcinoma, NOS, of gallbladder
+∞
107.9
89
*
130
Kela drug reimbursment
Malignant tumour
+∞
78.9
68
*
H02AB02
ATC
dexamethasone; systemic
308.9
44.8
43
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
41.8
38
*
A03FA01
ATC
metoclopramide; systemic, rectal
17.0
40.6
72
83
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
38.3
35
*
L01BC06
ATC
capecitabine; oral
+∞
36.0
33
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
58.9
27.9
32
7
JKA20
NOMESCO Finland
Cholecystectomy
49.3
26.2
31
8
Z51.5
ICD-10 Finland
Palliative care
28.8
26.0
35
16
8000/3-C23.9
ICD-O-3
Neoplasm, malignant of gallbladder
+∞
24.7
23
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
24.7
23
*
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
106.0
24.6
26
*
N02AA05
ATC
oxycodone; systemic
8.8
23.8
58
105
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
22.5
21
*
UJK02
NOMESCO Finland
ERCP
26.6
20.5
28
13
JN4CD
NOMESCO Finland
Very extensive body CT
54.7
19.9
23
5
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
45.5
19.2
23
6
K83.0
ICD-10 Finland
Cholangitis
40.8
17.2
21
6
JJB30
NOMESCO Finland
Excision of two segments of liver
+∞
17.0
16
*
JN4BD
NOMESCO Finland
Extensive body CT
10.9
16.4
32
37
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
7.3
15.9
41
75
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
15.9
15
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.4
15.7
55
150
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
64.1
15.2
17
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
8.9
14.6
32
45
K83.1
ICD-10 Finland
Obstruction of bile duct
48.1
14.5
17
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
13.6
14.0
24
21
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
83.3
13.9
15
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
13.8
13
*
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
22.7
12.8
18
9
JK3BT
NOMESCO Finland
Catherisation of bile duct with X-ray guidance
+∞
12.7
12
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.9
12.6
24
26
A04AA01
ATC
ondansetron; systemic, rectal
20.5
12.4
18
10
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
5.6
12.0
37
84
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.9
11.8
30
53
WX408
NOMESCO Finland
General anesthesy, balanced
4.3
11.6
50
161
C24.9
ICD-10 Finland
Malignant neoplasm: Biliary tract, unspecified
+∞
11.6
11
*
JN4AD
NOMESCO Finland
Body CT examination
12.0
10.7
19
18
JK3NB
NOMESCO Finland
Percutaneous transhepatic cholangiography
+∞
10.5
10
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
10.5
10
*
JJB10
NOMESCO Finland
Atypcal resection of liver
+∞
10.5
10
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
10.4
10.4
20
22
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
9.0
10.1
21
27
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
22.0
10.0
14
7
WZC30
NOMESCO Finland
Teaching
6.2
9.5
26
50
JAH00
NOMESCO Finland
Laparotomy
20.3
9.1
13
7
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
26.1
9.1
12
5
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
+∞
8.4
8
*
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
+∞
8.4
8
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
8.4
8
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
8.4
8
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
8.4
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.3
7.9
30
84
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
47.7
7.8
9
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
19.7
7.7
11
6
D77
ICPC
Malignant digestive neopl other/NOS
+∞
7.4
7
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
7.4
7
*
JK3FT
NOMESCO Finland
Exchange of bile duct catheter with radiological guidance
+∞
7.4
7
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
7.4
7
*
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
21.4
7.2
10
5
XX3DW
NOMESCO Finland
Time consuming IT work
7.4
7.1
16
24
WX402
NOMESCO Finland
General anaesthesia
4.3
6.8
25
67
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
23.9
6.8
9
*
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
7.5
6.7
15
22
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
13.1
6.7
11
9
ZXE30
NOMESCO Finland
More than five and less than seven hours
8.1
6.6
14
19
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
8.8
6.5
13
16
K82.9
ICD-10 Finland
Disease of gallbladder, unspecified
73.1
6.5
7
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
6.3
6
*
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
+∞
6.3
6
*
JKE12
NOMESCO Finland
Endoscopic extraction of calculus from bile duct
13.3
6.2
10
8

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_GALLBLADDER_EXALLC – Malignant neoplasm of gallbladder

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).