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Malignant neoplasm of other and ill-defined digestive organs

C3_DIGESTIVE_ORGANS_NAS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C26
  • Cause of death: ICD-9 15[8-9]
  • Cause of death: ICD-8 15[8-9]
  • Cancer registry: Topography ICD-O-3 C26
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

231

4. Check minimum number of events

None

231

5. Include endpoints

None

231

6. Filter based on genotype QC (FinnGen only)

220

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 220 104 116
Unadjusted period prevalence (%) 0.05 0.04 0.06
Median age at first event (years) 73.88 75.18 72.71

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
231
Matched controls
2310
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8140/3-C26.9
ICD-O-3
Adenocarcinoma, NOS, of gastrointestinal tract, NOS
+∞
85.9
77
*
C26.9
ICD-10 Finland
Malignant neoplasm: Ill-defined sites within the digestive system
396.7
83.4
79
*
130
Kela drug reimbursment
Malignant tumour
15.4
58.6
107
122
Z51.5
ICD-10 Finland
Palliative care
14.4
43.8
79
80
C26.0
ICD-10 Finland
Malignant neoplasm: Intestinal tract, part unspecified
461.3
40.4
39
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
23.4
38.6
56
31
8000/3-C26.9
ICD-O-3
Neoplasm, malignant of gastrointestinal tract, NOS
+∞
37.5
35
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
29.1
34.8
47
20
N02AA05
ATC
oxycodone; systemic
6.6
31.9
99
236
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
16.0
31.3
52
41
A04AA02
ATC
granisetron; systemic, transdermal
13.2
29.8
54
52
A03FA01
ATC
metoclopramide; systemic, rectal
5.4
27.8
105
308
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
46.0
26.6
32
8
H02AB02
ATC
dexamethasone; systemic
7.2
24.0
63
114
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
19.3
21.2
32
19
L01BC06
ATC
capecitabine; oral
12.0
19.5
36
35
JN4BD
NOMESCO Finland
Extensive body CT
5.1
17.8
62
155
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
12.1
17.1
31
29
C80.92
ICD-10 Finland
Malignant tumor without specified localization adenocarcinoma
+∞
16.9
16
*
C26.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of digestive system
182.4
16.7
17
*
8140/3-C26.0
ICD-O-3
Adenocarcinoma, NOS, of intestinal tract, NOS
+∞
15.8
15
*
JN4AD
NOMESCO Finland
Body CT examination
5.8
15.2
45
92
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
12.6
14.2
25
22
8000/3-C26.0
ICD-O-3
Neoplasm, malignant of intestinal tract, NOS
+∞
13.7
13
*
R18
ICD-10 Finland
Ascites
12.6
13.6
24
21
WF049
NOMESCO Finland
Radiotherapy of metastasis
10.7
13.6
26
27
JAH00
NOMESCO Finland
Laparotomy
9.6
12.9
26
30
8010/3-C26.9
ICD-O-3
Carcinoma, NOS, of gastrointestinal tract, NOS
+∞
12.6
12
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
5.9
12.3
35
68
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
17.6
11.9
18
11
8936/3-C26.9
ICD-O-3
Gastrointestinal stromal tumor of gastrointestinal tract, NOS
+∞
11.5
11
*
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
17.7
10.0
15
9
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
21.1
9.9
14
7
A04AA01
ATC
ondansetron; systemic, rectal
4.8
9.7
32
74
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
104.0
9.5
10
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
9.3
92
477
A06AH03
ATC
naloxegol; oral
28.7
8.6
11
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
21.0
8.6
12
6
C76.2
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Abdomen
93.2
8.5
9
*
WZC30
NOMESCO Finland
Teaching
3.2
8.1
44
157
WX302
NOMESCO Finland
Thoracal epidural anesthesy
5.0
7.8
24
52
H01CB03
ATC
lanreotide; parenteral
46.5
7.8
9
*
C49.49
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the abdomen other or unspecified tumor
46.5
7.8
9
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.3
7.4
83
452
C80.90
ICD-10 Finland
Malignant tumor without specified localization without histology
+∞
7.3
7
*
D77
ICPC
Malignant digestive neopl other/NOS
31.0
7.2
9
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
31.0
7.2
9
*
B01AB10
ATC
tinzaparin; parenteral
3.7
7.0
30
90
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.0
7.0
40
149
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
6.8
43
171
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.9
6.5
26
73
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
6.5
63
316
189
Kela drug reimbursment
Imatinib
71.7
6.5
7
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
9.7
6.4
12
13
8480/3-C26.9
ICD-O-3
Mucinous adenocarcinoma of gastrointestinal tract, NOS
+∞
6.3
6
*
8240/3-C26.9
ICD-O-3
Neuroendocrine tumor, NOS, of gastrointestinal tract, NOS
+∞
6.3
6
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.8
6.2
42
172

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_DIGESTIVE_ORGANS_NAS – Malignant neoplasm of other and ill-defined digestive organs

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).