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Malignant neoplasm of bone and articular cartilage of other and unspecified sites, excluding all cancers (controls excluding all cancers)

C3_BONE_CARTILAGE_NAS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C41
  • Hospital discharge: ICD-9 170
  • Hospital discharge: ICD-8 170
  • Cause of death: ICD-10 C41
  • Cause of death: ICD-9 170
  • Cause of death: ICD-8 170
  • Cause of death: excluded ICD-9 170[4-5]|170[7-8]
  • Cause of death: excluded ICD-8 170[4-5]|170[7-8]
  • Cancer registry: Topography ICD-O-3 C41
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

418

4. Check minimum number of events

None

418

5. Include endpoints

None

418

6. Filter based on genotype QC (FinnGen only)

418

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of bone and articular cartilage of other and unspecified sites, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 418 194 224
Unadjusted period prevalence (%) 0.08 0.07 0.10
Median age at first event (years) 55.85 55.82 55.87

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
155
Matched controls
1549
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB02
ATC
dexamethasone; systemic
140.4
54.1
55
6
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
98.2
45.1
48
7
130
Kela drug reimbursment
Malignant tumour
+∞
42.7
39
*
JN4BD
NOMESCO Finland
Extensive body CT
25.0
39.5
57
35
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
106.7
37.9
40
5
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
+∞
33.6
31
*
L03AA02
ATC
filgrastim; parenteral
402.9
33.2
32
*
XX3DW
NOMESCO Finland
Time consuming IT work
26.7
33.0
46
24
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
31.3
29
*
C90.0
ICD-10 Finland
Multiple myeloma
+∞
30.2
28
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
7.4
28.9
95
274
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
28.0
26
*
A04AA02
ATC
granisetron; systemic, transdermal
309.9
26.6
26
*
N02AA05
ATC
oxycodone; systemic
9.6
26.1
59
93
XW000
NOMESCO Finland
Bone marrow biopsy
25.6
25.8
36
18
WF002
NOMESCO Finland
Radical radiotherapy
+∞
25.7
24
*
A03FA01
ATC
metoclopramide; systemic, rectal
9.1
25.2
59
98
JN4AD
NOMESCO Finland
Body CT examination
20.7
24.7
37
23
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
23.5
22
*
A04AA01
ATC
ondansetron; systemic, rectal
23.9
21.9
31
16
NER30
NOMESCO Finland
Extended excision of soft tissue tumour of pelvis
+∞
21.3
20
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
21.3
20
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
21.3
20
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
+∞
18.1
17
*
C90.2
ICD-10 Finland
Extramedullary plasmacytoma
+∞
18.1
17
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
17.0
16
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
34.4
16.6
21
7
WW300
NOMESCO Finland
Transfer of autologic stem cells
+∞
15.9
15
*
WZC30
NOMESCO Finland
Teaching
7.5
15.8
39
66
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
17.5
15.5
24
16
N03AX16
ATC
pregabalin; oral
4.6
15.1
64
207
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.2
15.0
53
141
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
17.8
15.0
23
15
C41.49
ICD-10 Finland
Malignant tumor of the pelvic bones, sacrum and coccyx other or unspecified histology
+∞
14.8
14
*
153
Kela drug reimbursment
Lenalidomid
+∞
14.8
14
*
9220/3-C41.3
ICD-O-3
Chondrosarcoma, NOS, of rib, sternum, clavicle and associated joints
+∞
14.8
14
*
JN4CD
NOMESCO Finland
Very extensive body CT
22.7
14.2
20
10
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
13.7
13
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
13.7
13
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
13.7
13
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.7
13.5
98
491
WX408
NOMESCO Finland
General anesthesy, balanced
4.0
13.3
67
248
R4110
NOMESCO Finland
Physiotherapy
4.0
13.1
65
235
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
9.5
12.7
26
32
9370/3-C41.4
ICD-O-3
Chordoma, NOS, of pelvic bones, sacrum, coccyx and associated joints
+∞
12.7
12
*
L04AX04
ATC
lenalidomide; oral
+∞
12.7
12
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
12.7
12
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
12.7
12
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
12.7
12
*
Z51.5
ICD-10 Finland
Palliative care
13.3
12.3
21
18
WW500
NOMESCO Finland
Blood transfusion
16.4
12.2
19
13
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
50.9
12.1
14
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.8
12.0
31
55
B01AB05
ATC
enoxaparin; parenteral
3.6
12.0
71
296
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
70.4
11.8
13
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.7
11.7
35
75
C41.42
ICD-10 Finland
Chondrosarcoma of the pelvic bones, sacrum and coccyx
+∞
11.6
11
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
11.6
11
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
11.6
11
*
C41.32
ICD-10 Finland
Chondrosarcoma of the ribs, sternum and clavicle
+∞
11.6
11
*
NK6AN
NOMESCO Finland
Total body bone isotope imaging
+∞
11.6
11
*
GAE06
NOMESCO Finland
Excision of lesion of chest wall
+∞
11.6
11
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
12.6
11.4
20
18
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
7.4
10.9
26
41
C41.40
ICD-10 Finland
Pelvic bones, sacrum and coccyx
+∞
10.5
10
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
10.5
10
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
10.5
10
*
329
Kela drug reimbursment
Lenalidomide
+∞
10.5
10
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
10.5
10
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
10.5
10
*
B01AB10
ATC
tinzaparin; parenteral
9.2
10.2
21
26
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
18.3
10.1
15
9
NE1AA
NOMESCO Finland
Pelvis X-ray examination
5.4
9.8
30
66
ZX112
NOMESCO Finland
Subcutaneous
58.8
9.8
11
*
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
58.8
9.8
11
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
11.8
9.6
17
16
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
9.5
9
*
9731/3-C41.3
ICD-O-3
Plasmacytoma, NOS, of rib, sternum, clavicle and associated joints
+∞
9.5
9
*
9220/3-C41.4
ICD-O-3
Chondrosarcoma, NOS, of pelvic bones, sacrum, coccyx and associated joints
+∞
9.5
9
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
9.5
9
*
WX402
NOMESCO Finland
General anaesthesia
3.9
9.1
41
132
ZX120
NOMESCO Finland
Intravenous
5.1
9.1
29
67
AA1AA
NOMESCO Finland
Head X-ray examination
25.8
9.1
12
5
TPX10
NOMESCO Finland
Implantation of vascular injection port
15.2
8.9
14
10
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.6
8.8
31
79
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
10.3
8.5
16
17
R50.9
ICD-10 Finland
Fever, unspecified
3.8
8.5
38
122
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
8.4
8
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
+∞
8.4
8
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
8.4
8
*
9731/3-C41.2
ICD-O-3
Plasmacytoma, NOS, of vertebral column
+∞
8.4
8
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
8.4
8
*
JN6AD
NOMESCO Finland
CT of torso and neck
35.4
8.2
10
*
GD1AD
NOMESCO Finland
Thorax CT examination
9.2
8.0
16
19
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.7
7.8
22
44
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.6
7.7
37
125
C41.3
ICD-10 Finland
Malignant neoplasm: Ribs, sternum and clavicle
+∞
7.3
7
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
7.3
7
*
9680/3-C41.4
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of pelvic bones, sacrum, coccyx and associated joints
+∞
7.3
7
*
C41.22
ICD-10 Finland
Chondrosarcoma of the spine
+∞
7.3
7
*
C41.41
ICD-10 Finland
Osteosarcoma of the pelvic bones, sacrum and coccyx
+∞
7.3
7
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
7.3
7
*
NER20
NOMESCO Finland
Incomplete excision of soft tissue tumour of pelvis
+∞
7.3
7
*
GAE23
NOMESCO Finland
Resection of chest wall and prosthetic repair
+∞
7.3
7
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
7.3
7
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
7.3
64
321
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
21.2
7.2
10
5
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
7.8
6.9
15
21
A02BC02
ATC
pantoprazole; systemic
2.5
6.9
107
727
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
41.9
6.8
8
*
J05AB01
ATC
aciclovir; systemic
2.8
6.5
46
202
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
72.7
6.5
7
*
N02BE01
ATC
paracetamol; systemic, rectal
3.2
6.4
136
1074
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.8
6.3
20
46
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
27.9
6.3
8
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
6.3
6
*
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
+∞
6.3
6
*
NEA20
NOMESCO Finland
Exploration of soft tissue of pelvis,v
+∞
6.3
6
*
YNB10
NOMESCO Finland
Collection of stem cells for transplant
+∞
6.3
6
*
NK1AT
NOMESCO Finland
Muscle biopsy with ultrasound guidance
+∞
6.3
6
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
6.3
6
*
WW409
NOMESCO Finland
Other aferesis
+∞
6.3
6
*
9220/3-C41.0
ICD-O-3
Chondrosarcoma, NOS, of bones of skull and face and associated joints
+∞
6.3
6
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
6.3
6
*
A06AH03
ATC
naloxegol; oral
+∞
6.3
6
*
WW402
NOMESCO Finland
Leucoferesis
+∞
6.3
6
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
6.3
6
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
6.3
6
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
6.2
55
275

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_BONE_CARTILAGE_NAS_EXALLC – Malignant neoplasm of bone and articular cartilage of other and unspecified sites, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).