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Malignant neoplasm of bone and articular cartilage of limbs

C3_BONE_CARTILAGE_LIMBS

bone neoplasm: A benign, intermediate, or malignant neoplasm involving the bone or articular cartilage.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C40
  • Cause of death: ICD-9 170[4-5]|170[7-8]
  • Cause of death: ICD-8 170[4-5]|170[7-8]
  • Cancer registry: Topography ICD-O-3 C40
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

134

4. Check minimum number of events

None

134

5. Include endpoints

None

134

6. Filter based on genotype QC (FinnGen only)

129

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 129 52 77
Unadjusted period prevalence (%) 0.03 0.02 0.04
Median age at first event (years) 36.04 36.38 35.81

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
134
Matched controls
1340
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
206.9
67.2
65
6
9180/3-C40.2
ICD-O-3
Osteosarcoma, NOS, of long bones of lower limb and associated joints
+∞
49.0
44
*
C40.21
ICD-10 Finland
Osteosarcoma of the long bones of the lower extremity
+∞
44.2
40
*
C40.20
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity without histology
+∞
33.8
31
*
C40.22
ICD-10 Finland
Chondrosarcoma of the long bones of the lower extremity
+∞
30.4
28
*
130
Kela drug reimbursment
Malignant tumour
16.8
30.4
51
47
NF3AA
NOMESCO Finland
Femur X-ray examination
61.8
29.0
33
7
C40.29
ICD-10 Finland
Malignant tumor of the long bones of the lower extremity other or unspecified histology
+∞
25.9
24
*
9220/3-C40.2
ICD-O-3
Chondrosarcoma, NOS, of long bones of lower limb and associated joints
+∞
24.7
23
*
C40.2
ICD-10 Finland
Malignant neoplasm: Long bones of lower limb
+∞
24.7
23
*
NFR30
NOMESCO Finland
Extended excision of soft tissue tumour of hip or thigh
260.8
22.3
22
*
L03AA02
ATC
filgrastim; parenteral
29.1
21.0
28
12
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
+∞
20.3
19
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
17.3
18.3
29
21
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
14.6
18.2
31
27
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
8.4
18.1
43
71
17071
ICD-8 Finland
Malignant neoplasm of bone, Lower limb, long bones
+∞
17.0
16
*
NGB30
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part - connected prosthesis
68.7
16.2
18
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
43.8
15.9
19
5
TPX10
NOMESCO Finland
Implantation of vascular injection port
27.3
15.7
21
9
N02AA05
ATC
oxycodone; systemic
6.4
15.2
44
95
NGR30
NOMESCO Finland
Extensive or radikal excision of tumor of knee or lower leg
167.5
14.8
15
*
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
167.5
14.8
15
*
N03AX16
ATC
pregabalin; oral
5.2
14.4
52
145
R4110
NOMESCO Finland
Physiotherapy
4.7
14.2
60
198
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
83.5
13.9
15
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
24.3
13.8
19
9
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.1
13.8
84
386
ZXE20
NOMESCO Finland
More than three and less than five hours
5.8
13.6
42
97
C40.02
ICD-10 Finland
Chondrosarcoma of the scapula and long bones of the upper extremity
+∞
12.7
12
*
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
41.8
12.5
15
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
14.5
12.1
20
16
B01AB05
ATC
enoxaparin; parenteral
4.1
12.1
60
223
GD1AD
NOMESCO Finland
Thorax CT examination
12.9
12.0
21
19
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
33.4
11.9
15
5
WX306
NOMESCO Finland
Lumbar epidural anesthesy
9.1
11.8
25
33
TPX15
NOMESCO Finland
Removal of vascular injection port
+∞
11.6
11
*
C40.00
ICD-10 Finland
Malignant tumor of the scapula and the long bones of the upper extremity without histology
+∞
11.6
11
*
ZXA05
NOMESCO Finland
Left side
4.1
11.0
51
176
WW500
NOMESCO Finland
Blood transfusion
12.8
11.0
19
17
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
9.0
11.0
23
30
A04AA01
ATC
ondansetron; systemic, rectal
7.6
10.7
25
39
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
118.9
10.6
11
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
118.9
10.6
11
*
9220/3-C40.0
ICD-O-3
Chondrosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
10.6
10
*
C40.01
ICD-10 Finland
Osteosarcoma of the scapula and the long bones of the upper extremity
+∞
10.6
10
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
6.2
10.5
29
57
JN4BD
NOMESCO Finland
Extensive body CT
5.3
10.4
33
77
ZXE30
NOMESCO Finland
More than five and less than seven hours
8.2
10.3
23
33
A03FA01
ATC
metoclopramide; systemic, rectal
4.5
10.3
40
116
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
43.6
10.1
12
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.5
10.1
59
244
NG1AD
NOMESCO Finland
Knee CT examination
28.5
10.0
13
5
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.0
10.0
46
156
NB6AA
NOMESCO Finland
Humerus X-ray examination
32.7
9.6
12
*
NGA20
NOMESCO Finland
Exploration of soft tissue knee or lower leg, open
107.3
9.5
10
*
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
107.3
9.5
10
*
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
+∞
9.5
9
*
9101
FHL
Bone biopsy
+∞
9.5
9
*
1707A
ICD-9 Finland
Malignant neoplasm of bone and articular cartilage, Long bones of lower limb[ALARAAJAN PITKIEN LUIDEN SYÖPÄ,OSTEOSARCOMA]
+∞
9.5
9
*
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
15.2
9.4
15
11
B01AB10
ATC
tinzaparin; parenteral
7.1
9.1
22
36
WF049
NOMESCO Finland
Radiotherapy of metastasis
11.9
9.1
16
15
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
6.9
8.9
22
37
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.2
8.8
36
108
2392A
ICD-9 Finland
Neoplasm of unspecified nature, Bone, soft tissue and skin
+∞
8.4
8
*
NBR30
NOMESCO Finland
Extensive or radical excision of soft tissue tumour of shoulder or upper arm
+∞
8.4
8
*
L71
ICPC
Malignant neoplasm musculoskeletal
+∞
8.4
8
*
9180/3-C40.0
ICD-O-3
Osteosarcoma, NOS, of long bones of upper limb, scapula and associated joints
+∞
8.4
8
*
NFA20
NOMESCO Finland
Exploration of hip joint or femur
+∞
8.4
8
*
N02AX02
ATC
tramadol; systemic, rectal
3.0
8.2
67
339
WF004
NOMESCO Finland
Palliative radiotherapy
11.0
7.7
14
14
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.2
7.6
20
37
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
6.2
7.6
20
37
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
7.0
7.6
18
29
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
84.6
7.5
8
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
17.0
7.4
11
7
C40.11
ICD-10 Finland
Osteosarcoma of the short bones of the upper extremity
+∞
7.4
7
*
NBR20
NOMESCO Finland
Intralesional or marginal excision of soft tissue tumour of shoulder or upper arm
+∞
7.4
7
*
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
+∞
7.4
7
*
C40.91
ICD-10 Finland
Osteosarcoma in unspecified locations in the bones and articular cartilage of the extremities
+∞
7.4
7
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.8
7.1
65
341
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
9.1
7.0
14
17
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
6.6
6.9
17
29
J04AB02
ATC
rifampicin; systemic
17.8
6.9
10
6
NFQ20
NOMESCO Finland
Amputation of femur
23.9
6.8
9
*
ZX120
NOMESCO Finland
Intravenous
4.6
6.7
23
58
ZXE00
NOMESCO Finland
One hour or less
2.6
6.7
66
360
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
15.3
6.5
10
7
L03AA13
ATC
pegfilgrastim; parenteral
8.9
6.5
13
16
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
8.9
6.5
13
16
NGQ20
NOMESCO Finland
Amputation of lower leg
73.2
6.5
7
*
9102
FHL
Trepanation or removal of the local bone process
73.2
6.5
7
*
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
11.9
6.4
11
10
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
5.5
6.3
18
37
L28
ICPC
Limited function/disability (L)
3.7
6.3
28
90
NF3BA
NOMESCO Finland
Femur extensive X-ray examination
+∞
6.3
6
*
NGB99
NOMESCO Finland
Other primary prosthetic replacement of knee joint, other or unspecified
+∞
6.3
6
*
C40.23
ICD-10 Finland
Ewing's sarcoma in the long bones of the lower extremity
+∞
6.3
6
*
Z47.8
ICD-10 Finland
Other specified orthopaedic follow-up care
+∞
6.3
6
*
C40.12
ICD-10 Finland
Chondrosarcoma of the short bones of the upper extremity
+∞
6.3
6
*
NF3AD
NOMESCO Finland
Femur CT
+∞
6.3
6
*
C40.10
ICD-10 Finland
Malignant tumor of the upper limb's short bones without histology
+∞
6.3
6
*
NGR40
NOMESCO Finland
Extensive excision of tumor of knee or lower leg with repair
+∞
6.3
6
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.0
6.3
25
73
Z3226
NOMESCO Finland
Physiotherapist
3.2
6.3
35
134
NE1AA
NOMESCO Finland
Pelvis X-ray examination
6.6
6.2
15
25
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
6.6
6.2
15
25
H02AB02
ATC
dexamethasone; systemic
4.1
6.1
23
64
WX402
NOMESCO Finland
General anaesthesia
3.2
6.1
33
123

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_BONE_CARTILAGE_LIMBS – Malignant neoplasm of bone and articular cartilage of limbs

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).