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Malignant neoplasm of accessory sinuses

C3_ACCESSORY_SINUS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C31
  • Cause of death: ICD-9 160
  • Cause of death: ICD-8 160
  • Cause of death: excluded ICD-9 160[0-1]
  • Cause of death: excluded ICD-8 160[0-1]
  • Cancer registry: Topography ICD-O-3 C31
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 72 28 44
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 64.60 62.67 65.82

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
76
Matched controls
758
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
38.9
34
*
C31.0
ICD-10 Finland
Malignant neoplasm: Maxillary sinus
+∞
30.2
27
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
25.4
23
*
H02AB02
ATC
dexamethasone; systemic
285.0
21.8
21
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
20.8
19
*
8070/3-C31.0
ICD-O-3
Squamous cell carcinoma, NOS, of maxillary sinus
+∞
19.6
18
*
A03FA01
ATC
metoclopramide; systemic, rectal
14.1
18.5
34
41
C30.0
ICD-10 Finland
Malignant neoplasm: Nasal cavity
+∞
18.5
17
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
18.5
17
*
DHA10
NOMESCO Finland
Biopsy of cavity of nose
215.4
17.2
17
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
16.2
15
*
D38.51
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of other accessory sinus
+∞
16.2
15
*
C31.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of accessory sinuses
+∞
16.2
15
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
16.2
15
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
17.3
16.2
26
22
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
8.7
15.7
41
90
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
15.1
14
*
D14.0
ICD-10 Finland
Benign neoplasm: Middle ear, nasal cavity and accessory sinuses
183.9
15.0
15
*
N02AA05
ATC
oxycodone; systemic
11.7
14.3
28
36
UDM02
NOMESCO Finland
Sinoscopy
43.0
14.2
17
5
A04AA01
ATC
ondansetron; systemic, rectal
61.3
13.4
15
*
XX3DW
NOMESCO Finland
Time consuming IT work
22.5
13.4
19
11
DM1DG
NOMESCO Finland
Paranasal sinuses and face area very extensive MRI examination with high intensity magnet
+∞
12.9
12
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
11.8
11
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
11.8
11
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
51.5
11.3
13
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
51.5
11.3
13
*
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
51.5
11.3
13
*
JN4BD
NOMESCO Finland
Extensive body CT
22.0
11.3
16
9
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
38.6
10.7
13
*
DM1BD
NOMESCO Finland
Extensive CT of paranasal sinuses and face area
126.8
10.7
11
*
L03AA02
ATC
filgrastim; parenteral
+∞
10.7
10
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
10.7
10
*
Z51.5
ICD-10 Finland
Palliative care
24.1
10.2
14
7
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
12.5
9.6
17
17
JDB10
NOMESCO Finland
Percutaneous gastrostomy
+∞
9.6
9
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
9.6
9
*
EEB00
NOMESCO Finland
Partial excision of maxilla
+∞
9.6
9
*
C31.9
ICD-10 Finland
Malignant neoplasm: Accessory sinus, unspecified
+∞
9.6
9
*
DMA00
NOMESCO Finland
Biopsy of maxillary antrum
+∞
9.6
9
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
56.8
8.9
10
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
100.8
8.6
9
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
17.1
8.6
13
9
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
8.5
8
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
8.5
8
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
8.5
8
*
C31.1
ICD-10 Finland
Malignant neoplasm: Ethmoidal sinus
+∞
8.5
8
*
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
+∞
8.5
8
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
8.5
8
*
EEB10
NOMESCO Finland
Maxillectomy
+∞
8.5
8
*
D38.50
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of maxillary sinus
+∞
8.5
8
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
8.5
8
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
+∞
8.5
8
*
ZXE60
NOMESCO Finland
More than 12 and less than 15 hours
+∞
8.5
8
*
A04AD12
ATC
aprepitant; systemic
+∞
8.5
8
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.6
8.4
20
34
WW500
NOMESCO Finland
Blood transfusion
20.0
8.4
12
7
SAA03
NOMESCO Finland
Extended examination of mouth
4.3
8.3
40
155
EP1AE
NOMESCO Finland
Neck ultrasound examination
17.5
8.0
12
8
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
28.4
7.8
10
*
ZXC95
NOMESCO Finland
Use of surgical navigator
88.4
7.6
8
*
DM1CG
NOMESCO Finland
Paranasal sinuses and face area extensive MRI examination with high intensity magnet
+∞
7.4
7
*
AAE99
NOMESCO Finland
Other operation by cranial base approach
+∞
7.4
7
*
GBB00
NOMESCO Finland
Tracheostomy
25.2
6.8
9
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.8
6.8
24
67
WX402
NOMESCO Finland
General anaesthesia
5.7
6.6
19
42
DPA30
NOMESCO Finland
Sphenotomy
76.0
6.5
7
*
A07AA02
ATC
nystatin; oral
7.9
6.4
14
21
SBB10
NOMESCO Finland
Teeth copy
7.9
6.4
14
21
DPB00
NOMESCO Finland
Partial excision of frontal sinus
+∞
6.3
6
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
6.3
6
*
ZZQ20
NOMESCO Finland
Free microvascular graft of skin, muscle and bone
+∞
6.3
6
*
DNB30
NOMESCO Finland
Excision of lesion of ethmoidal sinus
+∞
6.3
6
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
6.3
6
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
6.2
6.1
16
31

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_ACCESSORY_SINUS_EXALLC – Malignant neoplasm of accessory sinuses

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).