This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Amputation of ankle
AMPUTATION_ANKLE
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
44 |
4. Check minimum number of eventsNone |
44 |
5. Include endpointsNone |
44 |
6. Filter based on genotype QC (FinnGen only) |
44 |
Control definitions (FinnGen only)
- Control exclude
- AMPUTATION
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Amputation of ankle
based on the number of shared cases.
Similar with more cases:
- Amputation
- Peripheral artery operations in Hilmo
- Peripheral artery disease
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 44 | 13 | 31 |
| Unadjusted period prevalence (%) | 0.01 | 0.00 | 0.01 |
| Median age at first event (years) | 69.81 | 74.52 | 67.83 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3042936) Bacteria identified in Isolate by Culture
19
40
7.60
9.66
4.7
2.2
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
16
31
7.54
8.69
10.2
3.5
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
17
38
6.66
8.00
5.5
1.7
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
11
20
7.00
6.15
10.5
5.7
mmol/l
23.9
25.3
0.54
11
20
(3023368) Bacteria identified in Blood by Culture
25
104
4.25
5.31
9.0
3.8
—
—
—
0
0
(3005715) Vancomycin [Mass/volume] in Serum or Plasma
5
0
+∞
5.30
7.4
0.0
mg/l
14.4
—
—
5
0
(3012095) Magnesium [Moles/volume] in Serum or Plasma
17
56
4.32
4.88
3.7
2.4
mmol/l
0.8
0.8
1.13
17
50
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
7
5
16.24
4.74
2.3
1.0
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
11
26
5.31
4.66
1.8
1.5
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
22
108
3.07
3.26
4.1
2.9
—
—
—
0
0
(3021901) Oxygen saturation in Capillary blood
5
5
11.03
3.05
3.4
3.4
—
—
—
0
0
(3018418) pH of Serum or Plasma
20
96
2.99
3.04
15.0
5.0
ph
7.4
7.4
—
5
17
(3027315) Oxygen [Partial pressure] in Blood
5
7
7.86
2.61
8.6
3.3
kpa
7.8
8.9
—
5
7
(3013290) Carbon dioxide [Partial pressure] in Blood
5
7
7.86
2.61
8.6
3.3
kpa
4.5
4.6
—
5
7
(3010421) pH of Blood
5
7
7.86
2.61
8.6
3.7
ph
7.4
7.4
—
5
7
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
25
147
2.62
2.47
8.1
3.6
—
—
—
0
0
(3015171) Extractable nuclear Ab [Units/volume] in Serum
5
8
6.87
2.43
1.2
1.6
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
19
100
2.58
2.32
5.6
2.2
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
25
152
2.49
2.24
37.2
9.1
inr
1.7
1.3
—
9
46
(40768443) Skin Pathology biopsy report
6
14
4.78
2.23
1.8
1.1
—
—
—
0
0
(3002173) Hemoglobin [Mass/volume] in Arterial blood
9
33
3.16
2.07
7.6
7.0
g/l
115.2
121.9
—
9
33
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
14
71
2.43
1.78
5.2
2.0
—
—
—
0
0
(40758558) Short blood count panel - Blood
15
81
2.29
1.66
10.8
8.4
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
6
20
3.30
1.64
2.3
1.3
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
6
21
3.14
1.56
8.5
4.2
—
—
—
0
0
(3015736) pH of Urine
20
127
2.05
1.46
4.1
3.8
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
5
112
0.38
1.38
2.0
3.2
ug/l
0.4
0.7
—
5
87
(3000991) Gas panel - Venous blood
8
34
2.65
1.38
10.3
7.4
—
—
—
0
0
(3046279) Procalcitonin [Mass/volume] in Serum or Plasma
5
18
3.00
1.32
1.2
1.7
ug/l
1.0
14.4
—
5
18
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
24
170
1.91
1.23
17.5
6.3
mmol/l
1.2
1.2
0.78
17
146
(3017143) Hepatitis C virus Ab [Presence] in Serum
7
33
2.33
1.11
2.9
1.7
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
12
70
1.98
1.05
1.8
1.3
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
21
148
1.80
1.05
10.0
5.4
%
65.7
60.3
2.17
21
136
(3009261) Glucose [Presence] in Urine by Test strip
23
167
1.79
1.04
5.2
4.0
estimate
0.0
0.0
—
5
23
(3002030) Lymphocytes/100 leukocytes in Blood
21
149
1.78
1.02
10.1
5.7
%
18.4
25.3
2.73
21
136
(3022096) Basophils/100 leukocytes in Blood
20
140
1.79
1.02
10.0
5.6
%
0.6
0.6
0.02
20
129
(3019060) Gas panel - Arterial blood
6
28
2.32
0.96
2.5
4.0
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
8
46
1.90
0.88
2.5
2.1
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
20
145
1.70
0.88
10.1
5.4
%
2.4
2.7
0.26
20
134
(42870588) Differential panel, method unspecified - Blood
16
109
1.74
0.87
8.3
4.9
—
—
—
0
0
(3019069) Monocytes/100 leukocytes in Blood
20
146
1.68
0.85
10.0
5.7
%
9.2
8.5
0.52
20
135
(3021601) Nitrite [Presence] in Urine by Test strip
22
165
1.67
0.84
6.1
5.6
estimate
0.0
0.0
—
5
26
(3015377) Calcium [Moles/volume] in Serum or Plasma
17
120
1.68
0.81
3.8
2.6
mmol/l
2.2
2.3
1.79
17
97
(3018095) Leukocytes [#/volume] in Urine
18
130
1.65
0.78
4.9
3.8
e6/l
394.3
28.8
0.61
13
94
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
7
38
2.00
0.78
5.7
2.1
umol/l
6.1
11.8
—
7
33
(3012544) pH of Venous blood
7
39
1.94
0.77
6.9
4.7
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
10
150
0.57
0.76
2.6
4.6
%
18.2
22.0
—
5
80
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
18
131
1.63
0.76
4.8
3.3
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
14
96
1.67
0.73
4.6
3.2
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
8
50
1.73
0.66
2.3
1.5
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
0
19
0.00
0.62
0.0
1.6
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
6
35
1.82
0.61
2.8
1.8
—
—
—
0
0
(3044889) 12 lead EKG panel
28
235
1.53
0.59
5.9
4.0
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
11
75
1.62
0.57
5.0
2.7
e6/l
5.3
3.8
0.32
11
67
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
10
68
1.61
0.52
2.4
1.5
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
27
229
1.46
0.51
5.8
4.4
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
7
46
1.62
0.51
2.4
1.4
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
11
79
1.52
0.46
4.5
3.2
—
—
—
0
0
(3027273) Bicarbonate [Moles/volume] in Venous blood
0
15
0.00
0.42
0.0
4.6
—
24.7
—
0
15
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
0
16
0.00
0.42
0.0
1.3
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
0
16
0.00
0.42
0.0
1.6
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
16
0.00
0.42
0.0
1.4
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
0
17
0.00
0.41
0.0
2.2
—
—
—
0
0
(4035726)
5
36
1.44
0.39
1.2
1.3
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
5
36
1.44
0.39
1.0
1.5
—
—
—
0
0
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
30
267
1.39
0.38
10.3
7.5
u/l
99.8
80.0
1.46
30
250
(40768804) Tissue Pathology biopsy report
16
130
1.36
0.35
2.3
2.4
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
6
45
1.38
0.35
2.2
1.3
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
7
55
1.32
0.32
5.6
5.5
—
—
—
0
0
(3026782) Osmolality of Urine
10
77
1.39
0.29
5.0
3.4
mosm/kgh2o
501.5
596.2
—
10
63
(3019150) Specific gravity of Urine by Refractometry
10
77
1.39
0.29
5.0
4.1
—
1.0
—
0
8
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
33
304
1.34
0.28
57.6
16.3
mg/l
48.3
25.9
2.25
33
248
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
9
72
1.31
0.28
3.1
2.8
mmol/l
2.5
2.4
—
9
59
(3013512) EKG study
8
103
0.73
0.24
4.4
5.3
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
28
256
1.26
0.23
69.6
19.0
%
15.2
13.8
3.73
28
249
(40768800) Prostate Pathology biopsy report
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
(1002224) Polysomnography panel
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(3021387) Prolactin [Units/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
1.4
—
247.8
—
0
10
(1761482) Bacteria [#/volume] in Urine by Culture
0
13
0.00
0.21
0.0
7.9
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
0
13
0.00
0.21
0.0
3.7
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
9
81
1.14
0.16
4.8
3.8
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
14
122
1.22
0.16
6.9
4.4
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
10
85
1.23
0.14
6.4
4.3
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
7
65
1.09
0.08
3.1
1.6
mg/l
3.5
1.2
—
7
56
(3013707) Erythrocyte sedimentation rate by Westergren method
23
243
0.89
0.08
4.3
4.2
mm/h
29.1
15.2
2.11
23
222
(3000963) Hemoglobin [Mass/volume] in Blood
33
339
0.89
0.04
73.8
23.9
g/l
119.2
135.5
4.53
33
330
(3024731) MCV [Entitic volume]
33
339
0.89
0.04
72.9
23.7
fl
91.3
91.3
0.02
33
330
(3035941) MCH [Entitic mass]
33
339
0.89
0.04
73.0
23.6
pg
29.9
30.4
0.65
33
330
(3026361) Erythrocytes [#/volume] in Blood
33
339
0.89
0.04
73.5
23.8
e12/l
4.0
4.5
3.71
33
322
(3007461) Platelets [#/volume] in Blood
33
339
0.89
0.04
73.3
23.8
e9/l
277.9
235.0
1.74
33
324
(3010813) Leukocytes [#/volume] in Blood
33
339
0.89
0.04
73.4
23.8
e9/l
8.3
6.8
2.12
33
322
(3019550) Sodium [Moles/volume] in Serum or Plasma
33
331
0.99
0.00
59.6
18.3
mmol/l
138.1
139.6
2.07
33
319
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
15
149
1.01
0.00
1.9
2.1
pmol/l
73.8
88.2
—
7
81
(3020564) Creatinine [Moles/volume] in Serum or Plasma
33
327
1.04
0.00
52.0
19.4
umol/l
104.8
87.9
0.56
33
327
(40761511) CBC panel - Blood by Automated count
32
322
0.98
0.00
57.7
15.1
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
33
332
0.98
0.00
61.6
18.3
mmol/l
4.1
4.0
1.05
33
319
(3009542) Hematocrit [Volume Fraction] of Blood
26
258
1.02
0.00
60.2
17.4
%
35.2
38.8
1.53
19
171
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(3005988) Vibrio sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.0
—
2.5
—
0
7
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3012568) Campylobacter sp identified in Specimen by Organism specific culture
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3024980) IgG subclass 4 [Mass/volume] in Serum
0
6
0.00
0.00
0.0
1.3
—
0.8
—
0
6
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
5.4
—
6.5
—
0
8
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
15
150
1.00
0.00
3.2
2.8
—
—
—
0
0
(3023323) Follitropin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
17.4
—
0
5
(3024522) Salmonella sp identified in Specimen by Organism specific culture
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3017569) Oxygen content in Arterial blood
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(4146454)
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
3.6
—
30.6
—
0
5
(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
2.4
—
5.3
—
0
8
(3025468) Yersinia sp identified in Specimen by Organism specific culture
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3005570) Glucose [Moles/volume] in Urine
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
4.5
—
3.9
—
0
6
(3035285) Chloride [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
4.5
—
105.5
—
0
6
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3008037) Lactate [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
5.4
—
1.5
—
0
8
(21494434) Karyotype in Bone marrow
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
4.5
—
—
—
0
0
(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3009214) Lutropin [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
4.9
—
0
6
(4094501)
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
0
9
0.00
-0.00
0.0
1.7
—
41.1
—
0
9
(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma
0
9
0.00
-0.00
0.0
2.1
—
108.2
—
0
9
(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation
0
9
0.00
-0.00
0.0
1.9
—
203.3
—
0
9
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: AMPUTATION_ANKLE – Amputation of ankle
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).