Monkeypox

AB1_MONKEYPOS

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B04 Cause of death: ICD-10 — B04 2 out of 7 registries used, show all original rules.	9
4. Check minimum number of events None	9
5. Include endpoints None	9
6. Filter based on genotype QC (FinnGen only)	9

Control definitions (FinnGen only)

Control exclude: AB1_VIRAL_SKIN_MUCOUS_MEMBRANE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_MONKEYPOS
CONTROL_EXCLUDE	AB1_VIRAL_SKIN_MUCOUS_MEMBRANE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B04
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B04
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Monkeypox based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	48	26	21
Only index persons	38	20	18
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	70.27	77.97	60.42
Only index persons	68.98	77.22	59.83

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	9	-	5
Unadjusted period prevalence (%)	0.00	-	0.00
Median age at first event (years)	52.88	-	45.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

0.00

1.59

0.0

3.1

—

(40768804) Tissue Pathology biopsy report

0.00

0.96

0.0

2.1

—

(3044640) Blood type and Crossmatch panel - Blood

0.00

0.70

0.0

1.6

—

(3003694) ABO and Rh group [Type] in Blood

0.00

0.70

0.0

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

0.00

0.46

0.0

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

0.00

0.46

0.0

1.8

—

1.2

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

0.00

0.45

0.0

1.9

—

0.7

—

(3042936) Bacteria identified in Isolate by Culture

0.00

0.23

0.0

1.6

—

(3000492) Spirometry study

0.00

0.23

0.0

1.5

—

(3005322) IgE [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

189.4

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.0

5.6

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

0.00

0.0

1.8

—

5.6

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

0.00

0.0

3.4

—

2.5

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3012544) pH of Venous blood

0.00

0.0

1.8

—

(3022621) pH of Urine by Test strip

0.00

0.0

2.0

—

(3019225) pH of Specimen

0.00

0.0

3.2

—

(3020630) Protein [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

63.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.0

1.1

—

(3027801) Oxygen [Partial pressure] in Arterial blood

0.00

0.0

2.9

—

11.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.0

1.3

—

(3022948) Iron [Moles/volume] in Serum or Plasma

0.00

0.0

1.7

—

10.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.00

0.0

6.3

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.0

3.0

—

0.0

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

2.2

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

0.00

0.0

2.5

—

318.5

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.0

5.5

—

(3022145) Colonoscopy Study observation

0.00

0.0

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.0

1.5

—

(3028026) IgM [Mass/volume] in Serum or Plasma

0.00

0.0

2.8

—

1.5

—

(3005719) IgG [Mass/volume] in Serum or Plasma

0.00

0.0

2.7

—

9.6

—

(3016502) Oxygen saturation in Arterial blood

0.00

0.0

2.9

—

88.7

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

0.00

0.0

1.7

—

17.7

—

Mortality – FinRegistry

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Association

Association between endpoint AB1_MONKEYPOS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_MONKEYPOS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: AB1_MONKEYPOS – Monkeypox

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Monkeypox

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints