Risteys · AB1_MALARIA

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B51 Hospital discharge: ICD-9 — 084[1] Hospital discharge: ICD-8 — 084[1] Cause of death: ICD-10 — B51 Cause of death: ICD-9 — 084[1] Cause of death: ICD-8 — 084[1] 2 out of 7 registries used, show all original rules.	21
4. Check minimum number of events None	21
5. Include endpoints None	21
6. Filter based on genotype QC (FinnGen only)	21

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	299	115	180
Only index persons	258	92	166
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.01
Only index persons	0.01	0.00	0.01
Median age at first event (years)
Whole population	35.53	39.84	32.63
Only index persons	34.27	37.59	32.43

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	21	-	17
Unadjusted period prevalence (%)	0.01	-	0.01
Median age at first event (years)	37.01	-	37.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.66

1.10

2.4

1.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

2.29

1.01

2.2

2.9

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

0.00

0.85

0.0

3.4

—

0.3

—

(3042936) Bacteria identified in Isolate by Culture

0.00

0.63

0.0

1.4

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

164

0.56

20.7

19.6

mmol/l

138.9

139.7

0.45

157

(3013512) EKG study

1.68

0.54

2.6

4.1

—

(3009542) Hematocrit [Volume Fraction] of Blood

134

1.81

0.47

9.9

18.4

33.6

38.7

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.67

0.45

3.2

2.6

mmol/l

2.5

—

(3002032) Base excess in Venous blood by calculation

0.00

0.43

0.0

4.9

—

0.8

—

(3016502) Oxygen saturation in Arterial blood

0.00

0.42

0.0

10.4

—

96.0

—

(4010399)

0.00

0.42

0.0

1.5

—

(3000991) Gas panel - Venous blood

0.00

0.42

0.0

11.0

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

0.00

0.42

0.0

10.4

—

114.3

—

(3000494) Fungus identified in Specimen by Culture

0.00

0.42

0.0

1.6

—

(3027801) Oxygen [Partial pressure] in Arterial blood

0.00

0.42

0.0

10.4

—

13.2

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

0.00

0.42

0.0

10.5

—

4.9

—

(3012544) pH of Venous blood

0.00

0.42

0.0

4.6

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

165

0.68

0.38

19.9

19.4

mmol/l

4.2

4.0

2.48

158

(42870588) Differential panel, method unspecified - Blood

1.56

0.37

8.9

4.7

—

(3002385) Erythrocyte distribution width [Ratio]

132

0.65

0.32

22.9

20.6

13.6

14.2

0.61

127

(3037467) Urinalysis macro (dipstick) panel - Urine

109

1.50

0.31

7.7

4.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.41

0.25

7.6

6.3

—

(3003694) ABO and Rh group [Type] in Blood

1.33

0.24

1.4

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

3.3

—

1.3

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.00

0.22

0.0

8.1

—

23.7

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.22

0.0

3.3

—

0.6

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.22

0.0

4.1

—

23.2

—

(3019060) Gas panel - Arterial blood

0.00

0.22

0.0

3.6

—

(40761511) CBC panel - Blood by Automated count

159

0.80

0.22

17.5

15.6

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.21

0.0

11.8

—

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.21

0.0

11.8

—

1.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.21

0.0

5.2

—

0.1

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

0.00

0.21

0.0

3.5

—

131.8

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

0.00

0.21

0.0

2.4

—

4.9

—

(3018095) Leukocytes [#/volume] in Urine

0.70

0.21

6.6

3.5

e6/l

39.0

43.8

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

10.6

—

1.4

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

0.00

0.21

0.0

5.2

—

232.8

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

0.73

0.19

13.3

10.5

e9/l

3.5

4.4

—

(3007461) Platelets [#/volume] in Blood

168

0.80

0.11

23.4

25.8

e9/l

235.2

237.4

0.07

163

(3026361) Erythrocytes [#/volume] in Blood

168

0.80

0.11

23.3

25.7

e12/l

4.4

4.5

0.32

163

(3010813) Leukocytes [#/volume] in Blood

168

0.80

0.11

23.3

25.7

e9/l

6.7

6.8

0.09

163

(3041096) Erythrocytes [Presence] in Urine by Automated

1.25

0.11

8.2

4.2

—

(3000850) Epithelial cells [#/volume] in Urine

1.21

0.11

6.6

2.7

e6/l

2.8

4.1

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

164

0.90

0.10

21.1

21.0

umol/l

90.1

88.1

0.11

164

(1761868) Lipid panel - Serum or Plasma

1.13

0.10

3.7

3.3

—

(3002582) Erythrocytes [#/volume] in Urine

0.80

0.10

6.6

3.4

e6/l

14.3

17.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.19

0.10

7.4

5.0

—

(3015736) pH of Urine

1.17

0.09

4.0

4.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.84

0.09

6.3

3.9

—

(3021589) Normoblasts [#/volume] in Blood

0.86

0.09

26.0

9.8

e9/l

0.0

—

(3044889) 12 lead EKG panel

119

0.84

0.05

6.8

4.5

—

(3023183) Ammonium ion [Moles/volume] in Plasma

0.00

0.0

1.2

—

34.8

—

(3013115) Eosinophils [#/volume] in Blood

0.96

0.00

11.0

6.2

e9/l

0.2

—

(3028626) Oxygen [Partial pressure] in Capillary blood

0.00

0.0

3.6

—

7.9

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

2.8

—

7.4

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.0

1.0

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

0.00

0.0

3.0

—

4.1

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

400.6

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3024928) Oxygen saturation in Venous blood

0.00

0.0

2.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.2

—

(4094501)

0.00

0.0

1.4

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

2.8

—

1.7

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

(3001604) Monocytes [#/volume] in Blood

1.00

0.00

10.6

6.0

e9/l

0.6

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

3.2

—

73.8

—

(3022313) Gas panel - Capillary blood

0.00

0.0

1.4

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

4.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.0

1.1

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

0.00

0.0

15.6

—

24.4

—

(3020891) Body temperature

0.00

0.0

4.9

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.0

2.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.02

0.00

4.0

4.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.9

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

0.00

0.0

3.2

—

24.3

—

(3019198) Lymphocytes [#/volume] in Blood

0.98

0.00

10.6

6.3

e9/l

1.7

1.6

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

10.9

—

(3006315) Basophils [#/volume] in Blood

1.00

0.00

10.6

6.2

e9/l

0.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.0

1.3

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

7.3

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

38.7

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

39.1

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.0

6.6

—

(3030467) Casts [#/volume] in Urine by Automated count

0.88

0.00

6.6

3.1

e6/l

0.5

0.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.6

—

250.9

—

(40768804) Tissue Pathology biopsy report

0.85

0.00

4.5

2.4

—

(36660697) Celiac disease serology panel - Serum

0.00

0.0

1.1

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.0

5.3

—

60.1

—

(3036489) Thrombin time

0.00

0.0

3.2

—

20.8

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

6.7

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.0

1.7

—

24.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.0

6.0

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.5

—

(36304419) Bacteria [Presence] in Urine

1.03

0.00

6.6

2.9

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_MALARIA_VIVAX and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_MALARIA_VIVAX.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_MALARIA_VIVAX – Plasmodium vivax malaria

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	AB1_MALARIA_VIVAX
CONTROL_EXCLUDE	AB1_PROTOZOAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B51
HD_ICD_9	084[1]
HD_ICD_8	084[1]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B51
COD_ICD_9	084[1]
COD_ICD_8	084[1]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Plasmodium vivax malaria

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints