Acute hepatitis B

AB1_HEPATITIS_B

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B16 Hospital discharge: ICD-9 — 070[2-3] Cause of death: ICD-10 — B16 Cause of death: ICD-9 — 070[2-3] 2 out of 7 registries used, show all original rules.	159
4. Check minimum number of events None	159
5. Include endpoints None	159
6. Filter based on genotype QC (FinnGen only)	159

Control definitions (FinnGen only)

Control exclude: AB1_VIRAL_HEPATITIS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: B15-B19
Name in latin: Hepatitis B acuta

NAME	AB1_HEPATITIS_B
CONTROL_EXCLUDE	AB1_VIRAL_HEPATITIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B16
HD_ICD_9	070[2-3]
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B16
COD_ICD_9	070[2-3]
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acute hepatitis B based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1640	629	974
Only index persons	1328	541	787
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.03
Only index persons	0.03	0.02	0.03
Median age at first event (years)
Whole population	30.79	27.28	32.85
Only index persons	30.02	26.63	32.34

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	159	78	81
Unadjusted period prevalence (%)	0.03	0.03	0.04
Median age at first event (years)	32.62	28.42	36.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
146: Matched controls
1459

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

B16.9

ICD-10 Finland

Acute hepatitis B without delta-agent and without hepatic coma

+∞

108.2

0703A

ICD-9 Finland

Viral hepatitis B without mention of hepatic coma

+∞

52.3

B18.2

ICD-10 Finland

Chronic viral hepatitis C

+∞

39.4

B18.1

ICD-10 Finland

Chronic viral hepatitis B without delta-agent

+∞

26.9

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

11.4

23.7

F15.2

ICD-10 Finland

Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome

+∞

20.3

K75.9

ICD-10 Finland

Inflammatory liver disease, unspecified

45.9

16.8

F19.29

ICD-10 Finland

Addiction caused by several drugs in combination and by other psychoactive substances UNS

89.3

14.9

N05BA01

ATC

diazepam; systemic, rectal

5.7

12.6

F15.1

ICD-10 Finland

Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use

+∞

11.6

N05AH04

ATC

quetiapine; oral

4.3

10.7

133

3049X

ICD-9 Finland

Drug dependence, Unspecified drug dependence

+∞

10.5

F19.21

ICD-10 Finland

Addiction caused by several drugs in combination and by other psychoactive substances currently independent but staying in a controlling environment

+∞

10.5

P19

ICPC

Drug abuse

43.3

10.1

F15.5

ICD-10 Finland

Mental and behavioural disorders due to use of other stimulants, including caffeine, psychotic disorder

+∞

9.5

3044A

ICD-9 Finland

Drug dependence, Amphetamine and other psychostimulant dependence

+∞

9.5

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

6.6

9.1

N05CD07

ATC

temazepam; oral

5.0

8.6

F19.1

ICD-10 Finland

Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use

95.3

8.5

F19.25

ICD-10 Finland

Addiction caused by several drugs in combination and by other psychoactive substances continuously used

95.3

8.5

F11.22

ICD-10 Finland

Addiction-induced dependence is currently independent but uses substitute intermittent medication

95.3

8.5

F19.20

ICD-10 Finland

Addiction relationship caused by several drugs in combination and by other psychoactive substances currently independent

95.3

8.5

JJ1LE

NOMESCO Finland

Ultrasound elastography of liver

+∞

8.4

F19.24

ICD-10 Finland

Addiction relationship caused by several drugs in combination and by other psychoactive substances active addiction

+∞

8.4

F11.25

ICD-10 Finland

Relationship caused by opiates continuously used

+∞

8.4

F10.21

ICD-10 Finland

Alcohol dependence currently abstinent, but staying in restrictive environment

18.5

8.2

T36

ICD-10 Finland

Poisoning by systemic antibiotics

8.2

7.9

F19.30

ICD-10 Finland

Withdrawal symptoms caused by several drugs in combination and by other psychoactive substances uncomplicated

+∞

7.3

0705A

ICD-9 Finland

Viral hepatitis, Other specified viral hepatitis without mention of hepatic coma

+∞

7.3

F60.2

ICD-10 Finland

Dissocial personality disorder

42.1

6.8

F13.25

ICD-10 Finland

Addiction caused by sedative and hypnotic continuous use

42.1

6.8

N05BA04

ATC

oxazepam; oral

2.9

6.8

206

N05BA02

ATC

chlordiazepoxide; systemic

9.4

6.7

K05.31

ICD-10 Finland

Periodontitis pronounced

4.7

6.7

3039X

ICD-9 Finland

Alcohol dependence syndrome, Other and unspecified alcohol dependence

15.2

6.5

F19.2

ICD-10 Finland

Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, dependence syndrome

72.9

6.5

A56.0

ICD-10 Finland

Chlamydial infection of lower genitourinary tract

19.0

6.3

O98.4

ICD-10 Finland

Viral hepatitis complicating pregnancy, childbirth and the puerperium

+∞

6.3

B19.9

ICD-10 Finland

Unspecified viral hepatitis without hepatic coma

+∞

6.3

K08.1

ICD-10 Finland

Loss of teeth due to accident, extraction or local periodontal disease

4.2

6.3

Z2221

NOMESCO Finland

Medical doctor

2.6

6.2

254

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

202

4.88

20.67

2.3

1.7

—

(3011288) Drugs identified in Urine by Screen method

8.95

19.29

11.6

1.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

101

5.64

19.23

2.1

1.6

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

11.37

18.90

1.4

1.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

8.69

18.83

1.6

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

250

4.32

18.17

2.6

1.9

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

33.26

17.99

2.0

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

167

4.38

16.22

2.3

1.8

—

(3013945) Hepatitis B virus e Ab [Presence] in Serum

+∞

15.89

2.4

0.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

9.25

14.82

1.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

7.65

13.95

1.1

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

473

3.51

13.57

4.9

3.7

u/l

114.8

33.1

1.16

453

(37021073) Hepatitis C virus genotype in Serum or Plasma by Sequencing

+∞

12.67

1.2

0.0

—

(3028707) Methadone [Presence] in Urine by Screen method

7.68

12.13

8.3

1.6

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

5.71

11.90

1.5

1.4

miu/ml

170.5

274.0

—

(40758558) Short blood count panel - Blood

323

3.09

10.77

8.9

7.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

5.61

10.37

7.4

1.4

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

9.19

9.47

1.0

—

(3004347) Hepatitis D virus Ab [Presence] in Serum

+∞

9.46

1.0

0.0

—

(3016879) Cocaine [Presence] in Urine

4.75

8.99

7.7

1.4

—

(42870588) Differential panel, method unspecified - Blood

412

2.68

8.54

9.2

5.6

—

(3022096) Basophils/100 leukocytes in Blood

585

2.69

8.40

9.0

6.0

0.7

0.20

547

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

409

2.64

8.27

2.3

1.9

pmol/l

94.1

92.5

0.13

233

(3027008) Opiates [Presence] in Urine

4.40

8.19

7.8

1.4

—

(3000764) Benzodiazepines [Presence] in Urine

4.40

8.19

7.8

1.4

—

(3028300) Cannabinoids [Presence] in Urine

4.40

8.19

7.8

1.4

—

(3006504) Eosinophils/100 leukocytes in Blood

606

2.61

7.88

9.0

6.0

3.1

2.8

0.67

568

(3021589) Normoblasts [#/volume] in Blood

572

2.57

7.78

11.5

9.0

e9/l

0.0

0.48

469

(3027944) Amphetamines [Presence] in Urine

4.17

7.36

8.0

1.4

—

(3018010) Neutrophils/100 leukocytes in Blood

619

2.52

7.34

8.7

5.9

55.5

57.4

0.75

587

(3006315) Basophils [#/volume] in Blood

101

648

2.53

7.29

9.0

6.2

e9/l

0.0

0.21

576

(3001604) Monocytes [#/volume] in Blood

101

648

2.53

7.29

9.0

6.2

e9/l

0.6

0.02

573

(3013115) Eosinophils [#/volume] in Blood

103

667

2.55

7.29

9.2

6.5

e9/l

0.2

0.06

602

(3019198) Lymphocytes [#/volume] in Blood

103

668

2.54

7.25

8.9

6.2

e9/l

1.8

2.0

0.38

602

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

21.19

7.23

1.1

1.0

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

21.19

7.23

1.1

1.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.84

7.15

1.6

1.3

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

17.65

6.84

1.1

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

263

2.52

6.56

3.3

2.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

167

2.77

6.47

3.6

2.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

150

2.81

6.28

3.4

1.9

—

(3044640) Blood type and Crossmatch panel - Blood

360

2.36

6.28

3.3

2.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

109

757

2.40

6.14

14.5

10.2

e9/l

3.7

4.0

1.27

670

(3034770) Mitochondria Ab [Titer] in Serum

4.34

6.06

1.2

1.3

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

4.02

5.82

1.8

1.3

—

(4198724)

13.52

5.65

5.9

1.1

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

509

2.21

5.64

6.1

5.8

mmol/l

1.2

0.21

469

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

129

992

2.59

5.40

11.6

8.0

u/l

86.5

76.4

0.77

122

932

(3018418) pH of Serum or Plasma

357

2.21

5.29

4.8

4.5

7.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

260

2.28

5.07

2.9

3.4

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

472

2.06

4.74

2.7

2.3

nmol/l

78.1

75.0

0.41

427

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

174

2.38

4.57

4.3

2.5

e6/l

0.9

2.3

1.15

(3000991) Gas panel - Venous blood

103

2.69

4.40

7.2

6.3

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

126

995

2.28

4.37

4.3

3.3

u/l

86.5

48.3

0.98

120

955

(3023368) Bacteria identified in Blood by Culture

302

2.07

4.20

6.7

4.3

—

(3032080) INR in Blood by Coagulation assay

436

1.98

4.17

7.7

8.1

inr

1.2

1.1

0.30

134

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

554

1.94

4.09

6.9

7.2

mmol/l

1.2

0.03

470

(3018095) Leukocytes [#/volume] in Urine

404

1.98

4.08

5.0

3.4

e6/l

14.0

22.2

0.65

287

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

266

2.09

4.05

1.8

1.7

mg/l

1.1

1.0

0.23

211

(3042936) Bacteria identified in Isolate by Culture

169

2.29

4.03

2.0

2.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

246

2.09

3.90

3.1

2.0

mg/l

3.0

3.2

0.19

211

(36304419) Bacteria [Presence] in Urine

319

1.99

3.83

4.5

2.5

—

(3012544) pH of Venous blood

111

2.49

3.79

4.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

414

1.91

3.74

4.4

3.0

—

(3030467) Casts [#/volume] in Urine by Automated count

322

1.97

3.72

4.5

2.7

e6/l

0.2

0.6

1.20

237

(3009508) Creatinine [Moles/volume] in Urine

366

1.92

3.63

7.1

3.0

mmol/l

7.5

8.3

0.59

319

(3019550) Sodium [Moles/volume] in Serum or Plasma

150

1339

3.12

3.60

20.1

13.4

mmol/l

139.2

139.7

2.12

145

1310

(3031040) Bacteria [#/volume] in Urine by Automated count

100

755

1.87

3.54

4.4

3.8

—

291.0

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

727

1.86

3.49

5.5

4.5

mmol/l

7.0

6.6

0.41

679

(3023103) Potassium [Moles/volume] in Serum or Plasma

150

1345

3.03

3.44

20.7

13.5

mmol/l

4.0

0.04

145

1313

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.76

3.34

1.2

1.1

—

(3002582) Erythrocytes [#/volume] in Urine

350

1.87

3.31

4.4

3.0

e6/l

23.9

204.8

0.49

268

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

145

1265

2.66

3.23

19.0

11.3

ml/min/173m2

90.3

86.7

1.35

120

1050

(3015377) Calcium [Moles/volume] in Serum or Plasma

389

1.82

3.15

3.9

3.5

mmol/l

2.3

1.11

349

(3021960) Folate [Moles/volume] in Serum or Plasma

242

1.94

3.07

1.7

1.5

nmol/l

18.3

20.6

0.45

205

(40768797) Stomach Pathology biopsy report

167

2.06

2.99

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

139

2.14

2.92

1.9

1.7

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.80

2.88

2.4

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

194

1.96

2.79

4.4

2.4

e6/l

0.7

1.0

0.39

112

(3019309) Folate [Moles/volume] in Red Blood Cells

179

1.99

2.78

2.2

1.7

nmol/l

1044.3

1328.1

1.01

138

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.50

2.65

2.4

ng/l

167.6

84.3

0.52

(3019832) Treponema pallidum Ab [Presence] in Serum

123

2.12

2.62

3.3

1.7

—

(3000093) Morphology [Interpretation] in Blood Narrative

7.33

2.56

1.0

1.6

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.60

2.53

5.8

2.2

—

(3035350) Ketones [Presence] in Urine by Test strip

609

1.63

2.39

3.2

3.3

estimate

0.0

—

115

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

189

1.87

2.37

3.6

2.7

mmol/l

2.5

2.4

0.61

168

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

4.75

2.29

1.0

1.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

218

1.78

2.18

5.9

3.2

ng/l

221.7

133.5

0.23

146

(3009261) Glucose [Presence] in Urine by Test strip

619

1.59

2.17

3.3

estimate

0.0

—

109

(3000492) Spirometry study

133

1.95

2.14

1.3

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

611

1.58

2.14

4.9

4.4

estimate

0.0

—

117

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

3.31

2.12

1.1

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

290

1.66

2.02

1.3

1.4

g/l

2.6

0.01

193

(21494755) Public health laboratory ask at order entry panel

196

0.43

2.02

1.1

1.4

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

4.65

1.95

2.4

1.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

1.91

0.0

1.7

—

(3037467) Urinalysis macro (dipstick) panel - Urine

101

840

1.55

1.90

4.2

3.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

124

1.90

1.87

4.0

3.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

172

1.76

1.83

2.2

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

560

1.52

1.82

4.2

4.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

138

1244

1.83

1.81

24.2

12.6

40.4

40.8

0.21

116

988

(3052851) Hemolysis interference index of Serum or Plasma

2.59

1.77

3.9

2.9

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

1.74

0.0

1.5

—

(40768441) Liver Pathology biopsy report

3.93

1.73

1.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

151

1419

2.27

1.71

22.3

14.3

umol/l

73.4

76.6

0.84

151

1419

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

131

1170

1.68

1.70

5.0

4.5

mu/l

1.9

1.8

0.03

122

1083

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.88

1.67

1.1

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.07

1.59

5.6

2.1

—

(3019150) Specific gravity of Urine by Refractometry

272

1.57

1.58

7.0

3.6

kg/l

1.0

—

(3044889) 12 lead EKG panel

107

922

1.49

1.54

3.9

3.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

117

1.81

1.53

2.2

1.7

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

3.19

1.45

1.0

1.1

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.48

1.41

1.1

1.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

143

1326

1.78

1.37

19.5

12.5

mg/l

24.4

22.3

0.35

123

1011

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

122

1.73

1.35

2.2

1.7

—

(40761511) CBC panel - Blood by Automated count

149

1401

2.01

1.33

15.9

11.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.16

1.32

1.4

1.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.42

1.31

1.4

1.6

—

(4035726)

108

1.75

1.29

1.4

1.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.45

1.25

1.8

1.4

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.45

1.25

1.3

1.5

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.55

1.16

1.6

1.5

—

(3013707) Erythrocyte sedimentation rate by Westergren method

108

960

1.39

1.12

3.7

3.8

mm/h

11.9

10.0

0.80

101

894

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.86

1.08

7.6

4.5

mmol/l

24.9

24.8

0.03

(3025941) Bacteria identified in Stool by Culture

1.77

1.02

1.4

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

308

1.40

0.99

1.3

u/ml

1.8

1.7

0.03

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.97

0.0

1.7

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.97

0.0

5.6

—

27.8

—

(3027945) Reticulocytes/100 erythrocytes in Blood

114

1.55

0.83

3.1

2.6

1.5

1.8

0.60

103

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

106

963

1.30

0.81

3.6

3.3

—

(40768800) Prostate Pathology biopsy report

0.00

0.79

0.0

1.2

—

(3022145) Colonoscopy Study observation

141

1.48

0.79

1.3

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.79

0.0

1.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.79

0.0

1.4

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

1.79

0.77

1.0

1.1

—

4.4

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.77

0.0

4.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.77

0.0

1.6

—

(3000850) Epithelial cells [#/volume] in Urine

240

1.36

0.75

3.3

2.6

e6/l

9.4

8.3

0.07

209

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.12

0.75

1.0

2.4

g/l

0.0

—

(3014051) Protein [Presence] in Urine by Test strip

2.12

0.75

1.6

1.3

—

(1761868) Lipid panel - Serum or Plasma

570

0.77

0.74

2.2

2.7

—

(3026782) Osmolality of Urine

225

1.35

0.70

3.4

2.4

mosm/kgh2o

523.7

583.6

0.62

190

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.88

0.69

1.2

—

(3016502) Oxygen saturation in Arterial blood

112

1.48

0.66

6.9

6.8

94.6

95.0

0.11

107

(3002256) Pathology report gross observation

138

1.43

0.66

1.2

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.67

0.63

4.3

7.8

—

(40768804) Tissue Pathology biopsy report

504

1.24

0.60

2.0

1.9

—

(40768443) Skin Pathology biopsy report

1.48

0.57

1.1

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.65

0.56

1.0

2.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

202

0.72

0.54

1.7

1.4

—

(3000494) Fungus identified in Specimen by Culture

144

1.36

0.53

1.7

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.53

0.51

1.0

2.6

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.51

0.48

1.4

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.51

0.48

1.4

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.48

0.47

1.4

1.2

—

(3045414) Leukocytes [Presence] in Urine

1.42

0.45

1.7

1.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.63

0.43

1.4

1.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.42

0.42

1.4

1.3

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.41

0.0

1.2

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.41

0.0

1.8

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.41

0.0

3.3

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.40

0.0

1.6

—

13.3

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

1.44

0.39

1.0

1.6

—

(40768793) Breast Pathology biopsy report

1.44

0.39

1.4

1.2

—

(1002224) Polysomnography panel

1.40

0.39

1.2

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.40

0.39

1.2

1.6

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.39

0.0

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

157

0.75

0.38

1.6

—

(3009343) pH of Capillary blood

0.65

0.36

1.2

3.7

—

7.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.48

0.36

2.2

1.7

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.45

0.36

1.3

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.45

0.36

2.2

2.0

—

(3012516) Albumin [Mass/volume] in Urine

333

1.19

0.35

4.3

3.3

mg/l

106.1

273.3

0.38

220

(4010399)

1.33

0.33

1.4

1.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

132

1277

1.20

0.32

4.4

4.1

mmol/l

6.2

5.9

0.83

123

1186

(3019225) pH of Specimen

1.31

0.31

2.1

4.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

280

1.18

0.30

1.7

1.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.29

0.30

1.9

2.1

—

(3000330) Specific gravity of Urine by Test strip

1.26

0.30

1.4

3.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

139

1355

1.21

0.28

4.8

4.5

mmol/l

2.7

2.8

0.77

130

1265

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

160

0.80

0.27

1.7

1.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

352

1.14

0.26

5.5

4.0

mg/mmol

14.0

11.9

0.14

228

(3003694) ABO and Rh group [Type] in Blood

352

1.14

0.26

1.8

1.5

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.21

0.25

1.7

3.6

g/l

122.8

130.5

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.18

0.25

4.4

4.1

pmol/l

4.7

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.33

0.23

2.0

3.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.76

0.23

1.3

1.9

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.23

0.22

2.2

1.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

364

0.88

0.22

3.6

4.1

26.8

21.2

0.43

154

(4027681)

0.00

0.21

0.0

1.1

—

(3009991) Angiotensin converting enzyme [Enzymatic activity/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

1.3

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.21

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

222.1

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.21

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.3

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.21

0.0

1.5

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.21

0.0

1.1

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

1.5

—

33.7

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

111

0.80

0.21

1.1

1.2

—

17.4

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

112

0.79

0.21

1.9

1.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.23

0.20

2.0

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

124

1208

1.12

0.20

5.8

5.3

mmol/mol

39.0

39.5

0.25

119

1146

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

127

1298

0.89

0.18

3.9

3.7

mmol/l

1.5

1.3

0.94

121

1210

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.72

0.17

2.2

2.8

2.3

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

368

0.90

0.16

3.4

2.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

172

0.86

0.16

1.5

1.4

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.79

0.16

4.5

7.8

mmol/l

24.5

24.2

—

(3013512) EKG study

314

1.11

0.16

2.3

3.3

—

(3022621) pH of Urine by Test strip

1.13

0.15

1.9

1.7

—

(3026493) Urate [Moles/volume] in Serum or Plasma

345

1.09

0.14

3.2

2.6

umol/l

330.6

7370.9

1.73

307

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

267

1.11

0.14

2.2

2.8

ug/l

0.6

0.7

0.58

155

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

238

1.11

0.14

1.3

1.2

iu/ml

89.6

35.2

—

(40761535) Cells panel - Urine sediment

1.18

0.13

2.3

3.8

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

124

1.14

0.11

1.7

2.1

nmol/l

366.1

372.5

0.04

112

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

1.17

0.10

2.6

1.8

—

59.9

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.07

0.09

1.0

1.1

—

(36660697) Celiac disease serology panel - Serum

107

1.13

0.09

1.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.10

0.08

1.3

3.7

72.9

52.5

—

(3008898) HLA-B27 [Presence]

1.06

0.07

1.0

1.1

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

121

0.90

0.06

2.2

—

6.0

—

(3029937) Albumin [Presence] in Urine by Test strip

336

1.05

0.06

3.5

estimate

0.0

—

109

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

444

0.96

0.05

2.6

3.5

ng/l

12.1

30.5

2.38

271

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

140

0.92

0.04

11.3

7.9

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

135

1341

1.04

0.03

4.4

4.2

mmol/l

4.6

4.7

0.66

126

1263

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

231

0.99

0.00

1.4

1.2

u/ml

31.0

12.2

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

449

1.00

0.00

3.4

4.3

ug/l

1.5

2.5

0.76

408

(3026008) Bacteria identified in Urine by Culture

283

0.99

0.00

4.3

2.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

327

1.01

0.00

5.2

5.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

497

1.01

0.00

3.4

3.3

—

(40761536) Microorganisms panel - Urine sediment

105

1.05

0.00

4.8

3.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

134

1338

1.01

0.00

4.3

4.1

mmol/l

1.3

1.4

2.51

126

1249

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

2.5

—

0.8

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.1

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3025577) Chromium [Mass/volume] in Blood

0.00

0.0

2.7

—

2.9

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.1

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.9

—

13.2

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.7

—

5.6

—

(3006441) Cardiolipin IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

12.7

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.2

—

(3006245) CD3-CD19+ cells/100 cells in Blood

0.00

0.0

3.8

—

13.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.97

0.00

1.3

4.1

mmol/l

26.0

24.5

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.5

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.7

—

(42868417) European tick borne encephalitis virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.7

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

0.00

0.0

1.0

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(3019060) Gas panel - Arterial blood

0.94

0.00

2.4

4.4

—

(3035544) Cardiolipin IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.1

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

3.2

—

(4024509)

0.00

0.0

1.0

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3000012) Reticulocyte production index

0.00

0.0

1.7

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

6.6

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

7.8

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.6

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.88

0.00

1.7

2.5

u/l

64.5

40.2

—

(3020891) Body temperature

0.96

0.00

3.4

4.8

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.4

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.4

—

(3020013) Alkaline phosphatase.intestinal [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.0

—

(40758355) Pancreatic polypeptide [Moles/volume] in Serum or Plasma

0.00

0.0

3.4

—

67.4

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.4

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

985.1

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.4

—

(3012565) Volume of 24 hour Urine

0.00

0.0

1.3

—

2456.4

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

2.6

—

52.5

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

3.7

—

732.7

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

11.4

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.4

—

(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood

0.00

0.0

4.0

—

25.4

—

(3022313) Gas panel - Capillary blood

0.87

0.00

1.0

4.2

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.6

—

(3017704) Immunofixation for Urine

0.00

0.0

1.1

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_HEPATITIS_B and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
AB1_HEPATITIS_B	3.56 [2.5, 5.06]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.011

During the follow-up period (1.1.1998 — 31.12.2019), 128 out of 555 males with AB1_HEPATITIS_B died.

Mortality risk

Mortality risk for people of age

years, who have AB1_HEPATITIS_B.

N-year risk	Females	Males
1	No data	0.522%
5	No data	4.322%
10	No data	10.091%
15	No data	17.924%
20	No data	29.368%

Relationships between endpoints

↥

Index endpoint: AB1_HEPATITIS_B – Acute hepatitis B

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acute hepatitis B

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints