This is a non-core endpoint: only basic statistics are computed.

Cryptococcosis

AB1_CRYPTOCOCCOSIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — B45 Hospital discharge: ICD-9 — 1175A Cause of death: ICD-10 — B45 Cause of death: ICD-9 — 1175A 2 out of 7 registries used, show all original rules.	14
4. Check minimum number of events None	14
5. Include endpoints None	14
6. Filter based on genotype QC (FinnGen only)	14

Control definitions (FinnGen only)

Control exclude: AB1_MYCOSES

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_CRYPTOCOCCOSIS
CONTROL_EXCLUDE	AB1_MYCOSES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	B45
HD_ICD_9	1175A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	B45
COD_ICD_9	1175A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Cryptococcosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	120	48	67
Only index persons	77	31	46
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	62.40	66.71	58.90
Only index persons	61.07	65.84	57.85

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	14	5	9
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	60.78	67.83	56.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3005719) IgG [Mass/volume] in Serum or Plasma

9.48

3.05

5.8

1.9

g/l

11.5

8.4

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

9.48

3.05

2.5

1.2

—

(42870588) Differential panel, method unspecified - Blood

5.13

2.33

12.4

7.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

5.71

2.22

1.8

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

5.71

2.22

3.2

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

5.00

2.01

2.0

1.8

—

(3042936) Bacteria identified in Isolate by Culture

4.44

1.82

2.7

1.6

—

(4035726)

4.92

1.79

2.4

1.2

—

(3000494) Fungus identified in Specimen by Culture

4.56

1.68

4.4

1.2

—

(40768804) Tissue Pathology biopsy report

3.76

1.45

2.3

2.1

—

(40768797) Stomach Pathology biopsy report

3.72

1.42

1.0

1.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

2.76

1.05

12.3

7.7

mmol/l

1.2

—

(3001604) Monocytes [#/volume] in Blood

2.60

1.00

15.2

7.1

e9/l

0.8

0.6

—

(3006315) Basophils [#/volume] in Blood

2.60

1.00

15.2

7.2

e9/l

0.0

—

(3023368) Bacteria identified in Blood by Culture

2.76

0.94

7.1

4.6

—

(3003694) ABO and Rh group [Type] in Blood

2.54

0.82

1.4

1.2

—

(3013115) Eosinophils [#/volume] in Blood

2.53

0.81

15.3

7.6

e9/l

0.1

0.2

—

(3019198) Lymphocytes [#/volume] in Blood

2.46

0.80

15.2

6.9

e9/l

2.0

1.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.42

0.80

4.2

3.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

2.24

0.64

3.6

2.2

nmol/l

76.2

74.0

—

(3026008) Bacteria identified in Urine by Culture

2.03

0.51

7.0

3.0

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

110

0.49

0.51

5.7

4.2

mmol/l

4.8

4.7

—

102

(40758558) Short blood count panel - Blood

1.94

0.50

7.0

8.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

109

0.51

0.50

5.7

4.3

mmol/l

1.6

1.4

—

100

(3026493) Urate [Moles/volume] in Serum or Plasma

1.87

0.49

5.2

2.7

umol/l

314.0

357.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

100

0.54

0.45

8.1

3.9

mu/l

2.3

2.1

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

105

0.60

0.45

5.7

3.8

mmol/l

1.7

1.2

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.43

0.0

1.5

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

1.79

0.39

16.8

10.6

e9/l

4.6

—

(3035350) Ketones [Presence] in Urine by Test strip

1.59

0.39

3.7

3.0

—

0.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.59

0.39

6.6

3.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.44

0.26

4.0

3.8

—

(3044640) Blood type and Crossmatch panel - Blood

1.44

0.26

5.2

2.0

—

(3015736) pH of Urine

1.39

0.26

4.4

3.0

—

(3009261) Glucose [Presence] in Urine by Test strip

1.54

0.24

3.9

3.1

—

0.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.37

0.23

3.4

2.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

0.22

0.0

1.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.25

0.12

4.6

3.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

1.23

0.11

5.0

4.1

—

0.0

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

0.75

0.11

5.1

3.1

pmol/l

15.3

15.1

—

(3044889) 12 lead EKG panel

1.26

0.11

4.0

3.5

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

21.1

—

1.0

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.00

0.0

15.3

—

27.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.0

1.6

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

21.1

—

0.5

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.0

2.3

—

0.1

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

0.0

1.2

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.0

1.3

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.0

2.6

—

48.2

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

4.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(1002224) Polysomnography panel

0.00

0.0

1.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.7

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

1.4

—

6.3

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.00

0.0

6.0

—

1.2

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

1.4

—

1.3

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

0.0

23.9

—

95.1

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.0

2.7

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

2.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_CRYPTOCOCCOSIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_CRYPTOCOCCOSIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_CRYPTOCOCCOSIS – Cryptococcosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cryptococcosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints