Risteys · AB1TUBERCU

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A19 Hospital discharge: ICD-9 — 01[8] Hospital discharge: ICD-8 — 01[8] Cause of death: ICD-10 — A19 Cause of death: ICD-9 — 01[8] Cause of death: ICD-8 — 01[8] 2 out of 7 registries used, show all original rules.	63
4. Check minimum number of events None	63
5. Include endpoints None	63
6. Filter based on genotype QC (FinnGen only)	63

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1151	536	575
Only index persons	525	252	273
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	69.91	73.54	66.67
Only index persons	65.62	67.62	63.77

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	63	24	39
Unadjusted period prevalence (%)	0.01	0.01	0.02
Median age at first event (years)	69.28	66.71	70.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
51: Matched controls
508

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A19.1

ICD-10 Finland

Acute miliary tuberculosis of multiple sites

+∞

18.9

A19.9

ICD-10 Finland

Miliary tuberculosis, unspecified

+∞

15.4

A19.0

ICD-10 Finland

Acute miliary tuberculosis of a single specified site

+∞

11.9

R50.9

ICD-10 Finland

Fever, unspecified

7.8

A19.2

ICD-10 Finland

Acute miliary tuberculosis, unspecified

+∞

7.5

A19.8

ICD-10 Finland

Other miliary tuberculosis

+∞

7.5

A15.0

ICD-10 Finland

Tuberculosis of lung, confirmed by sputum microscopy with or without culture

+∞

6.4

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

16.16

16.68

7.9

2.4

—

(3015479) Mycobacterium sp identified in Blood by Organism specific culture

+∞

12.94

1.9

0.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

7.30

12.10

1.2

1.8

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

19.42

7.00

1.2

1.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

4.65

5.80

1.0

1.6

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

3.88

5.52

2.6

2.4

mmol/l

0.8

0.04

(3009445) Proteinase 3 Ab [Units/volume] in Serum

5.85

5.49

1.7

1.0

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

3.72

5.06

6.6

6.8

mmol/l

1.0

1.1

1.53

(3023368) Bacteria identified in Blood by Culture

166

3.07

4.59

6.2

4.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

8.53

4.53

3.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

4.55

4.49

1.4

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

8.96

4.20

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

4.05

4.16

1.5

1.4

—

(3022313) Gas panel - Capillary blood

4.76

4.05

6.8

3.7

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

8.13

3.99

1.4

1.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

3.20

3.79

1.7

1.5

g/l

4.2

3.9

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

3.88

3.69

6.9

3.4

kpa

5.2

5.0

0.30

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.95

3.51

1.6

1.8

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

5.94

3.31

1.9

1.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.79

3.23

2.2

1.9

—

(3022096) Basophils/100 leukocytes in Blood

193

2.49

3.12

16.9

5.9

0.6

0.36

169

(42870588) Differential panel, method unspecified - Blood

153

2.49

3.05

18.9

5.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.23

3.03

1.5

1.2

—

(3006504) Eosinophils/100 leukocytes in Blood

196

2.44

2.99

16.8

5.9

2.7

2.5

0.22

173

(3019069) Monocytes/100 leukocytes in Blood

197

2.42

2.94

17.0

6.2

9.2

9.0

0.14

176

(3008757) Leukocyte morphology finding [Identifier] in Blood

7.22

2.93

2.3

5.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

7.22

2.93

1.5

1.1

—

(3002030) Lymphocytes/100 leukocytes in Blood

200

2.37

2.81

16.9

6.0

22.5

24.3

0.47

178

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.53

2.78

1.6

1.3

—

(3049717) Cytology report of Urine Cyto stain

4.02

2.69

5.4

2.8

—

(3023520) Reticulocytes [#/volume] in Blood

2.87

2.67

2.5

3.4

e9/l

68.7

68.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.86

2.60

3.1

1.9

—

(3018010) Neutrophils/100 leukocytes in Blood

197

2.27

2.57

15.2

5.5

62.6

59.7

0.72

174

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

5.40

2.46

1.2

1.1

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

247

2.21

2.39

8.9

6.2

mmol/l

1.2

0.37

196

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

5.92

2.25

1.6

1.1

—

(40761535) Cells panel - Urine sediment

2.89

2.23

7.0

4.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.94

2.12

1.2

1.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

5.32

2.11

2.0

1.0

—

(3018418) pH of Serum or Plasma

151

2.09

2.01

6.0

4.2

7.4

—

(3042936) Bacteria identified in Isolate by Culture

2.35

1.94

2.1

2.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

112

2.15

1.94

2.4

1.9

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

261

2.01

1.92

11.3

5.4

umol/l

9.1

12.1

2.31

245

(3011397) Hemoglobin [Presence] in Urine by Test strip

101

2.10

1.72

8.4

4.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

185

1.92

1.70

10.5

3.4

—

(3037756) Immunofixation for Serum or Plasma

3.38

1.70

1.3

1.1

—

(40768443) Skin Pathology biopsy report

3.38

1.70

1.7

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

3.78

1.65

1.0

1.8

—

(40760888) Immunoglobulin light chains.free panel - Serum

3.78

1.65

2.2

2.1

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

3.78

1.65

1.0

1.6

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.90

1.63

2.4

1.7

—

(4035726)

2.51

1.63

1.6

1.4

—

(3026008) Bacteria identified in Urine by Culture

170

1.90

1.62

6.8

3.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

323

1.90

1.56

9.0

5.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.68

1.50

1.4

1.1

—

(3000991) Gas panel - Venous blood

2.40

1.49

11.2

8.1

—

(3019225) pH of Specimen

2.34

1.42

6.0

3.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.33

1.40

1.1

1.4

—

(3012544) pH of Venous blood

2.17

1.31

5.9

—

(3000494) Fungus identified in Specimen by Culture

2.24

1.30

3.3

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.13

1.26

1.6

2.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.13

1.26

1.6

1.9

—

(3025941) Bacteria identified in Stool by Culture

2.77

1.24

1.8

1.2

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.44

1.21

12.7

7.1

—

(3032080) INR in Blood by Coagulation assay

216

1.63

1.07

8.4

12.7

inr

1.3

1.4

0.18

(40768804) Tissue Pathology biopsy report

171

1.65

1.05

2.2

2.3

—

(3016502) Oxygen saturation in Arterial blood

2.01

1.03

8.7

5.7

95.0

94.6

—

(40758558) Short blood count panel - Blood

111

1.73

1.01

8.5

6.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.26

0.94

2.2

2.7

—

(36304419) Bacteria [Presence] in Urine

131

1.64

0.93

10.8

3.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

195

1.57

0.90

2.6

2.1

pmol/l

87.5

82.5

0.19

(3015736) pH of Urine

178

1.56

0.87

7.5

4.7

—

(3044640) Blood type and Crossmatch panel - Blood

161

1.56

0.84

2.7

2.1

—

(3035350) Ketones [Presence] in Urine by Test strip

228

1.50

0.80

7.9

4.5

estimate

0.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

229

1.49

0.78

10.4

5.9

estimate

0.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

165

0.60

0.76

3.3

4.9

20.6

21.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

194

1.48

0.72

1.9

2.7

—

(3009261) Glucose [Presence] in Urine by Test strip

233

1.45

0.69

7.9

4.5

estimate

0.0

—

(1761868) Lipid panel - Serum or Plasma

121

0.61

0.62

1.9

4.0

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.00

0.61

0.0

1.2

—

44.7

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.61

0.0

6.2

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.55

0.60

1.5

3.4

ug/l

2.4

6.2

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.69

0.57

10.8

6.4

93.8

92.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.55

0.57

12.9

5.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.53

0.56

5.0

3.2

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.64

0.56

10.8

6.2

0.6

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.59

0.54

10.8

5.4

1.0

1.5

—

(3002256) Pathology report gross observation

1.59

0.50

1.6

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

216

1.35

0.48

4.1

4.0

—

(3029937) Albumin [Presence] in Urine by Test strip

141

1.39

0.47

8.6

4.7

estimate

0.0

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.45

0.47

11.0

6.0

g/l

92.9

118.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

403

0.75

0.46

4.5

4.8

mmol/l

1.5

1.4

0.26

350

(3007853) Bacteria identified in Skin by Aerobe culture

1.46

0.44

1.6

1.8

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.41

0.0

1.1

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.41

0.0

1.5

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.41

0.0

3.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.40

0.0

1.4

—

(3021589) Normoblasts [#/volume] in Blood

203

1.29

0.38

24.4

10.1

e9/l

0.0

1.15

164

(3023103) Potassium [Moles/volume] in Serum or Plasma

446

0.77

0.37

48.1

21.6

mmol/l

4.0

0.20

425

(3019060) Gas panel - Arterial blood

1.47

0.37

3.5

—

(40761536) Microorganisms panel - Urine sediment

1.44

0.36

7.7

4.0

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

445

0.77

0.36

47.5

21.6

mmol/l

139.1

139.6

0.50

424

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

405

0.79

0.34

4.5

4.7

mmol/l

4.3

0.04

356

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

414

0.79

0.33

4.7

5.4

mmol/l

2.3

2.5

0.43

362

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

306

1.24

0.31

3.2

3.9

pmol/l

15.3

15.1

0.16

259

(40761511) CBC panel - Blood by Automated count

441

0.80

0.30

32.7

17.9

—

(3009542) Hematocrit [Volume Fraction] of Blood

352

1.20

0.23

36.7

19.6

37.0

38.7

0.65

202

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.0

—

19.3

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

3.4

—

105.6

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

3.4

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

3.4

—

4.1

—

(3022145) Colonoscopy Study observation

1.28

0.21

1.0

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.20

0.0

1.3

—

(3003338) MCHC [Mass/volume]

315

0.85

0.19

50.3

25.8

g/l

327.0

330.4

0.92

310

(40768797) Stomach Pathology biopsy report

1.14

0.18

1.4

1.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

391

0.87

0.15

3.8

4.3

mmol/l

1.4

1.2

0.53

337

(3003694) ABO and Rh group [Type] in Blood

105

0.83

0.14

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

437

0.88

0.12

45.5

21.6

umol/l

96.2

90.3

0.31

437

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.12

0.10

2.8

3.1

ng/l

191.8

230.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.12

0.08

14.1

9.1

—

(3044889) 12 lead EKG panel

294

0.91

0.08

5.9

4.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

187

1.10

0.07

8.2

4.8

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

100

1.12

0.05

2.0

2.8

mmol/l

2.5

0.40

(3013512) EKG study

152

1.07

0.02

4.7

5.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

137

0.94

0.02

6.0

4.2

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

376

0.96

0.00

4.0

4.8

mu/l

2.0

2.1

0.13

317

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

403

0.98

0.00

5.0

5.4

mmol/l

6.1

6.2

0.23

347

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

5.2

—

4.5

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.5

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.7

—

(3016038) Potassium [Moles/volume] in Urine

0.00

0.0

1.0

—

52.5

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.7

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

2.3

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.0

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.8

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.0

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

1.2

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.4

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

1.0

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Mortality – FinRegistry

↥

Association

Association between endpoint AB1TUBERCU_MILIARY and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1TUBERCU_MILIARY	2.344 [1.68, 3.27]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.142

During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 196 females with AB1TUBERCU_MILIARY died.

Males

Parameter	HR [95% CI]	p-value
AB1TUBERCU_MILIARY	3.085 [2.04, 4.67]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 241 males with AB1TUBERCU_MILIARY died.

Mortality risk

Mortality risk for people of age

years, who have AB1TUBERCU_MILIARY.

N-year risk	Females	Males
1	0.247%	0.503%
5	1.401%	3.278%
10	3.368%	8.075%
15	6.323%	14.981%
20	11.127%	24.438%

Relationships between endpoints

↥

Index endpoint: AB1TUBERCU_MILIARY – Miliary tuberculosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	AB1TUBERCU_MILIARY
CONTROL_EXCLUDE	AB1_TUBERCULOSIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A19
HD_ICD_9	01[8]
HD_ICD_8	01[8]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A19
COD_ICD_9	01[8]
COD_ICD_8	01[8]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Miliary tuberculosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints