pigmented villonodular synovitis: Pigmented villonodular synovitis (PVNS) is a rare benign proliferative disorder of the synovial membrane primarily affecting young adults (with a peak age of onset in the second to fourth decade of life) characterized by proliferative, locally invasive tumor-like lesions, usually involving a single joint, tendon sheath or bursae (most commonly the joints of the knee and hip and rarely others such as the ankle, shoulder and temporomandibular joints). It presents with pain and limitation of motion along with swelling, heat and tenderness over the involved joint, eventually leading to arthritic degeneration and significant locomotor deficit, if left untreated. PVNS can recur in patients even after treatment.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
298 |
4. Check minimum number of eventsNone |
298 |
5. Include endpointsNone |
298 |
6. Filter based on genotype QC (FinnGen only) |
298 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M12
- Name in latin
- Synovitis villonodularis [pigmentata]
Similar endpoints
↥List of similar endpoints to
Villonodular synovitis (pigmented)
based on the number of shared cases.
Similar with more cases:
- Other specific arthropathies, wide
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2060 | 1083 | 962 |
| Only index persons | 1901 | 1014 | 887 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 39.12 | 40.66 | 37.21 |
| Only index persons | 38.21 | 39.93 | 36.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 298 | 183 | 115 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | 40.29 | 40.74 | 39.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 276
- Matched controls
- 2760
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M12.2
ICD-10 Finland
Villonodular synovitis (pigmented)
+∞
169.9
145
*
7192F
ICD-9 Finland
Other and unspecified disorder of joint, Villonodular synovitis[SYNOVITIS VILLONODULARIS, POLVI]
+∞
128.4
113
*
1220
FHL
Arthroscopy
79.8
72.6
80
14
M17.1
ICD-10 Finland
Other primary gonarthrosis
34.8
70.2
92
39
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
28.6
57.4
79
38
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
88.8
46.8
51
7
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
65.2
46.5
53
10
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
55.2
42.7
50
11
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
57.7
41.3
48
10
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
461.5
41.3
40
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
19.0
41.0
64
43
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
448.0
40.2
39
*
A07EC01
ATC
sulfasalazine; oral, rectal
20.7
38.4
58
35
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
421.1
38.0
37
*
M13.9
ICD-10 Finland
Arthritis, unspecified
40.1
37.7
47
14
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
70.4
37.4
42
7
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
21.8
37.2
55
31
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
36.5
36.1
46
15
P01BA02
ATC
hydroxychloroquine; oral
26.7
34.0
47
21
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
186.6
32.5
33
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
350.6
31.5
31
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
350.6
31.5
31
*
WX320
NOMESCO Finland
Spinalanesthesy
6.5
31.5
94
204
1222
FHL
Arthroscopy and synovial surgery
337.4
30.4
30
*
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
36.4
30.0
38
12
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
29.7
28
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
60.0
27.8
32
6
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
19.8
27.2
41
24
M25.5
ICD-10 Finland
Pain in joint
5.0
27.1
103
291
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
285.9
26.2
26
*
L88
ICPC
Rheumatoid/seropositive arthritis
77.4
25.3
28
*
L15
ICPC
Knee symptom/complaint
5.4
21.6
72
170
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
11.3
21.5
41
42
NGF10
NOMESCO Finland
Total synovectomy of knee, open
+∞
21.1
20
*
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
10.3
21.0
42
47
9311
FHL
Knee cleansing surgery (synovectomy, debridement)
+∞
19.0
18
*
1221
FHL
Arthroscopy and meniscus surgery
107.4
18.8
20
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
47.6
18.5
22
5
M19.0
ICD-10 Finland
Primary arthrosis of other joints
18.6
17.8
27
16
1225
FHL
Arthroscopy and other therapeutic procedure
191.8
17.7
18
*
ZXA00
NOMESCO Finland
Right side
3.7
17.2
89
314
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
16.8
16
*
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
+∞
16.8
16
*
N02AX02
ATC
tramadol; systemic, rectal
2.9
15.3
126
615
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
7.3
15.3
37
57
M09AX01
ATC
hyaluronic acid; parenteral
26.8
14.9
20
8
L04AA13
ATC
leflunomide; oral
84.7
14.7
16
*
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
14.7
14
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
14.7
14
*
H02AB06
ATC
prednisolone; systemic
2.8
14.3
133
688
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
146.9
13.6
14
*
M01AX05
ATC
glucosamine; oral
4.4
13.5
51
134
M01AH05
ATC
etoricoxib; oral
2.6
13.2
172
1067
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
30.0
13.1
17
6
M23.8
ICD-10 Finland
Other internal derangements of knee
18.4
12.7
19
11
B01AB05
ATC
enoxaparin; parenteral
3.0
12.6
85
353
TNG10
NOMESCO Finland
Puncture of knee
+∞
12.6
12
*
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
+∞
12.6
12
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
135.9
12.5
13
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
7.6
12.5
29
42
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.5
11.7
134
758
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
26.3
11.3
15
6
N02AJ06
ATC
codeine and paracetamol; systemic
2.5
11.3
111
577
ZXA05
NOMESCO Finland
Left side
2.9
10.9
75
314
WX111
NOMESCO Finland
Local infiltration anesthesia
114.2
10.5
11
*
M01CB01
ATC
sodium aurothiomalate; parenteral
114.2
10.5
11
*
M17.5
ICD-10 Finland
Other secondary gonarthrosis
+∞
10.5
10
*
M22.4
ICD-10 Finland
Chondromalacia patellae
34.0
10.4
13
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
5.6
10.4
30
59
M01AH02
ATC
rofecoxib; oral
3.8
10.2
45
136
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
6.0
10.0
27
49
J01AA02
ATC
doxycycline; systemic
2.5
9.9
219
1663
M01AH01
ATC
celecoxib; oral (coxibs)
3.1
9.9
58
216
A02BC02
ATC
pantoprazole; systemic
2.3
9.9
174
1180
SPAT1202
SPAT
Intra-articular injection
31.2
9.5
12
*
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
103.4
9.5
10
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
+∞
9.4
9
*
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
9.4
9
*
M01AE02
ATC
naproxen; oral, rectal
2.2
9.2
164
1103
B01AF01
ATC
rivaroxaban; oral
4.8
9.2
30
68
S18
ICPC
Laceration/cut
2.3
9.1
107
593
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
38.0
9.1
11
*
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
38.0
9.1
11
*
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
38.0
9.1
11
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
51.7
8.7
10
*
N03AX16
ATC
pregabalin; oral
2.7
8.7
65
282
N02BE01
ATC
paracetamol; systemic, rectal
2.5
8.6
231
1849
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
11.3
8.4
15
14
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
+∞
8.4
8
*
M01AE11
ATC
tiaprofenic acid; oral, rectal
7.9
8.3
18
24
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
34.5
8.1
10
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
4.8
7.8
25
56
M16.1
ICD-10 Finland
Other primary coxarthrosis
12.3
7.7
13
11
TQW40
NOMESCO Finland
Remowal of suture of skin
4.5
7.7
26
62
R4110
NOMESCO Finland
Physiotherapy
2.3
7.6
78
398
9243
FHL
Plastic of the patella and its tendons
82.2
7.5
8
*
M24.2
ICD-10 Finland
Disorder of ligament
82.2
7.5
8
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
8.7
7.4
15
18
N03AX12
ATC
gabapentin; oral
3.1
7.4
41
147
ZX140
NOMESCO Finland
Intra articular
+∞
7.3
7
*
M07.3
ICD-10 Finland
Other psoriatic arthropathies
+∞
7.3
7
*
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
+∞
7.3
7
*
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
30.9
7.2
9
*
M25.4
ICD-10 Finland
Effusion of joint
20.7
7.2
10
5
M01AC06
ATC
meloxicam; systemic, rectal
2.1
7.0
100
592
M02AA07
ATC
piroxicam; topical
2.1
6.9
95
553
M71.2
ICD-10 Finland
Synovial cyst of popliteal space [Baker]
11.3
6.9
12
11
L90
ICPC
Osteoarthrosis of knee
7.5
6.8
15
21
L04AA01
ATC
[U] ciclosporin; systemic
41.1
6.8
8
*
M01AX17
ATC
nimesulide; oral
2.4
6.7
63
307
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
8.1
6.7
14
18
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
6.5
60
291
M79.6
ICD-10 Finland
Pain in limb
2.1
6.5
92
541
L40.5
ICD-10 Finland
Arthropathic psoriasis
71.4
6.5
7
*
M19.2
ICD-10 Finland
Other secondary arthrosis
71.4
6.5
7
*
SPAT1153
SPAT
Removal of sutures
2.1
6.4
77
422
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.4
106
658
M20.1
ICD-10 Finland
Hallux valgus (acquired)
9.6
6.4
12
13
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
18.5
6.3
9
5
L04AA17
ATC
[U] adalimumab; parenteral
+∞
6.3
6
*
7190F
ICD-9 Finland
Other and unspecified disorder of joint, Effusion of joint[HYDROPS (HYDRARTHRON), POLVI]
+∞
6.3
6
*
7174A
ICD-9 Finland
Internal derangement of knee, Derangement of lateral meniscus
+∞
6.3
6
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
6.3
6
*
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
+∞
6.3
6
*
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
27.4
6.3
8
*
H02AB04
ATC
methylprednisolone; systemic
2.7
6.2
42
171
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.0
6.1
23
62
J01FF01
ATC
clindamycin; systemic
2.1
6.0
76
424
Mortality – FinRegistry
↥Association
Association between endpoint M13_VILLONODULAR and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_VILLONODULAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_VILLONODULAR – Villonodular synovitis (pigmented)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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