systemic scleroderma: A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
881 |
4. Check minimum number of eventsNone |
881 |
5. Include endpointsNone |
881 |
6. Filter based on genotype QC (FinnGen only) |
881 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M30-M36
- Name in latin
- Sclerosis systemica
Similar endpoints
↥List of similar endpoints to
Systemic sclerosis
based on the number of shared cases.
Similar with more cases:
- Systemic sclerosis (FG)
- Systemic connective tissue disorders
- Finngen Rheumatological endpoints
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4561 | 3620 | 887 |
| Only index persons | 3885 | 3150 | 735 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.02 |
| Only index persons | 0.10 | 0.12 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 56.25 | 56.54 | 55.13 |
| Only index persons | 55.13 | 55.34 | 54.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 881 | 728 | 153 |
| Unadjusted period prevalence (%) | 0.22 | 0.25 | 0.07 |
| Median age at first event (years) | 54.75 | 54.51 | 55.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 793
- Matched controls
- 7929
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
323.0
481
*
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
+∞
323.0
349
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
27.5
316.8
483
424
P01BA02
ATC
hydroxychloroquine; oral
27.7
286.9
424
316
C08CA05
ATC
nifedipine; systemic
25.8
233.5
344
228
I73.0
ICD-10 Finland
Raynaud syndrome
56.4
172.2
203
48
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
13.1
158.2
309
368
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
156.6
145
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
1746.0
152.2
143
*
XX9XE
NOMESCO Finland
Other ultrasound examination
67.7
122.4
140
25
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.6
108.0
217
250
XPX04
NOMESCO Finland
Angioscopy
225.7
97.8
99
5
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
131.2
97.6
103
9
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
93.6
88
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
8.7
91.8
218
330
L04AA06
ATC
mycophenolic acid; systemic
44.1
84.2
104
27
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.2
78.2
495
2256
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.5
77.2
145
139
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.1
70.9
392
1535
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.6
68.9
300
932
L04AX01
ATC
azathioprine; systemic
10.9
66.7
134
145
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
669.3
63.8
62
*
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
62.3
59
*
XG410
NOMESCO Finland
Flow-volume spirometry
11.7
61.7
119
118
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
7.9
57.6
141
212
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
82.6
54.8
61
8
H02AB06
ATC
prednisolone; systemic
3.3
54.2
493
2658
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
13.5
53.3
95
79
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
13.9
51.8
91
73
L88
ICPC
Rheumatoid/seropositive arthritis
8.8
48.6
109
141
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
94.6
48.5
53
6
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
5.9
47.1
142
281
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
462.4
44.7
44
*
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
24.0
39.3
56
25
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.7
38.3
384
2027
NH3EA
NOMESCO Finland
Feet X-ray examination with load
12.5
36.7
67
58
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
4.2
36.3
151
416
G04BE03
ATC
sildenafil; oral
37.5
36.3
46
13
C08CA02
ATC
felodipine; oral
4.6
34.7
130
323
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.3
33.9
198
721
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.6
33.2
124
306
M34
ICD-10 Finland
Systemic sclerosis
340.5
33.1
33
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.3
32.0
130
348
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
15.8
31.8
52
35
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
9.0
30.6
66
79
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.7
29.6
89
172
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
+∞
29.3
28
*
C02KX01
ATC
bosentan; oral
302.5
29.0
29
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
10.2
28.4
57
60
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
6.0
27.8
80
146
TGC00
NOMESCO Finland
Bronchial lavation
10.4
26.3
52
53
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.9
26.1
114
324
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
14.0
25.8
44
33
R06.0
ICD-10 Finland
Dyspnoea
2.5
25.7
249
1221
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.6
25.2
126
400
R4120
NOMESCO Finland
Occupational therapy
4.5
25.2
93
225
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
40.3
25.0
31
8
E0000UV
ATC
NA
2.2
24.3
375
2293
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
8.9
24.2
52
62
SBA10
NOMESCO Finland
Measurement of excretion of saliva
23.6
24.1
34
15
L04AD01
ATC
ciclosporin; systemic
9.4
23.6
49
55
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
+∞
23.0
22
*
C08CA01
ATC
amlodipine; oral
2.2
22.9
314
1804
K74.3
ICD-10 Finland
Primary biliary cirrhosis
18.6
22.3
34
19
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
22.1
221
1084
J01FF01
ATC
clindamycin; systemic
2.3
21.7
257
1369
WZA10
NOMESCO Finland
Long statement of health and health related matters
12.4
21.7
39
33
H04.10
ICD-10 Finland
Dry eye syndrome
3.0
20.7
129
477
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
20.6
402
2651
L04AA01
ATC
[U] ciclosporin; systemic
12.1
20.4
37
32
RT172
NOMESCO Finland
NA
+∞
19.9
19
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
6.8
19.6
50
78
A02BC02
ATC
pantoprazole; systemic
2.0
19.1
550
4178
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
19.0
195
962
RT160
NOMESCO Finland
NA
+∞
18.8
18
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.6
17.9
83
246
H02AB07
ATC
prednisone; oral
2.6
17.9
146
636
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
17.8
17
*
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
+∞
17.8
17
*
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
17.4
17.5
27
16
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
17.3
182
902
M01CC01
ATC
penicillamine; oral
51.2
17.0
20
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
17.0
354
2336
GD1AD
NOMESCO Finland
Thorax CT examination
4.7
16.8
58
131
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
16.7
16
*
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
+∞
16.7
16
*
C02KX04
ATC
macitentan; oral
173.5
16.6
17
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
12.5
16.4
29
24
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.3
16.3
84
271
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
6.6
16.3
42
67
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.5
16.3
78
238
A02BC01
ATC
omeprazole; systemic
2.0
16.2
248
1446
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.7
16.0
72
209
RT274
NOMESCO Finland
NA
+∞
15.7
15
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.9
14.8
94
350
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.8
14.5
96
368
A05AA02
ATC
ursodeoxycholic acid; oral
6.5
14.4
37
59
R13
ICD-10 Finland
Dysphagia
3.4
14.3
72
229
J01MA12
ATC
levofloxacin; systemic
2.2
14.1
155
778
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
4.5
14.0
50
118
I27.0
ICD-10 Finland
Primary pulmonary hypertension
30.6
13.9
18
6
RT272
NOMESCO Finland
NA
24.3
13.8
19
8
UJF32
NOMESCO Finland
Coloscopy
1.9
13.8
231
1381
C03CA01
ATC
furosemide; systemic
2.0
13.8
210
1211
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
13.6
13
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
13.6
13
*
N02AX02
ATC
tramadol; systemic, rectal
1.8
12.9
335
2316
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
50.9
12.9
15
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.7
12.7
43
96
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
12.5
12.7
22
18
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
12.5
12
*
L99
ICPC
Musculoskeletal disease other
5.7
12.4
35
64
M05BA04
ATC
alendronic acid; oral
2.6
12.3
94
392
M05BX04
ATC
denosumab; parenteral
3.3
12.3
62
198
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.7
12.0
86
346
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
12.0
120
575
E000001
ATC
NA
2.0
11.8
185
1068
RT271
NOMESCO Finland
NA
30.5
11.7
15
5
ZX120
NOMESCO Finland
Intravenous
2.5
11.5
92
393
R15
ICD-10 Finland
Faecal incontinence
4.4
11.5
41
97
RT231
NOMESCO Finland
NA
+∞
11.5
11
*
73409
ICD-8 Finland
Diffuse diseases of connective tissue, Sclerosis systematica NUD
+∞
11.5
11
*
J01DB01
ATC
cefalexin; oral
1.9
11.4
651
5618
D06BX01
ATC
metronidazole; topical
2.3
11.3
113
538
S18
ICPC
Laceration/cut
1.7
11.2
328
2318
A02BC05
ATC
esomeprazole; systemic
1.7
11.2
347
2500
R50.9
ICD-10 Finland
Fever, unspecified
2.3
11.1
112
537
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.6
11.1
50
146
M25.5
ICD-10 Finland
Pain in joint
1.8
11.1
249
1621
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
11.1
114
553
N03AX16
ATC
pregabalin; oral
1.9
11.0
201
1226
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.7
10.9
76
300
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
43.9
10.9
13
*
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
5.4
10.7
31
59
A02BC03
ATC
lansoprazole; oral
1.8
10.6
246
1619
R4190
NOMESCO Finland
Nutritional therapy
4.3
10.6
38
91
K62.3
ICD-10 Finland
Rectal prolapse
6.7
10.6
26
40
G73.7
ICD-10 Finland
Myopathy in other diseases classified elsewhere
+∞
10.4
10
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.8
10.4
237
1548
K22.7
ICD-10 Finland
Barrett oesophagus
8.3
10.4
22
27
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
4.4
10.3
36
84
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
4.0
10.2
40
104
SAA03
NOMESCO Finland
Extended examination of mouth
1.7
10.2
309
2189
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
8.6
10.1
21
25
SPAT1263
SPAT
Sampling
1.6
10.1
343
2510
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
5.4
10.1
29
55
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
4.9
10.0
32
68
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.7
10.0
28
51
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.7
10.0
69
269
M05BA07
ATC
risedronic acid; oral
3.3
9.8
48
151
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.2
9.8
51
168
NHQ40
NOMESCO Finland
Amputation of toe
6.9
9.7
23
34
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.6
9.5
70
284
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
6.3
9.4
24
39
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
9.4
9
*
M34.2
ICD-10 Finland
Systemic sclerosis induced by drugs and chemicals
+∞
9.4
9
*
M31.4
ICD-10 Finland
Aortic arch syndrome [Takayasu]
+∞
9.4
9
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.2
9.2
93
447
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
9.2
49
164
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.6
9.2
68
278
C02DE02
ATC
NA
6.8
9.2
22
33
M13.9
ICD-10 Finland
Arthritis, unspecified
2.6
9.1
65
261
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
10.2
9.1
17
17
XG466
NOMESCO Finland
Sleep oxymetry
4.0
9.0
35
91
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.4
9.0
43
133
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
9.0
91
437
UJF30
NOMESCO Finland
Ileoscopy through colon
2.2
9.0
93
451
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
8.9
206
1340
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
8.9
67
278
TEA00
NOMESCO Finland
Biopsy of lip
9.6
8.8
17
18
K22.1
ICD-10 Finland
Ulcer of oesophagus
5.7
8.8
24
43
J01MA14
ATC
moxifloxacin; systemic
2.3
8.8
78
353
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
8.7
136
779
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.9
8.6
142
828
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
8.6
91
446
EBA10
NOMESCO Finland
Surgical removal of tooth
2.2
8.6
86
410
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
11.7
8.6
15
13
J02AC01
ATC
fluconazole; systemic
1.6
8.6
364
2784
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.2
8.5
90
441
RT310
NOMESCO Finland
NA
27.8
8.5
11
*
RJ420
NOMESCO Finland
NA
27.8
8.5
11
*
M33.2
ICD-10 Finland
Polymyositis
91.0
8.4
9
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
91.0
8.4
9
*
GX1K5
NOMESCO Finland
Diffusion capacity
91.0
8.4
9
*
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
6.3
8.4
21
34
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.5
8.3
28
64
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.0
8.3
116
636
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.9
8.2
48
171
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
3.3
8.2
40
126
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
8.2
104
548
S97
ICPC
Chronic ulcer skin
2.9
8.1
48
173
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.2
8.1
41
133
H03AA01
ATC
levothyroxine sodium; systemic
1.7
8.1
214
1442
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
9.0
8.1
16
18
A07AA02
ATC
nystatin; oral
2.5
8.0
61
255
J01AA04
ATC
lymecycline; systemic
2.0
8.0
105
565
J01DA01
ATC
[U] cefalexin; systemic
1.5
8.0
484
3996
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.0
7.9
43
147
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
10.9
7.8
14
13
D07AC01
ATC
betamethasone; topical
1.6
7.8
261
1869
J01FA06
ATC
roxithromycin; oral
1.5
7.8
320
2412
NF1AA
NOMESCO Finland
Hip X-ray examination
2.2
7.8
76
361
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
15.2
7.7
12
8
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
45.4
7.7
9
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
7.7
75
354
SFA00
NOMESCO Finland
Small filling
2.0
7.7
106
579
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.5
7.6
60
256
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
2.1
7.6
82
406
NDQ20
NOMESCO Finland
Amputation of finger
12.0
7.6
13
11
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
7.6
310
2329
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
25.3
7.6
10
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.8
7.5
143
874
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
7.5
254
1819
I73.1
ICD-10 Finland
Thromboangiitis obliterans [Buerger]
80.8
7.4
8
*
M35
ICD-10 Finland
Other systemic involvement of connective tissue
80.8
7.4
8
*
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
7.7
7.4
16
21
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
7.4
120
696
L95
ICPC
Osteoporosis
3.0
7.4
42
147
A03FA02
ATC
cisapride; oral, rectal
2.2
7.3
71
336
C08DB01
ATC
diltiazem; oral
2.9
7.3
42
148
M43.9
ICD-10 Finland
Deforming dorsopathy, unspecified
+∞
7.3
7
*
L94.3
ICD-10 Finland
Sclerodactyly
+∞
7.3
7
*
GDG10
NOMESCO Finland
Bilateral transplantation of lung
+∞
7.3
7
*
M32
ICD-10 Finland
Systemic lupus erythematosus
+∞
7.3
7
*
286
Kela drug reimbursment
Ciclosporin eye drop
+∞
7.3
7
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
7.3
7
*
73401
ICD-8 Finland
Diffuse diseases of connective tissue, Sclerosis systematica acrosclerotica
+∞
7.3
7
*
SPAT1254
SPAT
Administration of medicine
1.9
7.2
112
640
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.0
7.1
38
129
NDL52
NOMESCO Finland
Tenosynovectomy of hand
8.0
7.1
15
19
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
6.1
7.1
18
30
L12
ICPC
Hand/finger symptom/complaint
1.8
7.0
117
685
E000003
ATC
NA
2.8
7.0
44
164
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
6.9
118
692
WX110
NOMESCO Finland
Local anesthesy
1.5
6.9
527
4504
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
6.9
535
4588
R4180
NOMESCO Finland
Podiatric therapy
6.8
6.8
16
24
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
6.8
6.8
16
24
S09
ICPC
Infected finger/toe
3.4
6.8
31
94
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
11.1
6.8
12
11
QCB05
NOMESCO Finland
Revision of wound of skin of upper limb
11.1
6.8
12
11
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.5
6.8
397
3203
ADA20
NOMESCO Finland
Thoracal sympathectomy
40.4
6.8
8
*
NGQ20
NOMESCO Finland
Amputation of lower leg
16.9
6.8
10
6
R1250
NOMESCO Finland
Evaluation of functional capability
4.0
6.7
25
64
WX002
NOMESCO Finland
Sedation and analgesia
1.7
6.7
154
993
J96.1
ICD-10 Finland
Chronic respiratory failure
5.0
6.7
20
41
RT171
NOMESCO Finland
NA
22.7
6.7
9
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.4
6.7
53
227
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
6.6
232
1668
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
12.4
6.6
11
9
R76.0
ICD-10 Finland
Raised antibody titre
12.4
6.6
11
9
M35.7
ICD-10 Finland
Hypermobility syndrome
12.4
6.6
11
9
D64.9
ICD-10 Finland
Anaemia, unspecified
2.1
6.6
72
358
RF210
NOMESCO Finland
NA
3.5
6.6
28
81
K59.09
ICD-10 Finland
Constipation, unspecified
2.5
6.6
47
192
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
2.3
6.6
60
275
JGC01
NOMESCO Finland
Laparoscopic rectopexy
6.9
6.5
15
22
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.7
6.5
143
909
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.3
6.5
58
265
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.6
6.5
43
168
C03DA01
ATC
spironolactone; oral
2.0
6.4
78
407
A01AB09
ATC
miconazole; local oral
2.0
6.4
78
407
GX1D5
NOMESCO Finland
Flow volume spirometry
70.4
6.4
7
*
Z94.2
ICD-10 Finland
Lung transplant status
70.4
6.4
7
*
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
70.4
6.4
7
*
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.6
6.4
184
1259
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.4
6.4
29
88
SAA04
NOMESCO Finland
Special inverstigation of mouth
2.5
6.4
48
199
M45
ICD-10 Finland
Ankylosing spondylitis
4.5
6.4
21
48
Z01.9
ICD-10 Finland
Special examination, unspecified
2.4
6.4
49
208
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.7
6.4
134
840
E000007
ATC
NA
2.4
6.4
52
228
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.3
668
6075
NDQ48
NOMESCO Finland
Revision or amputation or exarticulation of finger
18.2
6.3
9
5
B01AC27
ATC
selexipag; oral
+∞
6.3
6
*
XQ844
NOMESCO Finland
Other microscope or electron microscope examination
+∞
6.3
6
*
I27.1
ICD-10 Finland
Kyphoscoliotic heart disease
+∞
6.3
6
*
RJ126
NOMESCO Finland
NA
+∞
6.3
6
*
383
Kela drug reimbursment
Selexipag
+∞
6.3
6
*
K76.9
ICD-10 Finland
Liver disease, unspecified
4.8
6.3
19
40
NH3AE
NOMESCO Finland
Feet ultrasound examination
26.9
6.2
8
*
SPAT1325
SPAT
Vaccination
1.5
6.2
253
1880
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
5.1
6.2
18
36
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.2
6.2
30
96
K11.2
ICD-10 Finland
Sialoadenitis
3.0
6.1
32
108
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.8
6.1
116
704
N02AA05
ATC
oxycodone; systemic
1.8
6.1
101
587
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
6.1
60
287
GD1UN
NOMESCO Finland
Lung circulation SPECT
8.7
6.1
12
14
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
10.1
6.0
11
11
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
5.2
6.0
17
33
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYSTSLCE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTSLCE | 2.306 [2.03, 2.62] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 615 out of 2768 females with M13_SYSTSLCE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTSLCE | 2.516 [2.0, 3.17] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.068 |
During the follow-up period (1.1.1998 — 31.12.2019), 197 out of 642 males with M13_SYSTSLCE died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYSTSLCE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.559% |
| 5 | 1.311% | 3.123% |
| 10 | 3.181% | 8.172% |
| 15 | 6.414% | 15.352% |
| 20 | 11.51% | 24.944% |
Relationships between endpoints
↥Index endpoint: M13_SYSTSLCE – Systemic sclerosis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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