urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
775 |
4. Check minimum number of eventsNone |
775 |
5. Include endpointsNone |
775 |
6. Filter based on genotype QC (FinnGen only) |
775 |
Control definitions (FinnGen only)
- Control exclude
- L12_URTICARIAERYTHEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L50
- Name in latin
- Urticaria idiopathica
Similar endpoints
↥List of similar endpoints to
Idiopathic urticaria
based on the number of shared cases.
Similar with more cases:
- Urticaria
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5662 | 3560 | 2061 |
| Only index persons | 5072 | 3268 | 1804 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.06 |
| Only index persons | 0.10 | 0.12 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 30.93 | 35.13 | 23.53 |
| Only index persons | 33.36 | 36.62 | 27.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 775 | 589 | 186 |
| Unadjusted period prevalence (%) | 0.17 | 0.20 | 0.08 |
| Median age at first event (years) | 42.54 | 41.48 | 45.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 685
- Matched controls
- 6850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.1
ICD-10 Finland
Idiopathic urticaria
4503599627370496.0
323.0
624
*
L50.9
ICD-10 Finland
Urticaria, unspecified
72.1
187.2
211
42
L50.8
ICD-10 Finland
Other urticaria
290.2
121.1
120
5
L50.3
ICD-10 Finland
Dermatographic urticaria
398.4
103.1
101
*
H02AB06
ATC
prednisolone; systemic
5.7
97.2
477
1963
R06AX27
ATC
desloratadine; oral
4.9
80.9
385
1417
C01CA24
ATC
epinephrine; parenteral
9.8
78.2
171
225
L50.0
ICD-10 Finland
Allergic urticaria
36.2
75.2
97
31
R03DC03
ATC
montelukast; oral
5.5
72.5
260
683
R06AE07
ATC
cetirizine; oral
4.2
67.4
460
2245
7081A
ICD-9 Finland
Urticaria, Idiopathic urticaria
+∞
63.5
60
*
XQ800
NOMESCO Finland
Prick test
7.1
62.0
167
297
L50
ICD-10 Finland
Urticaria
31.2
54.8
73
26
R06AE09
ATC
levocetirizine; oral
4.7
53.9
220
631
344
Kela drug reimbursment
Omalizumab
+∞
51.7
49
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.7
49.1
157
340
R03DX05
ATC
omalizumab; parenteral
+∞
46.4
44
*
T78.3
ICD-10 Finland
Angioneurotic oedema
29.5
46.0
62
23
T78.4
ICD-10 Finland
Allergy, unspecified
7.8
45.1
110
164
R06AX22
ATC
ebastine; oral
3.4
33.7
199
744
H02AB07
ATC
prednisone; oral
3.9
31.6
145
439
A02BA02
ATC
ranitidine; systemic
3.0
23.6
154
597
A92
ICPC
Allergy/allergic reaction NOS
7.1
23.6
59
90
R03AC02
ATC
salbutamol; inhalant
2.2
20.8
410
2793
S98
ICPC
Urticaria
17.4
19.3
30
18
L04AD01
ATC
ciclosporin; systemic
9.9
18.1
36
38
H02AB04
ATC
methylprednisolone; systemic
2.7
15.8
115
470
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.4
15.7
148
697
R06AX13
ATC
loratadine; oral
2.4
15.1
147
705
E0000UV
ATC
NA
2.0
15.1
298
1937
ZX112
NOMESCO Finland
Subcutaneous
7.2
14.6
35
51
R03AK07
ATC
formoterol and budesonide; inhalant
2.2
13.8
154
786
L50.5
ICD-10 Finland
Cholinergic urticaria
76.7
13.6
15
*
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
12.5
13.2
23
19
J01FF01
ATC
clindamycin; systemic
2.1
13.2
189
1072
S88
ICPC
Dermatitis contact/allergic
6.6
13.1
33
52
N02AX02
ATC
tramadol; systemic, rectal
1.9
13.0
260
1675
X49
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
11.9
12.9
23
20
L50.2
ICD-10 Finland
Urticaria due to cold and heat
71.2
12.6
14
*
N05BB01
ATC
hydroxyzine; systemic
3.4
12.5
62
196
D07AB08
ATC
desonide; topical
2.5
11.7
93
398
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
11.7
126
629
XQ802
NOMESCO Finland
Epicutan test
3.6
11.5
52
153
XQ818
NOMESCO Finland
Conjunctival allergen provocation test
+∞
11.5
11
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.9
11.3
69
251
R03BA02
ATC
budesonide; inhalant
2.1
10.8
136
726
J01AA02
ATC
doxycycline; systemic
1.8
10.7
494
4050
R01AD08
ATC
fluticasone; nasal
1.8
10.7
211
1332
J01FA10
ATC
azithromycin; systemic
1.7
10.5
428
3367
3DX05
NOMESCO Finland
NA
+∞
10.4
10
*
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.9
10.3
169
998
S21
ICPC
Skin texture symptom/complaint
2.4
10.0
92
423
J01MA02
ATC
ciprofloxacin; systemic
1.8
9.9
227
1499
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.9
9.8
60
218
A02BC02
ATC
pantoprazole; systemic
1.7
9.7
397
3093
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
9.7
137
765
Z71.8
ICD-10 Finland
Other specified counselling
1.8
9.6
188
1176
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
9.6
174
1061
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
9.6
231
1544
R02
ICPC
Shortness of breath/dyspnoea
2.4
9.5
85
387
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
9.3
247
1696
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
9.1
122
665
R06.0
ICD-10 Finland
Dyspnoea
1.9
9.1
151
894
R06AX26
ATC
fexofenadine; oral
2.7
9.0
63
250
D07AC01
ATC
betamethasone; topical
1.7
8.6
212
1416
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.5
8.6
65
271
D07AA02
ATC
hydrocortisone; topical
2.1
8.6
107
566
P01AB01
ATC
metronidazole; oral, rectal
1.6
8.4
267
1913
L17
ICPC
Foot/toe symptom/complaint
1.8
8.4
163
1010
L20.0
ICD-10 Finland
Besnier prurigo
2.4
8.3
72
324
R51.80
ICD-10 Finland
Headache
1.9
8.2
121
682
R03BA08
ATC
ciclesonide; inhalant
2.5
8.2
66
285
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.7
8.2
34
95
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
8.1
254
1814
D02AX
ATC
Other emollients and protectives
3.5
8.0
36
107
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.8
7.9
169
1079
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.1
7.8
41
137
D07AB02
ATC
hydrocortisone butyrate; topical
1.7
7.8
187
1232
R01AD09
ATC
mometasone; nasal
1.6
7.7
313
2377
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
7.7
72
334
D07AC13
ATC
mometasone; topical
1.7
7.6
184
1217
M03BC01
ATC
orphenadrine (citrate); systemic
1.7
7.5
168
1088
XQ817
NOMESCO Finland
NA
80.9
7.4
8
*
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
7.4
345
2703
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.4
7.4
34
104
70891
ICD-8 Finland
Urticaria, Recidivans, Chronica
+∞
7.3
7
*
C07AA05
ATC
propranolol; systemic
1.8
7.3
141
869
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.3
7.3
18
29
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
7.3
91
480
X58
ICD-10 Finland
Exposure to other specified factors
2.0
7.3
93
496
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.4
7.3
60
264
N03AX16
ATC
pregabalin; oral
1.8
7.2
133
809
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
6.1
7.1
18
30
J31.0
ICD-10 Finland
Chronic rhinitis
2.4
7.0
58
254
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
7.0
123
734
J02AC01
ATC
fluconazole; systemic
1.6
7.0
285
2150
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
7.0
172
1140
R03AC13
ATC
formoterol; inhalant
3.0
7.0
37
126
R4110
NOMESCO Finland
Physiotherapy
1.7
6.9
160
1042
R05
ICPC
Cough
1.7
6.9
148
944
R03BA05
ATC
fluticasone; inhalant
1.8
6.7
127
779
R03AC03
ATC
terbutaline; inhalant
1.9
6.7
98
550
R03DA04
ATC
theophylline; systemic, rectal
3.8
6.6
26
70
J01FA06
ATC
roxithromycin; oral
1.6
6.6
250
1848
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.7
6.6
43
167
J30.4
ICD-10 Finland
Allergic rhinitis, unspecified
3.4
6.5
30
92
L15
ICPC
Knee symptom/complaint
1.8
6.5
122
746
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
6.5
156
1025
J45
ICD-10 Finland
Asthma
2.1
6.4
69
343
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
6.4
60
281
R60.0
ICD-10 Finland
Localized oedema
2.3
6.4
59
273
C08CA01
ATC
amlodipine; oral
1.7
6.4
148
960
X57
ICD-10 Finland
Unspecified privation
4.3
6.4
22
53
J01FA15
ATC
telithromycin; oral
2.2
6.3
65
316
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
6.3
82
442
R03BB04
ATC
tiotropium bromide; inhalant
2.6
6.3
44
177
J46
ICD-10 Finland
Status asthmaticus
3.7
6.2
25
69
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.1
549
4893
M54.5
ICD-10 Finland
Low back pain
1.6
6.1
215
1559
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
6.1
86
477
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
5.6
6.0
16
29
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTICA_IDIOPAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICA_IDIOPAT | 1.082 [0.86, 1.37] | 0.511 |
| Birth year | 0.995 [0.99, 1.0] | 0.272 |
During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 2558 females with L12_URTICA_IDIOPAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_URTICA_IDIOPAT | 1.073 [0.8, 1.43] | 0.632 |
| Birth year | 0.991 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 1446 males with L12_URTICA_IDIOPAT died.
Mortality risk
Mortality risk for people of age
years, who have L12_URTICA_IDIOPAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.094% | 0.229% |
| 5 | 0.676% | 1.245% |
| 10 | 1.577% | 3.287% |
| 15 | 3.005% | 6.357% |
| 20 | 5.357% | 10.726% |
Relationships between endpoints
↥Index endpoint: L12_URTICA_IDIOPAT – Idiopathic urticaria
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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