alopecia areata: Loss of scalp and body hair involving microscopically inflammatory patchy areas.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1003 |
4. Check minimum number of eventsNone |
1003 |
5. Include endpointsNone |
1003 |
6. Filter based on genotype QC (FinnGen only) |
1003 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60-L75
- Name in latin
- Alopecia areata
Similar endpoints
↥List of similar endpoints to
Alopecia areata
based on the number of shared cases.
Similar with more cases:
- Disorders of skin appendages
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7560 | 5187 | 2341 |
| Only index persons | 7028 | 4903 | 2125 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.15 | 0.07 |
| Only index persons | 0.15 | 0.18 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 32.57 | 36.09 | 24.73 |
| Only index persons | 33.86 | 37.07 | 26.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1003 | 781 | 222 |
| Unadjusted period prevalence (%) | 0.23 | 0.27 | 0.10 |
| Median age at first event (years) | 43.58 | 43.86 | 42.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 909
- Matched controls
- 9088
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L63.9
ICD-10 Finland
Alopecia areata, unspecified
1271.8
323.0
454
7
L63.8
ICD-10 Finland
Other alopecia areata
3540.9
323.0
387
*
L63.0
ICD-10 Finland
Alopecia (capitis) totalis
+∞
169.2
157
*
D07AC01
ATC
betamethasone; topical
5.1
111.2
518
1884
L63.1
ICD-10 Finland
Alopecia universalis
+∞
100.9
95
*
D07AD01
ATC
clobetasol; topical
5.6
86.8
299
733
L63
ICD-10 Finland
Alopecia areata
113.6
85.7
92
9
D07AC13
ATC
mometasone; topical
4.1
79.8
438
1694
S23
ICPC
Hair loss/baldness
34.3
47.0
61
19
D07AB02
ATC
hydrocortisone butyrate; topical
3.0
45.5
351
1576
70400
ICD-8 Finland
Diseases of hair and hair follicles, Alopecia areata (benigna, maligna)
+∞
38.8
37
*
E0000UV
ATC
NA
2.5
37.3
452
2573
L64.9
ICD-10 Finland
Androgenic alopecia, unspecified
187.2
35.0
36
*
L65.9
ICD-10 Finland
Nonscarring hair loss, unspecified
70.4
30.1
34
5
H02AB06
ATC
prednisolone; systemic
2.2
29.0
451
2782
XQ802
NOMESCO Finland
Epicutan test
5.4
27.4
85
169
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.8
26.3
120
351
D07AA02
ATC
hydrocortisone; topical
2.8
24.6
185
770
TQW80
NOMESCO Finland
Local dermatologic skincare
8.7
23.9
52
63
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.9
19.8
133
513
L20.0
ICD-10 Finland
Besnier prurigo
3.0
18.8
113
405
D07XC01
ATC
betamethasone, combinations; topical
2.8
18.2
124
482
E000002
ATC
NA
2.6
17.9
144
617
D07AB08
ATC
desonide; topical
2.7
17.5
127
513
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.3
17.0
180
889
L64.8
ICD-10 Finland
Other androgenic alopecia
+∞
16.7
16
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.7
16.4
122
499
E000001
ATC
NA
2.0
14.7
213
1195
D02AE01
ATC
carbamide; topical
3.1
14.6
84
292
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.4
14.3
131
599
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
7.2
13.9
33
47
L71.8
ICD-10 Finland
Other rosacea
26.2
13.4
18
7
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.9
12.5
204
1191
H03AA01
ATC
levothyroxine sodium; systemic
1.8
11.8
228
1410
L65.8
ICD-10 Finland
Other specified nonscarring hair loss
65.8
11.6
13
*
70401
ICD-8 Finland
Diseases of hair and hair follicles, Alopecia alia sive NUD
+∞
11.5
11
*
XQ845
NOMESCO Finland
Dermatoscopy
9.8
11.3
22
23
D11AH01
ATC
tacrolimus; topical
9.4
11.0
22
24
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.5
10.9
51
153
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.1
10.5
123
627
7040B
ICD-9 Finland
Diseases of hair and hair follicles, Alopecia[ALOPECIA AREATA]
+∞
10.4
10
*
L73.8
ICD-10 Finland
Other specified follicular disorders
32.9
10.3
13
*
R06AX27
ATC
desloratadine; oral
1.7
10.3
282
1922
L80
ICD-10 Finland
Vitiligo
23.7
10.3
14
6
L04AD01
ATC
ciclosporin; systemic
5.1
10.2
31
62
XQ848
NOMESCO Finland
Dermatological photography
5.2
10.1
30
59
E000003
ATC
NA
3.0
10.1
57
196
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
10.0
308
2168
R06AE07
ATC
cetirizine; oral
1.6
9.6
408
3108
D11AX14
ATC
[U] tacrolimus; topical
10.2
9.5
18
18
R06AX22
ATC
ebastine; oral
1.8
9.4
176
1068
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
9.3
153
887
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
5.5
9.3
26
48
D11AH02
ATC
pimecrolimus; topical
13.8
9.2
15
11
L04AA01
ATC
[U] ciclosporin; systemic
6.0
9.1
24
41
UJF32
NOMESCO Finland
Coloscopy
1.7
8.9
190
1200
XQ800
NOMESCO Finland
Prick test
2.2
8.7
89
427
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
8.6
239
1625
D11AX15
ATC
[U] pimecrolimus; topical
16.5
8.6
13
8
R01AD09
ATC
mometasone; nasal
1.5
8.4
414
3234
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.2
8.3
87
425
A07AA02
ATC
nystatin; oral
2.6
8.2
57
227
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.5
8.2
36
105
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.9
8.1
19
28
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
7.8
119
672
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
7.8
134
787
R03AC02
ATC
salbutamol; inhalant
1.5
7.7
457
3684
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
7.7
163
1023
D05AX52
ATC
calcipotriol, combinations; topical
2.8
7.7
47
173
E000006
ATC
NA
2.3
7.7
70
318
L70.0
ICD-10 Finland
Acne vulgaris
4.2
7.6
27
65
J05AB01
ATC
aciclovir; systemic
1.7
7.6
187
1223
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
5.2
7.6
22
43
D07AC14
ATC
methylprednisolone aceponate; topical
2.6
7.6
53
212
D06BX01
ATC
metronidazole; topical
2.0
7.5
92
477
L71.9
ICD-10 Finland
Rosacea, unspecified
5.1
7.4
22
44
H01.0
ICD-10 Finland
Blepharitis
2.5
7.4
58
245
C03DA01
ATC
spironolactone; oral
2.2
7.4
71
331
D07CC01
ATC
betamethasone and antibiotics; topical
1.9
7.4
116
663
D02AX
ATC
Other emollients and protectives
3.0
7.3
40
138
J01DA01
ATC
[U] cefalexin; systemic
1.5
7.2
522
4365
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.9
6.9
97
532
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
6.9
313
2373
L29.9
ICD-10 Finland
Pruritus, unspecified
3.6
6.8
29
83
L04AX01
ATC
azathioprine; systemic
2.6
6.8
48
193
104
Kela drug reimbursment
Thyroid insufficiency
2.2
6.7
66
313
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.0
6.6
81
420
J02AC02
ATC
itraconazole; systemic
1.7
6.6
151
970
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
6.4
86
464
L65.2
ICD-10 Finland
Alopecia mucinosa
70.3
6.4
7
*
H02AB04
ATC
methylprednisolone; systemic
1.8
6.4
116
691
A02BC02
ATC
pantoprazole; systemic
1.4
6.4
496
4155
P01BA02
ATC
hydroxychloroquine; oral
2.0
6.4
75
384
E000007
ATC
NA
2.3
6.4
59
272
J05AB11
ATC
valaciclovir; oral
1.8
6.2
113
678
N05BB01
ATC
hydroxyzine; systemic
2.2
6.2
61
292
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
3.3
6.0
28
87
Mortality – FinRegistry
↥Association
Association between endpoint L12_ALOPECAREATA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ALOPECAREATA | 1.002 [0.85, 1.18] | 0.981 |
| Birth year | 0.996 [0.99, 1.0] | 0.338 |
During the follow-up period (1.1.1998 — 31.12.2019), 192 out of 4322 females with L12_ALOPECAREATA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ALOPECAREATA | 0.868 [0.7, 1.08] | 0.206 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 1847 males with L12_ALOPECAREATA died.
Mortality risk
Mortality risk for people of age
years, who have L12_ALOPECAREATA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.179% |
| 5 | 0.573% | 1.007% |
| 10 | 1.445% | 2.59% |
| 15 | 2.937% | 4.999% |
| 20 | 5.217% | 8.461% |
Relationships between endpoints
↥Index endpoint: L12_ALOPECAREATA – Alopecia areata
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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