Food allergy

FOOD_ALLERGY

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L23.6 Cause of death: ICD-10 — L23.6 2 out of 7 registries used, show all original rules.	105
4. Check minimum number of events None	105
5. Include endpoints None	105
6. Filter based on genotype QC (FinnGen only)	105

Control definitions (FinnGen only)

Control exclude: ASTHMA_ALLERG

Extra metadata

First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L23
Name in latin: Eczema allergicum ex contactu nutrimentorum

NAME	FOOD_ALLERGY
CONTROL_EXCLUDE	ASTHMA_ALLERG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L236
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L236
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Food allergy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1444	806	635
Only index persons	1161	681	480
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.03	0.02
Median age at first event (years)
Whole population	15.11	23.09	4.90
Only index persons	19.59	26.47	9.83

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	105	77	28
Unadjusted period prevalence (%)	0.02	0.03	0.01
Median age at first event (years)	33.18	34.94	28.32

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
95: Matched controls
948

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L23.6

ICD-10 Finland

Allergic contact dermatitis due to food in contact with skin

+∞

134.9

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

14.9

24.6

XQ800

NOMESCO Finland

Prick test

16.8

20.1

L20.0

ICD-10 Finland

Besnier prurigo

8.4

14.2

C01CA24

ATC

epinephrine; parenteral

8.3

10.6

E0000UV

ATC

3.8

9.0

285

L20.9

ICD-10 Finland

Atopic dermatitis, unspecified

10.6

9.0

XQ802

NOMESCO Finland

Epicutan test

10.1

8.8

J45.0

ICD-10 Finland

Predominantly allergic asthma

8.9

7.8

E000002

ATC

4.8

7.6

J30.3

ICD-10 Finland

Other allergic rhinitis

11.4

7.3

E000001

ATC

3.7

7.3

139

D07AC13

ATC

mometasone; topical

3.6

7.2

160

J30.10

ICD-10 Finland

Allergic rhinitis due to pollen

7.2

T78.4

ICD-10 Finland

Allergy, unspecified

6.4

6.7

L23.2

ICD-10 Finland

Allergic contact dermatitis due to cosmetics

19.6

6.4

L23.9

ICD-10 Finland

Allergic contact dermatitis, unspecified cause

19.6

6.4

L27.2

ICD-10 Finland

Dermatitis due to ingested food

19.6

6.4

Mortality – FinRegistry

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Association

Association between endpoint FOOD_ALLERGY and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have FOOD_ALLERGY.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: FOOD_ALLERGY – Food allergy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Food allergy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints