primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
791 |
4. Check minimum number of eventsNone |
791 |
5. Include endpointsNone |
791 |
6. Filter based on genotype QC (FinnGen only) |
791 |
Control definitions (FinnGen only)
- Control exclude
- AUTOIMMUNE
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K74
- Name in latin
- Cirrhosis biliaris [primaria]
Similar endpoints
↥List of similar endpoints to
Primary biliary cholangitis (PBC)
based on the number of shared cases.
Similar with more cases:
- Fibrosis and cirrhosis of liver
- Diseases of liver
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Gastrointestinal diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4570 | 3617 | 916 |
| Only index persons | 3977 | 3212 | 765 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.03 |
| Only index persons | 0.10 | 0.12 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 60.86 | 60.40 | 62.52 |
| Only index persons | 59.55 | 59.08 | 61.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 791 | 650 | 141 |
| Unadjusted period prevalence (%) | 0.19 | 0.22 | 0.06 |
| Median age at first event (years) | 57.52 | 56.32 | 63.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 717
- Matched controls
- 7170
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
211.8
323.0
553
112
A05AA02
ATC
ursodeoxycholic acid; oral
2354.1
323.0
609
16
K74.3
ICD-10 Finland
Primary biliary cirrhosis
+∞
323.0
717
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
100.5
267.9
286
47
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
13.1
138.1
268
312
A07EA06
ATC
budesonide; oral, local oral
47.5
119.0
145
38
K76.9
ICD-10 Finland
Liver disease, unspecified
61.9
117.3
136
27
L04AX01
ATC
azathioprine; systemic
41.5
103.7
130
38
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.9
81.8
374
1307
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
439.4
80.6
79
*
K83.0
ICD-10 Finland
Cholangitis
47.5
78.1
95
23
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
80.0
76.2
85
12
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
61.3
58
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.7
60.7
197
443
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.8
59.9
392
1743
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
37.9
59.0
75
22
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
35.7
57.4
74
23
H03AA01
ATC
levothyroxine sodium; systemic
6.5
57.0
163
310
Z94.4
ICD-10 Finland
Liver transplant status
206.0
55.8
57
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
286.1
52.9
53
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
+∞
52.8
50
*
K51.5
ICD-10 Finland
Left sided colitis
522.5
50.0
49
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
522.5
50.0
49
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
6.9
49.7
134
232
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
114.3
49.5
53
5
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
11.5
45.3
87
85
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
163.5
44.3
46
*
5716A
ICD-9 Finland
Chronic liver disease and cirrhosis, Biliary cirrhosis[CIRRHOSIS BILIARIS PRIMARIA]
+∞
43.2
41
*
127
Kela drug reimbursment
Transplant complication
30.8
42.8
57
20
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
119.8
42.2
45
*
P01BA02
ATC
hydroxychloroquine; oral
9.3
42.2
91
110
A07EC02
ATC
mesalazine; oral, rectal
18.7
41.9
65
38
C10AC01
ATC
colestyramine; oral
15.4
41.9
70
50
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
13.2
41.3
74
62
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
32.2
38.8
51
17
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
37.8
36
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
23.3
37.6
54
25
H02AB06
ATC
prednisolone; systemic
2.8
37.0
381
2075
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
13.9
36.8
64
50
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
18.3
36.0
56
33
L04AA06
ATC
mycophenolic acid; systemic
27.6
35.9
49
19
L04AD01
ATC
ciclosporin; systemic
26.2
35.4
49
20
UJF32
NOMESCO Finland
Coloscopy
3.0
35.3
258
1120
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
68.6
34.3
39
6
K75.4
ICD-10 Finland
Autoimmune hepatitis
+∞
33.6
32
*
UJK02
NOMESCO Finland
ERCP
11.0
33.1
64
63
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
8.4
31.8
72
94
JJ5AT
NOMESCO Finland
NA
+∞
28.3
27
*
N02AX02
ATC
tramadol; systemic, rectal
2.4
27.8
352
2034
UJF30
NOMESCO Finland
Ileoscopy through colon
4.0
27.7
120
341
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
39.6
27.3
34
9
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
27.3
26
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
281.1
26.9
27
*
D97
ICPC
Liver disease NOS
35.6
26.7
34
10
K50.8
ICD-10 Finland
Other Crohn disease
+∞
26.2
25
*
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
22.9
25.9
37
17
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
269.8
25.9
26
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
140.1
25.8
27
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
24.9
347
2067
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
14.9
24.7
41
29
R94.5
ICD-10 Finland
Abnormal results of liver function studies
14.4
24.3
41
30
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
14.3
22.5
38
28
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
6.1
22.3
62
109
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
22.0
21
*
K51.8
ICD-10 Finland
Other ulcerative colitis
226.6
21.7
22
*
L04AA01
ATC
[U] ciclosporin; systemic
25.1
21.0
29
12
M05BA04
ATC
alendronic acid; oral
3.4
20.0
105
347
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
6.4
19.9
53
88
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
19.9
19
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
7.4
19.7
47
67
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
18.8
18
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.2
18.8
75
196
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
31.0
18.4
24
8
C03DA01
ATC
spironolactone; oral
3.1
18.4
109
392
K74.2
ICD-10 Finland
Hepatic fibrosis with hepatic sclerosis
+∞
17.8
17
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
97.5
17.6
19
*
C03CA01
ATC
furosemide; systemic
2.2
17.4
211
1129
JJA20
NOMESCO Finland
Open biopsy of liver
43.1
17.4
21
5
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
5.0
16.7
54
114
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
92.2
16.6
18
*
J01MA12
ATC
levofloxacin; systemic
2.5
16.5
149
687
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.6
16.2
125
530
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
16.2
173
868
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
12.0
16.2
29
25
I73.0
ICD-10 Finland
Raynaud syndrome
9.8
16.1
32
34
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
87.0
15.6
17
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
163.4
15.5
16
*
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
163.4
15.5
16
*
K74.0
ICD-10 Finland
Hepatic fibrosis
39.0
15.4
19
5
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
16.5
15.3
24
15
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
8.1
15.2
34
44
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
18.2
15.2
23
13
J01MA02
ATC
ciprofloxacin; systemic
1.9
15.2
290
1854
K74.4
ICD-10 Finland
Secondary biliary cirrhosis
+∞
14.6
14
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
+∞
14.6
14
*
107
Kela drug reimbursment
Pernicious anaemia
+∞
14.6
14
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
153.0
14.5
15
*
104
Kela drug reimbursment
Thyroid insufficiency
4.8
14.4
48
105
T89
ICPC
Diabetes insulin dependent
11.7
14.4
26
23
ZX120
NOMESCO Finland
Intravenous
3.0
14.3
88
323
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
19.6
14.3
21
11
H02AB04
ATC
methylprednisolone; systemic
2.4
13.9
127
586
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
30.7
13.9
18
6
A10AE04
ATC
insulin glargine; parenteral
3.6
13.8
64
191
K90.0
ICD-10 Finland
Coeliac disease
13.9
13.8
23
17
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
+∞
13.6
13
*
UJK12
NOMESCO Finland
Peroral cholangioscopy
142.6
13.5
14
*
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
40.9
13.2
16
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
5.4
12.9
38
73
H02AB07
ATC
prednisone; oral
2.5
12.7
109
485
L04AA05
ATC
[U] tacrolimus; systemic
71.1
12.6
14
*
6611
FHL
Needle biopsy in the operating room
+∞
12.5
12
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
12.5
12
*
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
+∞
12.5
12
*
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
+∞
12.5
12
*
R50.9
ICD-10 Finland
Fever, unspecified
2.5
12.5
100
429
A10AA01
ATC
NA
38.2
12.2
15
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
12.2
207
1246
XPX08
NOMESCO Finland
Intraoperative flow measurement
21.7
12.0
17
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
11.9
257
1678
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.1
11.9
46
118
E03
ICD-10 Finland
Other hypothyroidism
6.8
11.8
29
44
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.7
11.8
51
144
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
30.6
11.7
15
5
K75.3
ICD-10 Finland
Granulomatous hepatitis, not elsewhere classified
+∞
11.5
11
*
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
121.9
11.5
12
*
A02BC02
ATC
pantoprazole; systemic
1.8
11.4
473
3763
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
12.1
11.4
20
17
A10AA02
ATC
NA
13.0
11.2
19
15
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.4
11.1
102
469
E0000UV
ATC
NA
1.8
11.1
274
1860
A07EC01
ATC
sulfasalazine; oral, rectal
4.9
11.0
35
74
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
44.0
10.9
13
*
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
44.0
10.9
13
*
L01BB02
ATC
mercaptopurine; oral
44.0
10.9
13
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.6
10.8
49
145
J01FF01
ATC
clindamycin; systemic
1.9
10.8
193
1175
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.8
10.7
208
1301
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
10.6
160
915
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
11.4
10.6
19
17
R18
ICD-10 Finland
Ascites
5.8
10.5
29
52
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
111.6
10.4
11
*
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
111.6
10.4
11
*
L40.0
ICD-10 Finland
Psoriasis vulgaris
16.3
10.4
16
10
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
13.4
10.2
17
13
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
10.1
147
827
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
40.7
10.0
12
*
TK800
NOMESCO Finland
Hemodialysis
7.8
10.0
22
29
A07EA02
ATC
hydrocortisone; rectal
10.8
9.8
18
17
K72.9
ICD-10 Finland
Hepatic failure, unspecified
13.6
9.7
16
12
K83.1
ICD-10 Finland
Obstruction of bile duct
8.0
9.7
21
27
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.4
9.6
85
386
5739X
ICD-9 Finland
Other disorders of liver, Unspecified disorder of liver
101.3
9.4
10
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
9.4
62
237
K75.2
ICD-10 Finland
Nonspecific reactive hepatitis
+∞
9.4
9
*
PC2DE
NOMESCO Finland
Ultrasound examination of liver vasculature with Doppler method
+∞
9.4
9
*
5719X
ICD-9 Finland
Chronic liver disease and cirrhosis, Unspecified chronic liver disease without mention of alcohol
+∞
9.4
9
*
5714X
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ALIA SEU NUD]
+∞
9.4
9
*
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
+∞
9.4
9
*
WX002
NOMESCO Finland
Sedation and analgesia
1.9
9.3
155
912
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.0
9.2
52
181
H04.10
ICD-10 Finland
Dry eye syndrome
2.4
9.1
81
367
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
8.1
8.9
19
24
A06AD11
ATC
lactulose; oral
2.1
8.9
105
543
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.2
8.9
32
78
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
10.9
8.8
16
15
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
8.8
75
334
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
8.7
139
806
D64.9
ICD-10 Finland
Anaemia, unspecified
2.4
8.7
72
315
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.3
8.6
42
133
A10AE05
ATC
insulin detemir; parenteral
4.0
8.5
33
86
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
8.5
123
688
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.0
8.4
32
82
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
91.1
8.4
9
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
8.4
60
241
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
+∞
8.3
8
*
JJC60
NOMESCO Finland
Total excision of transplanted liver
+∞
8.3
8
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
8.3
8
*
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
6.6
8.2
20
31
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
7.7
8.2
18
24
XW000
NOMESCO Finland
Bone marrow biopsy
3.6
8.2
35
100
K29.3
ICD-10 Finland
Chronic superficial gastritis
3.7
8.1
34
96
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
6.4
8.1
20
32
H02AB09
ATC
hydrocortisone; systemic
6.0
8.0
21
36
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
22.3
8.0
11
5
N02BE01
ATC
paracetamol; systemic, rectal
0.6
7.8
481
5513
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.9
7.8
47
172
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
7.8
306
2299
K51
ICD-10 Finland
Ulcerative colitis
45.5
7.7
9
*
D07AC01
ATC
betamethasone; topical
1.6
7.7
219
1514
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
9.0
7.6
15
17
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
5.8
7.6
20
35
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.3
7.6
37
118
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
3.7
7.5
31
86
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
7.5
268
1961
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.2
7.5
72
340
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
4.1
7.4
27
67
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
80.9
7.4
8
*
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
80.9
7.4
8
*
D07AC13
ATC
mometasone; topical
1.7
7.4
188
1257
XG410
NOMESCO Finland
Flow-volume spirometry
3.2
7.4
37
120
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.1
7.3
81
405
H3600, E103
ICD-10 Finland
NA
+∞
7.3
7
*
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
7.3
7
*
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
+∞
7.3
7
*
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
7.3
7
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.0
7.3
39
133
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
7.3
177
1171
M05BA07
ATC
risedronic acid; oral
3.5
7.2
32
95
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.9
7.2
42
151
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
30.3
7.2
9
*
K72.1
ICD-10 Finland
Chronic hepatic failure
30.3
7.2
9
*
M81.4
ICD-10 Finland
Drug-induced osteoporosis
20.2
7.1
10
5
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.9
7.1
111
637
SBA10
NOMESCO Finland
Measurement of excretion of saliva
12.2
7.1
12
10
R06AE07
ATC
cetirizine; oral
1.5
7.1
307
2342
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
4.0
7.0
26
66
L88
ICPC
Rheumatoid/seropositive arthritis
5.5
7.0
19
35
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
6.9
96
527
C08CA05
ATC
nifedipine; systemic
2.5
6.9
52
219
H04AA01
ATC
glucagon; nasal, parenteral
40.4
6.8
8
*
M01CB01
ATC
sodium aurothiomalate; parenteral
40.4
6.8
8
*
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
16.9
6.8
10
6
A07AA02
ATC
nystatin; oral
2.5
6.8
50
206
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
6.7
89
478
J01AA02
ATC
doxycycline; systemic
1.6
6.7
546
4788
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.2
6.7
33
107
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.1
6.6
34
113
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.9
6.6
25
65
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
4.2
6.5
23
56
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
10.1
6.5
12
12
J01DB01
ATC
cefalexin; oral
1.6
6.5
544
4778
B03BA03
ATC
hydroxocobalamin; parenteral
3.3
6.5
31
98
E03.89
ICD-10 Finland
Other specified hypothyroidism
5.8
6.5
17
30
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
6.5
93
519
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
70.4
6.4
7
*
A07AA11
ATC
rifaximin; oral
70.4
6.4
7
*
N02AA05
ATC
oxycodone; systemic
1.9
6.4
96
544
M05BX04
ATC
denosumab; parenteral
2.5
6.4
48
201
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.9
6.4
92
513
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
6.3
6
*
57198
ICD-8 Finland
Cirrhosis of liver, Alia definita, alcoholismo non indicato
+∞
6.3
6
*
H3603, E103
ICD-10 Finland
NA
+∞
6.3
6
*
57199
ICD-8 Finland
Cirrhosis of liver, Unspecified
+∞
6.3
6
*
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
6.3
6
*
H26.3
ICD-10 Finland
Drug-induced cataract
26.9
6.2
8
*
XX9XE
NOMESCO Finland
Other ultrasound examination
26.9
6.2
8
*
A46
ICD-10 Finland
Erysipelas
1.9
6.2
84
458
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.1
6.2
67
334
Z94.0
ICD-10 Finland
Kidney transplant status
7.8
6.1
13
17
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
6.1
83
453
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
6.1
120
743
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.2
6.1
60
289
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
6.1
6.0
15
25
Mortality – FinRegistry
↥Association
Association between endpoint CHIRBIL_PRIM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHIRBIL_PRIM | 2.18 [1.95, 2.44] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.801 |
During the follow-up period (1.1.1998 — 31.12.2019), 822 out of 3020 females with CHIRBIL_PRIM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHIRBIL_PRIM | 2.489 [2.04, 3.04] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 293 out of 744 males with CHIRBIL_PRIM died.
Mortality risk
Mortality risk for people of age
years, who have CHIRBIL_PRIM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.199% | 0.429% |
| 5 | 1.305% | 2.574% |
| 10 | 3.684% | 6.805% |
| 15 | 7.08% | 12.789% |
| 20 | 12.048% | 21.548% |
Relationships between endpoints
↥Index endpoint: CHIRBIL_PRIM – Primary biliary cholangitis (PBC)
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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