No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
276 |
4. Check minimum number of eventsNone |
276 |
5. Include endpointsNone |
276 |
6. Filter based on genotype QC (FinnGen only) |
276 |
Control definitions (FinnGen only)
- Control exclude
- AUTOIMMUNE
Extra metadata
- First used in FinnGen datafreeze
- DF11
Similar endpoints
↥List of similar endpoints to
Autoimmune hepatitis
based on the number of shared cases.
Similar with more cases:
- Other inflammatory liver diseases
- Diseases of liver
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Gastrointestinal diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 276 | 211 | 65 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | 61.14 | 62.41 | 57.02 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 240
- Matched controls
- 2399
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K75.4
ICD-10 Finland
Autoimmune hepatitis
+∞
323.0
240
*
L04AX01
ATC
azathioprine; systemic
651.6
189.9
165
8
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
3418.7
167.4
142
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
262.5
145.6
137
12
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
97.6
128.6
137
32
A07EA06
ATC
budesonide; oral, local oral
297.8
118.5
112
7
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
106.7
65.2
69
9
H02AB06
ATC
prednisolone; systemic
12.7
63.4
199
662
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
+∞
55.4
51
*
A05AA02
ATC
ursodeoxycholic acid; oral
108.4
54.8
58
7
K76.9
ICD-10 Finland
Liver disease, unspecified
141.8
53.4
55
5
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
14.9
52.5
95
101
L01BB02
ATC
mercaptopurine; oral
275.3
45.6
45
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.4
38.8
148
484
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.7
32.4
123
375
K74.3
ICD-10 Finland
Primary biliary cirrhosis
+∞
32.0
30
*
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
81.4
31.8
35
5
H03AA01
ATC
levothyroxine sodium; systemic
9.2
30.9
70
103
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
32.9
30.0
39
14
L04AA06
ATC
mycophenolic acid; systemic
109.4
27.3
29
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
23.5
26.6
38
19
K51.5
ICD-10 Finland
Left sided colitis
+∞
26.5
25
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
24.4
23
*
A07EC02
ATC
mesalazine; oral, rectal
39.3
22.6
28
8
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
29.7
21.9
29
11
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.8
21.5
67
149
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
31.4
21.5
28
10
K83.0
ICD-10 Finland
Cholangitis
39.6
20.3
25
7
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
+∞
19.0
18
*
P01BA02
ATC
hydroxychloroquine; oral
13.0
16.6
29
25
L04AD01
ATC
ciclosporin; systemic
36.1
16.0
20
6
A02BC02
ATC
pantoprazole; systemic
3.4
16.0
182
1157
R94.5
ICD-10 Finland
Abnormal results of liver function studies
28.6
15.9
21
8
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
91.1
15.8
17
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
170.6
15.7
16
*
H02AB07
ATC
prednisone; oral
4.8
15.7
56
142
K90.0
ICD-10 Finland
Coeliac disease
38.7
14.7
18
5
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
10.4
14.4
28
30
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
21.7
14.0
20
10
UJF30
NOMESCO Finland
Ileoscopy through colon
5.2
12.9
41
91
ZX120
NOMESCO Finland
Intravenous
5.1
12.8
42
96
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
73.8
12.7
14
*
104
Kela drug reimbursment
Thyroid insufficiency
10.9
12.3
23
23
UJF32
NOMESCO Finland
Coloscopy
3.1
12.1
81
341
E03
ICD-10 Finland
Other hypothyroidism
14.6
11.7
19
14
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
+∞
11.5
11
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
12.8
11.0
19
16
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
22.7
10.8
15
7
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
114.8
10.5
11
*
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
10.5
10
*
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
10.5
10
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
10.5
10
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
9.8
10.2
20
22
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
27.3
9.9
13
5
Z94.4
ICD-10 Finland
Liver transplant status
57.3
9.7
11
*
JJA20
NOMESCO Finland
Open biopsy of liver
57.3
9.7
11
*
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
31.4
9.5
12
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
103.9
9.5
10
*
K50.8
ICD-10 Finland
Other Crohn disease
+∞
9.4
9
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.4
9.2
47
161
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
5.9
9.2
25
46
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.9
9.0
29
65
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
8.2
8.8
19
25
N02AX02
ATC
tramadol; systemic, rectal
2.3
8.8
106
606
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
93.2
8.5
9
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
8.4
8
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
8.4
8
*
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
3.1
7.7
43
157
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.7
7.6
33
99
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
7.3
54
234
UJF92
NOMESCO Finland
Capsular endoscopy
31.0
7.2
9
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
7.2
48
197
M13.9
ICD-10 Finland
Arthritis, unspecified
5.0
6.9
21
45
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
3.0
6.5
37
136
E03.89
ICD-10 Finland
Other specified hypothyroidism
9.6
6.4
12
13
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
6.3
6
*
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
27.5
6.3
8
*
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: AUTOHEP – Autoimmune hepatitis
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).